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Background : Direct activation of platelets by addition of CaCl2 leads coagulation of platelet-rich plasma [2]

Background : Direct activation of platelets by addition of CaCl2 leads coagulation of platelet-rich plasma [2]

author: Toshihisa Toyoda, Kazushige Isobe, Tetsuhiro Tsujino, Yasuo Koyata, Fumitaka Ohyagi, Taisuke Watanabe, Masayuki Nakamura, Yutaka | publisher: drg. Andreas Tjandra, Sp. Perio, FISID

In this study, we attempted to dissociate platelets from the coagulation pathway and to evaluate possible direct action of Ca2+ on platelet functions in citrated whole-blood samples. In addition, in response to recent increasingly frequent requests for scheduled or outsourced, but not immediate on-site, preparation of various platelet concentrate types [4, 5], we examined time course changes in platelet responsiveness to added CaCl2 along with coagulation time in stored whole-blood samples.

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