Open hour: senin - sabtu 09:00:00 - 20:00:00; minggu & tanggal merah tutup

Fig. 7 Second stage surgery of patient in Fig. 1. ...

Fig. 7 Second stage surgery of patient in Fig. 1. a Vestibular depth reduction after augmentation and implant placement. b Partial thickness and apical repositioned flap. c CMX healing and soft tissue dehiscence with CCXBB exposure. d Dehiscence healing after re-contouring and buccal emergency profile. e Buccal aspect of the final restoration. f Buccal ridge contour

Fig. 6 Immunohistochemical analysis of slices from...

Fig. 6 Immunohistochemical analysis of slices from the same sample with four different markers. a TRAP. b OPN. c ALP. d OSC

Fig. 5. Histomorphometric analysis of the same sam...

ple. a Ground section stained with Levai-Laczkó. b Tissue identification of the ROI. c Closer view a bone and CCXBB. d Closer view of b Fig. 5. Histomorphometric analysis of the same sample. a Ground section stained with Levai-Laczkó. b Tissue identification of the ROI. c Closer view a arrow pointing a cement line between new mineralized bone and CCXBB. d Closer view of b

Fig. 4. Histological samples. a CCXBB control with...

Fig. 4. Histological samples. a CCXBB control without implantation. b Histologic samples with acute inflammatory infiltration. c Histologic sample with limited remaining CCXBB and large bone ingrowth Fig. 4. Histological samples. a CCXBB control without implantation. b Histologic samples with acute inflammatory infiltration. c Histologic sample with limited remaining CCXBB and large bone ingr...

Fig. 3. Re-entry procedure of patient in Fig. 1. ...

Fig. 3. Re-entry procedure of patient in Fig. 1. a Buccal aspect of the augmented region. b Horizontal bone augmentation. c Screws and pins removal and bone trephine sampling. d Implants placement and buccal bone width from the implant shoulder. e Primary flap closure. f Implants submerged healing Fig. 3. Re-entry procedure of patient in Fig. 1. a Buccal aspect of the augmented region. b Ho...

Fig. 2. Lateral bone augmentation of the alveolar ...

Fig. 2. Lateral bone augmentation of the alveolar crest (a) atrophic ridge. b Perforations and adaptation of the cortical layer. c Shaping, pre-wetting and fixation of CCXBB with titanium screws. d Horizontal contour and peripheral gap between CCXBB and bone layer. e Outlying DBBM filling. f CM stabilized with pins Fig. 2. Lateral bone augmentation of the alveolar crest (a) atrophic ridge. b ...

Fig. 1. Study chart and follow-up visits : Histomo...

Fig. 1. Study chart and follow-up visits Fig. 1. Study chart and follow-up visits

Table 4 Implant loss and tissue characteristics : ...

Differentiated tissues Implant lost (Yes/no) Mean SD Percentage SD (%) ...

Table 3 Immunohistochemical markers proportions (i...

Patient TRAP (%) OPN (%) ALP (%) OSC (%) 1 ...

Table 2 Quantitative histological analysis : Histo...

Tissue type Mean Standard deviation Median CI 95% Mineralized bone ...

Table 1 Clinical and histomorphometry assessments ...

Patient Soft tissue dehiscence Mineralized bone (%) CCXBB (%) Bone marrow (%) Connect...

About this article : Histomorphometric and immunoh...

Ortiz-Vigón, A., Martinez-Villa, S., Suarez, I. et al. Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement. Int J Implant Dent 3, 24 (2017). https://doi.org/10.1186/s40729-017-0087-1 Download citation Received: 21 March 2017 Accepted: 12 June 2017 Published: 21 Ju...

Rights and permissions : Histomorphometric and imm...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...

Author information : Histomorphometric and immunoh...

ETEP Research Group, Facultad de Odontología, Universidad Complutense de Madrid, Plaza Ramón y Cajal, 28040, Madrid, Spain Alberto Ortiz-Vigón, Sergio Martinez-Villa, Iñaki Suarez, Fabio Vignoletti & Mariano Sanz You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar ...

Acknowledgements : Histomorphometric and immunohis...

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Acknowledgements : Histomorphometric and immunohis...

We wish to acknowledge the dedication and scientific advise of Prof. Dr. Tord Berglundh on the histological analysis as well as the diligent work in processing the histological samples to Estela Maldonado for the immunohistochemistry and Asal Shikhan and Fernando Muñoz for the histomorphometry. The work of Esperanza Gross on the statistical analysis is highly acknowledged. This study was partial...

References : Histomorphometric and immunohistochem...

Patti A, Gennari L, Merlotti D, Dotta F, Nuti R. Endocrine actions of osteocalcin. Int J Endocrinol. 2013;2013:846480. Schwarz F, Herten M, Sager M, Wieland M, Dard M, Becker J. Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA titanium implants: preliminary results of a pilot study in dogs. Clin Oral Implants Res. 2...

References : Histomorphometric and immunohistochem...

Araujo MG, Linder E, Lindhe J. Bio-Oss collagen in the buccal gap at immediate implants: a 6-month study in the dog. Clin Oral Implants Res. 2011;22:1–8. Chiapasco M, Colletti G, Coggiola A, Di Martino G, Anello T, Romeo E. Clinical outcome of the use of fresh frozen allogeneic bone grafts for the reconstruction of severely resorbed alveolar ridges: preliminary results of a prospective study. I...

References : Histomorphometric and immunohistochem...

Jeno L, Geza L. A simple differential staining method for semi-thin sections of ossifying cartilage and bone tissues embedded in epoxy resin. Mikroskopie. 1975;31:1–4. Dias RR, Sehn FP, de Santana Santos T, Silva ER, Chaushu G, Xavier SP. Corticocancellous fresh-frozen allograft bone blocks for augmenting atrophied posterior mandibles in humans. Clin Oral Implants Res. 2016;27:39–46. Nissan ...

References : Histomorphometric and immunohistochem...

Cremonini CC, Dumas M, Pannuti C, Lima LA, Cavalcanti MG. Assessment of the availability of bone volume for grafting in the donor retromolar region using computed tomography: a pilot study. Int J Oral Maxillofac Implants. 2010;25:374–8. Nkenke E, Weisbach V, Winckler E, Kessler P, Schultze-Mosgau S, Wiltfang J, et al. Morbidity of harvesting of bone grafts from the iliac crest for preprosthetic...

References : Histomorphometric and immunohistochem...

Sanz M, Vignoletti F. Key aspects on the use of bone substitutes for bone regeneration of edentulous ridges. Dent Mater. 2015;31:640–7. Benic GI, Hammerle CH. Horizontal bone augmentation by means of guided bone regeneration. Periodontology. 2014;66:13–40. Beretta M, Cicciu M, Poli PP, Rancitelli D, Bassi G, Grossi GB, et al. A Retrospective Evaluation of 192 Implants Placed in Augmented Bon...

Abbreviations : Histomorphometric and immunohistoc...

Alkaline phosphatase Cone beam computed tomography Collagen containing xenogeneic bone block Native collagen membrane Deproteinized bovine bone mineral Etiology and Therapy of Periodontal Diseases Osteopontin Osteocalcine Tartrate-resistant acid phosphatase

Conclusions : Histomorphometric and immunohistoche...

Within the limitations of this clinical study, we may conclude that the use of CCXBB in combination with DBBM particles and a native bilayer collagen membrane for staged lateral bone augmentation in severe atrophic alveolar crests achieved significant horizontal crestal width allowing for staged implant placement in most of the patients. Histological analysis and implant survival records indicate ...

Discussion : Histomorphometric and immunohistochem...

The immune-histochemical results reported expression of osteopontin mainly at the border between mineralized vital bone (MVB) with CCXBB, what coincides with findings from previous reports [38,39,40]. Alkaline phosphatase (ALP) is considered as an early osteoblast differentiation marker [41]. ALP-positive cells were detectable, in all specimens on the periphery of MVB, associated to areas of new b...

Discussion : Histomorphometric and immunohistochem...

When correlating the clinical results and the histological outcomes, there was a positive association between the presence of soft tissue dehiscence with CCXBB exposure and a diminished amount of new mineralized bone (p = 0.06). This lower amount of new bone within the xenogeneic graft suggests a lack of full graft integration and diminished vascular supply, what may have caused the soft tissu...

Discussion : Histomorphometric and immunohistochem...

The purpose of this investigation was to evaluate histologically and immunohistochemically the behavior of CCXBB blocks when used for staged lateral bone augmentation in severe human horizontal residual bone defects. Six months after the regenerative intervention using the CCXBB blocks, the mean increase in bone width was 4.12 mm and hence, this outcome allowed for the placement of dental implant...

Results : Histomorphometric and immunohistochemica...

The results from the histomorphometric measurements are depicted in Table 2. Bone biopsies were composed by 21.37% (SD 7.36) of residual CCXBB, 26.90% (SD 12.21) of mineralized vital bone (MVB), 47.13% (SD 19.15) of non-mineralized tissue and 0.92% of DBBM (Fig. 5b). Biopsies from patients who lost their implants had a statistical significant lower amount of MVB (p = 0.01u) and a statistical...

Results : Histomorphometric and immunohistochemica...

Twenty-eight CCXBB blocks were placed in 15 patients that fulfilled the selection criteria (12 women and 3 men) with a mean age of 54.5 (SD 8.34). The detailed clinical and radiographical outcomes have been reported previously [21]. In brief, one patient experienced pain and soft tissue dehiscence leading to removal of the graft material 3 days after the regenerative procedure. Another patient r...

Methods : Histomorphometric and immunohistochemica...

