Our study supports systemic administration of MSCs to enable accelerated soft tissue sealing of the Ti surface in our rat oral implantation model. Although local MSC administration had little positive effect in our model, the MSCs accumulated around the peri-implant oral mucosa and were identified in various organs, indicating a wide range of possible applications. This study highlights that clinical cases should be considered individually prior to practical application of MSCs, and that further investigations are needed to understand the exact cellular and molecular mechanisms of MSCs following their local administration.