Implants have been considered to improve treatment outcomes of completely edentulous patients with anatomical challenges compromising the retention and stability. The root form dental implants which are 3–5 mm in diameter are considered standard diameter implants while less than 3 mm diameter implants are termed mini-implants [1]. Initially, mini-implants were used as a temporary measure, with an objective to replace it with standard diameter implants at a later date. However, they provided good stability and healing [2]. In 1997, they were approved for long-term use by the FDA. They are recently being used for complete and partial denture stabilization and also for fixed bridges [2, 3]. They are primarily indicated when there is lack of space or insufficient bone to support a standard diameter implant [3]. The survival rate of mini-implants has been reported to be 94.2% [4]. They are commonly used with ball attachment, O-rings, or a soft reline material and are usually placed using a flapless surgical procedure. Although the utility of mini-implants for implant-supported overdentures has been tested in various randomized controlled trials and case reports, a comparison between standard diameter implants and mini-implants in terms of patient satisfaction and other clinical parameters is of prime importance. Hence, the aim of this systematic review and meta-analysis is to identify patient satisfaction with mini-implant-retained overdentures compared to standard diameter implant-retained overdentures.