For the immunohistochemical analysis, the semi-thin sections were incubated over night with primary antibodies at 4 °C (Santa Cruz Biotechnology Inc., Santa Cruz, Calif., USA). The antibody dilutions used were alkaline phosphatase (ALP) 1:100, osteopontin (OPN) 1:100, osteocalcin (OSC) 1:100, and tatrate resistant acid phosphatase (TRAP) 1:100. The obtained semi-thin sections were evaluated wit...

Methods : Histomorphometric and immunohistochemica...

Twenty-six weeks after the regenerative procedure the patient returned for the re-entry intervention for placement of dental implants. After raising full-thickness flaps, the augmented area was exposed and horizontal crestal width measurements were performed. Then, the surgeon evaluated the bone availability and if implant placement was considered possible, a core bone biopsy was harvested with th...

Methods : Histomorphometric and immunohistochemica...

CCXBB (Bio-Graft® Geistlich Pharma) is a bone substitute material in a natural block form. The dimensions of the Bio-Graft block are 10 mm in height, 10 mm in length and 5 mm in width. It consists of a natural cancellous bone structure of hydroxyapatite and endogenous collagen type I and III, equine origin and is a class III medical device according to the Medical Device Directive 93/42 EECsâ€...

Methods : Histomorphometric and immunohistochemica...

The present manuscript reports the histological outcomes of a prospective single arm study evaluating the safety and clinical performance of CCXBB blocks when used as replacement bone grafts for lateral bone augmentation prior to staged implant placement. The results of the clinical and radiographic outcomes have been reported in a previous publication [21]. For correlation of the histological wit...

Background : Histomorphometric and immunohistochem...

Different techniques and grafting materials have been used for the horizontal reconstruction of deficient alveolar processes before implant placement, resulting in different degrees of predictability and clinical outcomes [1]. Among the grafting materials, particulated xenogeneic materials have been extensively studied in both experimental and clinical studies and when combined with porcine-derive...

Abstract : Histomorphometric and immunohistochemic...

The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures. In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed us...

About this article : Clinical outcome of alveolar ...

Sagheb, K., Schiegnitz, E., Moergel, M. et al. Clinical outcome of alveolar ridge augmentation with individualized CAD-CAM-produced titanium mesh. Int J Implant Dent 3, 36 (2017). https://doi.org/10.1186/s40729-017-0097-z Download citation Received: 15 March 2017 Accepted: 13 July 2017 Published: 26 July 2017 DOI: https://doi.org/10.1186/s40729-017-0097-z

Rights and permissions : Clinical outcome of alveo...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...

Ethics declarations : Clinical outcome of alveolar...

Keyvan Sagheb reports personal fees and grants from Dentsply, Geistlich, and Nobel Biocare outside the submitted work. Eik Schiegnitz reports personal fees and grants from Septodont, Dentsply, Geistlich, and Straumann outside the submitted work. Maximilian Moergel reports grants from Camlog outside the submitted work. Christian Walter reports grants and personal fees from Straumann outside the sub...

Author information : Clinical outcome of alveolar ...

Correspondence to E. Schiegnitz.

Author information : Clinical outcome of alveolar ...

K. Sagheb and E. Schiegnitz contributed equally to this work. Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany K. Sagheb, E. Schiegnitz, M. Moergel, C. Walter, B. Al-Nawas & W. Wagner Mediplus, Oral and Maxillofacial Surgery, Private Praxis, Mainz, Germany C. Walter You can also search for...

References : Clinical outcome of alveolar ridge au...

Ali S, Bakry SA, Abd-Elhakam H. Platelet-rich fibrin in maxillary sinus augmentation: a systematic review. The Journal of oral implantology. 2015;41(6):746–53. PubMed PMID: 25536095 Moraschini V, Barboza ES. Effect of autologous platelet concentrates for alveolar socket preservation: a systematic review. Int J Oral Maxillofac Surg. 2015;44(5):632–41. PubMed PMID: 25631334 Torres J, Tamimi F,...

References : Clinical outcome of alveolar ridge au...

Pieri F, Corinaldesi G, Fini M, Aldini NN, Giardino R, Marchetti C. Alveolar ridge augmentation with titanium mesh and a combination of autogenous bone and anorganic bovine bone: a 2-year prospective study. J Periodontol. 2008;79(11):2093–103. PubMed PMID: 18980518 Proussaefs P, Lozada J. Use of titanium mesh for staged localized alveolar ridge augmentation: clinical and histologic-histomorphom...

References : Clinical outcome of alveolar ridge au...

von Arx T, Kurt B. Implant placement and simultaneous peri-implant bone grafting using a micro titanium mesh for graft stabilization. Int J Periodontics Restorative Dent. 1998;18(2):117–27. PubMed PMID: 9663090 von Arx T, Kurt B. Implant placement and simultaneous ridge augmentation using autogenous bone and a micro titanium mesh: a prospective clinical study with 20 implants. Clin Oral Implant...

References : Clinical outcome of alveolar ridge au...

Moraschini V, Poubel LA, Ferreira VF, Barboza ES. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review. Int J Oral Maxillofac Surg. 2015;44(3):377–88. PubMed PMID: 25467739 Al-Nawas B, Kammerer PW, Morbach T, Ladwein C, Wegener J, Wagner W. Ten-year retrospective follow-up study of the TiO...

Conclusions : Clinical outcome of alveolar ridge a...

Within the limitations of this study, being retrospective and having no control group, the results show that individualized CAD-CAM-produced titanium meshes are a safe and predictable procedure for large vertical and horizontal ridge augmentations. The soft tissue covering remains one of the most critical steps using this technique. However, exposure of the mesh does not result in complete loss of...

Discussion : Clinical outcome of alveolar ridge au...

The results showed that in all 21 augmented sites, a significant ridge augmentation was achieved, with a mean vertical augmentation of 6.5 ± 1.7 mm and a mean horizontal augmentation of 5.5 ± 1.9 mm. To our best knowledge, this is the first study investigating these parameters in individualized CAD-CAM-produced titanium meshes. For conventional titanium meshes, several studies were publish...

Discussion : Clinical outcome of alveolar ridge au...

In our study, PRF membranes were additionally to collagen membranes used to cover the CAD-CAM mesh. The aim of this clinical approach was to improve and accelerate wound healing. The results with the low exposure rates and the sufficient augmentation heights indicated that these PRF membranes are a promising technique. However, due to low case number in the control group without a PRF membrane, de...

Discussion : Clinical outcome of alveolar ridge au...

The vertical and horizontal regeneration of resorbed alveolar ridges remains a challenging surgical procedure, especially in the case of extensive bone atrophy. During the past years, different augmentation techniques have been proposed to restore an adequate bone volume. The aim of this study was to evaluate a technique for ridge augmentation in the maxilla and mandible using an individualized CA...

Results : Clinical outcome of alveolar ridge augme...

In the investigated time period, 17 patients received 21 TM augmentations. Fourteen of these patients were women and three men. Mean age at the time of augmentation was 37 ± 15 years (17–64 years). Twelve of the patients were non-smoker, and 5 patients were smoker. In 8 patients, a steady periodontal disease could be detected. Sixty-five percent (n = 11) of the patients presented a thin g...

Methods : Clinical outcome of alveolar ridge augme...

Cone beam computed tomography (CBCT) of the treated sites was performed before augmentation procedure and 6 months postoperatively at time of reentry. Craniofacial bone and TM showed different radio-opacity, which allowed their easy differentiation on the scans after regulating the brightness and contrast. In our department, two different CBCTs were available (Accuitomo, J. Morita Corporation, Ja...

Methods : Clinical outcome of alveolar ridge augme...

In a retrospective study, the clinical outcome of an individualized CAD-CAM-produced TM (Yxoss CBR®, Filderstadt, Germany) inserted by experienced surgeons in the Department of Oral and Maxillofacial Surgery of the University Medical Centre Mainz, Germany, between December 2014 and January 2017, was analyzed. Therefore, all patients with this CAD-CAM mesh augmentation and reentry operation for im...

Background : Clinical outcome of alveolar ridge au...

The aim of this clinical study was to present the clinical outcome of individualized CAD-CAM-produced TM in combination with particulate autogenous bone mixed with deproteinized bovine bone mineral (DBBM) used to augment horizontal and/or vertical bony defects in both maxillary and mandibular arches, within a two-stage technique. Furthermore, gained horizontal and vertical bone height and the infl...

Background : Clinical outcome of alveolar ridge au...

Dental implant placement is an effective treatment method for the replacement of lost teeth with high survival rates after long-term follow-up [1,2,3]. However, the long-term success and stability of implants in function are directly correlated with the quality and quantity of the available bone at the prospective implant site [4, 5]. Despite the development of various techniques and augmentation ...

Abstract : Clinical outcome of alveolar ridge augm...

The augmentation of the jaw has been and continues to be a sophisticated therapy in implantology. Modern CAD-CAM technologies lead to revival of old and established augmentation techniques such as the use of titanium mesh (TM) for bone augmentation. The aim of this retrospective study was to evaluate the clinical outcome of an individualized CAD-CAM-produced TM based on the CT/DVT-DICOM data of th...

Fig. 2. Clinical image of patient 4: a region 21 b...

Fig. 2. Clinical image of patient 4: a region 21 before implant placement. b, c Implant placement using the GBR procedure with a synthetic bone substitute material composed of HA + β-TCP Fig. 2. Clinical image of patient 4: a region 21 before implant placement. b, c Implant placement using the GBR procedure with a synthetic bone substitute material composed of HA + β-TCP

Fig. 1. Schematic representation of the technical ...

Fig. 1. Schematic representation of the technical characteristics of the investigated C-Tech Esthetic Line implant system (provided by the manufacturer) Fig. 1. Schematic representation of the technical characteristics of the investigated C-Tech Esthetic Line implant system (provided by the manufacturer)

Table 2 Results from the clinical and radiological...

