Table 2 Characteristics of selected studies : Maxillary sinus augmentation using chairside bone marrow aspirate concentrates for implant site development: a systematic review of histomorphometric studies

author: Miriam Ting, Philip Afshar, Arik Adhami, Stanton M Braid, Jon B Suzuki | publisher: drg. Andreas Tjandra, Sp. Perio, FISID

Study	Treatment groups	No. of patients (age range)	No. of maxillary sinuses evaluated	Donor site for BMAC	Clinical findings/implant survival	Timing of biopsy	Histologic outcomes
de Oliveira et al. [12]	SCG (BMAC obtained by single centrifugation and bone graft) DCG (BMAC obtained by double centrifugation and bone graft) Control (xenogenous bone graft alone)	15 (mean age 55.4 years)	21	Posterior iliac crest	- 68 implants were placed in the previously grafted sites, and 100% osseointegrated - Loading was applied after 6 months	6 months	Vital mineralized tissue: - SCG 38.44% - DCG 34.63% - Control 27.30% - Not statistically different Non-vital mineralized tissue: - SCG 13.70% - DCG 19.63% - Control 22.79% - Not statistically different	Non-mineralized tissue: - SCG 47.87% - DCG 45.73% - Control 49.90% - Not statistically different
Pasquali et al. [7]	Test (BMAC and xenogenous bone graft) Control (xenogenous bone graft alone)	8 (mean age 55.4 years)	16	Superior posterior iliac crest	- At least two implants were placed in each previously grafted sites, and all implants osseointegrated - Loading was applied after a 6-month healing period	6 months	Vital mineralized tissue: - Test 55.15% - Control 27.30% - Statistically significant Non-vital mineralized tissue: - Test 6.32% - Control 22.79% - Statistically significant	Non-mineralized tissue: - Test 38.53% - Control 49.90% - Not statistically significant
Payer et al. [2]	Test (porous bovine bone mineral together with tibial bone marrow aspirate) Control (bovine bone graft without any additive)	6 (mean age 58.2 years)	12	Tibia	- 44 implants were stable and osseointegrated at radiographic and Periotest evaluation	3 months 6 months	Newly formed bone: 3 months -Test 10.36% - Control 9.45% - Not statistically significant 6 months - Test 14.12% - Control 10.41% - Not statistically significant 3 and 6 months: - Not statistically significant	Bone-to-bone substitute contact: 3 months -Test 16.40% - Control 15.06% - Not statistically significant 6 months - Test 20.26% - Control 17.89% - Not statistically significant 3 and 6 months: - Not statistically significant
Sauerbier et al. [11]	Open bone marrow-derived mononuclear cell isolation by synthetic poylsaccharide (FICOLL) method with bovine bone mineral (BBM) Closed bone marrow aspirate concentrate (BMAC) system with BBM	FICOLL group 4 (mean age 59.5 years) BMAC group 7 (mean age 55 years)	FICOLL group 6 BMAC group 12	Superior posterior iliac spine	- 50 implants were placed (17 FICOLL group and 33 BMAC group) - Implant survival was evaluated after 1 year - No implant out of 17 was lost in the FICOLL group, before prosthetic loading - 1 implant out of 33 failed in the BMAC group, before prosthetic loading - No implant was lost after loading - All 49 osseointegrated implants were loaded and in function	3 months	New bone formation: - FICOLL group 15.5%, - BMAC group 19.9%, - Not statistically significant Value of biomaterial: - FICOLL group 19.7% - BMAC group 31.9% Value of marrow space: - FICOLL group 64.8% - BMAC group 47.4% - Marrow space is significantly less for BMAC
Sauerbier et al. [14]	Test: bovine bone mineral (BMM) and BMAC Control 70% BBM and autogenous bone 30% harvested from the retromolar area	25 test 11 control (mean age 56.6 years)	34 test 11 control	Superior posterior iliac spine	Radiologic gain and augmented bone height: - Test 1.74% - Control 1.33% - Statistically significant	3–4 months	New bone formation: - Test 12.6% - Control 14.3% - Not statistically significant
Wildburger et al. [15]	Test: bovine bone mineral (BBM) mixed with a concentrate harvested from the posterior iliac crest Control: BBM alone	7 (mean age 58 years)	14	Superior posterior iliac crest	- 52 implants were placed - Average dental implant healing time was 4 months - Prosthetic treatment was achieved in all patients	3 months 6 months	New bone formation: 3 months - Test 7.4% - Control 11.8% - Not statistically significant 6 months - Test 13.5% - Control 13.9% - Not statistically significant	Fraction of bovine bone material 3 months - Test 42.6% - Control 34.9% 6 months - Test 36.2%, - Control 39.5%

Table 2 Characteristics of selected studies

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