Table 2
Assessment of risk of bias and heterogeneity within and across the included studies
: Genomic analyses of early peri-implant bone healing in humans: a systematic review
Table 2 Assessment of risk of bias and heterogeneity within and across the included studies : Genomic analyses of early peri-implant bone healing in humans: a systematic review
author: Siddharth Shanbhag, Vivek Shanbhag, Andreas Stavropoulos | publisher: drg. Andreas Tjandra, Sp. Perio, FISID
Category | Ivanovski et al. [ 34 ] | Donos et al. 2011 [ 35 ] | Bryington et al. [ 36 ] | Thalji et al. [ 37 ] |
---|---|---|---|---|
Study design | ||||
Comparison | None (only SLActive) | SLA vs. SLActive | TiOBlast vs. Osseospeed | TiOBlast vs. Osseospeed |
Setting | University | University | University | University |
Population, inclusion criteria | 9 healthy volunteers with no mandibular third molars, no contraindications for oral surgery; age 21 to 48, median 29 years | 9 healthy volunteers with no mandibular third molars; age 21 to 48, median 29 years | 6 women, 4 men; implant patients, systemically healthy (no HTN, diabetes, CVD); age 25 to 58, mean 36.2 years | 9 women, 2 men; implant patients, systemically healthy; age 47 to 69, mean 60.2 years |
Exclusion criteria | Smokers | Smokers | Smokers, pregnancy, periodontal/periapical disease, subjects taking bisphosphonates, hormone replacement therapy, corticosteroids | Smokers, uncontrolled diabetes, history of head/neck radiotherapy, taking corticosteroids, bisphosphonates |
Comparability of groups | Unclear | Unclear | Unclear | Unclear |
Potential confounders, e.g., post-op medication | Unclear | Unclear | Unclear | Unclear |
Power calculation | No | No | No | No |
Statistical correction | For multiple sampling | For multiple sampling | Unclear | For multiple sampling |
Methods | ||||
Tissue analyzed | Peri-implant tissue | Peri-implant tissue | Implant-adherent cells | Implant-adherent cells |
Genetic material analyzed | Total RNA | Total RNA | Total RNA | Total RNA |
Success rate | Unclear | 16/18 samples (88.8%) | 7/10 subject samples (70%) | Unclear |
Genotyping method | Microarray | Microarray | RT-PCR | Whole-genome microarray |
Genotype counts | Yes | Yes | Yes | Yes |
Blinding | Unclear | Unclear | Yes | Unclear |
Reproducibility, validated genotyping accuracy | No | No | No | No |
Table 2 Assessment of risk of bias and heterogeneity within and across the included studies
Serial posts:
- Abstract : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Review : Genomic analyses of early peri-implant bone healing in humans: a systematic review [1]
- Review : Genomic analyses of early peri-implant bone healing in humans: a systematic review [2]
- Methods : Genomic analyses of early peri-implant bone healing in humans: a systematic review [1]
- Methods : Genomic analyses of early peri-implant bone healing in humans: a systematic review [2]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [1]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [2]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [3]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [4]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [5]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [6]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [7]
- Conclusions : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [1]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [2]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [3]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [4]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [5]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [6]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [7]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [8]
- Author information : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Additional information : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Rights and permissions : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- About this article : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Table 1 Assessment of the genotyping methodology in the included studies : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Table 2 Assessment of risk of bias and heterogeneity within and across the included studies : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Table 3 Summary of findings from the included studies (n = 4) : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Table 4 Summary of biological processes and associated genes reported in the included studies : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Figure 1. Flowchart for study selection (n = number of studies). : Genomic analyses of early peri-implant
- Figure 2. Summary of biological processes identified via gene expression during early peri-implant bone healing. CKs, cytokines; GFs, growth factors; EPC, endothelial progenitor cells; EC, endothelial cells; MSC, mesenchymal stem cells; OB, osteoblasts; ECM, extracellular matrix; HSC, haematopoietic stem cells; MP, macrophages; OC, osteoclasts. : Genomic analyses of early peri-implant