Patient Implant-localization (region) Implant loss (+/−) Buccal width of keratinized peri-implant gingiva (mm) Buccal thickness of keratinized peri-implant gi...

Table 1 Participating patients and the number and ...

Patient Gender (m/f) Age (years) Implant localization (region) Implant diameter (mm) ...

About this article : Investigation of peri-implant...

Lorenz, J., Lerner, H., Sader, R.A. et al. Investigation of peri-implant tissue conditions and peri-implant tissue stability in implants placed with simultaneous augmentation procedure: a 3-year retrospective follow-up analysis of a newly developed bone level implant system. Int J Implant Dent 3, 41 (2017). https://doi.org/10.1186/s40729-017-0104-4 Download citation Received...

Rights and permissions : Investigation of peri-imp...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...

Ethics declarations : Investigation of peri-implan...

This study was conducted in compliance with the principles of the Declaration of Helsinki, and the approval of the ethics committee required for the study was obtained from the Ethics Committee of the Medical Center of the Goethe University Frankfurt. The procedures to be performed were explained in detail, and the patients signed the consent form. Jonas Lorenz, Henriette Lerner, Robert Sader, an...

Author information : Investigation of peri-implant...

Department for Oral, FORM-Lab, Cranio-Maxillofacial, and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany Jonas Lorenz, Robert A. Sader & Shahram Ghanaati HL-Dentclinic, Baden-Baden, Germany Henriette Lerner You can also search for this author in PubMed Google Scholar You can also search for this author in ...

References : Investigation of peri-implant tissue ...

Lerner H, Lorenz J, Sader R, Ghanaati S. Two-year retrospective study of periimplant health and periimplant bone stability after immediate implant placement of a newly developed bone level implant system—a first report. EDI Journal (European Association of Dental Implantologists, Teamwork Media); 2017; ahead of print. Ghanaati S, Lorenz J, Obreja K, Choukroun J, Landes C, Sader R. Nanocrystalli...

References : Investigation of peri-implant tissue ...

Gurgel BC, Montenegro SC, Dantas PM, Pascoal AL, Lima KC, Calderon PD. Frequency of peri-implant diseases and associated factors. Clin Oral Implants Res. 2016; doi: 10.1111/clr.12944 Qian J, Wennerberg A, Albrektsson T. Reasons for marginal bone loss around oral implants. Clin Implant Dent Relat Res. 2012;14(6):792–807. Berglundh T, Lindhe J, Ericsson I, Marinello C, Liljenberg B, Thomsen P....

Abbreviations : Investigation of peri-implant tiss...

β-tricalcium phosphate Bleeding on probing Fixed prosthetics Guided bone regeneration Hydroxyapatite Multinucleated giant cells Pink Esthetic Score Removable prosthetics

Conclusions : Investigation of peri-implant tissue...

In the present study, the implant and peri-implant hard- and soft-tissue stability was analyzed in a bone level implant system placed simultaneously with a GBR procedure 3 years after prosthetic loading. Peri-implant hard- and soft-tissue parameters such as width and thickness of peri-implant keratinized gingiva, probing depth, BOP, PES, peri-implant bone loss, and the presence of peri-implant os...

Discussion : Investigation of peri-implant tissue ...

Comparing the present results to the aforementioned study with the same implant system on immediately placed implants, it seems that the GBR augmentation procedure has no influence on the long-term stability of the implants. In both studies with different placement modalities and protocols, comparable clinical and radiological results were achieved. This leads to the assumption that the investigat...

Discussion : Investigation of peri-implant tissue ...

The tissue reaction, however, did not only differ in bone substitute materials of different origin but also in bone substitute materials of the same origin. In an in vivo trial, two xenogeneic bone substitute materials processed with different techniques were implanted subcutaneously in CD-1 mice for up to 60 days. Both bone substitute materials showed good integration within the peri-implant tis...

Discussion : Investigation of peri-implant tissue ...

In the present retrospective study, C-Tech bone level implants placed simultaneously with a GBR procedure around the implant shoulder were investigated clinically and radiologically after at least 3 years of loading to assess peri-implant tissue conditions and document peri-implant tissue stability. A total of 47 implants were placed in the upper (23 implants) and lower jaw (24 implants) of 20 p...

Results : Investigation of peri-implant tissue con...

Investigation of the esthetic appearance via PES revealed a mean point score of 10.1 (ranging from 7 to 13) from a maximum of 14. The highest values and therefore acceptance were found in the alveolar process deficiency and the soft-tissue level, which can be interpreted as a benefit of the augmentation procedure around the implant shoulder. Peri-implant bone loss calculated using the average bon...

Results : Investigation of peri-implant tissue con...

Altogether, 47 implants were placed in the upper and lower jaws of a total of 20 patients. In all implants, lateral augmentation in a GBR process was performed simultaneously with implant placement due to reduced horizontal or vertical height of the alveolar crest. A total of 23 implants were placed in the upper jaw and 24 implants in the lower jaw. The implant diameter varied between 3.5 mm (32 ...

Methods : Investigation of peri-implant tissue con...

Investigation parameters: Implant being in situ Width and thickness of peri-implant keratinized gingiva Pink Esthetic Score (PES) Probing depth BOP Peri-implant bone loss Presence of peri-implant osteolysis

Methods : Investigation of peri-implant tissue con...

In the present retrospective study, bone level implants (C-Tech Esthetic Line implants) were investigated clinically and radiologically. The bone level implant system has a Morse-locking conical implant-abutment connection with platform switching and an indexing hex that allows subcrestal implant placement and aims to prevent peri-implant bone loss. The surface of the implant system is manufacture...

Methods : Investigation of peri-implant tissue con...

In the present retrospective study, 47 dental implants (C-Tech Esthetic Line implants) from 20 patients (11 female, 9 male) with a mean age of 58.5 years (45–75 years) were analyzed clinically and radiologically. Implant placement and follow-up investigation was performed at the HL Dentclinic in Baden-Baden, Germany. The study was approved by the ethics commission of the medical department of ...

Background : Investigation of peri-implant tissue ...

The aim of the present retrospective investigation was to assess clinically and radiologically peri-implant tissue conditions and document peri-implant tissue stability in C-Tech implants when placed simultaneously with a GBR augmentation procedure after at least 3 years of loading.

Background : Investigation of peri-implant tissue ...

The ability of bone substitute materials to form a sufficient and stable implantation bed has been proven in numerous clinical trials; however, it is still to a certain degree unclear if the different tissue reactions have an impact on the establishment of a peri-implant infection, especially when these biomaterials are used for augmentations around the implant shoulder. Due to the two-stage desig...

Background : Investigation of peri-implant tissue ...

The prevalence of peri-implantitis has grown in the past few years and has become a major issue in implant dentistry. Long-term stable and healthy soft- and hard-tissue conditions should be achieved in combination with esthetically and functionally satisfying results. However, the rising number of placed implants in the past decades has come with an increase in the prevalence of peri-implantitis [...

Abstract : Investigation of peri-implant tissue co...

Guided bone regeneration (GBR) has been proven to be a reliable therapy to regenerate missing bone in cases of atrophy of the alveolar crest. The aim of the present retrospective analysis was to assess peri-implant tissue conditions and document peri-implant tissue stability in C-Tech implants when placed simultaneously with a GBR augmentation procedure. A total of 47 implants, which were placed ...

Fig. 8. Soft tissue dehiscence (a) CCXBB exposure ...

Fig. 8. Soft tissue dehiscence (a) CCXBB exposure 15 weeks after bone augmentation, the dehiscence healed 2 weeks later after reducing the graft exposure (b) after soft tissue augmentation and abutment connection leading to the loss of the mesial implant. After partial removal of the bone graft and place a connective tissue graft the area healed properly and a month later it was possible to re...

Fig. 7. Second stage surgery of patient in Fig. 1...

Fig. 7. Second stage surgery of patient in Fig. 1. a Vestibular depth reduction after augmentation and implant placement. b Partial thickness and apical repositioned flap. c CMX healing and soft tissue dehiscence with CCXBB exposure. d Dehiscence healing after re-contouring and buccal emergency profile. e Buccal aspect of the final restoration. f Buccal ridge contour Fig. 7. Second stage sur...

Fig. 6. Immunohistochemical analysis of slices fro...

Fig. 6. Immunohistochemical analysis of slices from the same sample with four different markers. a TRAP. b OPN. c ALP. d OSC Fig. 6. Immunohistochemical analysis of slices from the same sample with four different markers. a TRAP. b OPN. c ALP. d OSC

Fig. 5. Histomorphometric analysis of the same sam...

section stained with Levai-Laczkó. b Tissue identification of the ROI. c Closer view aized bone and CCXBB. d Closer view of b Fig. 5. Histomorphometric analysis of the same sample. a Ground section stained with Levai-Laczkó. b Tissue identification of the ROI. c Closer view a arrow pointing a cement line between new mineralized bone and CCXBB. d Closer view of b

Fig. 4. Histological samples. a CCXBB control with...

Fig. 4. Histological samples. a CCXBB control without implantation. b Histologic samples with acute inflammatory infiltration. c Histologic sample with limited remaining CCXBB and large bone ingrowth Fig. 4. Histological samples. a CCXBB control without implantation. b Histologic samples with acute inflammatory infiltration. c Histologic sample with limited remaining CCXBB and large bone ingr...

Fig. 3. Re-entry procedure of patient in Fig. 1. ...

