What are the histomorphometric outcomes of sinus augmentation with bone marrow aspirate concentrates obtained chairside?

PubMed, Web of Science, Cochrane Library, and Google Scholar were searched up to January 2017. Google scholar was searched for gray literature. The following keywords were used: “bone marrow aspirate concentrates,” “stem cells,” “histomorphometric,” and “bone grafting.” The reference list of the selected articles was further hand searched for any articles not included in the initial search.

Clinical studies involving only intraoral bone grafting applications of BMAC in the maxillary sinus of humans were included

Clinical studies including histomorphometric evaluation were included

Only chairside BMAC methods of harvesting BMAC are included

Animal studies, in vitro studies, and case reports are excluded

The “title and abstract” were independently screened by two reviewers (AA, PA); articles were excluded if they obviously did not meet the inclusion criteria. The full text was independently analyzed by three reviewers (AA, PA, MT). A previously pilot-tested data extraction sheet was used by two reviewers (PA, MT) to independently extract data. Any disagreements were resolved through discussion with a fourth reviewer (SMB).

The risk of bias tool [13] by the Office of Health Assessment and Translation (OHAT) was used to assess the risk of bias (Table 1). Two reviewers (MT and PA) independently scored the risk of bias for the selected studies, and disagreements were resolved through discussion with another reviewer (SMB).