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Fig. 4. Comparative illustration of mean ISQ value...

Fig. 4. Comparative illustration of mean ISQ values Fig. 4. Comparative illustration of mean ISQ values

Fig. 3. Implants were placed after application of ...

Fig. 3. Implants were placed after application of CGF membrane Fig. 3. Implants were placed after application of CGF membrane

Fig. 2. CGF membrane was applied in study group im...

Fig. 2. CGF membrane was applied in study group implant sockets Fig. 2. CGF membrane was applied in study group implant sockets

Fig. 1. CGF was obtained after centrifugation : Ev...

Fig. 1. CGF was obtained after centrifugation Fig. 1. CGF was obtained after centrifugation

Table 3 Mean ISQ value changes between study and c...

  Control group Study group Immediate–1st week −2.25 ± 1.713 1.40 ± 1.847 Immediate–4th week −2.30 ± 2.774 0.60 ± 2.798 1st Week–4th week −0.05 ± 1.572 −0.80 ± 2.215   Table 3 Mean ISQ value changes between study and control groups

Table 2 Mean ISQ values in the study and control g...

  Control group Study group Immediate 75.75 ± 5.552 78.00 ± 2.828 1st week 73.50 ± 5.226 79.40 ± 2.604 4th week 73.45 ± 5.680 78.60 ± 3.136   Table 2 Mean ISQ values in the study and control groups

Table 1 Demographic data of patients : Evaluation ...

Case no. Age Sex Group Implant number 1 20 F Study 1 2 28 M Control 3 3 35 F Study 4 4 32 F Study 4 5 60 M Control 5 6 64 F Study 5 7 52 F Study 5 8 34 M Study 1 9 45 F Control 3 10 48 F Control 2 11 42 M Control 3 12 68 F Control 4   Table 1 Demographic data of patien...

About this article : Evaluation of effectiveness o...

Pirpir, C., Yilmaz, O., Candirli, C. et al. Evaluation of effectiveness of concentrated growth factor on osseointegration. Int J Implant Dent 3, 7 (2017). https://doi.org/10.1186/s40729-017-0069-3 Download citation Received: 16 December 2016 Accepted: 16 February 2017 Published: 03 March 2017 DOI: https://doi.org/10.1186/s40729-017-0069-3

Rights and permissions : Evaluation of effectivene...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...

Author information : Evaluation of effectiveness o...

Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Karadeniz Technical University, Trabzon, Turkey Cagasan Pirpir, Onur Yilmaz, Celal Candirli & Emre Balaban You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this a...

References : Evaluation of effectiveness of concen...

Prakash S, Thakur A. Platelet concentrates: past, present and future. J Maxillofac Oral Surg. 2011;10(1):45–9. Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scari G, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech. 2011;74(8):772–7. Ademokun JA, Chapman C, Dunn J, Lander D, Mair K, Proctor SJ, et al...

References : Evaluation of effectiveness of concen...

Huwiler MA, Pjetursson BE, Bosshardt DD, Salvi GE, Lang NP. Resonance frequency analysis in relation to jawbone characteristics and during early healing of implant installation. Clin Oral Implants Res. 2007;18(3):275–80. Kroese-Deutman HC, Vehof JW, Spauwen PH, Stoelinga PJ, Jansen JA. Orthotopic bone formation in titanium fiber mesh loaded with platelet-rich plasma and placed in segmental defe...

References : Evaluation of effectiveness of concen...

Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci. 2008;13:3532–48. Anitua E, Sanchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, et al. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009;42(2):162–70. He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and ...

References : Evaluation of effectiveness of concen...

Raghavendra S, Wood MC, Taylor TD. Early wound healing around endosseous implants: a review of the literature. Int J Oral Maxillofac Implants. 2005;20(3):425–31. Oncu E, Bayram B, Kantarci A, Gulsever S, Alaaddinoglu EE. Positive effect of platelet rich fibrin on osseointegration. Med Oral Patol Oral Cir Bucal. 2016;21(5):e601–7. Anitua E. Plasma rich in growth factors: preliminary results o...