Fig. 3. Re-entry procedure of patient in Fig. 1. a Buccal aspect of the augmented region. b Horizontal bone augmentation. c Screws and pins removal and bone trephine sampling. d Implants placement and buccal bone width from the implant shoulder. e Primary flap closure. f Implants submerged healing Fig. 3. Re-entry procedure of patient in Fig. 1. a Buccal aspect of the augmented region. b Ho...

Fig. 2. Lateral bone augmentation of the alveolar ...

Fig. 2. Lateral bone augmentation of the alveolar crest (a) atrophic ridge. b Perforations and adaptation of the cortical layer. c Shaping, pre-wetting and fixation of CCXBB with titanium screws. d Horizontal contour and peripheral gap between CCXBB and bone layer. e Outlying DBBM filling. f CM stabilized with pins Fig. 2. Lateral bone augmentation of the alveolar crest (a) atrophic ridge. b ...

Fig. 1. Study chart and follow-up visits : Histomo...

Fig. 1. Study chart and follow-up visits Fig. 1. Study chart and follow-up visits

Table 4 Implant loss and tissue characteristics : ...

Differentiated tissues Implant lost (Yes/no) Mean SD Percentage SD (%) ...

Table 3 Immunohistochemical markers proportions (i...

Patient TRAP (%) OPN (%) ALP (%) OSC (%) 1 ...

Table 2 Quantitative histological analysis : Histo...

Tissue type Mean Standard deviation Median CI 95% Mineralized bone ...

Table 1 Clinical and histomorphometry assessments ...

Patient Soft tissue dehiscence Mineralized bone (%) CCXBB (%) Bone marrow (%) Connect...

About this article : Histomorphometric and immunoh...

Ortiz-Vigón, A., Martinez-Villa, S., Suarez, I. et al. Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement. Int J Implant Dent 3, 24 (2017). https://doi.org/10.1186/s40729-017-0087-1 Download citation Received: 21 March 2017 Accepted: 12 June 2017 Published: 21 Ju...

Rights and permissions : Histomorphometric and imm...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...

Author information : Histomorphometric and immunoh...

ETEP Research Group, Facultad de Odontología, Universidad Complutense de Madrid, Plaza Ramón y Cajal, 28040, Madrid, Spain Alberto Ortiz-Vigón, Sergio Martinez-Villa, Iñaki Suarez, Fabio Vignoletti & Mariano Sanz You can also search for this author in PubMed Google Scholar You can also search for this author in PubMed Google Scholar ...

Acknowledgements : Histomorphometric and immunohis...

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Acknowledgements : Histomorphometric and immunohis...

We wish to acknowledge the dedication and scientific advise of Prof. Dr. Tord Berglundh on the histological analysis as well as the diligent work in processing the histological samples to Estela Maldonado for the immunohistochemistry and Asal Shikhan and Fernando Muñoz for the histomorphometry. The work of Esperanza Gross on the statistical analysis is highly acknowledged. This study was partial...

References : Histomorphometric and immunohistochem...

Patti A, Gennari L, Merlotti D, Dotta F, Nuti R. Endocrine actions of osteocalcin. Int J Endocrinol. 2013;2013:846480. Schwarz F, Herten M, Sager M, Wieland M, Dard M, Becker J. Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA titanium implants: preliminary results of a pilot study in dogs. Clin Oral Implants Res. 2...

References : Histomorphometric and immunohistochem...

Araujo MG, Linder E, Lindhe J. Bio-Oss collagen in the buccal gap at immediate implants: a 6-month study in the dog. Clin Oral Implants Res. 2011;22:1–8. Chiapasco M, Colletti G, Coggiola A, Di Martino G, Anello T, Romeo E. Clinical outcome of the use of fresh frozen allogeneic bone grafts for the reconstruction of severely resorbed alveolar ridges: preliminary results of a prospective study. I...

References : Histomorphometric and immunohistochem...

Jeno L, Geza L. A simple differential staining method for semi-thin sections of ossifying cartilage and bone tissues embedded in epoxy resin. Mikroskopie. 1975;31:1–4. Dias RR, Sehn FP, de Santana Santos T, Silva ER, Chaushu G, Xavier SP. Corticocancellous fresh-frozen allograft bone blocks for augmenting atrophied posterior mandibles in humans. Clin Oral Implants Res. 2016;27:39–46. Nissan ...

References : Histomorphometric and immunohistochem...

Cremonini CC, Dumas M, Pannuti C, Lima LA, Cavalcanti MG. Assessment of the availability of bone volume for grafting in the donor retromolar region using computed tomography: a pilot study. Int J Oral Maxillofac Implants. 2010;25:374–8. Nkenke E, Weisbach V, Winckler E, Kessler P, Schultze-Mosgau S, Wiltfang J, et al. Morbidity of harvesting of bone grafts from the iliac crest for preprosthetic...

References : Histomorphometric and immunohistochem...

Sanz M, Vignoletti F. Key aspects on the use of bone substitutes for bone regeneration of edentulous ridges. Dent Mater. 2015;31:640–7. Benic GI, Hammerle CH. Horizontal bone augmentation by means of guided bone regeneration. Periodontology. 2014;66:13–40. Beretta M, Cicciu M, Poli PP, Rancitelli D, Bassi G, Grossi GB, et al. A Retrospective Evaluation of 192 Implants Placed in Augmented Bon...

Abbreviations : Histomorphometric and immunohistoc...

Alkaline phosphatase Cone beam computed tomography Collagen containing xenogeneic bone block Native collagen membrane Deproteinized bovine bone mineral Etiology and Therapy of Periodontal Diseases Osteopontin Osteocalcine Tartrate-resistant acid phosphatase

Conclusions : Histomorphometric and immunohistoche...

Within the limitations of this clinical study, we may conclude that the use of CCXBB in combination with DBBM particles and a native bilayer collagen membrane for staged lateral bone augmentation in severe atrophic alveolar crests achieved significant horizontal crestal width allowing for staged implant placement in most of the patients. Histological analysis and implant survival records indicate ...

Discussion : Histomorphometric and immunohistochem...

The immune-histochemical results reported expression of osteopontin mainly at the border between mineralized vital bone (MVB) with CCXBB, what coincides with findings from previous reports [38,39,40]. Alkaline phosphatase (ALP) is considered as an early osteoblast differentiation marker [41]. ALP-positive cells were detectable, in all specimens on the periphery of MVB, associated to areas of new b...

Discussion : Histomorphometric and immunohistochem...

When correlating the clinical results and the histological outcomes, there was a positive association between the presence of soft tissue dehiscence with CCXBB exposure and a diminished amount of new mineralized bone (p = 0.06). This lower amount of new bone within the xenogeneic graft suggests a lack of full graft integration and diminished vascular supply, what may have caused the soft tissu...

Discussion : Histomorphometric and immunohistochem...

The purpose of this investigation was to evaluate histologically and immunohistochemically the behavior of CCXBB blocks when used for staged lateral bone augmentation in severe human horizontal residual bone defects. Six months after the regenerative intervention using the CCXBB blocks, the mean increase in bone width was 4.12 mm and hence, this outcome allowed for the placement of dental implant...

Results : Histomorphometric and immunohistochemica...

The results from the histomorphometric measurements are depicted in Table 2. Bone biopsies were composed by 21.37% (SD 7.36) of residual CCXBB, 26.90% (SD 12.21) of mineralized vital bone (MVB), 47.13% (SD 19.15) of non-mineralized tissue and 0.92% of DBBM (Fig. 5b). Biopsies from patients who lost their implants had a statistical significant lower amount of MVB (p = 0.01u) and a statistical...

Results : Histomorphometric and immunohistochemica...

Twenty-eight CCXBB blocks were placed in 15 patients that fulfilled the selection criteria (12 women and 3 men) with a mean age of 54.5 (SD 8.34). The detailed clinical and radiographical outcomes have been reported previously [21]. In brief, one patient experienced pain and soft tissue dehiscence leading to removal of the graft material 3 days after the regenerative procedure. Another patient r...

Methods : Histomorphometric and immunohistochemica...

For the immunohistochemical analysis, the semi-thin sections were incubated over night with primary antibodies at 4 °C (Santa Cruz Biotechnology Inc., Santa Cruz, Calif., USA). The antibody dilutions used were alkaline phosphatase (ALP) 1:100, osteopontin (OPN) 1:100, osteocalcin (OSC) 1:100, and tatrate resistant acid phosphatase (TRAP) 1:100. The obtained semi-thin sections were evaluated wit...

Methods : Histomorphometric and immunohistochemica...

Twenty-six weeks after the regenerative procedure the patient returned for the re-entry intervention for placement of dental implants. After raising full-thickness flaps, the augmented area was exposed and horizontal crestal width measurements were performed. Then, the surgeon evaluated the bone availability and if implant placement was considered possible, a core bone biopsy was harvested with th...

Methods : Histomorphometric and immunohistochemica...

CCXBB (Bio-Graft® Geistlich Pharma) is a bone substitute material in a natural block form. The dimensions of the Bio-Graft block are 10 mm in height, 10 mm in length and 5 mm in width. It consists of a natural cancellous bone structure of hydroxyapatite and endogenous collagen type I and III, equine origin and is a class III medical device according to the Medical Device Directive 93/42 EECsâ€...

Methods : Histomorphometric and immunohistochemica...

The present manuscript reports the histological outcomes of a prospective single arm study evaluating the safety and clinical performance of CCXBB blocks when used as replacement bone grafts for lateral bone augmentation prior to staged implant placement. The results of the clinical and radiographic outcomes have been reported in a previous publication [21]. For correlation of the histological wit...

Background : Histomorphometric and immunohistochem...

Different techniques and grafting materials have been used for the horizontal reconstruction of deficient alveolar processes before implant placement, resulting in different degrees of predictability and clinical outcomes [1]. Among the grafting materials, particulated xenogeneic materials have been extensively studied in both experimental and clinical studies and when combined with porcine-derive...

