Fig. 5. Change in BoP values according to the percentage of sites with a score of 1, 2 or 3 by visit
Fig. 5. Change in BoP values according to the percentage of sites with a score of 1, 2 or 3 by visit
Fig. 4. Percentages of sites with PPD 1–3, 4–5 and ≥6 mm by visit (pÂ
Fig. 3. Changes in BoP values between baseline and the various examination time points
Fig. 3. Changes in BoP values between baseline and the various examination time points
Fig. 2. Changes in PPD values between baseline and the various examination time points
Fig. 2. Changes in PPD values between baseline and the various examination time points
Fig. 1. A chitosan brush (LBC, BioClean®, LABRIDA AS) seated in an oscillating dental handpiece
Fig. 1. A chitosan brush (LBC, BioClean®, LABRIDA AS) seated in an oscillating dental handpiece
Â
Baseline
n = 306
2Â weeks
n = 272
4Â weeks
n = 267
12Â weeks
n = 282
24Â weeks
n = 294
P
...
Center
Oslo
Jonkoping
Rome
Stavanger
Kristianstad
Tons...
Wohlfahrt, J.C., Evensen, B.J., Zeza, B. et al. A novel non-surgical method for mild peri-implantitis- a multicenter consecutive case series.
Int J Implant Dent 3, 38 (2017). https://doi.org/10.1186/s40729-017-0098-y
Download citation
Received: 08 April 2017
Accepted: 13 July 2017
Published: 03 August 2017
DOI: https://doi.org/10.1186/s40729-017-0098-y
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
J.C. Wohlfahrt is the inventor and patent holder of BioClean and is a shareholder in LABRIDA AS. B.J. Evensen, B. Zeza, H. Jansson, A. Pilloni, A.M. Roos-Jansåker, G.L. Di Tanna, A.M. Aass, M. Klepp and O.C. Koldsland state that there were no conflicts of interests during the undertaking of the study.
Ethical approval was provided by the regional ethical review boards of each center (Norway: 201...
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JCW, BJE, BZ, HJ, AP, AMR-J, AMA, MK and OCK par...
Department of Periodontology, Institute of Clinical Dentistry, University of Oslo, Pb. 1109 Blindern, 0317, Oslo, Norway
J. C. Wohlfahrt, A. M. Aass & O. C. Koldsland
Private Practice, Tønsberg, Norway
B. J. Evensen
Department of Dental and Maxillofacial Sciences, Section of Periodontology, Sapienza, University of Rome, Rome, Italy
B. Zeza & A. Pilloni
Center for Oral Health, Departmen...
Salvi GE, et al. Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans. Clin Oral Implants Res. 2012;23(2):182–90.
Korsch M, Obst U, Walther W. Cement-associated peri-implantitis: a retrospective clinical observational study of fixed implant-supported restorations using a methacrylate cement. Clin Oral Implants Res. 2014;25(7):797–802.
Download ...
Muthukuru M, et al. Non-surgical therapy for the management of peri-implantitis: a systematic review. Clin Oral Implants Res. 2012;23(Suppl 6):77–83.
Esposito M, Grusovin MG, Worthington HV. Treatment of peri-implantitis: what interventions are effective? A Cochrane systematic review. Eur J Oral Implantol. 2012;5(Suppl):S21–41.
Armitage GC, Xenoudi P. Post-treatment supportive care for the n...
Rokn A, et al. Prevalence of peri-implantitis in patients not participating in well-designed supportive periodontal treatments: a cross-sectional study. Clin Oral Implants Res. 2017;28(3):314–9.
Faggion CM Jr, et al. A systematic review and Bayesian network meta-analysis of randomized clinical trials on non-surgical treatments for peri-implantitis. J Clin Periodontol. 2014;41(10):1015–25.
Me...
Koldsland OC, Scheie AA, Aass AM. Prevalence of peri-implantitis related to severity of the disease with different degrees of bone loss. J Periodontol. 2010;81(2):231–8.
Roos-Jansaker AM, et al. Nine- to fourteen-year follow-up of implant treatment. Part II: presence of peri-implant lesions. J Clin Periodontol. 2006;33(4):290–5.
