This retrospective analysis aimed at comparing the clinical outcomes following combined surgical therapy of peri-implantitis at initially grafted and non-grafted (i.e., pristine) implant sites.

A total of 39 patients exhibiting 57 implants diagnosed with peri-implantitis (i.e., 16 implants at grafted and 41 implants at non-grafted sites) were included. Each subject had received a combined (i.e., implantoplasty and augmentative therapy) surgical treatment procedures at respective implants (grafted sites: 10 patients, 16 implants, non-grafted sites: 29 patients, 41 implants). A chi-squared test (χ²) was used to assess whether the initial grafting procedure did affect the treatment outcomes (i.e., disease resolution, bleeding on probing (BOP), probing pocket depths (PD)). The mean follow-up period was 41.9 ± 34.75 months.

At the patient level, disease resolution (i.e., absence of BOP and PD ≥ 6 mm) was obtained in 4/10 (40%) at grafted and in 7/27 (24.1%) at non-grafted implant sites (p = 0.579). BOP reductions was found to be 60.64 ± 40.81% at non-grafted and 77.45 ± 30.92% at grafted sites (p = 0.778). PD reductions amounted to 2.20 ± 2.22 mm at non-grafted and 1.57 ± 1.54 mm at grafted sites (p = 0.969).

The initial bone-grafting procedures at the implant sites did not influence the effectiveness of combined surgical therapy of peri-implantitis.