Material and methods : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [1]
This review was executed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) [26], and the Cochrane Handbook for Systematic Reviews of Interventions [27].
Animal studies in which the methodology/results included parameters regarding the use of systemic administration of non-radioactive Sr to enhance the osseointegration of implants and/or the remodeling of bone (and bone substitute materials) grafts qualified for inclusion. Retrieval of information focused on (1) the used posology (dose and timing), (2) the type of treatment, (3) the assessed outcome, and (4) the side effects of the treatment. Studies which failed reporting one or more of these four topics still qualified for inclusion, but the missing information was acknowledged as non-declared.
The MEDLINE (Medical Literature Analysis and Retrieval System Online, via PubMed) and Scopus databases were searched until October 2017 for studies evaluating the use of systemic non-radioactive Sr to enhance to enhance the osseointegration of titanium implants and the remodeling of bone grafts. The search strategy was restricted to English language publications using the combined terms: (strontium) and (implant or graft or biomaterial or bone substitute). Systematic reviews, reviews, and case reports were immediately excluded.
Unpublished data were sought by searching a database listing unpublished studies (OpenGray-www.opengrey.eu). A manual search was additionally conducted based on the reference lists of the selected papers. Further, electronic databases of the following journals, which were considered important to this review, were separately manually searched: Clinical Oral Implants Research, Bone, International Journal of Implant Dentistry, Osteoporosis International, Journal of Periodontology, Journal of Clinical Periodontology, Journal of Dentistry, Dentomaxillofacial Radiology, and Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. Further, the bibliographic references of the included studies were also sought for possible relevant studies.
Titles, abstracts, and full texts of the search results were independently screened in duplicate by three reviewers (CRS, CBS, and RSN). When there was a disagreement, the reviewers discussed the study and reached consensus.
Serial posts:
- Abstract : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies
- Introduction : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [1]
- Introduction : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [2]
- Material and methods : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [1]
- Material and methods : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [2]
- Review : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [1]
- Review : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [2]
- Discussion : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [1]
- Discussion : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [2]
- Discussion : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [3]
- Conclusions : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies
- Abbreviations : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies
- References : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [1]
- References : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [2]
- References : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [3]
- References : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [4]
- References : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [5]
- Author information : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [1]
- Author information : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies [2]
- Ethics declarations : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies
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- About this article : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies
- Table 1 Included studies and sample characteristics. Animal model, study groups, treatment start point and its duration, period of evaluation, implants specification, and evaluation methods : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies
- Table 2 Included studies and the evaluation methods employed, together with major outcomes for each method : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies
- Table 3 Assessment of risk of bias using SYRCLE’s tool : Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies
- Fig. 1. PRISMA flow diagram : Systemic administration of strontium ranelate to enhance the osseointegration of implant