Derks J, et al. Effectiveness of implant therapy analyzed in a ...
In this multicenter case series of implants affected by mild peri-implantitis, significant reductions in the clinical parameters of inflammation were demonstrated at all time points after the initial treatment with a chitosan brush. The use of an oscillating chitosan device appears to be safe and has potential merits for the treatment of mild peri-implantitis and for the maintenance of dental impl...
The chitosan brush used in this study is made of a material that is soft with the aim to make a device optimized for removal of the biofilm within the implant threads. The soft bristles on the contrary make the device suboptimal for removal of hard deposits, such as calculus and cement remnants. It has been reported that such cement remnants are a common finding around dental implants [41], and in...
In the present study, significant reductions were observed in the clinical parameters of peri-implant inflammation at 2, 4, 12 and 24Â weeks relative to baseline after debridement with the chitosan brush seated in an oscillating dental drill piece. No progression in radiographic bone loss was reported at any of the implants at the final evaluation, and the method was thus judged safe to use in cas...
Identifying peri-implant disease at an early stage and promptly treating the inflammatory condition is crucial to prevent the progression of peri-implant bone loss and ensure long-term implant survival [23,24,25]. After completion of active treatment and when the condition is controlled, supportive peri-implant therapy will reduce the risk of disease re-occurrence [9]. A number of scientific repor...
During this study, all 63 implants were reported to have stable radiographic levels of osseous support as validated by the six different local examiners. No adverse events were reported during the study.
In total, 63 implants in 63 patients were ultimately included in the analysis. Demographic information is presented in Tables 1 and 2.
Significant reductions in both PPD and mBoP were seen at all time points relative to the baseline clinical measurements (pÂ
Mann-Whitney rank sum tests were used to compare changes in the clinical parameters between baseline and subsequent time points. To assess the hierarchical structure of the data (center > patient > site), a linear mixed model using the restricted maximum likelihood method (multilevel logistic models for binary outcomes) was constructed to analyse the PPD, mBoP and suppuration, adjusting for fac...
All patient-related information and clinical recordings were recorded in a web-based clinical research form (VieDoc version 3.24, PCG solutions, Uppsala, Sweden).
Patients under 18Â years of age; current smokers; patients who had undergone radiotherapy in the head and neck region, chemotherapy or systemic long-term corticosteroid treatment; patients who were pregnant or nursing; patients receivin...
A 6-month multicenter prospective consecutive case series was performed in six different periodontal specialist clinics in Norway, Sweden and Italy.
Ethical approval was provided by the regional ethical review boards of each center (Norway: 2014/852/REK sør-øst; Italy: Sapienza 2011/15, 3547; and Sweden: EPN Lund 2014/695.) Fifteen patients at each center were planned to be included in the stud...
A number of other studies also report that leaving fragments of the instrument on the implant surface or scratching the surface may impede optimal peri-implant healing [17,18,19,20].
Chitosan is a marine biopolymer which is based on chitin derived from the shells of marine crustaceans. The material has been approved for use in surgical bandages, as a haemostatic agent and as a dietary supplement ...
Inflammation and loss of attachment around dental implants (i.e. peri-implantitis) has become a growing concern within the field of dental implantology [1,2,3,4,5,6,7]. Peri-implantitis is a microbial infection-driven soft tissue inflammation with loss of bony attachment around an implant. Peri-implant mucositis is the precursor of peri-implantitis, as gingivitis is for periodontitis [8]. It is cl...
The aim of the present study was to evaluate the effect on peri-implant mucosal inflammation from the use of a novel instrument made of chitosan in the non-surgical treatment of mild peri-implantitis across several clinical centers.
In this 6-month multicenter prospective consecutive case series performed in six different periodontal specialist clinics, 63 implants in 63 patients were finally inc...
