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Fig. 1. PRISMA flow diagram of literature search :...

Fig. 1. PRISMA flow diagram of literature search Fig. 1. PRISMA flow diagram of literature search

Table 8 In vivo studies using animal models that ...

Study (year) Sample (size) Treatment group (size) Methodology Parameter ...

Table 7 Clinical studies that investigated the eff...

Study (year) Sample (size) Treatment group (size) Methodology Parameter ...

Table 6 In vitro studies that investigated the eff...

Study (year) Sample Treatment group Methodology Parameter Outco...

Table 5 Items of the ARRIVE Guidelines [18] : The ...

Item Domain 5 Ethical statement 6 Study design ...

Table 4 Quality assessment of the methodology of t...

Study 5 6 7 8 9 ...

Table 3 Quality and bias assessment of human clini...

Study Random sequence generation Allocation concealment Blinding of participants/personnel Blinding of outcome assessment ...

Table 2 Modified CONSORT checklist of items for re...

Item Domain 1 Abstract: structured summary of trial design, methods, results, and conclusions Introduction ...

Table 1 Quality assessment of in vitro studies acc...

Study 1 2 3 4 5 ...

About this article : The effect of non-steroidal a...

Luo, J., Miller, C., Jirjis, T. et al. The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review. Int J Implant Dent 4, 30 (2018). https://doi.org/10.1186/s40729-018-0141-7 Download citation Received: 22 May 2018 Accepted: 13 July 2018 Published: 09 October 2018 DOI: https://doi.org/10.1186/s40729-018-0141-7

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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...

Ethics declarations : The effect of non-steroidal ...

Not applicable Not applicable Jie Denny Luo, Catherine Miller, Tamara Jirjis, Masoud Nasir, and Dileep Sharma declare that they have no competing interests. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Author information : The effect of non-steroidal a...

College of Medicine & Dentistry, James Cook University, 14-88 McGregor Road, Smithfield, QLD, 4878, Australia Jie Denny Luo, Tamara Jirjis, Masoud Nasir & Dileep Sharma College of Public Health, Medical and Veterinary Sciences, James Cook University, 14-88 McGregor Road, Smithfield, QLD, 4878, Australia Catherine Miller You can also search for this author in PubMed...

Acknowledgements : The effect of non-steroidal ant...

The authors acknowledge and are grateful for the help and preparation of manuscript by the supporting research supervisors: Dr. Ernest Jennings and Prof. Alan Nimmo. The systematic review is funded by James Cook University College of Medicine and Dentistry as part of a Dentistry Honours Research Project. A meta-analysis was not conducted for this systematic review. The critical analysis tables t...

References : The effect of non-steroidal anti-infl...

Winnett B, Tenenbaum HC, Ganss B, Jokstad A. Perioperative use of non-steroidal anti-inflammatory drugs might impair dental implant osseointegration. Clin Oral Implants Res. 2016;27(2):E1–7. Goodman SB, Ma T, Mitsunaga L, Miyanishi K, Genovese MC, Smith RL. Temporal effects of a COX-2-selective NSAID on bone ingrowth. J Biomed Mater Res A. 2005;72((3):279–87. Ribeiro FV, Cesar-Neto JB, Nocit...

References : The effect of non-steroidal anti-infl...

Marquez-Lara A, Hutchinson ID, Nuñez F, Smith TL, Miller AN. Nonsteroidal anti-inflammatory drugs and bone-healing: a systematic review of research quality. JBJS Rev. 2016;4(3). https://doi.org/10.2106/JBJS.RVW.O.00055. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate...

References : The effect of non-steroidal anti-infl...

Salari P, Abdollahi M. Controversial effects of non-steroidal anti-inflammatory drugs on bone: a review. Inflamm Allergy Drug Targets. 2009;8(3):169–75. Boursinos LA, Karachalios T, Poultsides L, Malizos KN. Do steroids, conventional non-steroidal anti-inflammatory drugs and selective Cox-2 inhibitors adversely affect fracture healing? J Musculoskelet Neuronal Interact. 2009;9(1):44–52. Kaly...

