Relation between the stability of dental implants and two biological markers
Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study
Abstract
Objectives
The purposes of this study were to examine the correlation between the stability of dental implants and bone formation markers during the healing period and to monitor the stability of dental implants using the resonance frequency analysis (RFA) method. The null hypothesis of the study is no correlation between the stability of dental implant and bone formation markers.
Methods
The study is a prospective clinical study during the 3-month healing period of implant. At implant placement (PW Plus, Nakhon Pathom, Thailand) and after 1, 2, 3, 4, 6, 8, 10, and 12 weeks, RFA assessments were performed and gingival (GCF)/peri-implant crevicular fluids (PICF) were collected from ten patients. The level of osteocalcin (OC) was measured by using ELISA kits, and the level of alkaline phosphatase (ALP) activity was measured by colorimetric analysis. Repeated measures analysis of variance, the Friedman test, the Mann-Whitney U test, and the Pearson correlation were performed for data analysis.
Results
There was a statistical decrease in the mean implant stability quotient (ISQ) values between 1 and 3 weeks (P < 0.05). The ISQ values recovered to the initial values at 4 weeks. There was no statistical difference in the ALP level at each measurement, while there was a statistical increase in the OC level at 6, 8, 10, and 12 weeks when compared with 1 week (P < 0.05). There was a significant correlation between ALP levels and ISQ values (r = 0.226, P < 0.05). There was a statistically significant correlation between OC levels and ISQ values at 1–12 weeks (r = 0.245, P < 0.05).
Conclusions
The ISQ values were weakly correlated with both ALP and OC. The three-thread-design implant showed a high stability through healing period.
Serial posts:
- Relation between the stability of dental implants and two biological markers
- Background : Relation between the stability of dental implants (1)
- Background : Relation between the stability of dental implants (2)
- Methods : Relation between the stability of dental implants (1)
- Methods : Relation between the stability of dental implants (2)
- Methods : Relation between the stability of dental implants (3)
- Methods : Relation between the stability of dental implants (4)
- Results : Relation between the stability of dental implants
- Discussion : Relation between the stability of dental implants (1)
- Discussion : Relation between the stability of dental implants (2)
- Discussion : Relation between the stability of dental implants (3)
- Reference : Relation between the stability of dental implants
- Table 1 Inclusion and exclusion criteria
- Table 2 Profile of patients
- Table 3 ISQ values according to gender and bone quality
- Table 4 Crevicular fluid volume
- Table 5 Crevicular fluid ALP and OC levels
- Figure 1. Timeline of the clinical study
- Figure 2. Change in the mean ISQ values over time
- Figure 3. Change in the median values
- Figure 4. Change in the median values of the ALP level over time
- Figure 5. Change in the median values of the OC level over time
- Figure 6. There were weakly significant and positive correlations
- Figure 7. Comparison between biomarker levels & ISQ values
- Figure 8. There were moderately significant and positive correlations