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Fig. 6. Radiographic examination: The relationship...

Fig. 6. Radiographic examination: The relationship between changes in the maxillary sinus floor associated with a reduction in the grafted bone and the implant tip (a immediately after surgery, b 5 years after surgery) Fig. 6. Radiographic examination: The relationship between changes in the maxillary sinus floor associated with a reduction in the grafted bone and the implant tip (a immediat...

Fig. 5. Radiographic examination (long-term change...

Fig. 5. Radiographic examination (long-term changes in bone height surrounding the implant) n = 20 Number of implants. A total of 5 CBCT scans were taken prior to surgery, immediately after surgery, 6 months after surgery, 1–2 years after surgery, and 3–5 years after surgery Fig. 5. Radiographic examination (long-term changes in bone height surrounding the implant) n = 20 Numbe...

Fig. 4. Clinical findings of the second surgery on...

Fig. 4. Clinical findings of the second surgery on biopsy at 6 months. The degree of residual grafting materials varied depending on the patient. a most of the β-TCP remained. b Replacement of the β-TCP by new bone had progressed Fig. 4. Clinical findings of the second surgery on biopsy at 6 months. The degree of residual grafting materials varied depending on the patient. a most of the ...

Fig. 3. Radiographic examination of the height of ...

Fig. 3. Radiographic examination of the height of the bone surrounding the implant (BH): Measurement of changes in the height of the implant tip to the bone fixation part over time in the frontal plane: the distance measured from the intersecting point of the long axis of the implant and the maxillary sinus floor to the implant tip: +maxillary side, −alveolar crest side. The liner valuables: r...

Fig. 2. Radiographic examination of the volume of ...

Fig. 2. Radiographic examination of the volume of the bone graft (BV): Calculation of area on the frontal plane prior to and immediately after surgery using polygon tool. The polygon tool is included in the CT device, which was dragged around the perimeter of the target site to measure area. Graft volume calculation method (sum of the area and calculation of volume). Volume cm3 = area cm2 ...

Fig. 1. Treatment protocol for the present study. ...

Fig. 1. Treatment protocol for the present study. Postoperative CBCT was performed a minimum of three times, i.e., immediately, 6 months, and 2.5 years after implant placement Fig. 1. Treatment protocol for the present study. Postoperative CBCT was performed a minimum of three times, i.e., immediately, 6 months, and 2.5 years after implant placement

Table 8 Examination of the impact of RBH, IL, SW, ...

  Coefficient Standard error 95 % CI P value Time (months) −0.087 ...

Table 7 The radiographic measurements of liner par...

Parameter Mean (mm) SD (mm) RBH 4.48 1.51 ...

Table 6 Radiographic examination of BH (changes in...

NoneTable 6 Radiographic examination of BH (changes in bone height surrounding the implant)

Table 5 Radiographic examination of BV (volumetric...

BV Mean Reduction rate Immediately after surgery (n = 30) 1206 ...

Table 4 The distribution of CBCT examination after...

CBCT examination (year) Number of patients 0–1 0 1–2 14 ...

Table 3 The number of implants according to site :...

Implant site Number of implants 4 6 5 16 6 24 7 12 Total: 58 implants   Table 3 The number of implants according to site

Table 2 Observation period : Long-term radiographi...

Observation period (months) Number of patients 12–18 11 19–24 4 ...

Table 1 Age groups of the 30 patients : Long-term ...

Age group (years) Number of patients 40–49 7 50–59 10 ...

About this article : Long-term radiographic assess...

Okada, T., Kanai, T., Tachikawa, N. et al. Long-term radiographic assessment of maxillary sinus floor augmentation using beta-tricalcium phosphate: analysis by cone-beam computed tomography. Int J Implant Dent 2, 8 (2016). https://doi.org/10.1186/s40729-016-0042-6 Download citation Received: 25 November 2015 Accepted: 23 March 2016 Published: 01 April 2016 DOI: https://do...

