Introduced in 1998 by Marx, PRP is used in oral and maxillofacial surgeries to speed up the recovery of grafts in bone-grafted areas [14, 26–30]. Although many studies have shown that platelet-rich plasma affects bone healing positively, the results of some other studies suggest otherwise [31, 32].

In recent years, the platelet-rich fibrin (PRF) was described by Choukroun as a second-generation platelet concentrate [33]. PRF is defined as leukocyte and platelet-rich fibrin biomaterial. PRF is used to accelerate healing in maxillary sinus augmentation, socket healing after tooth extraction, filling of the cyst cavity, treatment of furcation defects in periodontology, and soft tissue injuries [34].

The positive effects of blood products on healing have also triggered the development of products in different concentrations. One of these products, the concentrated growth factor (CGF), was defined by Sacco in 2006 [35]. CGF also has its own centrifugal technique in a manner similar to PRF. A longer and denser fibrin matrix with higher growth factor content was obtained by the different centrifugation technique [35].

Regional CGF administration increases FGF-β or VEGF release, which plays an active role in angiogenesis, as well as enhancing neutrophil migration by performing integrin release. It has also been shown that CGF contains such growth factors and CD34-positive cells [35]. It has been reported that CD34-positive cells in the cells also provide angiogenesis, neovascularization, and vascular continuity [36, 37].

In an animal study, CGF, PRF, and PRP were placed separately in the defects formed in the rabbit skull in the study group; the defects were left empty in the control group. Histomorphometric analysis revealed statistically significant differences between control and study groups in the growth of new bone formation at 6 and 12 weeks. In the study group, the greatest bone formation was observed in the CGF-treated group but this difference was not statistically significant [38]. In a study by Takeda et al. performed on rats, it was observed that cell proliferation and osteoblastic differentiation in the cell culture from the CGF-treated group was significantly higher than in the other groups [39].