SBP (mmHg)
DBP (mmHg)
PR (bpm)
RPP (bpm × mmHg)
Normotensive patients (N = 410)
On arrival at the office
133.0 ± 18.4
76.4 ± 12.5
79.2 ± 13...
SBP (>160 mmHg)
RPP (>12,000 bpm × mmHg)
Normotensive group (N = 410)
On arrival at the office
41 (10.0%)
111 (27.1%)
Prior to sedation
...
Normotensive group
Hypertensive group
p
value
Number (male: female)
410 (127: 283)
106 (37: 69)
0.170
Age (year mean ± SD)
...
Kimura, M., Takasugi, Y., Hanano, S. et al. Efficacy of intravenous sedation and oral nifedipine in dental implant patients with preoperative hypertension - a retrospective study of 516 cases. Int J Implant Dent 1, 6 (2015). https://doi.org/10.1186/s40729-015-0004-4
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Received: 08 October 2014
Accepted: 14 January 2015
Published: 18 March 2015
DOI: https://doi.org/10.1186/s407...
Motoshi Kimura, Yoshihiro Takasugi, Shigeyoshi Hanano, Katsuyuki Terabe and Yuko Kimura declare that they have no competing interests.
YT and MK designed the study; MK, SH, and KT performed the surgeries; YT performed the intravenous sedation. YT, MK, and YK collected and analyzed the data; MK wrote the manuscript. YT revised the manuscript. All authors read and approved the final manuscript.
Hanano Dental Clinic, 4-2-3 Yamanoue, Hirakata, Osaka, 573-0047, Japan
Motoshi Kimura & Shigeyoshi Hanano
Department of Anesthesiology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan
Yoshihiro Takasugi
Terabe Dental Clinic, 4-249 Sakae-cho, Tsu, Mie, 514-0004, Japan
Katsuyuki Terabe
First Department of Internal Medicine, Osaka Medical College...
Abraham-Inpijn L, Borgmeijer-Hoelen A, Gortzak RAT. Changes in blood pressure, heart rate, and electrocardiogram during dental treatment with use of local anesthesia. J Am Dent Assoc. 1988;116:531–6.
Brand HS, Gortzak RA, Palmer-Bouva CC, Abraham RE, Abraham-Inpijn L. Cardiovascular and neuroendocrine responses during acute stress induced by different types of dental treatment. Int Dent J. 1995...
Little JW. The impact on dentistry of recent advances in the management of hypertension. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:591–9.
Aubertin MA. The hypertensive patient in dental practice: updated recommendations for classification, prevention, monitoring, and dental management. Gen Dent. 2004;52:544–52.
Vaughan CJ, Delanty N. Hypertensive emergencies. Lancet. 2000;356...
Systolic blood pressure
Diastolic blood pressure
Pulse rate
Rate pressure product
Electrocardiogram
Percutaneous oxygen saturation
Analysis of variance
Immediate-release
In this study, we showed that the stable hemodynamic was obtained by performing intravenous sedation and oral administration of nifedipine for patients with hypertension. It is important not only to understand the systemic management of the patient but also to obtain stabled hemodynamic by performing intravenous sedation and oral administration of nifedipine for patients with hypertension in order...
Implant surgery is performed in patients with a wide age range, including elderly patients with hypertension. Dentists or oral surgeons often encounter hypertensive patients who are undiagnosed or noncompliant. Among Japanese over the age of 30, 60% of men and 44.6% of women suffer from high blood pressure, and 33.8% of men and 25.6% of women with a history of hypertension have not been managed me...
For patients with stage 2 hypertension before operation, it is difficult to maintain the recommended blood pressure during surgery using only intravenous sedation, and it is necessary to decrease blood pressure by antihypertensive drugs. In this study, the blood pressure of patients with sustained hypertension was reduced to stage I hypertension about 30 min after administration of oral nifedipin...
In 44 (8.5%) of the 516 implant surgery cases, oral nifedipine had to be administered, since preoperative SBP was higher than 160 mmHg in these patients. Within 30 min of administration of nifedipine, SBP of hypertensive patients decreased to a similar range as that of hypertensive patients who did not need administration of oral nifedipine. Intravenous sedation after nifedipine administration t...
In patients with oral nifedipine in the hypertensive group, the PR value slightly increased prior to initiation of intravenous sedation (p = 0.224) and then significantly decreased until completion of the operation (p 160 mmHg during and at completion of operation showed maximum SBP of 180 mmHg in the normotensive group, 190 mmHg on the hypertensive group without preoperative oral nifedip...
Patient demographics and clinical characteristics are summarized in Table 1. There were significant differences in age (p
This study protocol was approved by the ethics committee of Japanese Dental Society of Anesthesiology (No. 2015–4).
Following confirmation of a sufficient anesthetic effect, intravenous sedation with continuous infusion of propofol 1 to 2 mg/kg/h and midazolam 20 to 40 μg/kg bolus together with inhalation of oxygen 3 L/min via nasal cannula was initiated. After confirming Verrill sign, implant surgery was initiated. During operation, the propofol dose was adjusted to maintain the optimum conscious sedative ...
A retrospective review of the clinical records was conducted for 336 patients who received dental implant-related surgeries combined with intravenous sedation between January 2008 and February 2012 at our outpatient dental offices. Among the patients, 125 patients received multiple surgeries during the observation period: 4 patients underwent surgery five times, 7 patients four times, 29 patients ...
Osseointegrated dental implants were introduced in Japan in 1983, and the procedures are now performed very frequently. Dental implants are placed in a wide age range of patients, including elderly patients with hypertension. Patients with very high blood pressure are at great risk for acute medical problems when undergoing stressful dental procedures, such as oral surgery, periodontal surgery, an...
To examine the effects of intravenous sedation and oral nifedipine on blood pressure and pulse rate in patients with perioperative high blood pressure undergoing implant surgery, the clinical records of dental implant patients managed by intravenous sedation at our outpatient dental offices were retrospectively evaluated.
A total of 516 clinical charts were evaluated. The subjects were divided in...