Abstract : Histomorphometric and immunohistochemic...

The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures. In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed us...

About this article : Clinical outcome of alveolar ...

Sagheb, K., Schiegnitz, E., Moergel, M. et al. Clinical outcome of alveolar ridge augmentation with individualized CAD-CAM-produced titanium mesh. Int J Implant Dent 3, 36 (2017). https://doi.org/10.1186/s40729-017-0097-z Download citation Received: 15 March 2017 Accepted: 13 July 2017 Published: 26 July 2017 DOI: https://doi.org/10.1186/s40729-017-0097-z

Rights and permissions : Clinical outcome of alveo...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...

Ethics declarations : Clinical outcome of alveolar...

Keyvan Sagheb reports personal fees and grants from Dentsply, Geistlich, and Nobel Biocare outside the submitted work. Eik Schiegnitz reports personal fees and grants from Septodont, Dentsply, Geistlich, and Straumann outside the submitted work. Maximilian Moergel reports grants from Camlog outside the submitted work. Christian Walter reports grants and personal fees from Straumann outside the sub...

Author information : Clinical outcome of alveolar ...

Correspondence to E. Schiegnitz.

Author information : Clinical outcome of alveolar ...

K. Sagheb and E. Schiegnitz contributed equally to this work. Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany K. Sagheb, E. Schiegnitz, M. Moergel, C. Walter, B. Al-Nawas & W. Wagner Mediplus, Oral and Maxillofacial Surgery, Private Praxis, Mainz, Germany C. Walter You can also search for...

References : Clinical outcome of alveolar ridge au...

Ali S, Bakry SA, Abd-Elhakam H. Platelet-rich fibrin in maxillary sinus augmentation: a systematic review. The Journal of oral implantology. 2015;41(6):746–53. PubMed PMID: 25536095 Moraschini V, Barboza ES. Effect of autologous platelet concentrates for alveolar socket preservation: a systematic review. Int J Oral Maxillofac Surg. 2015;44(5):632–41. PubMed PMID: 25631334 Torres J, Tamimi F,...

References : Clinical outcome of alveolar ridge au...

Pieri F, Corinaldesi G, Fini M, Aldini NN, Giardino R, Marchetti C. Alveolar ridge augmentation with titanium mesh and a combination of autogenous bone and anorganic bovine bone: a 2-year prospective study. J Periodontol. 2008;79(11):2093–103. PubMed PMID: 18980518 Proussaefs P, Lozada J. Use of titanium mesh for staged localized alveolar ridge augmentation: clinical and histologic-histomorphom...

References : Clinical outcome of alveolar ridge au...

von Arx T, Kurt B. Implant placement and simultaneous peri-implant bone grafting using a micro titanium mesh for graft stabilization. Int J Periodontics Restorative Dent. 1998;18(2):117–27. PubMed PMID: 9663090 von Arx T, Kurt B. Implant placement and simultaneous ridge augmentation using autogenous bone and a micro titanium mesh: a prospective clinical study with 20 implants. Clin Oral Implant...

References : Clinical outcome of alveolar ridge au...

Moraschini V, Poubel LA, Ferreira VF, Barboza ES. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review. Int J Oral Maxillofac Surg. 2015;44(3):377–88. PubMed PMID: 25467739 Al-Nawas B, Kammerer PW, Morbach T, Ladwein C, Wegener J, Wagner W. Ten-year retrospective follow-up study of the TiO...

Conclusions : Clinical outcome of alveolar ridge a...

Within the limitations of this study, being retrospective and having no control group, the results show that individualized CAD-CAM-produced titanium meshes are a safe and predictable procedure for large vertical and horizontal ridge augmentations. The soft tissue covering remains one of the most critical steps using this technique. However, exposure of the mesh does not result in complete loss of...

Discussion : Clinical outcome of alveolar ridge au...

The results showed that in all 21 augmented sites, a significant ridge augmentation was achieved, with a mean vertical augmentation of 6.5 ± 1.7 mm and a mean horizontal augmentation of 5.5 ± 1.9 mm. To our best knowledge, this is the first study investigating these parameters in individualized CAD-CAM-produced titanium meshes. For conventional titanium meshes, several studies were publish...

Discussion : Clinical outcome of alveolar ridge au...

In our study, PRF membranes were additionally to collagen membranes used to cover the CAD-CAM mesh. The aim of this clinical approach was to improve and accelerate wound healing. The results with the low exposure rates and the sufficient augmentation heights indicated that these PRF membranes are a promising technique. However, due to low case number in the control group without a PRF membrane, de...

Discussion : Clinical outcome of alveolar ridge au...

The vertical and horizontal regeneration of resorbed alveolar ridges remains a challenging surgical procedure, especially in the case of extensive bone atrophy. During the past years, different augmentation techniques have been proposed to restore an adequate bone volume. The aim of this study was to evaluate a technique for ridge augmentation in the maxilla and mandible using an individualized CA...

Results : Clinical outcome of alveolar ridge augme...

In the investigated time period, 17 patients received 21 TM augmentations. Fourteen of these patients were women and three men. Mean age at the time of augmentation was 37 ± 15 years (17–64 years). Twelve of the patients were non-smoker, and 5 patients were smoker. In 8 patients, a steady periodontal disease could be detected. Sixty-five percent (n = 11) of the patients presented a thin g...

Methods : Clinical outcome of alveolar ridge augme...

Cone beam computed tomography (CBCT) of the treated sites was performed before augmentation procedure and 6 months postoperatively at time of reentry. Craniofacial bone and TM showed different radio-opacity, which allowed their easy differentiation on the scans after regulating the brightness and contrast. In our department, two different CBCTs were available (Accuitomo, J. Morita Corporation, Ja...

Methods : Clinical outcome of alveolar ridge augme...

In a retrospective study, the clinical outcome of an individualized CAD-CAM-produced TM (Yxoss CBR®, Filderstadt, Germany) inserted by experienced surgeons in the Department of Oral and Maxillofacial Surgery of the University Medical Centre Mainz, Germany, between December 2014 and January 2017, was analyzed. Therefore, all patients with this CAD-CAM mesh augmentation and reentry operation for im...

Background : Clinical outcome of alveolar ridge au...

The aim of this clinical study was to present the clinical outcome of individualized CAD-CAM-produced TM in combination with particulate autogenous bone mixed with deproteinized bovine bone mineral (DBBM) used to augment horizontal and/or vertical bony defects in both maxillary and mandibular arches, within a two-stage technique. Furthermore, gained horizontal and vertical bone height and the infl...

Background : Clinical outcome of alveolar ridge au...

Dental implant placement is an effective treatment method for the replacement of lost teeth with high survival rates after long-term follow-up [1,2,3]. However, the long-term success and stability of implants in function are directly correlated with the quality and quantity of the available bone at the prospective implant site [4, 5]. Despite the development of various techniques and augmentation ...

Abstract : Clinical outcome of alveolar ridge augm...

The augmentation of the jaw has been and continues to be a sophisticated therapy in implantology. Modern CAD-CAM technologies lead to revival of old and established augmentation techniques such as the use of titanium mesh (TM) for bone augmentation. The aim of this retrospective study was to evaluate the clinical outcome of an individualized CAD-CAM-produced TM based on the CT/DVT-DICOM data of th...

Fig. 4. Statistical analysis for different variabl...

Fig. 4. Statistical analysis for different variables. a Weighted mean survival rate. b Implant survival rate according to degree of penetration. c Analysis of clinical complications. d Analysis of radiographic complications Fig. 4. Statistical analysis for different variables. a Weighted mean survival rate. b Implant survival rate according to degree of penetration. c Analysis of clinical com...

Fig. 3. Graphic representation of group 1 ≤ 4â...

Fig. 3. Graphic representation of group 1 ≤ 4 mm penetration and group 2 > 4 mm penetrations Fig. 3. Graphic representation of group 1 ≤ 4 mm penetration and group 2 > 4 mm penetrations

Fig. 1. Graphic representation of implants intrudi...

Fig. 1. Graphic representation of implants intruding sinus perforating or not the Schneiderian membrane Fig. 1. Graphic representation of implants intruding sinus perforating or not the Schneiderian membrane

Fig. 2. PRISMA flowchart of the screening process ...

Fig. 2. PRISMA flowchart of the screening process Fig. 2. PRISMA flowchart of the screening process

Table 3 Articles excluded and reasons for exclusio...

Reason for exclusion Investigations Study design (case series or case report) Kim et al. (2017), Hatano et al. (2007) Different grafting techn...

Table 2 Characteristics of the included investigat...

Author (year) Study design Follow-up (months) N of patients N of implants Smokers Le...

Table 1 Clinical and radiographic complications re...

Clinical complications Radiographic complications Sinusitis Thickening of Schneiderian membrane Nasal bleeding, nasal obstruction, nasal secre...

About this article : Influence of exposing dental ...

Ragucci, G.M., Elnayef, B., Suárez-López del Amo, F. et al. Influence of exposing dental implants into the sinus cavity on survival and complications rate: a systematic review. Int J Implant Dent 5, 6 (2019). https://doi.org/10.1186/s40729-019-0157-7 Download citation Received: 09 October 2018 Accepted: 06 January 2019 Published: 05 February 2019 DOI: https://doi.org/10...

Rights and permissions : Influence of exposing den...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...

Ethics declarations : Influence of exposing dental...

Not applicable Not applicable Gian Maria Ragucci, Basel Elnayef, Fernando Suárez López del Amo, Hom-Lay Wang, Federico Hernández-Alfaro, and Jordi Gargallo-Albiol declare that they have no competing interests. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Author information : Influence of exposing dental ...

