Osseointegration of dental implants is important for long-term success and stability. There is no standardization in terms of the time of osseointegration and the timing of prosthetic loading. This process varies between 0–6 months [1]. Various strategies are being explored to shorten this period. Changes in implant surface properties and design have increased primer stability and helped the peri-implant tissue remain healthy. These changes have aimed to increase bone-implant surface connectivity and accelerate healing. Another method of accelerating osseointegration is the modulation of healing after the placement of the implant [2]. This modulation, in turn, can be achieved by bioactive molecules that increase osteoblastic differentiation and accelerate bone healing around the implant [2].

Growth factors are bioactive proteins that control the wound healing process. The platelet-containing preparations derived from human blood contain many growth factors such as bone morphogenetic protein (BMP), platelet-derived growth factor (PDGF), insulin-like growth factor (IGF), vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1), and transforming growth factor-β2 (TGF-β2), which also play a key role in bone healing [3–5]. These growth factors attract the undifferentiated mesenchymal cells to the wound site, thus facilitating angiogenesis, chemotaxis, and cell proliferation [2].

Various platelet concentrates such as platelet-rich plasma (PRP), platelet-rich fibrin (PRF), and concentrated growth factor (CGF) are used to reconstruct bone defects [6]. PRF has been shown to have very successful results in tissue engineering in many studies [7–9]. Furthermore, a study by Sohn et al. has shown the higher regeneration capacity and multipurpose use of CGF in 2009 [10].

This preparation’s potential is because it contains growth factor-containing fibrin network; it contains fibroblast, platelet, leukocyte, and endothelial cell for angiogenesis and tissue remodeling; and it provides matrix for cell migration [11]. Platelets, in particular, contain biologically active proteins at high concentrations and support healing, growth, and cell morphogenesis [12–14].