We wish to acknowledge the dedication and scientific advise of Prof. Dr. Tord Berglundh on the histological analysis as well as the diligent work in processing the histological samples to Estela Maldonado for the immunohistochemistry and Asal Shikhan and Fernando Muñoz for the histomorphometry. The work of Esperanza Gross on the statistical analysis is highly acknowledged.

This study was partially supported through a research contract between Geistlich Pharma AG and the University Complutense of Madrid.

Data supporting our findings can be found in Complutense University data base.

This study has involved the direct participation of the following investigators whom we propose as authors in this manuscript. AOV contributed to the protocol design, surgical procedures, histological analysis, critical data analysis, and writing of the manuscript. SMV contributed to the immunohistochemical analysis. IS contributed to the patient’s follow-up and data collection. FV contributed to the protocol design and manuscript edition. MS contributed to the protocol design, manuscript writing, and editing. All authors read and approved the final manuscript.

Alberto Ortiz-Vigón, Sergio Martinez-Villa, Iñaki Suarez, Fabio Vignoletti, and Mariano Sanz, declare that they have no competing interests.

Not applicable.

The study was conducted, recorded and reported in accordance with the Helsinki Declaration of 1975, as revised in 2000 and 2008 and prior to the commencement, the ethics committee of the Clinical San Carlos Hospital, Madrid, Spain, approved the protocol and informed consent forms under the registration number 13/404-P. This study was conducted in the ETEP (Etiology and Therapy of Periodontal Diseases) Research Group at the University Complutense of Madrid (Spain) from 11 of December 2013 to 12 of September 2016. All the investigators were trained on ISO-GCP standard before study start and on all study procedures during the site initiation visit by the sponsor. A clinical monitor of the sponsor in accordance with ISO 14155:2011 monitored this study. This study was performed in accordance with national regulations on ordinary care trials with CE marked medical devices within their intended use as well as with national regulations on data protection: Circular No. 07/2004, Decree 414/1996, DPA 15/1999, Royal Decree 1720/2007.