Patients
Intervention
Follow-up
Outcome
Study
Reference
No.
Agea
No. of implants
Position
Supra-structure
Change
Declarations
(DAVIS et al. 1999) [17]
44
61.2
NG
Symphyseal
Fixed
6.6 Ya
VBH (−.8 to +3.3 mm)
–
R
(Powers et al. 1994) [32]
146
52
NG
TMI
Fixed
18–51 M
BF (+2 to 9 mm)
–
R
(Adell et al. 1981) [58]
410
53
276...
Focus question
In patient with implant restoration, what is the chance of residual alveolar ridge preserving and bone formation in the adaptive remodeling and what are the features of this preservation?
Search strategy
Population
#1—edentulous patient
Intervention
#2—implant OR overdenture OR fixed bridge OR transmandibular implant OR full rehabilitation
O...
Khalifa, A.K., Wada, M., Ikebe, K. et al. To what extent residual alveolar ridge can be preserved by implant? A systematic review. Int J Implant Dent 2, 22 (2016). https://doi.org/10.1186/s40729-016-0057-z
Download citation
Received: 21 May 2016
Accepted: 16 November 2016
Published: 23 November 2016
DOI: https://doi.org/10.1186/s40729-016-0057-z
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Department of Prosthodontics, Faculty of Dentistry, Mansoura University, 68 ElGomhoria Street, ElMansoura, 35516, Egypt
Ahmed Khalifa Khalifa
Department of Prosthodontics, Gerodontology and Oral Rehabilitation, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka, 565-0871, Japan
Ahmed Khalifa Khalifa, Masahiro Wada, Kazunori Ikebe & Yoshinobu Maeda
You can also searc...
Murphy WM, Williams KR, Gregory MC. Stress in bone adjacent to dental implants. J Oral Rehabil. 1995;22(12):897–903.
Chou HY, Jagodnik JJ, Müftü S. Predictions of bone remodeling around dental implant systems. J Biomech. 2008;41(6):1365–73.
Chang S-H, Huang S-R, Huang S-F, Lin C-L. Mechanical response comparison in an implant overdenture retained by ball attachments on conventional regular...
Kremer U, Schindler S, Enkling N, Worni A, Katsoulis J, Mericske-Stern R. Bone resorption in different parts of the mandible in patients restored with an implant overdenture. A retrospective radiographic analysis. Clin Oral Implants Res. 2016;27(3):267-72.
von Wowern N, Gotfredsen K. Implant-supported overdentures, a prevention of bone loss in edentulous mandibles? A 5-year follow-up study. Clin ...
de Jong MHM, Wright PS, Meijer HJA, Tymstra N. Posterior mandibular residual ridge resorption in patients with overdentures supported by two or four endosseous implants in a 10-year prospective comparative study. Int J Oral Maxillofac Implants. 2010;25(6):1168–74.
Jacobs R, Schotte A, van Steenberghe D, Quirynen M, Naert I. Posterior jaw bone resorption in osseointegrated implant-supported over...
Block MS, Kent JN, Finger IM. Use of the integral implant for overdenture stabilization. Int J Oral Maxillofac Implants. 1990;5(2):140–7.
Norton MR, Gamble C. Bone classification: an objective scale of bone density using the computerized tomography scan. Clin Oral Implants Res. 2001;12(1):79–84.
de Oliveira RCG, Leles CR, Normanha LM, Lindh C, Ribeiro-Rotta RF. Assessments of trabecular bone...
Cowin SC. Bone stress adaptation models. J Biomech Eng. 1993;115(4B):528.
Byrne G. Fundamentals of implant dentistry. New Jersey: Wiley; 2014. 264 p.
Traini T, Degidi M, Iezzi G, Artese L, Piattelli A. Comparative evaluation of the peri-implant bone tissue mineral density around unloaded titanium dental implants. J Dent. 2007;35(1):84–92.
Hoshaw SJ, Brunski JB, Cochran GVB. Mechanical loading...
Roberts WE, Helm FR, Marshall KJ, Gongloff RK. Rigid endosseous implants for orthodontic and orthopedic anchorage. Angle Orthod. 1989;59(4):247–56.
Roberts WE, Smith RK, Zilberman Y, Mozsary PG, Smith RS. Osseous adaptation to continuous loading of rigid endosseous implants. Am J Orthod. 1984;86(2):95–111.
Wyatt CCLL. The effect of prosthodontic treatment on alveolar bone loss: a review of t...
Klemetti E, Kolmakow S. Morphology of the mandibular cortex on panoramic radiographs as an indicator of bone quality. Dentomaxillofacial Radiol. 1997;26(1):22–5.
Ortman LF, McHenry K, Hausmann E. Relationship between alveolar bone measured by 125I absorptiometry with analysis of standardized radiographs: 2. Bjorn technique. J Periodontol. 1982;53(5):311–4.
Davis WH, Lam PS, Marshall MW, Dorc...
Petersen PE, Bourgeois D, Ogawa H, Estupinan-Day S, Ndiaye C. The global burden of oral diseases and risks to oral health. Bull World Health Organ. 2005;83(9):661–9.