Correspondence to Basel Elnayef.

Author information : Influence of exposing dental ...

Department of Oral and Maxillofacial Surgery, International University of Catalonia, C/Josep Trueta Sn, Sant Cugat del Vallés, C.P 08195, Barcelona, Spain Gian Maria Ragucci, Basel Elnayef, Federico Hernández-Alfaro & Jordi Gargallo-Albiol Department of Periodontics, University of Oklahoma Health Sciences Center – College of Dentistry, Oklahoma City, OK, USA Fernando Suárez-López del ...

Acknowledgements : Influence of exposing dental im...

The authors want to thank Mr Juan Luis Gómez Martínez for the support in the statistical analysis. Not applicable Not applicable The authors do not have any financial interests, either directly or indirectly, in the products or information listed in the paper.

References : Influence of exposing dental implants...

Schwarz L, Schiebel V, Hof M, Ulm C, Watzek G, Pommer B. Risk factors of membrane perforation and postoperative complications in sinus floor elevation surgery: review of 407 augmentation procedures. J Oral Maxillofac Surg. 2015;73:1275–82. Jung JA, Choi BH, Zhu SJ, Lee SH, Huh JY, You TM, Lee HJ, Li J. The effects of exposing dental implants to the maxillary sinus cavity on sinus complications....

References : Influence of exposing dental implants...

Ardekian L, Oved-Peleg E, Mactei EE, Peled M. The clinical significance of sinus membrane perforation during augmentation of the maxillary sinus. J Oral Maxillofac Surg. 2006 Feb;64(2):277–82. Anavi Y, Allon DM, Avishai G, Calderon S. Complications of maxillary sinus augmentations in a selective series of patients. Oral Surg Oral Med Oral Patho Oral RadiolEndod. 2008;106(1):34–8. Van den Ber...

References : Influence of exposing dental implants...

Curi MM, Cardoso CL, de Ribeiro C. Retrospective study of pterygoid implants in the atrophic posterior maxilla: implant and prosthesis survival rates up to 3 years. Int J Oral Maxillofac Implants. 2015;30(2):378–83. Boyne PJ, James RA. Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg. 1980;38(8):613–6. Tatum H.Jr. Maxillary and sinus implant reconstructions....

References : Influence of exposing dental implants...

Roccuzzo M, Bonino L, Dalmasso P, Aglietta M. Long-term results of a three arms prospective cohort study on implants in periodontally compromised patients: 10-year data around sandblasted and acid-etched (SLA) surface. Clin Oral Implants Res. 2014;25(10):1105–12. Esposito M, Grusovin MG, Rees J, Karasoulos D, Felice P, Alissa R, Worthington H, Coulthard P. Effectiveness of sinus lift procedures...

Conclusions : Influence of exposing dental implant...

The current review showed that the exposure of dental implants in the sinus cavity without the augmentation procedure or graft materials shows a high survival rate of 95.6%, without statistically significant differences according to the level of penetration (lower or higher to 4 mm). Changes in maxillary sinuses in relation to protruding implants within the sinus cavity do not statically affect ...

Discussion : Influence of exposing dental implants...

Consequently, it seems that maxillary sinus changes in relation to protruded implants inside the sinus cavity and does not statically affect to implant survival rate neither to clinical nor radiographic complications. Several limitations could be described for the present review. Firstly, there is a lack of a control group in the included studies, to compare outcomes and complications, with impla...

Discussion : Influence of exposing dental implants...

Pneumatization of the maxillary sinus and resorption of the residual alveolar ridge following tooth extraction can compromise the dental implant placement. Similarly, extension of the dental implants inside the maxillary sinus cavity is not rare. Some studies have observed some differences in relation to the depth of the implant extension inside the sinus cavity. When the implants penetrate inside...

Results : Influence of exposing dental implants in...

Seven studies [27,28,29,30,31,32,33] provide information on clinical complications with a global sample of 232 patients. Clinical complications among the different authors range from 0 to 14.3%, being the weighted mean complication rate 3.4% with an IC 95% [0 7.5] (Fig. 4c) Clinical complications analyzed in the studies were sinusitis, nasal bleeding, nasal obstruction, nasal secretion, mucopurul...

Results : Influence of exposing dental implants in...

An initial screening yielded a total of 3551 publications of which 26 potentially relevant articles were selected after an evaluation of their titles and abstracts. Full text of these articles was obtained and evaluated thoroughly. Of these, eight articles [26,27,28,29,30,31,32,33] (Table 2) fulfilled the inclusion criteria and subsequently were included in the qualitative analysis (Fig. 2). Rea...

Materials and methods : Influence of exposing dent...

Heterogeneity was assessed based on calculation of the I2 statistic (percentage variability of estimated effect that can be attributed to the heterogeneity of the effects) and the null statistic test. Galbraith graphs displayed the degree of heterogeneity. In studies where great heterogeneity was detected, a sensitivity analysis was performed to determine its source. Funnel plots and the Egger tes...

Materials and methods : Influence of exposing dent...

Articles were included in this systematic review if they met the following inclusion criteria: human prospective or retrospective studies, reporting outcomes of implant placed perforating the sinus floor with implant burs, and without regenerative procedure (lateral sinus lift or transalveolar technique) and graft material. The intrusion into the sinus cavity can occur during drilling or implant p...

Materials and methods : Influence of exposing dent...

This systematic review and subsequent meta-analysis follow the guidelines of the PRISMA statement. The following focus question was developed: Is the intrusion of dental implants into the sinus cavity during implant drilling or implant placement, without regenerative procedure (lateral sinus lift or transalveolar technique) and graft material, has an effect on implant survival or increase clinica...

Introduction : Influence of exposing dental implan...

Intrusion of dental implants into the maxillary sinus perforating through the Schneiderian membrane is considered a cause of undesirable complications [24, 25]. However, this phenomenon has never been properly evaluated and systematically studied. For this reason, the aim of this systematic review was to assess the implant survival and complication rates of implants intruding into the sinus cavity...

Introduction : Influence of exposing dental implan...

The edentulous posterior maxillary region often presents with unique challenging conditions in implant dentistry [1]. Limited bone height secondary to pneumatization of the maxillary sinus and the resorption of the alveolar ridge preclude in many instances the installation of dental implants. To compensate for the lack of bone height, several treatment options have been proposed. The most conserv...

Abstract : Influence of exposing dental implants i...

The overall survival rate of the implants into the sinus cavity was 95.6%, without statistical differences according to the level of penetration. The clinical and radiological complications were 3.4% and 14.8% respectively. The most frequent clinical complication was the epistaxis, and the radiological complication was thickening of the Schneiderian membrane, without reaching statistical significa...

Abstract : Influence of exposing dental implants i...

After tooth loss, the posterior maxilla is usually characterized by limited bone height secondary to pneumatization of the maxillary sinus and/or collapse of the alveolar ridge that preclude in many instances the installation of dental implants. In order to compensate for the lack of bone height, several treatment options have been proposed. These treatment alternatives aimed at the installation o...

Figure 2. Clinical image of patient 4

  Figure 2. Clinical image of patient 4: a region 21 before implant placement. b, c Implant placement using the GBR procedure with a synthetic bone substitute material composed of HA + β-TCP

Figure 1. Schematic representation of the technica...

    Figure 1. Schematic representation of the technical characteristics of the investigated C-Tech Esthetic Line implant system (provided by the manufacturer)

Table 2 Results from the clinical and radiological...

Patient Implant-localization (region) Implant loss (+/−) Buccal width of keratinized peri-implant gingiva (mm) Buccal thickness of keratinized peri-implant gingiva (mm) Pink Esthetic Score (PES) Probing depth (mm) at four sites (mb, db, mo, do) Bleeding on Probing (+/−) at four sites (mb, db, mo, do) Peri-implant bone loss (mm) Presence of peri-implant osteolysis (+/−) ...

Table 1 Participating patients and the number and ...

Patient Gender (m/f) Age (years) Implant localization (region) Implant diameter (mm) Implant length (mm) Augmentation material Prosthetic rehabilitation 1 f 50 32 3.5 13 HA + β-TCP r.p       34 4.3 11 HA + β-TCP r.p       42 3.5 13 HA + β-TCP r.p       44 4.3 11 HA + β-TCP r.p 2 m 61 36 3.5 11 HA + β-TCP ...

Discussion: Investigation of peri-implant in impla...

Abbreviations β-TCP: β-tricalcium phosphate BOP: Bleeding on probing F.P.: Fixed prosthetics GBR: Guided bone regeneration HA: Hydroxyapatite MNGCs: Multinucleated giant cells PES: Pink Esthetic Score R.P.: Removable prosthetics References Gurgel BC, Montenegro SC, Dantas PM, Pascoal AL, Lima KC, Calderon PD. Frequency o...

Discussion: Investigation of peri-implant in impla...

Comparing the present results to the aforementioned study with the same implant system on immediately placed implants, it seems that the GBR augmentation procedure has no influence on the long-term stability of the implants. In both studies with different placement modalities and protocols, comparable clinical and radiological results were achieved. This leads to the assumption that the inve...

Discussion: Investigation of peri-implant in impla...

The tissue reaction, however, did not only differ in bone substitute materials of different origin but also in bone substitute materials of the same origin. In an in vivo trial, two xenogeneic bone substitute materials processed with different techniques were implanted subcutaneously in CD-1 mice for up to 60 days. Both bone substitute materials showed good integration within the peri-impla...

Discussion: Investigation of peri-implant in impla...