Abbreviations : Evaluation of effectiveness of con...

Bone morphogenetic protein Concentrated growth factor Computed tomography Insulin-like growth factor Platelet-derived growth factor Platelet-rich fibrin Platelet-rich plasma Resonance frequency analysis Transforming growth factor-β1 Transforming growth factor-β2 Vascular endothelial growth factor

Conclusions : Evaluation of effectiveness of conce...

Considering this data, it appears that application of CGF enhanced stability of implants and accelerated osseointegration in the early period. CGF has positive effects on the ISQ value at the first week and fourth week. Further laboratory studies are needed to demonstrate the positive effects of blood products on the osseointegration process at the histopathological level.

Discussion : Evaluation of effectiveness of concen...

In a study by Monov et al. using PRP around the implant, a higher stability value was obtained in the study group during the early recovery period (6 weeks) although difference between the groups was not statistically significant [23]. Kim et al. reported in a study that there was a statistically significant increase in bone-implant contact with PRP administration in the vicinity of the implant [...

Discussion : Evaluation of effectiveness of concen...

Introduced in 1998 by Marx, PRP is used in oral and maxillofacial surgeries to speed up the recovery of grafts in bone-grafted areas [14, 26–30]. Although many studies have shown that platelet-rich plasma affects bone healing positively, the results of some other studies suggest otherwise [31, 32]. In recent years, the platelet-rich fibrin (PRF) was described by Choukroun as a second-generation...

Discussion : Evaluation of effectiveness of concen...

Implant stability is one of the important parameters that assess the loading time and dental implant success. Investigators have recommended that implants with ISQ 

Results : Evaluation of effectiveness of concentra...

The study includes 12 patients (5 males, 7 females). Patients participating in the study are between 20–68 years of age and the mean age is 44 years. A total of 40 implants were placed, 20 of these were included in the study group (50%), and the other 20 were included in the control group (50%). Twenty-one implants were placed in type 2 bone, 19 implants in type 3 bone (Table 1). The distribu...

Methods : Evaluation of effectiveness of concentra...

Independent sample t test was applied between the two groups by taking the differences between the data obtained in these periods. Two-way ANOVA and Fisher’s LSD test was used for evaluating the associations among group and insertion torque. A value of p 

Methods : Evaluation of effectiveness of concentra...

All surgical procedures were performed under local anesthesia by the same surgeon. A full-thickness mucoperiosteal flap was removed by incision on the alveolar crest. Implant cavities were prepared according to the surgical protocol of the Bego Semados implant system (BEGO Implant Systems GmbH & Co. KG, Bremen, Germany). The final osteotomy diameters were the same as the placed implants. In the st...

Methods : Evaluation of effectiveness of concentra...

This study was conducted in compliance with the principles of the Declaration of Helsinki, and approval of the ethics committee required for the study was obtained from the Ethics Committee of the Karadeniz Technical University (2015/21). The procedures to be performed were explained in detail and patients signed the consent forms. The study was carried out on individuals who applied to Karadeniz ...

Background : Evaluation of effectiveness of concen...

That the implant has sufficient stability after placement is important for providing the necessary bone formation around the implant and for the optimal distribution of functional forces at the implant-bone interface during healing [15–17]. It can be said that resonance frequency analysis (RFA) is a very important tool for tracking the osseointegration process [18, 19]. RFA is a technique that ...

Background : Evaluation of effectiveness of concen...

Osseointegration of dental implants is important for long-term success and stability. There is no standardization in terms of the time of osseointegration and the timing of prosthetic loading. This process varies between 0–6 months [1]. Various strategies are being explored to shorten this period. Changes in implant surface properties and design have increased primer stability and helped the pe...

Abstract : Evaluation of effectiveness of concentr...