Rights and permissions : Long-term radiographic as...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...

Additional information : Long-term radiographic as...

Tsuneji Okada, Toru Kanai, Noriko Tachikawa, Motohiro Munakata, and Shohei Kasugai declare that they have no competing interests. TO performed the data acquisition, both of surgical and prosthodontic treatments, the data analysis, statistical analysis, and wrote the manuscript. TK performed the treatment plan, making of pictures, and collecting of references. NT and MM performed the data acquisit...

Author information : Long-term radiographic assess...

Clinic for Implant Dentistry, Dental Hospital, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan Tsuneji Okada, Toru Kanai & Noriko Tachikawa Oral Implantology Department of Prosthodontic Dentistry for Function of TMJ and Occlusion, Kanagawa Dental University, 82, Inaokachou, Yokosuka-shi, 238-8580, Kanagawa, Japan Motohiro Munakata Oral Implantology and...

Acknowledgements : Long-term radiographic assessme...

The bone grafting agent, β-TCP (OSferion), was kindly supplied by Olympus Terumo Biomaterials Corp.

References : Long-term radiographic assessment of ...

Boyne PJ, James RA. Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Maxillofac Surg. 1980;38:613–6. Jensen OT, Shulman LB, Block MS, et al. Report of the sinus consensus conference of 1996. Int J Oral Maxillofac Implants. 1998;13:11–45. Artzi Z, Weinreb M, Givol N, et al. Biomaterial resorption rate and healing site morphology of inorganic bovine bone and β-tri...

References : Long-term radiographic assessment of ...

Chanavaz M. Maxillary sinus: anatomy, physiology, surgery, and bone grafting related to implantology: eleven years of surgical experience (1979–1990). J Oral Implantol. 1990;16:199–209. Misch CE. Maxillary sinus lift and elevation with subantral augmentation. In: Misch CE, editor. Contemporary implant dentistry. St. Louis, MO: Mosby; 1993. p. 545–74. Sharan A, Madjar D. Maxillary sinus pne...

Conclusions : Long-term radiographic assessment of...

Maxillary sinus graft augmentation using β-TCP is clinically effective. Analysis by CBCT provides superior spatial resolution and allows for extremely accurate postoperative evaluation of maxillary sinus floor augmentation and bone volume measurements. On the basis of CBCT examinations, although maxillary sinus pneumatization continues to progress ≥1 year after surgery, it stabilizes 3 year...

Discussion : Long-term radiographic assessment of ...

During the observation period, there was no clinical implant failure and the suvival rate for implantation and maxillary sinus floor augmentation was 100 %. Histological examination in a previous report on maxillary sinus augmentation using β-TCP (Cerasorb®), Szabo et al. compared bilateral maxillary sinus augmentation in the same patients using β-TCP and iliac bone at 6 months after surgery ...

Discussion : Long-term radiographic assessment of ...

As grafting materials for maxillary sinus floor augmentation, autogenous bone, which is considered as the gold standard and reported first by Boyne et al. using iliac bone graft, has been used as the first-choice material. In terms of osteogenic, osteoinductive, and osteoconductive properties, autogenous bone is considered ideal; however, the use of autogenous bone places great physical stress on ...

Results : Long-term radiographic assessment of max...

Change in height of bone surrounding the implant (height from the maxillary sinus floor to the implant tip): Immediately after surgery, all patients had grafted bone between the implant tip and the maxillary sinus floor, with a mean of 2.00 ± 1.51 mm. This height decreased to 0.73 ± 1.33 mm at 6 months after surgery and −0.72 ± 1.11 mm at 2.5 years after surgery (Fig. 5). 41...

Results : Long-term radiographic assessment of max...

The mean age of the 30 patients was 57.4 (40–75) years, and the male/female ratio was 4:26. The mean postoperative observation period was 3 years and 8 months (the maximum period was 5 years and 0 months; the minimum period was 2 years and 2 months). Total of 58 implants were placed at premolar and molar region. There were no dropouts, such as participants not visiting the clinic, during t...