Fig. 5. Change in BoP values according to the percentage of sites with a score of 1, 2 or 3 by visit
Fig. 5. Change in BoP values according to the percentage of sites with a score of 1, 2 or 3 by visit
Fig. 4. Percentages of sites with PPD 1–3, 4–5 and ≥6 mm by visit (pÂ
Fig. 3. Changes in BoP values between baseline and the various examination time points
Fig. 3. Changes in BoP values between baseline and the various examination time points
Fig. 2. Changes in PPD values between baseline and the various examination time points
Fig. 2. Changes in PPD values between baseline and the various examination time points
Fig. 1. A chitosan brush (LBC, BioClean®, LABRIDA AS) seated in an oscillating dental handpiece
Fig. 1. A chitosan brush (LBC, BioClean®, LABRIDA AS) seated in an oscillating dental handpiece
Â
Baseline
n = 306
2Â weeks
n = 272
4Â weeks
n = 267
12Â weeks
n = 282
24Â weeks
n = 294
P
...
Center
Oslo
Jonkoping
Rome
Stavanger
Kristianstad
Tons...
Variable
Number (%)
SD
Range (min; max)
Gender (female/male)
45/18 (71.4/28.6)
 Â...
Wohlfahrt, J.C., Evensen, B.J., Zeza, B. et al. A novel non-surgical method for mild peri-implantitis- a multicenter consecutive case series.
Int J Implant Dent 3, 38 (2017). https://doi.org/10.1186/s40729-017-0098-y
Download citation
Received: 08 April 2017
Accepted: 13 July 2017
Published: 03 August 2017
DOI: https://doi.org/10.1186/s40729-017-0098-y
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
J.C. Wohlfahrt is the inventor and patent holder of BioClean and is a shareholder in LABRIDA AS. B.J. Evensen, B. Zeza, H. Jansson, A. Pilloni, A.M. Roos-Jansåker, G.L. Di Tanna, A.M. Aass, M. Klepp and O.C. Koldsland state that there were no conflicts of interests during the undertaking of the study.
Ethical approval was provided by the regional ethical review boards of each center (Norway: 201...
You can also search for this author in
PubMed Google Scholar
You can also search for this author in
PubMed Google Scholar
You can also search for this author in
PubMed Google Scholar
You can also search for this author in
PubMed Google Scholar
JCW, BJE, BZ, HJ, AP, AMR-J, AMA, MK and OCK par...
Department of Periodontology, Institute of Clinical Dentistry, University of Oslo, Pb. 1109 Blindern, 0317, Oslo, Norway
J. C. Wohlfahrt, A. M. Aass & O. C. Koldsland
Private Practice, Tønsberg, Norway
B. J. Evensen
Department of Dental and Maxillofacial Sciences, Section of Periodontology, Sapienza, University of Rome, Rome, Italy
B. Zeza & A. Pilloni
Center for Oral Health, Departmen...
Salvi GE, et al. Reversibility of experimental peri-implant mucositis compared with experimental gingivitis in humans. Clin Oral Implants Res. 2012;23(2):182–90.
Korsch M, Obst U, Walther W. Cement-associated peri-implantitis: a retrospective clinical observational study of fixed implant-supported restorations using a methacrylate cement. Clin Oral Implants Res. 2014;25(7):797–802.
Download ...
Muthukuru M, et al. Non-surgical therapy for the management of peri-implantitis: a systematic review. Clin Oral Implants Res. 2012;23(Suppl 6):77–83.
Esposito M, Grusovin MG, Worthington HV. Treatment of peri-implantitis: what interventions are effective? A Cochrane systematic review. Eur J Oral Implantol. 2012;5(Suppl):S21–41.
Armitage GC, Xenoudi P. Post-treatment supportive care for the n...
Rokn A, et al. Prevalence of peri-implantitis in patients not participating in well-designed supportive periodontal treatments: a cross-sectional study. Clin Oral Implants Res. 2017;28(3):314–9.
Faggion CM Jr, et al. A systematic review and Bayesian network meta-analysis of randomized clinical trials on non-surgical treatments for peri-implantitis. J Clin Periodontol. 2014;41(10):1015–25.
Me...
Koldsland OC, Scheie AA, Aass AM. Prevalence of peri-implantitis related to severity of the disease with different degrees of bone loss. J Periodontol. 2010;81(2):231–8.
Roos-Jansaker AM, et al. Nine- to fourteen-year follow-up of implant treatment. Part II: presence of peri-implant lesions. J Clin Periodontol. 2006;33(4):290–5.
