The Joint United Nations Programme on HIV/AIDS estimates that 36.9 million (34.3–41.4 million) people are living with human immunodeficiency virus (HIV) infection [1]. In America, the Centers for Disease Control and Prevention (CDC) estimated that 1.2 million people aged 13 or older were HIV infected by the end of 2012 [2] and the cumulative population of persons surviving for more than 36 months after an acquired immune deficiency syndrome (AIDS) diagnosis to be 83 % [3]. As with the non-infected population, AIDS patients are in need of routine dental care, including implants. According to a 2015 systemic review, there have been only nine high-quality studies that have examined the implant outcomes in HIV-positive patients [4] and no studies looking at the implant outcomes in patients with the diagnosis of AIDS with a long-term follow-up. For this reason, a new prospective cohort study is needed. Although a great deal of research has been conducted in the pathophysiology, epidemiology, and treatment of AIDS, little is known with regard to the predictability of dental implants in this population. The purpose of this study is to evaluate implant outcomes in patients who have a diagnosis of AIDS, in order to provide some concrete data that may guide the dental practitioner and our medical counterparts when faced with treatment planning of these patients.