Methods : Long-term radiographic assessment of max...

Residual bone height (RBH): existing bone height to the maxillary sinus at the implant site Implant length (IL): the length of the part of the implant that projects into the maxillary sinus Width of sinus (SW): the width of the maxillary sinus from lateral wall to medial wall at the height of the center of the IL In the present study, the radiographic examinations were statistically analyzed fo...

Methods : Long-term radiographic assessment of max...

In the present study, we used the superior spatial resolution of CBCT to measure changes over time in (a) the volume of the bone graft (BV) and (b) the height of the bone surrounding the implant (BH). The method of calculating the volume of the implant site is shown below (Fig. 2). The slice thickness (voxel value) was resized (0.146 mm → 1 mm) to derive the volume of the grafting agent...

Methods : Long-term radiographic assessment of max...

This study is a prospective observational study. The subjects included patients who had undergone maxillary sinus floor augmentation using β-TCP and implant placement at the Clinic for Implant Dentistry, Dental Hospital, Tokyo Medical and Dental University during the 3-year period from January 2009 to December 2011. All patients underwent maxillary sinus floor augmentation at the same time as imp...

Background : Long-term radiographic assessment of ...

Radiographic examinations to determine changes in bone mass in maxillary sinus floor augmentation have been conducted primarily using panoramic radiography [8–12], which allows for the assessment of the height of the maxillary sinus in only two dimensions. In addition, it does not allow for detailed examination or measurement of the interior of the maxillary sinus without factoring in magnificat...

Background : Long-term radiographic assessment of ...

The maxillary sinus gradually expands after birth and becomes fully pneumatized with the eruption of all permanent teeth. Although the physiological cause and maxillary sinus pneumatization are largely unknown, it is believed that genetics, atmospheric pressure, and hormones are involved in it. This sinus is closely related to the root apex of the premolar and molar teeth, and it is either separat...

Abstract : Long-term radiographic assessment of ma...

The long-term stability of maxillary sinus floor augmentation with β-TCP remains largely unknown. We report the long-term assessment of volumetric changes in maxillary sinus floor augmentation with β-TCP by cone-beam computed tomography (CBCT). The subjects included 30 patients who underwent maxillary sinus floor augmentation using β-TCP and 58 implant placement for unilateral maxillary defect...

Fig. 6. Histomorphometric evaluation results (cons...

Fig. 6. Histomorphometric evaluation results (considering six sections for each biopsy), for newly formed bone, soft tissues, and others Fig. 6. Histomorphometric evaluation results (considering six sections for each biopsy), for newly formed bone, soft tissues, and others

Fig. 5. Histomicrograph of a biopsy from the BC ...

Fig. 5. Histomicrograph of a biopsy from the BC + EMD group, showing an aspect of newly formed bone. Section stained with picrosirius-hematoxylin and digitalized with bright-field (d) and linearly polarized light (e and f). e, f Results of near 45° section rotation (between axes B–B’ and C–C’) to compensate some of the orientation-related effects associated with linearly polarized l...

Fig. 4. Histomicrograph of a biopsy from the BC gr...

Fig. 4. Histomicrograph of a biopsy from the BC group, showing an aspect of newly formed bone. Section stained with picrosirius-hematoxylin and digitalized with bright-field (a) and linearly polarized light (b and c). b, c Results of near 45° section rotation (between axes B–B’ and C–C’) to compensate some of the orientation-related effects associated with linearly polarized light. In a...

Fig. 3. Histomicrograph of a biopsy from the BC ...

Fig. 3. Histomicrograph of a biopsy from the BC + EMD group. Overview—×25 magnification; b ×30 magnification; c ×60 magnification. Areas corresponding to BC + EMD removed during histological processing (square) surrounded by newly formed bone (asterisk), with large numbers of osteocytes and soft tissue (arrow) can be observed. There is direct contact between the BC reminiscent, soft...

