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Conclusions : Direct activation of platelets by addition of CaCl2 leads coagulation of platelet-rich plasma

Conclusions : Direct activation of platelets by addition of CaCl2 leads coagulation of platelet-rich plasma

author: Toshihisa Toyoda, Kazushige Isobe, Tetsuhiro Tsujino, Yasuo Koyata, Fumitaka Ohyagi, Taisuke Watanabe, Masayuki Nakamura, Yutaka | publisher: drg. Andreas Tjandra, Sp. Perio, FISID

In addition to the well-known intrinsic coagulation pathway, which activates platelets via thrombin conversion, added Ca2+ may directly activate washed platelets and promote clot formation alone and in cooperation with the coagulation pathway as illustrated in Fig. 8. Therefore, it is possible to control platelet activation levels and the consequent growth factor release by modulating not only indirect but also direct activation pathways.

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