Growth factor-containing products have been reported to increase implant stability and accelerate osseointegration. Concentrated growth factor (CGF) can be used for this purpose with the growth factors it contains. The aim of this study is to assess the effect of CGF on implant stability and osseointegration. Twelve patients with maxillary anterior toothless were included in the study. Implant ca...

Fig. 4. Comparative illustration of mean ISQ value...

Fig. 4. Comparative illustration of mean ISQ values Fig. 4. Comparative illustration of mean ISQ values

Fig. 3. Implants were placed after application of ...

Fig. 3. Implants were placed after application of CGF membrane Fig. 3. Implants were placed after application of CGF membrane

Fig. 2. CGF membrane was applied in study group im...

Fig. 2. CGF membrane was applied in study group implant sockets Fig. 2. CGF membrane was applied in study group implant sockets

Fig. 1. CGF was obtained after centrifugation : Ev...

Fig. 1. CGF was obtained after centrifugation Fig. 1. CGF was obtained after centrifugation

Table 3 Mean ISQ value changes between study and c...

  Control group Study group Immediate–1st week −2.25 ± 1.713 1.40 ± 1.847 Immediate–4th wee...

Table 2 Mean ISQ values in the study and control g...

  Control group Study group Immediate 75.75 ± 5.552 78.00 ± 2.828 1st week ...

Table 1 Demographic data of patients : Evaluation ...

Case no. Age Sex Group Implant number 1 20 ...

About this article : Evaluation of effectiveness o...

Pirpir, C., Yilmaz, O., Candirli, C. et al. Evaluation of effectiveness of concentrated growth factor on osseointegration. Int J Implant Dent 3, 7 (2017). https://doi.org/10.1186/s40729-017-0069-3 Download citation Received: 16 December 2016 Accepted: 16 February 2017 Published: 03 March 2017 DOI: https://doi.org/10.1186/s40729-017-0069-3

Rights and permissions : Evaluation of effectivene...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...

Author information : Evaluation of effectiveness o...

Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Karadeniz Technical University, Trabzon, Turkey Cagasan Pirpir, Onur Yilmaz, Celal Candirli & Emre Balaban You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar You can also search for this author in ...

References : Evaluation of effectiveness of concen...

Prakash S, Thakur A. Platelet concentrates: past, present and future. J Maxillofac Oral Surg. 2011;10(1):45–9. Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scari G, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech. 2011;74(8):772–7. Ademokun JA, Chapman C, Dunn J, Lander D, Mair K, Proctor SJ, et al...

References : Evaluation of effectiveness of concen...

Huwiler MA, Pjetursson BE, Bosshardt DD, Salvi GE, Lang NP. Resonance frequency analysis in relation to jawbone characteristics and during early healing of implant installation. Clin Oral Implants Res. 2007;18(3):275–80. Kroese-Deutman HC, Vehof JW, Spauwen PH, Stoelinga PJ, Jansen JA. Orthotopic bone formation in titanium fiber mesh loaded with platelet-rich plasma and placed in segmental defe...

References : Evaluation of effectiveness of concen...

Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci. 2008;13:3532–48. Anitua E, Sanchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, et al. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009;42(2):162–70. He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and ...

References : Evaluation of effectiveness of concen...

Raghavendra S, Wood MC, Taylor TD. Early wound healing around endosseous implants: a review of the literature. Int J Oral Maxillofac Implants. 2005;20(3):425–31. Oncu E, Bayram B, Kantarci A, Gulsever S, Alaaddinoglu EE. Positive effect of platelet rich fibrin on osseointegration. Med Oral Patol Oral Cir Bucal. 2016;21(5):e601–7. Anitua E. Plasma rich in growth factors: preliminary results o...

Abbreviations : Evaluation of effectiveness of con...

