Our study found a slightly higher failure rate of 10 % in patients with AIDS, compared to widely accepted failure rates in healthy patients at 5–7 %. A cohort sample size of 33 may be considered small for statistical power; however, the results from this study could lead to larger future prospective cohort studies with additional funding to recruit a larger cohort and comparison groups. The advent of new medical therapies has changed the face of HIV/AIDS in the western world. These patients live long and productive lives and should be offered the option of root-formed implants as a viable alternative to fixed and removable prosthetics.