Fig. 2. Histomicrograph of a biopsy from the BC gr...

Fig. 2. Histomicrograph of a biopsy from the BC group. a Overview—×25 magnification; b ×30 magnification; c ×60 magnification. Areas corresponding to BC removed during histological processing (square) in direct contact with newly formed bone (asterisk), containing a large number of osteocytes, and with soft tissue (arrow) can be observed (hematoxylin-eosin stain) Fig. 2. Histomicrograph ...

Fig. 1. Histomicrograph illustrating the various t...

Fig. 1. Histomicrograph illustrating the various tissue areas measured on the sections: newly formed bone (green mask), soft tissues (purple mask), and “others”, including residual bone substitute particles and empty spaces either due to removal of the bone substitute particles during to the decalcification processing or due to artifacts (white mask) Fig. 1. Histomicrograph illustrating t...

About this article : β-TCP/HA with or without ena...

Nery, J.C., Pereira, L.A.V.D., Guimarães, G.F. et al. β-TCP/HA with or without enamel matrix proteins for maxillary sinus floor augmentation: a histomorphometric analysis of human biopsies. Int J Implant Dent 3, 18 (2017). https://doi.org/10.1186/s40729-017-0080-8 Download citation Received: 08 December 2016 Accepted: 22 April 2017 Published: 04 May 2017 DOI: https://do...

Rights and permissions : β-TCP/HA with or without...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...

Author information : β-TCP/HA with or without ena...

You can also search for this author in PubMed Google Scholar Correspondence to James Carlos Nery.

Author information : β-TCP/HA with or without ena...

Department of Implantology, São Leopoldo Mandic Research Center, Brasília, DF, Brazil James Carlos Nery, George Furtado Guimarães & Fabiana Mantovani Gomes França Department of Biochemistry and Tissue Biology, UNICAMP – State University of Campinas, Institute of Biology, Campinas, São Paulo, Brazil Luís Antônio Violin Dias Pereira Department of Periodontology, UNESP – Univ. Estad...

References : β-TCP/HA with or without enamel matr...

Wikesjo UM, Sorensen RG, Kinoshita A, Wozney JM. RhBMP-2/alphaBSM induces significant vertical alveolar ridge augmentation and dental implant osseointegration. Clin Implant Dent Relat Res. 2002;4:174–82. Carinci F, Brunelli G, Franco M, Viscioni A, Rigo L, Guidi R, et al. A retrospective study on 287 implants installed in resorbed maxillae grafted with fresh frozen allogenous bone. Clin Implant...

References : β-TCP/HA with or without enamel matr...

Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, et al. Twenty years of enamel matrix derivative: the past, the present and the future. J Clin Periodontol. 2016;43:668–83. Sculean A, Nikolidakis D, Nikou G, Ivanovic A, Chapple IL, Stavropoulos A. Biomaterials for promoting periodontal regeneration in human intrabony defects: a systematic review. Periodontol 2000. 2015;68:182...

References : β-TCP/HA with or without enamel matr...

Esposito M, Felice P, Worthington HV. Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus. Cochrane Database Syst Rev. 2014;17:CD008397. Jungner M, Cricchio G, Salata LA, Sennerby L, Lundqvist C, Hultcrantz M, et al. On the early mechanisms of bone formation after maxillary sinus membrane elevation: an experimental histological and immunohistochemical study. ...

Conclusions : β-TCP/HA with or without enamel mat...

The present study showed that maxillary sinus floor augmentation with BC resulted in adequate amounts of new bone formation allowing successful implant installation, while adding EMD did not have a significant effect.

Discussion : β-TCP/HA with or without enamel matr...

Nevertheless, the amount of bone generated with BC or BC + EMD herein was adequate to support successful implant placement and osseointegration of implants. In fact, more or less similar amounts of bone formation have been reported in studies evaluating human sinus biopsies after grafting with a variety of biomaterials (bone formation ranging approximately from 30 to 50%) [19]. On the other ha...