Nowjack-Raymer RE, Sheiham A. Association of edentulism and diet and Nutrition in US adults. J Dent Res. 2003;82(2):123–6.
Araújo MG, Lindhe J. Dimensional ridge alterations following tooth extraction. An experimental study in ...
Within the limitation of this review and based on previous studies, implant restoration has a noticeable residual alveolar ridge preservation which varies from reducing rate of physiologic resorption to bone apposition. However, the extension of this preservation from the implant to surrounding bony area, horizontally and vertically, is unknown. So, further studies are needed to elaborate the exte...
As most of the previous studies declared the favorable bone preservation of the residual alveolar ridge anteriorly around implants, biomechanically, and according to finite element analysis, bone modifying shows variations depending on the cancellous or cortical nature. Bone density is enhanced gradually from the third month to the end of the first year of loading coming stable after 30 months. W...
Despite age-related [71], local and/or systemic factors causing prolonged ridge resorption [9], authors reported the probability of preservative effect and overhaul to maintain the residual alveolar ridge with different restoration [70, 71]. In the previous study, bone formation was noticed with the distal implant in severely resorbed atrophied mandibular ridge [20]. Sennerby et al. [72] concluded...
Many procedures are used to recover denture foundation, but the majority is considered sophisticated techniques [51–53]. Observations tried to notify bone modifications with different types of implant-assisted restoration [23, 40, 54]. The clinical and radiographic investigations, detection of the altered mineral levels, or bone density within the bone may give a valuable data for the bony state...
Bone changes were reported after implant placement in three phases: healing, remodeling, and equilibrium. The remodeling phase is launched confronting the altered pattern of force transmission to the bone tissue. To withstand the applied functional load, continuous remodeling is conducted to reach a “steady state.” Mechanical stimulus is the primary bone modifier influenced by other in situ va...
Apparently, there is an enduring adaptive process surrounding the implant which sustains the rigid interface between alveolar bone and implant after non-destructive surgical and loading procedures. Like other body bones, and according to Wolff’s law, bone has the ability to differentiate with different stresses applied [22]. This reform is started from the time of surgical conduction of implant ...
The required documents were collected from PubMed, Web of Science, and Ovid databases. For expanding the traces of researching, further readings for the bibliography of the relevant publications and hand searching for some denoted articles were done. The keywords, for intervention and outcome, used in research engines in databases as “implant overdenture,” “implant bone resorption,” “alv...
Edentulism is rated between 7 and 69% internationally [1]. Many biological and non-bilogical predisposing factors lead to the main result of edentulism [2]. Regardless the debate to understand the way of resorption [3], the loss of periodontal ligament by tooth extraction leaves alveolar bone without a chance of reformation which leads to bone resorption only. The resorption shows variation in rat...
It has been reported that the load for (or to) implant-supported restoration may lead to bone remodeling as bone resorption and/or formation. While many authors supported the process of bone resorption, others elaborated bone apposition and increasing bone density close and remote to implant body (or fixture). This may suggest the role of the implant to reserve alveolar ridge from physiologic/path...
Fig. 1. PRISMA flow diagram
Fig. 1. PRISMA flow diagram
Risk of bias
Study
Maïmoun et al. 2010 [29]
Li et al. 2010 [32]
Li et al. 2012 [33]
...
Study
Tests and overall results
Bone mineral density
Histomorphometric
Biomechanical
...
Study
Sample characteristics
Animal model
Study groups
Treatment start
Duration of ...
Scardueli, C.R., Bizelli-Silveira, C., Marcantonio, R.A.C. et al. Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies.
Int J Implant Dent 4, 21 (2018). https://doi.org/10.1186/s40729-018-0132-8
Download citation
Received: 14 November 2017
Accepted: 23 April 2018
Published: 17 July 2018
DOI: https:/...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
This review was executed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), and the Cochrane Handbook for Systematic Reviews of Interventions, and no approval by an ethics committee is demanded.
All participants consented to publish their information details.
Cássio Rocha Scardueli, Carolina Bizelli-Silveira, Rosemary Adriana C. Marcantonio, Elcio Ma...
Correspondence to
Cassio Rocha Scardueli.
Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark
Cassio Rocha Scardueli, Carolina Bizelli-Silveira & Rubens Spin-Neto
Department of Periodontology, São Paulo State University (Unesp), School of Dentistry, Araraquara, São Paulo, Brazil
Cassio Rocha Scardueli, Rosemary Adriana C. Marcantonio & Elcio Marcantonio Jr
Department of Periodontology, Faculty of Odonto...
Berardi D, Carlesi T, Rossi F, Calderini M, Volpi R, Perfetti G. Potential applications of biphosphonates in dental surgical implants. Int J Immunopathol Pharmacol. 2007;20:455–65.
Javed F, Almas K. Osseointegration of dental implants in patients undergoing bisphosphonate treatment: a literature review. J Periodontol. 2010;81:479–84.
Jonville-Bera A, Autret-Leca E. Ranélate de strontium (Pr...
