Table 2 Summary of implant survival and implant success in autogenous bone grafts|palmerah.implantgigi.com

					Implant survival				Implant success
Author	Year of publication	Donor site of autogenous bone graft	Radiotherapy/chemotherapy to bone graft site	Complications	Implant survival				Implant success
Author	Year of publication	Donor site of autogenous bone graft	Radiotherapy/chemotherapy to bone graft site	Complications	No. of patients who had implants placed into autogenous bone grafts (and failures)	Overall patient implant survival in autogenous bone grafts	No. of implants placed into autogenous bone grafts (and failures)	Overall implant survival in autogenous bone grafts	No. of patients who had implants placed into autogenous bone grafts (and unsuccessful)	Overall patient implant success in autogenous bone grafts	No. of implants placed into autogenous bone grafts (and unsuccessful)	Overall implant success in autogenous bone grafts	Reasons for a lack of implant success
Studies with an average follow-up of 3 years or greater
Watzinger et al. [29]	1996	Vascularised iliac bone graft and non-vascularised iliac and rib bone graft	Yes—all patients had chemotherapy and RDX	Marginal bone loss, periodontal pocketing, gingival index and sulcus bleeding index showed wide variation	Not reported	N/A	52 (14)	73.1%*	Not reported	N/A	52 (22)	57.7%*	Non-functioning implants (not prosthetically loaded)
Teoh et al. [26]	2005	Vascularised fibula free flap	Yes—5 patients had chemotherapy, 1 patients had chemo/RDX (pre-implant placement), 6 patients had pre-op RDX and 1 patient had post-op RDX.	13 patients had soft tissue hyperplasia that need debulking or skin grafting	22 (2)	90.9%*	71 (3)	95.8%*	Not reported	N/A	Not reported	N/A	N/A
Wu et al. [30]	2008	Fibula free flap	Yes—3 patients had RDX (unsure if pre or post-op)	Soft tissue hyperplasia needed surgical removal in 6 patients (17 implants).	29 (not reported)	N/A	100 (9)	91.0%	29 (not reported)	N/A	100 (14)	86.0%	Unfavourable local soft tissue and implant left as sleepers. Peri-implant bone loss greater than 2 mm
Fenlon et al. [19]	2012	Vascularised free flap—DCIA, radial, fibula and rib	Yes—35 implants had RDX	High rate of poor implant positioning in primary implant placement.	41 (10)	75.6%*	145 (18)	87.5%*	Not reported	N/A	145 (34)	76.6%*	Implants osseointegrated but prosthetically unusable
Ch’ng et al. [20]	2014	Vascularised fibula free flap	Yes −66/243 patients had RDX (43 patients pre-op RDX, 23 patients post-op RDX)	ORN 7.7% of all implants (19 patients, 4 cases in vascularised fibula free flap and 15 in native bone) smoking was shown to be a significant risk factors. Also modification of peri-implant soft tissue required such as debulking of soft tissue and vestibuloplasty as required.	54 (10)	81.5%*	243 (20)	91.8%	Not reported	N/A	Not reported	N/A	N/A
Shaw et al. [31]	2005	Vascularised composite DCIA, fibula and radius and non-vascularised bone grafts	Yes—47% of patients had RDX	Soft tissue overgrowth in 3 patients (5 implants). Also, surgical debulk of soft tissue reported in number of cases.	33 (12)	63.6%*	123 (32)	69.0%	Not reported	N/A	Not reported	N/A	N/A
Wang et al. [21]	2015	Vascularised fibula free flap (double barrel or vertical distraction osteogenesis techniques)	NO	Implant hygiene and bleeding increased over time. 6 patients (11 implants) required soft tissue reduction however recurrence of soft tissue overgrowth occurred.	19 (0)	100%	51 (0)	100%*	Not reported	N/A	51 (7)	86.3%*	Peri-implant bone loss greater than criteria (radiographic assessment)
Yerit et al. [16]	2006	Vascularised and non-vascularised iliac bone graft	No—No RDX to bone graft sites	None noted only documenting causes of implant loss	Not reported	N/A	78 (13)	54.0%	Not reported	N/A	Not reported	N/A	N/A
