The use of zygoma implants in the rehabilitation of patients who underwent surgical resection for oral cancer has been widely described [1–3]. There are several possibilities that can be considered when evaluating the possibility of surgical reconstruction after the first cancer resection, such as microvascular free flaps or rotation flaps, but it is sometimes necessary to monitor the healing process and the defect site in order to readily detect recurrences that may occur in high-risk patients [4, 5]. While dealing with facial defects, it is mandatory to consider that this kind of defect has a big impact on the patient’s quality of life [6, 7]. For this reason, medical science made a strong effort in developing rehabilitation solutions that enable operated patients to re-achieve a normal life as soon as possible. According to this objective, zygoma implants allow to reconstruct full arch even in case of conspicuous bone defects with no indication to grafting procedures [6, 8]. Furthermore, in case of wide midfacial resections with oronasal communication, zygoma implants may be used through the communication to support an extraoral nasal prosthesis. This article describes the rehabilitation of two defects, one intraoral and one extraoral, resulting from a single surgical act. Both intra- and extraoral prosthetic rehabilitation are supported by four zygoma implants positioned in the resected maxilla in order to create an artificial nose and a prosthetic denture.