Rethinking globally of the possible indications to the adoption of this technique and its advantages compared to reconstructive microsurgery, the use of zygoma-implant-supported prosthesis may be suitable for patients whose systemic conditions are poor. The duration of surgery and of the postoperative recovery would be remarkably shortened avoiding the complications related to the harvesting of a free flap. Closely related to this aspect, the cost-benefit ratio is definitely more convenient. This technique proves itself to be more easily manageable also in non-compliant patients or in patients with limited prognosis or high risk of recurrence, allowing the clinician a more effective inspection of the resected site during follow-up consults.