Results : The effect of PRF (platelet-rich fibrin) inserted with a split-flap technique on soft tissue thickening and initial marginal bone loss around implants: results of a randomized, controlled clinical trial [2]

The mean marginal bone level alterations are displayed in Fig. 3.

Six months after surgery, both groups showed a statistically significant peri-implant bone loss.

The mesial resp. distal defect depth was 0.70 mm ± 0.72 SD resp. 0.64 mm ± 0.66 SD at baseline. Six months later, the marginal bone defect increased to 1.47 mm ± 0.65 SD on the mesial side resp. 1.46 mm ± 0.54 SD on the distal side. The corresponding defect width changed from 0.7 mm ± 0.72 SD to 1.22 mm ± 0.57 SD (mesially) and from 0.65 mm ± 0.64 SD to 1.27 mm ± 0.55 SD (distally).

In the control group, defect depth changed from 0.13 mm ± 0.26 SD to 0.86 mm ± 0.52 SD (mesially) and from 0.2 mm ± 0.37 SD to 1.02 mm ± 0.62 SD (distally). Defect width increased from 0.09 mm ± 0.17 SD to 0.60 mm ± 0.47 SD (mesially) and from 0.24 mm ± 0.42 SD to 0.81 mm ± 0.44 SD (distally).

The test group showed a mean bone loss of 0.77 mm ± 0.42 SD/0.57 mm ± 0.44 SD (defect depth/defect width) on the mesial side and 0.82 mm ± 0.42 SD/0.62 mm ± 0.36 SD (defect depth/defect width) on the distal side.

In the control group, a mean bone loss of 0.72 mm ± 0.61 SD/0.51 mm ± 0.48 mm (defect depth/defect width) on the mesial side and 0.82 mm ± 0.77 SD/0.57 mm ± 0.58 SD (defect depth/defect width) on the distal side was measured.

However, the comparison of the differences in bone loss showed no significance between the control and test groups (all p > 0.05, Mann–Whitney U test).