Discussion In the present retrospective study, C-Tech bone level implants placed simultaneously with a GBR procedure around the implant shoulder were investigated clinically and radiologically after at least 3 years of loading to assess peri-implant tissue conditions and document peri-implant tissue stability. A total of 47 implants were placed in the upper (23 implants) and lower jaw (24...

Results: Investigation of peri-implant in implants

Results Altogether, 47 implants were placed in the upper and lower jaws of a total of 20 patients. In all implants, lateral augmentation in a GBR process was performed simultaneously with implant placement due to reduced horizontal or vertical height of the alveolar crest. A total of 23 implants were placed in the upper jaw and 24 implants in the lower jaw. The implant diameter varied between 3...

Methods: Investigation of peri-implant in implants...

C-Tech implant system In the present retrospective study, bone level implants (C-Tech Esthetic Line implants) were investigated clinically and radiologically. The bone level implant system has a Morse-locking conical implant-abutment connection with platform switching and an indexing hex that allows subcrestal implant placement and aims to prevent peri-implant bone loss. The surface of the implan...

Methods: Investigation of peri-implant in implants...

Methods Patient population In the present retrospective study, 47 dental implants (C-Tech Esthetic Line implants) from 20 patients (11 female, 9 male) with a mean age of 58.5 years (45–75 years) were analyzed clinically and radiologically. Implant placement and follow-up investigation was performed at the HL Dentclinic in Baden-Baden, Germany. The study was approved by the ethics commissio...

Background: Investigation of peri-implant in impla...

Regarding the stability of peri-implant hard and soft tissue, biological or anatomical factors are not the only elements that could be proven to have an impact. Technical factors such as the implant-abutment connection are also known to be key factors for long-term stable hard- and soft-tissue health [11]. Regarding the implant-abutment connection, which seems to be the key issue, located on the i...

Background: Investigation of peri-implant in impla...

However, in most patients, the local bone amount is reduced due to atrophy, inflammatory processes, or resectional defects. Therefore, in the past few years, different techniques have been described to enlarge the local bone amount in prospective implant sites [7]. Besides methods such as GBR or the sinus augmentation technique, different augmentation materials have been investigated and establish...

Background: Investigation of peri-implant in impla...

Background   The prevalence of peri-implantitis has grown in the past few years and has become a major issue in implant dentistry. Long-term stable and healthy soft- and hard-tissue conditions should be achieved in combination with esthetically and functionally satisfying results. However, the rising number of placed implants in the past decades has come with an increase in the prevalence of ...

Investigation of peri-implant in implants

Investigation of peri-implant tissue conditions and peri-implant tissue stability in implants placed with simultaneous augmentation procedure: a 3-year retrospective follow-up analysis of a newly developed bone level implant system Abstract Background Guided bone regeneration (GBR) has been proven to be a reliable therapy to regenerate missing bone in cases of atrophy of the alveolar crest. T...

Figure 3. Data from the VAS of patient-related out...

  Figure 3. Data from the VAS of patient-related outcome measures at the time of mounting of the implant-supported crown and at the final follow-up of the PRF and control group

Figure 2. Box plot of the radiographic peri-implan...

  Figure 2. Box plot of the radiographic peri-implant marginal bone level at different time points in millimeter. Baseline: the time of implant placement; abutment: the time of abutment operation; impression: the time of impression taking; follow-up: the time of the final follow-up

Figure 1. Intraoperative photos illustrating bone ...

  Figure 1. Intraoperative photos illustrating bone harvesting and lateral bone augmentation in the PRF group. Initially, an incision is made at the lateral aspect of the posterior part of the mandibular corpus (a) followed by exposing the mucoperiosteal flap (b), before making the osteotomy line (c). The bone block (d) is then retrieved before adjusted to the contour at the recipient site and...

Table 4 Patient-related outcome measures at baseli...

Table 4 Patient-related outcome measures at baseline and at the final follow-up   Test group Control group Difference p value Mean (95% CI) Mean (95% CI) Mean (95% CI) Baseline 9.44 (9.09 to 9.78) 9.57 (9.20 to 9.95) 0.13 (− 0.40 to 0.66) 0.61 Follow-up 9.66 (9.30 to 10.02) 9.55 (9.15 to 9.96) − 0.10 (-0.66 to 0.46) 0.71 Difference 0.22 (...

Table 3 Radiographic marginal bone level and clini...

Table 3 Radiographic marginal bone level and clinical recession on neighbouring tooth surface Group Baseline (mean, 95% CI) Follow-up (mean, 95% CI) Difference (mean, 95% CI) p value Radiographic marginal bone level in mm  Test 1.94 (1.50 to 2.38) 2.07 (1.64 to 2.51) − 0.14 (− 0.25 to − 0.02) p = 0.03  Control 2.34 (1.62 to 3.08) 2.49 (1.73...

Table 2 Radiographic peri-implant marginal bone le...

Table 2 Radiographic peri-implant marginal bone level in mm Test group Control group Mean difference 95% CI p value Obs Mean 95% CI Obs Mean 95% CI Baseline 14 − 0.24 − 0.48 to 0.00 13 − 0.28 − 0.52 to 0.03 0.04 − 0.314 to 0.39 p = 0.82 Abutment 14 0.07 − 0.17 to 0.30 13 − 0.01 − 0.26 to 0.25 0.08 − 0.278...

Table 1 Demographics and survival rates of implant...

Table 1 Demographics and survival rates of implants and implant crowns   Test group (PRF) Control group Number of implants 14 13 Mean age, years (range) 47.9 (23–66) 52.3 (24–72) Gender  Female 6 6  Male 8 7 Smokers Total 2 1   20 cigarettes per day 1 1 Number of implants 14 13 Implant length (mm) and imp...

Abbreviations & References: A clinical and radiogr...

Abbreviations ASC: Angulated screw channel BOP: Bleeding on probing DBBM: Deproteinised bovine bone mineral GBR: Guided bone regeneration ICC: Intraclass correlation coefficient KT: Keratinised peri-implant tissue PCR: Plaque control record PD: Probing depth PRF: Platelet-rich fibrin PROM: Patient-related outcome measures RCF: ...

Discussion: A clinical and radiographic study of i...

A minor, but statistically significant, radiographic bone loss occurred from baseline to the final follow-up at the neighbouring tooth surfaces in both groups. Moreover, both groups experienced a minor recession of the marginal gingiva from baseline to the final follow-up, but the change was not significant. Recession and the bone level of the neighbouring tooth surfaces to implants placed in ...

Discussion: A clinical and radiographic study of i...

The combination of the NobelParallel CC implant launched in 2015 and an abutment with ASC is relatively new and has so far been lined to only few mechanical problems [39, 40], among which rotation of the crown when torqueing the abutment screw was not stated. In both patients, a new implant was placed without any need for additional bone augmentation and without further complications. ...

Discussion: A clinical and radiographic study of i...

Discussion The present study focused on clinical and radiographic characteristics of staged implants placed in autogenous bone grafts covered by either a PRF membrane (PRF group) or a standard procedure (gold standard) involving coverage of the autogenous bone graft using a deproteinised bovine bone mineral and a resorbable collagen membrane (control group). The PRF group demonstrated a hi...

Results: A clinical and radiographic study of impl...

One patient (control group) expressed minimally changed extraoral sensation in the chin region at both the 1- and 2-week follow-up. However, the extra- and intraoral clinical examination revealed no sensory disturbances. The patient was not affected by this and described the same changed sensation at the final clinical follow-up after 29 months. Another patient (PRF group) experienced sensory d...

Results: A clinical and radiographic study of impl...

Radiographic peri-implant marginal bone change The mean peri-implant marginal bone level at the different time points is shown in Table 2 and Fig. 2. The mean marginal bone level at follow-up was 0.26 mm (95% CI: 0.01–0.50 mm) in the PRF group and 0.68 mm (95% CI: 0.41–0.96 mm) in the control group. The difference between the groups was − 0.43 mm (95% CI: − 0.80 to − 0....

Results: A clinical and radiographic study of impl...

Bleeding on probing The estimated probability or observed proportion of BOP for implants was 0.31 (95% CI: 0.14–0.70) in the PRF group and 0.30 (95% CI: 0.12–0.77) in the control group. The ratio of the probability of observing BOP was 1.046 (95% CI: 0.91–1.20), indicating that the probability of observing BOP is 4.6% higher in the PRF group than in the control group. No statistical differe...

Results: A clinical and radiographic study of impl...

Results Implant survival Two of the 27 initially placed implants were lost in the control group (Table 1). Twenty months after placement of the implant-supported crown, one implant (first premolar, regular platform (4.3 mm), length: 13 mm) was lost due to failed osseointegration. No periodontitis or peri-implant marginal bone resorption was obvious at the time of implant removal. A second...

Material & methods: A clinical and radiographic st...

The distance from the implant-abutment connection to the peri-implant marginal bone level was measured mesially and distally in parallel with the long axis of the implant using open-source software (ImageJ, National Institutes of Health, Bethesda, MD, USA). The distance from the cemento-enamel junction to the marginal bone level at the neighbouring tooth surfaces was also measured in parallel with...

Material & methods: A clinical and radiographic st...

Prosthodontic treatment Forty-nine days (range: 27–113 days) after placement of the healing abutment, the abutment was removed and the implant position was registered by an impression coping on the implant. The final implant-supported restoration was fabricated by using an individually designed angulated screw channel (ASC) zirconium abutment (Nobel Biocare®, Zürich, Switzerland) and venee...

Material & methods: A clinical and radiographic st...

  Methylprednisolone was prescribed the following morning (16 mg) and evening (16 mg). Additionally, postoperative ibuprofen (400 mg, four times daily) and paracetamol (1000 mg, four times daily) were prescribed for 1 week. The patients were instructed to rinse with 0.12% chlorhexidine digluconate twice daily and discontinue the use of their prostheses (if any). Patients were seen for ...

