From a clinical perspective, an alloplastic bone graft's long-term maturation is crucial. A block-form graft in the first generation (Osteon I) produced a satisfactory result, demonstrating a steady result in preserving the volume with a non-resorbable composition of HA27. However, because the first generation was hard to employ in particulate form, the second generation (osteon II) was created. Particulate Osteon II may be utilized for ridge augmentation, sinus grafting, and socket preservation. The substance was a biphasic scaffold made of β-TCP and HA combined. At first, the material's radiopacity was minimal, but when it reached the crest region, its density rose. However, due to the composition of β-TCP, Osteon II had a lower aspect in relation to the first generation in terms of volume. It would be simple to get around this by building up as much as the expected absorption. When creating the next generation, a modification to the production process raised the relative quantity of HA in order to counteract this absorption propensity.

Osteon III, the third generation, had a composition of 60% HA and 40% β-TCP with improved interconnectivity, which resulted in increased porosity and interconnection. By raising the sintering temperature to compensate for the decreased strength, the particulate form of osteon III demonstrated superior interconnectivity and enhanced crystallinity. In an animal (rabbit calvaria) study, the material demonstrated superior scaffold qualities in terms of its osteoblast and osteoclast activity when compared to a traditional alloplastic bone graft. In contrast to a xenograft (Bio-OssⓇ), a combination of resorbable membrane (BioGideⓇ) and alloplastic graft could result in superior bone regeneration in a dog model35. Therefore, Osteon III alone, which had the benefit of superior interconnective porosity, might be used to obtain satisfactory results in peri-implantitis without a membrane in addition to horizontal and vertical GBR.