Results from the present in vivo analysis revealed that both sandblasted and acid-etched titanium implants and laser-treated titanium implants, compared to the machined ones, have higher values of osseointegration in less healing time.

Indeed, both groups A and B at 15 days had higher values of the BIC% if compared to group C and were able to significantly increase their BIC% in the passage from 15 to 30 days, allowing safe early occlusal load protocol.

The superior initial bone feeling could be ascribed to the micro-geometry that ensures great osteoblasts adhesion and proliferation.

Data of the present study confirmed that the use of laser or sandblasted and acid-etched implant surfaces should be preferable to machined ones, especially in the case of low-density bone or immediate loading protocols.

Future clinical studies are needed to confirm the results of the present in vivo animal study.