Materials and methods : Bone turnover markers to assess jawbone quality prior to dental implant treatment (1)
Patient selection
Patients treated at Hiroshima University Hospital were included in the study if they remained partially edentulous in the planning area for at least 3 months, if one or two splinting fixed prostheses in the mandible posterior area were planned, if they had never been treated for osteoporosis, and if they had no subjective or objective symptoms of osteoporosis, such as back pain caused by a fractured or collapsed vertebra, loss of height over time, or stooped posture. Eighteen patients (11 women, 7 men) fulfilled the inclusion criteria. The study was approved by the Ethics Committee at Hiroshima University Graduate School of Biomedical and Health Sciences. All patients provided written informed consent after receiving a detailed explanation of the study, including its timeline, aims, risks and benefits of participation, and expectations regarding compliance.
Computed tomography and radiographic superposition
Each patient underwent a spiral computed tomography (CT) scan. The data were stored in Digital Imaging and Communications in Medicine format and loaded into implant planning software (Simplant®, Dentsply Implants, Leuven, Belgium). This allowed the implant placement sites to be pinpointed on the corresponding cross-sectional CT slices. Bone density was measured in Hounsfield units on buccopalatal or buccolingual cross-sectional CT slices at the sites of implant placement. The mean bone density values for the internal and external sides were used as the cancellous bone densities (Fig. 1).
Measurement of BTMs
BTM levels were measured in blood samples obtained simultaneously with routine blood testing before implant surgery by using ELISA. Sampling was performed in the morning in fasting subjects who had abstained from physical exercise for 24 h as recommended.
Serial posts:
- Bone turnover markers to assess jawbone quality prior to dental implant treatment: a case-control study
- Background : Bone turnover markers to assess jawbone quality prior to dental implant treatment
- Background : Bone turnover markers to assess jawbone quality prior to dental implant treatment (1)
- Background : Bone turnover markers to assess jawbone quality prior to dental implant treatment (2)
- Materials and methods : Bone turnover markers to assess jawbone quality prior to dental implant treatment (1)
- Results : Bone turnover markers to assess jawbone quality prior to dental implant treatment (2)
- Discussion : Bone turnover markers to assess jawbone quality prior to dental implant treatment (1)
- Discussion : Bone turnover markers to assess jawbone quality prior to dental implant treatment (2)
- Discussion : Bone turnover markers to assess jawbone quality prior to dental implant treatment (3)
- Figure 1. Measure the bone density at the implant placement sites
- Figure 2. Measurement of marginal bone loss (MBL) on dental radiography.
- Table 1 Each parameter of the 18 patients who fulfilled the inclusion criteria
- Table 2 Age, sex, and follow-up period between the normal and abnormal group
- Figure 3. The overview on BTM values are shown
- Figure 4. Cancellous bone densities in the normal and abnormal groups of women
- Figure 5. Cancellous bone densities in SLA and MK-III implants
- Figure 6. Marginal bone loss (MBL) in SLA and MK-III implants