Abbreviations : The effect of non-steroidal anti-i...

Cyclooxygenase Non-steroidal anti-inflammatory drug/s Prostaglandin Prostaglandin E2

Conclusions : The effect of non-steroidal anti-inf...

The analgesic and therapeutic effects of NSAIDs are achieved by COX-2 inhibition [4]. It is likely that COX inhibition by NSAIDs is detrimental to the bone healing process, given the favourable actions of PG on this process [4]. Osteoblasts have the capacity to produce PGs, where PGE2 is most abundant, through the COX pathway though the evidence asserting that PGs have a direct role in bone healin...

Review : The effect of non-steroidal anti-inflamma...

The majority of the included studies revealed a high risk of bias, and conclusions from studies that have a high risk of bias are sufficient to affect interpretation of data [16,17,18]. Publication and selection bias is apparent in several included studies, as the negative effects of NSAIDs on osseointegration can be expected in the studies that administered NSAID at a high concentration and/or fo...

Review : The effect of non-steroidal anti-inflamma...

The influence of NSAIDS on bone healing in animal models has been shown to be related to the duration of treatment and drug selectivity [5]. A total of seven studies were identified that investigated the effect of NSAIDs on the osseointegration of titanium implants in animals: mice, rabbits, and rats (Table 8). The duration of treatment is a factor to consider when using NSAIDs, and a study cond...

Review : The effect of non-steroidal anti-inflamma...

The effects of NSAIDs on the osteogenic activity of osteoblasts have been extensively studied at the molecular pharmacological level [23]. However, only two studies have been identified that investigated the effect of NSAIDs on osteoblasts attached to titanium surfaces (Table 6). In the study conducted by Boyan et al., their results demonstrated that a non-selective COX inhibitor (indomethacin, 0...

Review : The effect of non-steroidal anti-inflamma...

The eligibility and study selection criteria as mentioned above were applied to the 79 full-text articles. A total of 66 studies were excluded after a full-text assessment for the following reasons: The study did not explore the role of COX pathway in osseointegration (n = 26). The effects of NSAIDs on osteoblasts were not investigated on titanium (n = 24). The study was a systematic re...

Review : The effect of non-steroidal anti-inflamma...

The full-text manuscripts of included studies were catalogued into in vitro, clinical, and in vivo studies. The data from the included studies were independently extracted by the primary (JDL) and the second reviewer (TJ) according to the “Data items” section as listed below. Disagreements or uncertainties were discussed with the third reviewer (MN) until an agreement was reached. The data co...

Review : The effect of non-steroidal anti-inflamma...

An electronic search into four databases: Ovid, Pubmed, Scopus, and Web of Science was performed to systematically identify the available literature. Articles published between January 1, 1999, and July 7, 2018, were considered. The focus question, used to guide the search strategy, according to the PICO schema is “Will variables such as the dosage, duration of administration, and selectivity o...

Review : The effect of non-steroidal anti-inflamma...

Cyclooxygenases have an important role in the production of PGs where these enzymes in bone tissues show increased activity under the influence of hypoxia-inducible factors [6, 11]. Therefore, local activity of COX enzymes promotes bone formation and resorption through the production of PGs [12]. Non-selective NSAIDs are reported to inhibit the activity of COX-1 equally, if not more than COX-2 [2]...

Review : The effect of non-steroidal anti-inflamma...

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs with anti-inflammatory, analgesic, and antipyretic effects. They are commonly used in dentistry for management of dental pain associated with inflammation. NSAIDs exert their effects through the inhibition of the cyclooxygenase (COX) enzyme, therefore interfering with the synthesis of prostaglandins (PG) and thromboxanes; PGs and ...

Abstract : The effect of non-steroidal anti-inflam...

Non-steroidal anti-inflammatory drugs are commonly used in implant dentistry for management of post-operative pain. The objective of this systematic review was to analyse the effect of non-steroidal anti-inflammatory drugs on the osteogenic activity of osteoblasts with an emphasis on its effect on osseointegration. A systematic literature search for in vitro, animal models, and clinical trials was...