An 84-year-old white woman was referred to private dental clinic for an implant rehabilitation treatment. Intraoral examination revealed healthy mucosa and there was not any sign of infection. Her past medical history was unremarkable. The radiography of the molar region showed with a quite ill-defined radiolucent area presenting irregular borders associated to dental implant (Fig. 1). This condition was asymptomatic and no expansion of the mandibular cortical bone was detected. Under local anesthesia, a biopsy was performed and the tissue submitted to the Bauru School of Dentistry Oral Pathology Biopsy Service of the University of São Paulo. The histopathological examination revealed normal hematopoietic bone marrow characterized by erythroid, granulocytic, monocytic, and lymphocytic series (Fig. 2). In addition, megakaryocytes, fat cells, and bone trabeculae were also observed (Fig. 3). Abnormal morphology of the hematopoietic cells or malignant cells was not seen. The histopathological findings confirmed the diagnosis of focal osteoporotic bone marrow defect of the mandible.