Linsen et al. [17]	2009	Avascularised iliac bone graft	Yes—39 implants had RDX, 44 implants did not have RDX	Peri-implantitis in 12 patients (31 implants).	Not reported	N/A	79 (8)	89.9%*	Not reported	N/A	Not reported	N/A	N/A
Studies with an average follow-up of less than 3 years or no average follow-up reported
Fierz et al. [25]	2013	Vascularised free flap—fibula, radius, scapula	Yes—20 out of 46 implants had RDX	Frail patients limited treatment, and prosthetic rehabilitation was challenging	Not reported	N/A	46 (8)	82.6%*	Not reported	N/A	Not reported	N/A	N/A
Barrowman et al. [7]	2011	Vascularised free flap—illiac, DCIA and fibula and non-vascularised bone graft.	Yes—15 implants in to irradiated vascularised free flap	Inability of patients to tolerate prosthesis. Peri-implantitis and lack of integration of some implants.	Not reported	N/A	38 (5)	86.8%*	Not reported	N/A	Not reported	N/A	N/A
Zou et al. [22]	2013	Vascularised iliac bone graft	No	Increase in plaque index over time. Prosthodontic complications overtime after prosthesis fitted also tumour recurrence	32 (not reported)	N/A	110 (4)	96.4%	Not reported	N/A	110 (9)	91.8%	Severe gingival hyperplasia and bone resorption in peri-implant area
Schultes et al. [15]	2002	Vascularised scapula and iliac bone graft	Yes—all patients had RDX 60 Gys.	Increased pocket depth around implants placed into non-native bone in comparison to native bone. 7 implants with pocketing greater than 5 mm were all in vascularised free flaps	38 (2)	94.7%*	96 (2)	97.9%*	Not reported	N/A	96 (4)	95.8%*	Implants inadequately positioned and could not be used for further prosthetic treatment
Buddula et al. [24]	2010	Bone graft—fibula, iliac and scapula (unsure of vascularised or non-vascularised)	Yes—all patients had RDX	None noted only documenting implant survival	Not reported	N/A	59 (8)	83.3%	Not reported	N/A	Not reported	N/A	N/A
Klein et al. [32]	2009	Avascular iliac bone graft	Yes—some patients had RDX	None noted only documenting implant survival	Not reported	N/A	128 (22)	78.4%	Not reported	N/A	Not reported	N/A	N/A
Burgess et al. [27]	2017	Vascularized bone grafts—fibula, DCIA, scapula and radial	Yes—some patients had RDX	None noted only documenting implant survival	59 (not reported)	N/A	199 (11)	93.6%	Not reported	N/A	Not reported	N/A	N/A
Chiapasco et al. [18]	2006	Vascularised fibula free flap	Yes—some patients had RDX and chemo—unknown number	Soft tissue overgrowth in 2 patients that required removal and palatal mucosal graft placed	14 (1)	92.9%*	62 (1)	98.3%*	14 (2)	85.7%*	62 (5)	91.9%*	Peri-implant bone loss greater than criteria (radiographic assessment)
Chiapasco et al. [23]	2008	Non-vascularised—Calvarium or iliac bone graft	Unknown	Soft tissue grafting required around implants in 3 patients	16 (1)	93.8%*	60 (2)	96.7%	16 (2)	87.5%*	60 (4)	93.3%	Peri-implant bone loss greater than criteria (radiographic assessment)
Chiapasco et al. [33]	2000	Non-vascularised—ilieum and fibula, and vascularised free flap—ilieum and fibula	Yes—3 patients had RDX (unknown if pre or post)	Soft tissue grafting required around implants in 3 patients	18 (2)	88.9%*	72 (3)	95.8%*	18 (2)	88.9%*	72 (3)	95.8%*	N/A
Hessling et al. [28]	2015	Free iliac crest, microvascular iliac, microvascular fibula, microvascular scapula, calavarial bone graft	Yes—some patients had RDX and chemo (pre- and post-op) unknown number	67% peri-implantitis due to a lack of attached gingivae	Not reported	N/A	93 (8)	91.4%*	Not reported	N/A	Not reported	N/A	N/A

Table 2 Summary of implant survival and implant success in autogenous bone grafts

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