A total of 1,991 implants (475 patients) with 10 years of functional loading met the inclusion criteria and were included in this study: 90 patients were totally edentulous (559 implants), 155 patients were partially edentulous (732 implants), and 230 patients were mono‐edentulous (700 implants) (Tables 1 and 2).

Table 3 shows the life table analysis and cumulative survival and success rate and the number of peri‐implantitis developed in each year of observation at the level of the patient and at the implant level.

The cumulative survival and success rates for the study population were 91.3% and 72.2%, respectively, while among implants, the cumulative survival and success rates were 96.0% and 82.4%, respectively (Table 3).

At the implant level, 22 peri‐implantitis were observed between the sixth and seventh year, while among the seventh and eighth year, 41 peri‐implantitis were observed (Fig. 1).

The results for all 475 patients showed a survival and success rate of 91.8% and 75.4%, respectively. The analysis of implants showed a 96.1% survival rate and 83.7% success rate (Table 4). The rate of peri‐implantitis observed was 12.9% among implants, including 247 instances of peri‐implantitis over the remaining 1,918 implants, and a 24.4% (116 patients) among patients (Table 4).

The total number of failures among patients at the end of the 10‐year‐period was 39 (78 implants). During the first 5 years of functional loading, 15 patients (3.16%) and 31 implants (1.56%) failed. Forty patients (8.42%) and 61 implants (3.19%) showed signs of peri‐implantitis. Between the fifth and the tenth year, 24 patients (5.05%) and 47 implants (2.36%) failed, while 76 patients (16%) and 186 implants (9.72%) developed peri‐implantitis.

The difference between the rates of failures observed at the end of each of the two periods of observation was 1.89% among patients and 0.80% among implants, while the rate of peri‐implantitis increased by 7.58% among patients and 6.53% among implants at the tenth year (Table 5).

See supplementary Table S1 in online Journal of Periodontology to observe that co‐intervention as well as sample or implant features cannot modify the results in a statistically significant way.