Implant-supported prosthesis is a valid method to restore resected oral and head cancer patients and offers a good chance to social reintegration. The aesthetic result and facial camouflage are more achievable by means of dentures and epithesis than with several reconstructive interventions. Furthermore, due to the high risk of recurrences, it is sometime mandatory to keep the defect inspectionable. Despite the average poor lifespan of prosthetic materials and the accurate professional and home care required by intraoral implants, prosthetic rehabilitation could be considered an effective and suitable method for rehabilitation of extensively resected head and neck cancer patients (Figs. 6 and 7).