All metal prostheses except the implant screw and abutment were removed, and the eczema reaction was reduced to 30%; the symptoms still remained. The removal of the titanium implant screw and abutment in 2014 led to a full recovery. In Korea, allergy condition has also been reported after the installation of titanium implants. In 2012, a 70-year-old woman exhibited a stomatitis that appeared to be an allergic reaction. There was no evidence of metal hypersensitivity in this patient. There were no problems with the implant placement; however, after the abutment was raised and the prosthesis was made, the patient complained of pain. Removal of the prosthesis confirmed erythema on the gingiva around the abdominal cavity. Allergic symptoms were suspected to be due to TiN-coated abutments, and symptoms improved after the use of titanium abutments. A patch test showed a positive result for TiN.

Allergic reactions to titanium materials have also been reported with orthopedic prostheses. Thomas et al. reported eczema symptoms and improper bone formation in the case of a 35-year-old male patient with a titanium implant in the fracture of his hand. In this case, the patch test showed a negative reaction to titanium, nickel, chromium, cobalt, etc. However, the lymphocyte transformation test showed an increased pattern for titanium. Additionally, in 1991, Lalor et al. also reported hypersensitivity reactions to titanium and reported the proliferation of inflammatory cells in patients with failed orthopedic prostheses.

Although the biocompatibility of titanium has been evaluated to be good because it causes less hypersensitive reaction than other metals, it does not mean that allergy symptoms related to titanium do not exist. Previous reports have shown that hypersensitive reactions to titanium and titanium alloys can lead to failures in clinical treatment. Therefore, allergy symptoms of titanium or titanium alloy components should also be accounted for a related factor to dental implants failures.