Material & methods: A clinical and radiographic st...

The bone graft was retrieved by making a continuous osteotomy line with a cylindrical and a round bur at the lateral part of the mandible, with a uniform size of approximately 15 × 25 mm (Fig. 1c, d). The bone block containing mainly cortical bone was then gently separated from the mandible using a raspartorium. The block graft was covered with a saline-moistened gauze until used. In the PRF g...

Material & methods: A clinical and radiographic st...

At the time of the bone augmentation procedure, two patients (14%) in the PRF group and one (8%) patient in the control group were smokers. Patients were partially edentulous due to trauma (n = 22), agenesis (n = 3) or marginal periodontitis [2]. Two patients were unavailable for the final follow-up. The referring dentist followed the non-attenders, and telephone interview revealed no subjective o...

Material & methods: A clinical and radiographic st...

Material and methods   The study was performed according to the Declaration of Helsinki and internationally accepted guidelines for RCT, including the CONSORT statement (www.consort-statement.org). The volumetric changes of the augmented bone [26], the histological composition of the augmented bone [27] and pain after the primary bone augmentation procedure [28] were previously described in d...

Background: A clinical and radiographic study of i...

Despite the shape of a membrane, the PRF membrane does not have the properties of a resorbable barrier membrane [21, 22], due to its fast degradation in the same manner as a natural blood clot (1–2 weeks) [23]. Therefore, the PRF membrane is not believed to replace a barrier membrane in the classic understanding of guide bone regeneration (GBR), but rather to enhance the healing capacity of t...

Background: A clinical and radiographic study of i...

Background Implant-supported single crowns are characterised by high long-term survival and few biological and technical complications, which typically includes peri-implant marginal bone loss, screw-loosening and fracture of veneering material complications [1,2,3]. To achieve a successful treatment outcome, the implants must be inserted in sufficient bone volume of an adequate quality to obta...

A clinical and radiographic study of implants plac...

A clinical and radiographic study of implants placed in autogenous bone grafts covered by either a platelet-rich fibrin membrane or deproteinised bovine bone mineral and a collagen membrane: a pilot randomised controlled clinical trial with a 2-year follow-up   Abstract Purpose To compare the survival and clinical performance of implants placed in sites previously augmented with autogenous ...

Table 3 Articles excluded and reasons for exclusio...

Reason for exclusion Investigations Study design (case series or case report) Kim et al. (2017), Hatano et al. (2007) Different grafting technique (lateral sinus lift or transalveolar technique) Jensen et al. (1994), Winter et al. (2002), Toffler et al. (2004), Chappuis et al. (2009), Soltan et al. (2011), Xiao et al. (2011), Cricchio et al. (2011), Scala et al. (2012), Brus...

Table 2 Characteristics of the included investigat...

Author (year) Study design Follow-up (months) N of patients N of implants Smokers Length and diameter (mm) Implant system  Shihab 2017 Retrospective 60 35 70 NA 5–12 × 3.0–5.7 IDI FMD Nucleoss  Ghanem 2014 Retrospective 72 10 10 NA NA NA  Nooh 2013 Prospective 12 56 63 0 4 × 8 4.3 × 10 5 × 8 5 × 10 Nobel Biocare ...

Table 1 Clinical and radiographic complications re...

Clinical complications Radiographic complications Sinusitis Thickening of Schneiderian membrane Nasal bleeding, nasal obstruction, nasal secretion Bone reaction to the implants Headache and pain or tenderness in the region of the sinus Sinus pathology Decreased sense of smell  

Figure 4. Statistical analysis for different varia...

  Figure 4. Statistical analysis for different variables. a Weighted mean survival rate. b Implant survival rate according to degree of penetration. c Analysis of clinical complications. d Analysis of radiographic complications

Figure 3. Graphic representation of group 1 ≤ ...

  Figure 3. Graphic representation of group 1 ≤ 4 mm penetration and group 2 > 4 mm penetrations    

Figure 2. PRISMA flowchart of the screening proces...

  Figure 2. PRISMA flowchart of the screening process

Discussion : Influence of exposing dental implants...

The secondary outcome of this review was the analysis of the clinical and radiological complications related to the penetration of implants in the maxillary sinus. Clinical complication among the different authors ranges from 0 to 14.3%, with a weighted mean complication rate of 3.4%, without finding statistical difference according to the level of implant penetration. The most common clinic...

Figure 1. Graphic representation of implants intru...

  Figure 1. Graphic representation of implants intruding sinus perforating or not the Schneiderian membrane

Results : Influence of exposing dental implants in...

  Analysis of clinical complications Seven studies provide information on clinical complications with a global sample of 232 patients. Clinical complications among the different authors range from 0 to 14.3%, being the weighted mean complication rate 3.4% with an IC 95% [0 7.5] (Fig. 4c) Clinical complications analyzed in the studies were sinusitis, nasal bleeding, nasal obstruction, nasal sec...

Results : Influence of exposing dental implants in...

Results Study screening An initial screening yielded a total of 3551 publications of which 26 potentially relevant articles were selected after an evaluation of their titles and abstracts. Full text of these articles was obtained and evaluated thoroughly. Of these, eight articles (Table 2) fulfilled the inclusion criteria and subsequently were included in the qualitative analysis (Fig. 2). Re...

Materials & methods : Influence of exposing dental...

  Eligibility criteria Articles were included in this systematic review if they met the following inclusion criteria: human prospective or retrospective studies, reporting outcomes of implant placed perforating the sinus floor with implant burs, and without regenerative procedure (lateral sinus lift or transalveolar technique) and graft material. The intrusion into the sinus cavity can occur du...

Materials & methods : Influence of exposing dental...

Materials and methods This systematic review and subsequent meta-analysis follow the guidelines of the PRISMA statement. Focus question The following focus question was developed: Is the intrusion of dental implants into the sinus cavity during implant drilling or implant placement, without regenerative procedure (lateral sinus lift or transalveolar technique) and graft material, has an effec...

Introduction ; Influence of exposing dental implan...

Introduction The edentulous posterior maxillary region often presents with unique challenging conditions in implant dentistry. Limited bone height secondary to pneumatization of the maxillary sinus and the resorption of the alveolar ridge preclude in many instances the installation of dental implants. To compensate for the lack of bone height, several treatment options have been proposed. The ...

Influence of exposing dental implants into the sin...

Influence of exposing dental implants into the sinus cavity on survival and complications rate: a systematic review   Abstract Background After tooth loss, the posterior maxilla is usually characterized by limited bone height secondary to pneumatization of the maxillary sinus and/or collapse of the alveolar ridge that preclude in many instances the installation of dental implants. In order ...

Conclusions: Porous collagen-hydroxyapatite scaffo...

Conclusions The porous Col-HA composites developed in the present study are biocompatible and can be used as scaffolds for bone tissue regeneration. The Col-HA ratio is an important factor in promoting the attachment and proliferation of mouse MSCs. The Col-HA composite complexes have strong potentials in bone tissue regeneration applications. hPDSCs may be a suitable resource of cells for maxi...

Discussion: Porous collagen-hydroxyapatite scaffol...

Discussion The findings of the presented study indicate that the porous sponge-like Col-HA composites have good biocompatibility and biomimetic properties and may be used as scaffolds for bone tissue regeneration. The Col-HA composites with ratios 80:20 and 50:50 supported the attachments and proliferations of mouse MSCs and hPDSCs. These findings indicate that Col-HA composite complexes have str...

Results: Porous collagen-hydroxyapatite scaffolds ...

Results The sponge-like plugs of prototype Col-HA composites were successfully fabricated with different collagen and HA ratios. The macroscopic and SEM views of the prototype type I collagen without HA and 3 different ratios of collagen-HA (20%Col-80%HA; 50%Col-50%HA; 80%Col-20%HA) composites are shown in Figure 1. The SEM views show the inside microstructures of the prototype pure type I colla...

Materials & methods: Porous collagen-hydroxyapatit...

Materials and Methods Synthesis of the Col-HA composites by direct precipitation in situ Solutions of calcium salt and phosphoric acid (Ca/P = 1.66 mol) were used to synthesize HA particles and incorporate them on bovine type I collagen fibrils by a direct precipitation technique in situ. This technique was optimized to produce 3 different ratios of Col-HA composites (20%Col-80%HA; 50%Col-50%H...

Introduction: Porous collagen-hydroxyapatite scaff...

Introduction Combining a scaffold and living cells to form a tissue-engineering construct is an important concept for promoting the repair and regeneration of bone tissues. Mesenchymal stem cells are often used in such constructs due to their abilities to proliferate and differentiate toward bone-forming cells. The design and fabrication of scaffolds, stem cell isolation and characterization, and...

Abstract: Porous collagen-hydroxyapatite scaffolds...

Abstract Current bone grafting materials have significant limitations for repairing maxillofacial and dentoalveolar bone deficiencies. An ideal bone tissue-engineering construct is still lacking. The purpose of the present study was first to synthesize and develop a collagen-hydroxyapatite (Col-HA) composite through controlled in situ mineralization on type I collagen fibrils with nanometer-sized...

Porous collagen-hydroxyapatite scaffolds with mese...

  RESEARCH Porous Collagen-Hydroxyapatite Scaffolds With Mesenchymal Stem Cells for Bone Regeneration Li Ning, DDS, PhD , Hans Malmström, DDS , Yan-Fang Ren, DDS, MPH, PhD Correspondence: * Corresponding author, e-mail: yanfang_ren@urmc.rochester.edu Article Citation: Li Ning, Hans Malmström, Yan-Fang Ren, Porous Collagen-Hydroxyapatite Scaffolds With Mesench...