When further interpreting the present study, the peri-implant osteocyte lacunae density after 1 to 27 years in function was reported [28]. In line with our findings, empty osteocytic lacunae adjacent to zirconia implants diagnosed with peri-implantitis were described [29]. Based on counting the osteocyte lacunae, we observed that numerous filled but also empty osteocytic lacunae were present within the residual bone. To which extend the osteocytes in the remaining peri-implant bone control bone remodeling [30] , the adaptation to functional loading termed modeling [16], and also the progression of inflammatory osteolysis [17] is unknown and opens pathways for future research.