Table 4
Summary of biological processes and associated genes reported in the included studies
: Genomic analyses of early peri-implant bone healing in humans: a systematic review
Table 4 Summary of biological processes and associated genes reported in the included studies : Genomic analyses of early peri-implant bone healing in humans: a systematic review
author: Siddharth Shanbhag, Vivek Shanbhag, Andreas Stavropoulos | publisher: drg. Andreas Tjandra, Sp. Perio, FISID
Process | Upregulated genes |
---|---|
Category (gene code) | |
Inflammation/immune response | |
Pro-inflammatory cytokines | Tumor necrosis factor (TNF-a, TNFSF9) |
Interleukin (IL-6, IL-2, IL-1 F9, IL-23A, IL-6ST) | |
Interferon (IFNA2) | |
Nuclear factor-kB (I-kB kinase/NF-kB) | |
Anti-inflammatory cytokines | Interleukin (IL-22, IL-9) |
Toll interacting protein (TOLLIP) | |
Cells | Lymphocyte, macrophage negative proliferation (BTLA, LST1) |
Macrophage scavenger receptor (MSR1) | |
Chemotaxis | Chemokines (CCR8, CCL18, CCL22, CXCL10, CXCL14) |
Osteoinduction/osteogenesis | |
Growth factors (GF)/signaling pathways | Insulin-like GF (IGF1) |
Transforming GF (TGF-b, TGF-b receptor 1, 2 and 3, TGF-a) | |
Platelet-derived GF (PDGF receptor) | |
Bone morphogenetic proteins (BMP4, BMP6, BMP receptor 1A, BMP2-K) | |
Growth and differentiation factor (GDF10) | |
Wnt frizzled receptor (FZD3, FZD8, FRZB) | |
Notch (NOTCH2) | |
Ras-protein signal transduction (RAP1B, RAP1A, RASGRP4) | |
Mitogen activated protein kinase (MAP3K7IP2, MAPK9, MAP2K3, MAP3K2) | |
Transcription factors | ‘Master switches’ [RUNX2, SP7 (OSX)] |
Homeobox (DLX1, DLX5, HOXD12, MSX1, HOXA5, HOXB1, HOXB6, HOXC6) | |
SP [SP1, SP3, SP7 (Osx)] | |
Twist (TWIST 1-receptor) | |
ECM deposition/organization | Collagen (Col1A1, Col12A1, Col6A3, Col3A1, Col6A1, Col11A1, Col11A2, Col13A1, Col5A2) |
Non-collagen proteins [BGLAP (OC), SPARC (ON), SPP1 (OP), BSP, IBSP, POSTN, ECM1] | |
Small leucine-rich proteoglycans (SLRP) (DCN, BGN, LUM) | |
Heat-shock protein 47 (HSP47) | |
Alkaline phosphatase (ALPL) | |
Cadherin (CDH11) | |
Integrin (ITGB4, ITGB5) | |
Laminin (LAMA2, LAMA3) | |
Pro-collagen lysyl-hydroxylase (PLOD1, PLOD2, PLOD3) | |
Pro-collagen C-endopeptidase enhancer (PCOLCE) | |
Lysyl-oxidase (LOX) | |
Osteoclast activity/remodeling | Cathepsin K (CTSK, CTSK-receptor) |
Tartarate-resistant acid phosphatase (TRAP/ACP5) | |
Matrix metallopeptidase (MMP2, MMP12, MMP9, MMP7, MMP13) | |
Tissue inhibitor metallopeptidase (TIMP2, TIMP3) | |
Angiogenesis | Vascular endothelial GF-signaling (EPAS1, ANXA2, EGR1-binding protein) |
Phosphatidyl-inositol 3-kinase (PI3K)-Akt signaling | |
Neurogenesis | Brain-derived neurotrophic factor (BDNF) |
Neurotrophin 3 (NTF3) | |
NK2 homeobox 2(NKX2-2) | |
Tubby-like protein 3 (TULP3) |
Table 4 Summary of biological processes and associated genes reported in the included studies
Serial posts:
- Abstract : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Review : Genomic analyses of early peri-implant bone healing in humans: a systematic review [1]
- Review : Genomic analyses of early peri-implant bone healing in humans: a systematic review [2]
- Methods : Genomic analyses of early peri-implant bone healing in humans: a systematic review [1]
- Methods : Genomic analyses of early peri-implant bone healing in humans: a systematic review [2]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [1]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [2]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [3]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [4]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [5]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [6]
- Results and discussion : Genomic analyses of early peri-implant bone healing in humans: a systematic review [7]
- Conclusions : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [1]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [2]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [3]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [4]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [5]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [6]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [7]
- References : Genomic analyses of early peri-implant bone healing in humans: a systematic review [8]
- Author information : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Additional information : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Rights and permissions : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- About this article : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Table 1 Assessment of the genotyping methodology in the included studies : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Table 2 Assessment of risk of bias and heterogeneity within and across the included studies : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Table 3 Summary of findings from the included studies (n = 4) : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Table 4 Summary of biological processes and associated genes reported in the included studies : Genomic analyses of early peri-implant bone healing in humans: a systematic review
- Figure 1. Flowchart for study selection (n = number of studies). : Genomic analyses of early peri-implant
- Figure 2. Summary of biological processes identified via gene expression during early peri-implant bone healing. CKs, cytokines; GFs, growth factors; EPC, endothelial progenitor cells; EC, endothelial cells; MSC, mesenchymal stem cells; OB, osteoblasts; ECM, extracellular matrix; HSC, haematopoietic stem cells; MP, macrophages; OC, osteoclasts. : Genomic analyses of early peri-implant