Derks J, et al. Effectiveness of implant therapy analyzed in a ...
In this multicenter case series of implants affected by mild peri-implantitis, significant reductions in the clinical parameters of inflammation were demonstrated at all time points after the initial treatment with a chitosan brush. The use of an oscillating chitosan device appears to be safe and has potential merits for the treatment of mild peri-implantitis and for the maintenance of dental impl...
In this multicenter case series of implants affected by mild peri-implantitis, significant reductions in the clinical parameters of inflammation were demonstrated at all time points after the initial treatment with a chitosan brush. The use of an oscillating chitosan device appears to be safe and has potential merits for the treatment of mild peri-implantitis and for the maintenance of dental impl...
The chitosan brush used in this study is made of a material that is soft with the aim to make a device optimized for removal of the biofilm within the implant threads. The soft bristles on the contrary make the device suboptimal for removal of hard deposits, such as calculus and cement remnants. It has been reported that such cement remnants are a common finding around dental implants [41], and in...
In the present study, significant reductions were observed in the clinical parameters of peri-implant inflammation at 2, 4, 12 and 24Â weeks relative to baseline after debridement with the chitosan brush seated in an oscillating dental drill piece. No progression in radiographic bone loss was reported at any of the implants at the final evaluation, and the method was thus judged safe to use in cas...
Identifying peri-implant disease at an early stage and promptly treating the inflammatory condition is crucial to prevent the progression of peri-implant bone loss and ensure long-term implant survival [23,24,25]. After completion of active treatment and when the condition is controlled, supportive peri-implant therapy will reduce the risk of disease re-occurrence [9]. A number of scientific repor...
During this study, all 63 implants were reported to have stable radiographic levels of osseous support as validated by the six different local examiners. No adverse events were reported during the study.
In total, 63 implants in 63 patients were ultimately included in the analysis. Demographic information is presented in Tables 1 and 2.
Significant reductions in both PPD and mBoP were seen at all time points relative to the baseline clinical measurements (pÂ
Mann-Whitney rank sum tests were used to compare changes in the clinical parameters between baseline and subsequent time points. To assess the hierarchical structure of the data (center > patient > site), a linear mixed model using the restricted maximum likelihood method (multilevel logistic models for binary outcomes) was constructed to analyse the PPD, mBoP and suppuration, adjusting for fac...
All patient-related information and clinical recordings were recorded in a web-based clinical research form (VieDoc version 3.24, PCG solutions, Uppsala, Sweden).
Patients under 18Â years of age; current smokers; patients who had undergone radiotherapy in the head and neck region, chemotherapy or systemic long-term corticosteroid treatment; patients who were pregnant or nursing; patients receivin...
A 6-month multicenter prospective consecutive case series was performed in six different periodontal specialist clinics in Norway, Sweden and Italy.
Ethical approval was provided by the regional ethical review boards of each center (Norway: 2014/852/REK sør-øst; Italy: Sapienza 2011/15, 3547; and Sweden: EPN Lund 2014/695.) Fifteen patients at each center were planned to be included in the stud...
A number of other studies also report that leaving fragments of the instrument on the implant surface or scratching the surface may impede optimal peri-implant healing [17,18,19,20].
Chitosan is a marine biopolymer which is based on chitin derived from the shells of marine crustaceans. The material has been approved for use in surgical bandages, as a haemostatic agent and as a dietary supplement ...
Inflammation and loss of attachment around dental implants (i.e. peri-implantitis) has become a growing concern within the field of dental implantology [1,2,3,4,5,6,7]. Peri-implantitis is a microbial infection-driven soft tissue inflammation with loss of bony attachment around an implant. Peri-implant mucositis is the precursor of peri-implantitis, as gingivitis is for periodontitis [8]. It is cl...
The aim of the present study was to evaluate the effect on peri-implant mucosal inflammation from the use of a novel instrument made of chitosan in the non-surgical treatment of mild peri-implantitis across several clinical centers.
In this 6-month multicenter prospective consecutive case series performed in six different periodontal specialist clinics, 63 implants in 63 patients were finally inc...