Discussion : β-TCP/HA with or without enamel matr...

The present study compared the histological and histomorphometrical outcome of healing after maxillary sinus floor augmentation with BC with or without EMD, based on human biopsies. The results showed that addition of EMD did not enhance the outcome of healing, neither in terms of quality nor quantity of new bone. Nevertheless, the amount of bone generated after maxillary sinus floor augmentation ...

Results : β-TCP/HA with or without enamel matrix ...

All ten patients showed uneventful healing after the sinus floor augmentation procedure as well as after dental implant placement, with no overt postoperative inflammation or infection. Consistently, in all ten patients, no significant jiggling of the drill was noticed during biopsy harvesting, while subjective drilling resistance during implant placement was similar in both groups and all implant...

Methods : β-TCP/HA with or without enamel matrix ...

The data for each tissue component from the three histological sections were averaged to represent the biopsy. Commercially available software (GraphPad Prism 5.0 for Windows, GraphPad Software Inc., USA) was utilized for statistical comparisons between groups and for drawing the graphics. The assumption of normality was checked using D’Agostino & Pearson omnibus test. The data for each evaluate...

Methods : β-TCP/HA with or without enamel matrix ...

Six months after grafting, another CBCT examination was carried out for implant planning. In the sequence, following the previously described antiseptic and anesthetic procedures, two implants with a sand-blasted and acid etching surface were installed in each of the grafted sinuses, i.e., 40 implants in total (32—Neoporous, Neodent, Curitiba, Paraná, Brazil; 8—SLA, Straumann, Basel, Switzerl...

Methods : β-TCP/HA with or without enamel matrix ...

This research project was approved by the Ethics Committee of the School of Dentistry and Dental Research Center São Leopoldo Mandic, Brazil, under the protocol 2010/0360. Ten consecutive patients (age range 35–75 years) with the need of bilateral maxillary sinus floor augmentation prior to the placement of four dental implants (two in each side of posterior maxilla) were selected for the stu...

Background : β-TCP/HA with or without enamel matr...

The aim of the present study was to compare histomorphometrically the outcome of maxillary sinus floor augmentation with β-TCP/HA with or without enamel matrix proteins (BC + EMD and EMD, respectively) in humans.

Background : β-TCP/HA with or without enamel matr...

Reconstruction of the edentulous and severely atrophied posterior maxilla is often performed by means of maxillary sinus floor augmentation in combination with dental implants [1, 2]. Various bone graft materials are typically used for enhancing bone formation within the sinus cavity; autogenous bone (AB) is considered as the gold standard due to its osteogenic, osteoinductive, and osteoconductive...

Abstract : β-TCP/HA with or without enamel matrix...

It is still unclear whether enamel matrix proteins (EMD) as adjunct to bone grafting enhance bone healing. This study compared histomorphometrically maxillary sinus floor augmentation (MSFA) with β-TCP/HA in combination with or without EMD in humans. In ten systemically healthy patients needing bilateral MSFA, one side was randomly treated using β-TCP/HA mixed with EMD (BC + EMD) and the ot...

Fig. 6. Histomorphometric evaluation results (cons...

Fig. 6. Histomorphometric evaluation results (considering six sections for each biopsy), for newly formed bone, soft tissues, and others Fig. 6. Histomorphometric evaluation results (considering six sections for each biopsy), for newly formed bone, soft tissues, and others

Fig. 5. Histomicrograph of a biopsy from the BC ...

Fig. 5. Histomicrograph of a biopsy from the BC + EMD group, showing an aspect of newly formed bone. Section stained with picrosirius-hematoxylin and digitalized with bright-field (d) and linearly polarized light (e and f). e, f Results of near 45° section rotation (between axes B–B’ and C–C’) to compensate some of the orientation-related effects associated with linearly polarized l...

