Table 7 Clinical studies that investigated the effect of NSAIDs on osseointegration : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
Table 7 Clinical studies that investigated the effect of NSAIDs on osseointegration : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
author: Jie Denny Luo, Catherine Miller, Tamara Jirjis, Masoud Nasir, Dileep Sharma | publisher: drg. Andreas Tjandra, Sp. Perio, FISID
Study (year) | Sample (size) | Treatment group (size) | Methodology | Parameter | Outcome |
---|---|---|---|---|---|
Alissa et al. (2009) [21] |
Eligible human patients (n = 61). Implants inserted (n = 132). |
Ibuprofen (n = 31), implants (n = 67). Placebo (n = 30), implants (n = 65). | Ibuprofen, 600 mg q.i.d. for 7 days orally | Post-operative radiographic marginal bone height at 3 and 6 months | No statistically significant differences in mean marginal bone level changes at 3 or 6 months. |
Sakka et al. (2013) [24] |
Eligible human patients (n = 28). Implants inserted (n = 57). |
Ibuprofen (n = 14), implants (n = 31). Non-Ibuprofen (n = 14), implants (n = 26). | Ibuprofen, 600 mg q.i.d. for 7 days orally | Post-operative radiographic marginal bone height at 3 and 6 months | No statistically significant differences in mean marginal bone level changes at 3 or 6 months. |
Winnett et al. (2014) [25] | Patients treated between 1979 and 2012 with failed and surgically removed dental implants |
Cohort that used post-operative NSAIDs (n = 60, with 119 failed implants). Cohort that did not use post-operative NSAIDs (n = 44, with 78 failed implants). |
Ibuprofen was the most commonly prescribed, 600 mg q.i.d. Other prescribed analgesics were ketorolac, vioxx, celebrex, diflunisal, meloxicam, paracetamol, and naproxen. |
Radiographic bone loss. Vertical bone height of remaining implants. |
NSAID cohort experienced more implant failures than the non-NSAID cohort. The NSAID cohort experienced more cases of radiographic bone loss greater than 30% of the vertical height of their remaining implants. |
Table 7 Clinical studies that investigated the effect of NSAIDs on osseointegration
Serial posts:
- Abstract : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Review : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [1]
- Review : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [2]
- Review : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [3]
- Review : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [4]
- Review : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [5]
- Review : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [6]
- Review : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [7]
- Review : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [8]
- Conclusions : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Abbreviations : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- References : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [1]
- References : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [2]
- References : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review [3]
- Acknowledgements : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Author information : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Ethics declarations : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Rights and permissions : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- About this article : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Table 1 Quality assessment of in vitro studies according to the items of the Modified CONSORT checklist [16] : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Table 2 Modified CONSORT checklist of items for reporting in vitro studies of dental materials [16] : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Table 3 Quality and bias assessment of human clinical studies using The Cochrane Collaboration’s Tool [17] : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Table 4 Quality assessment of the methodology of the animal studies according to the items of the ARRIVE guidelines [18] : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Table 5 Items of the ARRIVE Guidelines [18] : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Table 6 In vitro studies that investigated the effect of NSAIDs on osteoblasts attached to titanium surfaces : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Table 7 Clinical studies that investigated the effect of NSAIDs on osseointegration : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Table 8 In vivo studies using animal models that investigated the effect of NSAIDs on osseointegration : The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review
- Fig. 1. PRISMA flow diagram of literature search : The effect of non-steroidal anti-inflammatory drug