Marie PJ, Felsenberg D, Brandi ML. How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis. Osteoporos Int. 2011;22:1659–67.
Canalis E, Hott M, Deloffre P, Tsouderos Y, Marie PJ. The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone. 1996;18:517–23.
Peng S, Liu XS, Wang T, Li Z, Zhou G, Luk KD, et al. ...
Arlot ME, Jiang Y, Genant HK, Zhao J, Burt-Pichat B, Roux JP, et al. Histomorphometric and microCT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate. J Bone Miner Res. 2008;23:215–22.
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.
J...
Pemmer B, Hofstaetter JG, Meirer F, Smolek S, Wobrauschek P, Simon R, et al. Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride. J Synchrotron Radiat. 2011;18:835–41.
Peng S, Liu XS, Zhou G, Li Z, Luk KD, Guo XE, et al. Osteoprotegerin deficiency attenuates strontium-mediated inhibition of osteoclastogenes...
Davies JE. Mechanisms of endosseous integration. Int J Prosthodont. 1998;11:391–401.
Davies JE. Understanding peri-implant endosseous healing. J Dent Educ. 2003;67:932–49.
Sakka S, Baroudi K, Nassani MZ. Factors associated with early and late failure of dental implants. J Investig Clin Dent. 2012;3:258–61.
Bastos AS, Spin-Neto R, Conte-Neto N, Galina K, Boeck-Neto RJ, Marcantonio C, et al...
Medical Literature Analysis and Retrieval System Online
Ovariectomy
Strontium
Strontium ranelate
Systematic Review Centre for Laboratory animal Experimentation
Based on the few studies included in this systematic review, it is possible to state that the systemic administration of Sr, in the form of SRAN, seems to enhance peri-implant bone quality and implant osseointegration, however, to a moderate extent. Further studies should focus on standardization of the study designs to properly assess the effects of Sr, including parameters such SRAN dose, admini...
The variability in the results of the studies included in this review, may not only relate to SRAN dose, but may somehow relate to differences in the time-period after ovariectomy, before the animals were included in the study, which differed greatly among studies (from 4 to 12 weeks). Although it is already defined in the literature that initial osteoporosis features appear already at 4 weeks a...
All studies included in this review tested the hypothesis that non-radioactive Sr supplementation would enhance implant osseointegration. Overall, the results of the included studies suggest that the systemic Sr administration enhances peri-implant bone quality and implant osseointegration, however to a moderate extent. Positive results regarding implant osseointegration and the quality of peri-im...
Sr is a metabolic trace element closely related to calcium. Sr2+ ions are incorporated into bone by two main mechanisms: (a) a rapid uptake mechanism, dependent on osteoblast activity, whereby Sr2+ becomes absorbed via ion exchange processes with Ca2+ or binding to osteoid proteins, and (b) Sr2+ ions incorporate into the crystal lattice of the bone mineral phase. [34] When Sr2+ is present in highe...
In three studies from the same research group, female rats with ovariectomy-induced (OVX) osteoporosis were included [31,32,33]. Although the same research group performed the studies, the results were based on diverse animal populations, as it can be inferred from the studies. Rats receiving a high dose of SRAN (SRANH, 1000 mg/kg/day) showed an increased ratio between bone and total voxels in di...
The initial search for publications yielded 578 titles in MEDLINE (PubMed) database, and 152 in Scopus database. After duplicates were removed, there were a total of 553 titles to be screened. After initial screening, using the abstracts and key words, 37 publications remained (31 from PubMed and 6 from Scopus), that potentially met the inclusion criteria. Hand-searching did not reveal any additio...
Three independent researchers (CRS, CBS, and RSN) conducted data extraction and validity assessment of the studies that met the inclusion criteria. Data was extracted focusing on the animal model, study groups, treatment start, duration of the treatment, period of examination, implant specification, evaluation methods, and results (outcomes), according to what was reported in each study (i.e., his...
This review was executed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) [26], and the Cochrane Handbook for Systematic Reviews of Interventions [27].
Animal studies in which the methodology/results included parameters regarding the use of systemic administration of non-radioactive Sr to enhance the osseointegration of implants and/or the remodeling ...
Thus, the aim of this review was to undertake a systematic review of the literature on the available evidence—deriving from animal studies—on the systemic administration of non-radioactive Sr to enhance the osseointegration of titanium implants and/or the bone regeneration (i.e., remodeling) in association with bone grafting techniques.
Following the trauma induced to the bone tissue during dental implant installation, wound healing involves the fine-tuned coupling of bone resorption and formation [1, 2], which finally leads to the direct bone-to-implant contact, i.e., implant osseointegration [3]. The same biological mechanisms are involved in the wound healing (i.e., remodeling) of a bone defect filled with bone graft and/or bo...
The literature states that Strontium (Sr) is able to simultaneously stimulate bone formation and suppress bone resorption. Recent animal studies suggest that the systemic administration of Sr, in the form of strontium ranelate (SRAN), would enhance the osseointegration of implants. The purpose of the present study was to undertake a systematic review on animal studies evaluating the systemic admin...