Fig. 1. PRISMA flow diagram
Fig. 1. PRISMA flow diagram
Risk of bias
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Maïmoun et al. 2010 [29]
Li et al. 2010 [32]
Li et al. 2012 [33]
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Tests and overall results
Bone mineral density
Histomorphometric
Biomechanical
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Sample characteristics
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Scardueli, C.R., Bizelli-Silveira, C., Marcantonio, R.A.C. et al. Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies.
Int J Implant Dent 4, 21 (2018). https://doi.org/10.1186/s40729-018-0132-8
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Received: 14 November 2017
Accepted: 23 April 2018
Published: 17 July 2018
DOI: https:/...
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This review was executed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), and the Cochrane Handbook for Systematic Reviews of Interventions, and no approval by an ethics committee is demanded.
All participants consented to publish their information details.
Cássio Rocha Scardueli, Carolina Bizelli-Silveira, Rosemary Adriana C. Marcantonio, Elcio Ma...
Correspondence to
Cassio Rocha Scardueli.
Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark
Cassio Rocha Scardueli, Carolina Bizelli-Silveira & Rubens Spin-Neto
Department of Periodontology, São Paulo State University (Unesp), School of Dentistry, Araraquara, São Paulo, Brazil
Cassio Rocha Scardueli, Rosemary Adriana C. Marcantonio & Elcio Marcantonio Jr
Department of Periodontology, Faculty of Odonto...
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Ovariectomy
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Based on the few studies included in this systematic review, it is possible to state that the systemic administration of Sr, in the form of SRAN, seems to enhance peri-implant bone quality and implant osseointegration, however, to a moderate extent. Further studies should focus on standardization of the study designs to properly assess the effects of Sr, including parameters such SRAN dose, admini...
The variability in the results of the studies included in this review, may not only relate to SRAN dose, but may somehow relate to differences in the time-period after ovariectomy, before the animals were included in the study, which differed greatly among studies (from 4 to 12 weeks). Although it is already defined in the literature that initial osteoporosis features appear already at 4 weeks a...
All studies included in this review tested the hypothesis that non-radioactive Sr supplementation would enhance implant osseointegration. Overall, the results of the included studies suggest that the systemic Sr administration enhances peri-implant bone quality and implant osseointegration, however to a moderate extent. Positive results regarding implant osseointegration and the quality of peri-im...
Sr is a metabolic trace element closely related to calcium. Sr2+ ions are incorporated into bone by two main mechanisms: (a) a rapid uptake mechanism, dependent on osteoblast activity, whereby Sr2+ becomes absorbed via ion exchange processes with Ca2+ or binding to osteoid proteins, and (b) Sr2+ ions incorporate into the crystal lattice of the bone mineral phase. [34] When Sr2+ is present in highe...
In three studies from the same research group, female rats with ovariectomy-induced (OVX) osteoporosis were included [31,32,33]. Although the same research group performed the studies, the results were based on diverse animal populations, as it can be inferred from the studies. Rats receiving a high dose of SRAN (SRANH, 1000 mg/kg/day) showed an increased ratio between bone and total voxels in di...
The initial search for publications yielded 578 titles in MEDLINE (PubMed) database, and 152 in Scopus database. After duplicates were removed, there were a total of 553 titles to be screened. After initial screening, using the abstracts and key words, 37 publications remained (31 from PubMed and 6 from Scopus), that potentially met the inclusion criteria. Hand-searching did not reveal any additio...
Three independent researchers (CRS, CBS, and RSN) conducted data extraction and validity assessment of the studies that met the inclusion criteria. Data was extracted focusing on the animal model, study groups, treatment start, duration of the treatment, period of examination, implant specification, evaluation methods, and results (outcomes), according to what was reported in each study (i.e., his...
This review was executed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) [26], and the Cochrane Handbook for Systematic Reviews of Interventions [27].
Animal studies in which the methodology/results included parameters regarding the use of systemic administration of non-radioactive Sr to enhance the osseointegration of implants and/or the remodeling ...
Thus, the aim of this review was to undertake a systematic review of the literature on the available evidence—deriving from animal studies—on the systemic administration of non-radioactive Sr to enhance the osseointegration of titanium implants and/or the bone regeneration (i.e., remodeling) in association with bone grafting techniques.
Following the trauma induced to the bone tissue during dental implant installation, wound healing involves the fine-tuned coupling of bone resorption and formation [1, 2], which finally leads to the direct bone-to-implant contact, i.e., implant osseointegration [3]. The same biological mechanisms are involved in the wound healing (i.e., remodeling) of a bone defect filled with bone graft and/or bo...
The literature states that Strontium (Sr) is able to simultaneously stimulate bone formation and suppress bone resorption. Recent animal studies suggest that the systemic administration of Sr, in the form of strontium ranelate (SRAN), would enhance the osseointegration of implants. The purpose of the present study was to undertake a systematic review on animal studies evaluating the systemic admin...