4. Future alloplastic graft development

Block bone alloplastic grafts have also been created and can be employed as a tenting function with screw-on augmentation for major deformities. In this instance, it ought to be produced in a way that makes it simple to drill, trim, and fasten screws for operation. For these reasons, several grafts with a collagen coating have been created. Furthermore, because it is more difficult to secure alloplastic block bone with a traditional screw than autogenous block bone, an anchoring device, such as a screw type, would need to be developed.

If the technology develops further, a 3D printed bone graft is anticipated, and a tailored design using alloplastic graft materials for different alveolar abnormalities may be accessible based on the CT data. After 3D printing, a reinforced tailored graft structure with sintering could be produced. Numerous attempts have been made to improve bone quality by adding DNA or glycoprotein in order to get around the drawbacks of an alloplastic graft. The healing process on angiogenesis may be accelerated by the addition of elements like polydeoxyribonucleotide (PDRN), which is DNA with anti-ischemic and anti-inflammatory properties. Although a recent study on rabbit calvaria suggested that regeneration could be accelerated, the effect was not as strong as that of rhBMP-2. Combining these growth factors with the creation of tailored grafts may be the best course of action. Before this kind of transplant can be employed in clinical settings, more data will need to be gathered as technology advances.