Implant stability is one of the important parameters that assess the loading time and dental implant success. Investigators have recommended that implants with ISQ < 49 measured when placed should not be loaded during the 3-month healing period; implants with ISQ ≥ 54 may be loaded. It is emphasized that implants with low primer stabilization value should be waited to reach a stabilization value adequate for prosthetic loading and that they must be protected against mechanical trauma and infection during this time [21].

In some studies, there is a meaningful reduction in ISQ values measured sometime after the placement of implants [22–24]. Huwiler et al. [24] have indicated that this reduction occurs during 2nd–4th week period while Monov et al. [23] have stated that it occurs as early as 4 days after the operation. In this study also, a decrease in the 1st week ISQ values was observed in the control group. Investigators have suggested that this decrease in stability values and subsequent increase are due to remodeling occurring during bone healing [22–24]. In the implants in the study group, an increase or stability was observed. A statistically significant difference was found between the study and control groups in each period of analysis. This suggests that CGF administration affects the implant primer stability by accelerating the osseointegration process.

Growth factors indicate that they accelerate tissue healing when they function effectively. Studies in the literature have reported that thrombocytes secrete growth factors from α-granules and that these releasing growth factors promote collagen synthesis. Increased collagen synthesis is thought to play a role in increasing soft tissue resistance and in the initiation of callus formation in bone tissue [14, 25–27].

Thrombocytes (platelets) also coexist with other thrombocytes, allowing the fibrin network to remain stable [28]. Within this stable, fibrin clot formation are chemical attractants in surrounding cells such as cell adhesion proteins, thrombocytes, and plasma growth factor; some of these mitogens are related to direct osteogenic cell function [29].