Results : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [1]
At time of surgery, the patients ranged in age from 33 to 79 years (mean age 53.8 years).
The first surgeries for implant placement in the test group were carried out as described above. Two layers of a PRF matrix were placed on top of the implant. Though surgical flaps were all sutured completely free of tension, a post-operative dehiscence above the implant could be observed in all test patients within the first week. This process resulted in a complete loss of mucosal and augmented tissues above the implant. The open areas were healed by secondary intention (illustration 11). The wounds in the control group healed uneventfully by primary intention; no dehiscences occurred.
Due to ethical reasons, the test group had to be terminated after 10 patients. The already recruited, remaining patients were consequently all added to the control group. Finally, the study was finished with a total number of 31 consecutive patients (16 males and 15 females, 10 patients in the test group, 21 in the control group).
No drop-out occurred within the 6 months. All implants were clinically osseointegrated and stable and showed no sign of infection.
Crestal mucosa thickness in test group dropped from 2.20 mm ± 0.48 SD at baseline to 0.90 mm ± 1.02 SD at reentry. This loss was statistically significant. Buccal mucosa thickness was 1.85 mm ± 0.41 SD at baseline and 2.15 mm ± 0.78 SD at 3-month follow-up, and lingual thickness started from 1.55 mm ± 0.44 SD and resulted in 1.80 mm ± 0.63 SD. Buccal and lingual data did not reach statistical significance. Within the limited data provided by the early termination of the study, it can be stated that PRF under the condition of a split-flap design failed to improve the thickness of the mucosa.
In the control group, crestal mucosa thickness decreased from 2.64 mm ± 0.48 SD at baseline to 2.62 mm ± 0.61 SD at 3-month follow-up. Buccal and lingual mucosa was 2.29 mm ± 0.54 SD resp. 1.62 mm ± 0.55 SD at baseline and dropped to 2.36 mm ± 0.48 SD resp. 1.86 mm ± 0.53 SD. The differences of all three measuring points were not statistically significant (Figs. 1 and 2).
Serial posts:
- Abstract : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial
- Background : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [1]
- Background : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [2]
- Methods : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [1]
- Methods : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [2]
- Methods : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [3]
- Results : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [1]
- Results : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [2]
- Discussion : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [1]
- Discussion : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [2]
- Conclusions : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial
- Abbreviations : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial
- References : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [1]
- References : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [2]
- References : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [3]
- Acknowledgements : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial
- Author information : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial
- Additional information : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial
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- About this article : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial
- Illustration 1. Measurement of tissue thickness with an endodontic micro-opener : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Illustration 2. Crestal incision and preparation of a split-flap : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Illustration 3. Insertion of the implant : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Illustration 4. NobelSpeedy Replace® (source: https://www.nobelbiocare.com/de/de/home/products-and-solutions/implant-systems/nobelspeedy.html) : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Illustration 5. Implant placed with a split-flap technique : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Illustration 6. PRF membrane made by centrifugating and pressing the patient’s blood : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Illustration 7. Insertion of PRF membranes in a double-layered technique for tissue augmentation : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Illustration 8. Fixation of the flap with Seralene® 6.0 : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Illustration 9. a–c Radiographic control a at time of implant placement (a), 3 months post-operative (b), and 6 months post-operative (c) : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Illustration 10. a–d Second measuring, reentry, and insertion of a screwed, full ceramic crown : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Illustration 11. a–d Post-operative healing process at 3 days post-operative (a), 1 week post-operative (b), 1 month post-operative (c), and 3 months post-operative (d) : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Fig. 1. Control group (no PRF augmentation) : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Fig. 2. Test group (PRF augmentation) : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant
- Fig. 3. Peri-implant bone level at baseline, 3 months post-operative, and 6 months post-operative. a Mesial defect depth. b Mesial defect width. c Distal defect depth. d Distal defect width : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implant