Bone morphogenetic protein Concentrated growth factor Computed tomography Insulin-like growth factor Platelet-derived growth factor Platelet-rich fibrin Platelet-rich plasma Resonance frequency analysis Transforming growth factor-β1 Transforming growth factor-β2 Vascular endothelial growth factor

Conclusions : Evaluation of effectiveness of conce...

Considering this data, it appears that application of CGF enhanced stability of implants and accelerated osseointegration in the early period. CGF has positive effects on the ISQ value at the first week and fourth week. Further laboratory studies are needed to demonstrate the positive effects of blood products on the osseointegration process at the histopathological level.

Discussion : Evaluation of effectiveness of concen...

In a study by Monov et al. using PRP around the implant, a higher stability value was obtained in the study group during the early recovery period (6 weeks) although difference between the groups was not statistically significant [23]. Kim et al. reported in a study that there was a statistically significant increase in bone-implant contact with PRP administration in the vicinity of the implant [...

Discussion : Evaluation of effectiveness of concen...

Introduced in 1998 by Marx, PRP is used in oral and maxillofacial surgeries to speed up the recovery of grafts in bone-grafted areas [14, 26–30]. Although many studies have shown that platelet-rich plasma affects bone healing positively, the results of some other studies suggest otherwise [31, 32]. In recent years, the platelet-rich fibrin (PRF) was described by Choukroun as a second-generation...

Discussion : Evaluation of effectiveness of concen...

Implant stability is one of the important parameters that assess the loading time and dental implant success. Investigators have recommended that implants with ISQ 

Results : Evaluation of effectiveness of concentra...

The study includes 12 patients (5 males, 7 females). Patients participating in the study are between 20–68 years of age and the mean age is 44 years. A total of 40 implants were placed, 20 of these were included in the study group (50%), and the other 20 were included in the control group (50%). Twenty-one implants were placed in type 2 bone, 19 implants in type 3 bone (Table 1). The distribu...

Methods : Evaluation of effectiveness of concentra...

Independent sample t test was applied between the two groups by taking the differences between the data obtained in these periods. Two-way ANOVA and Fisher’s LSD test was used for evaluating the associations among group and insertion torque. A value of p 

Methods : Evaluation of effectiveness of concentra...

All surgical procedures were performed under local anesthesia by the same surgeon. A full-thickness mucoperiosteal flap was removed by incision on the alveolar crest. Implant cavities were prepared according to the surgical protocol of the Bego Semados implant system (BEGO Implant Systems GmbH & Co. KG, Bremen, Germany). The final osteotomy diameters were the same as the placed implants. In the st...

Methods : Evaluation of effectiveness of concentra...

This study was conducted in compliance with the principles of the Declaration of Helsinki, and approval of the ethics committee required for the study was obtained from the Ethics Committee of the Karadeniz Technical University (2015/21). The procedures to be performed were explained in detail and patients signed the consent forms. The study was carried out on individuals who applied to Karadeniz ...

Background : Evaluation of effectiveness of concen...

That the implant has sufficient stability after placement is important for providing the necessary bone formation around the implant and for the optimal distribution of functional forces at the implant-bone interface during healing [15–17]. It can be said that resonance frequency analysis (RFA) is a very important tool for tracking the osseointegration process [18, 19]. RFA is a technique that ...

Background : Evaluation of effectiveness of concen...

Osseointegration of dental implants is important for long-term success and stability. There is no standardization in terms of the time of osseointegration and the timing of prosthetic loading. This process varies between 0–6 months [1]. Various strategies are being explored to shorten this period. Changes in implant surface properties and design have increased primer stability and helped the pe...

Abstract : Evaluation of effectiveness of concentr...

Growth factor-containing products have been reported to increase implant stability and accelerate osseointegration. Concentrated growth factor (CGF) can be used for this purpose with the growth factors it contains. The aim of this study is to assess the effect of CGF on implant stability and osseointegration. Twelve patients with maxillary anterior toothless were included in the study. Implant ca...