Background : Histological characteristics of advanced peri-implantitis bone defects in humans
Peri-implantitis was recently defined as a “pathological condition occurring in tissues around dental implants”, which is “characterized by inflammation in the peri-implant connective tissue and a progressive loss of supporting bone” [1,2,3,4].
Human biopsies confirmed the presence of plasma cells, macrophages, and neutrophils [5] and elevated expression of inflammatory cytokines [6, 7] at peri-implantitis sites. Moreover, bone matrix molecules were decreased and cells had a fibroblastic phenotype [8]. Together, human biopsies of the respective soft tissue revealed the conserved cellular and molecular principles of acute inflammatory osteolysis [9].
Peri-implantitis lesions extend apical and are commonly associated with a circumferential pattern of bone loss [1, 10]. Intraoperative clinical and radiographic assessments, however, do not fully represent the extension of peri-implantitis defects [11,12,13,14]. Moreover, the morphology of the remaining bone being exposed to masticatory forces has not been described so far. Considering that the remaining peri-implant bone has to adapt to occlusal load [15], it requires vital osteocytes to translate mechanical forces into molecular signals controlling bone adaptation [16]. It also requires vital osteocytes for inflammatory osteolysis [17]. These biological principles let us to hypothesize that the bone in peri-implantitis defects has a high density and contains vital osteocytes. Therefore, the present study reports on the characteristics of bone at sites of advanced peri-implantitis.
Serial posts:
- Abstract : Histological characteristics of advanced peri-implantitis bone defects in humans
- Background : Histological characteristics of advanced peri-implantitis bone defects in humans
- Materials and methods : Histological characteristics of advanced peri-implantitis bone defects in humans [1]
- Materials and methods : Histological characteristics of advanced peri-implantitis bone defects in humans [2]
- Materials and methods : Histological characteristics of advanced peri-implantitis bone defects in humans [3]
- Results : Histological characteristics of advanced peri-implantitis bone defects in humans
- Discussion : Histological characteristics of advanced peri-implantitis bone defects in humans [1]
- Discussion : Histological characteristics of advanced peri-implantitis bone defects in humans [2]
- Conclusions : Histological characteristics of advanced peri-implantitis bone defects in humans
- Availability of data and materials : Histological characteristics of advanced peri-implantitis bone defects in humans
- Abbreviations : Histological characteristics of advanced peri-implantitis bone defects in humans
- References : Histological characteristics of advanced peri-implantitis bone defects in humans [1]
- References : Histological characteristics of advanced peri-implantitis bone defects in humans [2]
- References : Histological characteristics of advanced peri-implantitis bone defects in humans [3]
- References : Histological characteristics of advanced peri-implantitis bone defects in humans [4]
- Acknowledgements : Histological characteristics of advanced peri-implantitis bone defects in humans
- Funding : Histological characteristics of advanced peri-implantitis bone defects in humans
- Author information : Histological characteristics of advanced peri-implantitis bone defects in humans [1]
- Author information : Histological characteristics of advanced peri-implantitis bone defects in humans [2]
- Ethics declarations : Histological characteristics of advanced peri-implantitis bone defects in humans
- Additional information : Histological characteristics of advanced peri-implantitis bone defects in humans
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- About this article : Histological characteristics of advanced peri-implantitis bone defects in humans
- Table 1 Patient and implant site characteristics : Histological characteristics of advanced peri-implantitis bone defects in humans
- Table 2 Results from histomorphometric measurements exhibiting DL, RB, bone density (%), residual bone-to-implant contact (%) values : Histological characteristics of advanced peri-implantitis bone
- Table 3 Mean osteocyte (OD) and empty lacunae density (ELD) at peri-implant residual bone : Histological characteristics of advanced peri-implantitis bone defects in humans
- Fig. 1. Histological section illustrating the landmarks to determine the conducted histomorphometrical length measurements: DL, RB, and BIC at buccal RB. The red square frames the intra-thread area (ROI) for OD and ELD analysis : Histological characteristics of advanced peri-implant
- Fig. 2. Histological view (buccal aspect) displaying mean BIC (%) and mean bone density (%) at corresponding regions (500 μm zones) from BD to A. Blue lines along the implant perimeter display BIC presence and yellow lines display BIC absence : Histological characteristics of advanced peri-implant
- Fig. 3. Histological magnifications of specimens exposing a significant areas of lamellar bone in-between and parallel to the surface of older trabeculae (accentuated by green overlay), b osteoclastic activity, and c active bone formation at intrabony marginal regions : Histological characteristics of advanced peri-implant