Fig. 4. Histomicrograph of a biopsy from the BC gr...

Fig. 4. Histomicrograph of a biopsy from the BC group, showing an aspect of newly formed bone. Section stained with picrosirius-hematoxylin and digitalized with bright-field (a) and linearly polarized light (b and c). b, c Results of near 45° section rotation (between axes B–B’ and C–C’) to compensate some of the orientation-related effects associated with linearly polarized light. In a...

Fig. 3. Histomicrograph of a biopsy from the BC ...

Fig. 3. Histomicrograph of a biopsy from the BC + EMD group. Overview—×25 magnification; b ×30 magnification; c ×60 magnification. Areas corresponding to BC + EMD removed during histological processing (square) surrounded by newly formed bone (asterisk), with large numbers of osteocytes and soft tissue (arrow) can be observed. There is direct contact between the BC reminiscent, soft...

Fig. 2. Histomicrograph of a biopsy from the BC gr...

Fig. 2. Histomicrograph of a biopsy from the BC group. a Overview—×25 magnification; b ×30 magnification; c ×60 magnification. Areas corresponding to BC removed during histological processing (square) in direct contact with newly formed bone (asterisk), containing a large number of osteocytes, and with soft tissue (arrow) can be observed (hematoxylin-eosin stain) Fig. 2. Histomicrograph ...

Fig. 1. Histomicrograph illustrating the various t...

Fig. 1. Histomicrograph illustrating the various tissue areas measured on the sections: newly formed bone (green mask), soft tissues (purple mask), and “others”, including residual bone substitute particles and empty spaces either due to removal of the bone substitute particles during to the decalcification processing or due to artifacts (white mask) Fig. 1. Histomicrograph illustrating t...

About this article : β-TCP/HA with or without ena...

Nery, J.C., Pereira, L.A.V.D., Guimarães, G.F. et al. β-TCP/HA with or without enamel matrix proteins for maxillary sinus floor augmentation: a histomorphometric analysis of human biopsies. Int J Implant Dent 3, 18 (2017). https://doi.org/10.1186/s40729-017-0080-8 Download citation Received: 08 December 2016 Accepted: 22 April 2017 Published: 04 May 2017 DOI: https://do...

Rights and permissions : β-TCP/HA with or without...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...

Author information : β-TCP/HA with or without ena...

You can also search for this author in PubMed Google Scholar Correspondence to James Carlos Nery.

Author information : β-TCP/HA with or without ena...

Department of Implantology, São Leopoldo Mandic Research Center, Brasília, DF, Brazil James Carlos Nery, George Furtado Guimarães & Fabiana Mantovani Gomes França Department of Biochemistry and Tissue Biology, UNICAMP – State University of Campinas, Institute of Biology, Campinas, São Paulo, Brazil Luís Antônio Violin Dias Pereira Department of Periodontology, UNESP – Univ. Estad...

References : β-TCP/HA with or without enamel matr...

Wikesjo UM, Sorensen RG, Kinoshita A, Wozney JM. RhBMP-2/alphaBSM induces significant vertical alveolar ridge augmentation and dental implant osseointegration. Clin Implant Dent Relat Res. 2002;4:174–82. Carinci F, Brunelli G, Franco M, Viscioni A, Rigo L, Guidi R, et al. A retrospective study on 287 implants installed in resorbed maxillae grafted with fresh frozen allogenous bone. Clin Implant...

References : β-TCP/HA with or without enamel matr...

Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, et al. Twenty years of enamel matrix derivative: the past, the present and the future. J Clin Periodontol. 2016;43:668–83. Sculean A, Nikolidakis D, Nikou G, Ivanovic A, Chapple IL, Stavropoulos A. Biomaterials for promoting periodontal regeneration in human intrabony defects: a systematic review. Periodontol 2000. 2015;68:182...

References : β-TCP/HA with or without enamel matr...

Esposito M, Felice P, Worthington HV. Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus. Cochrane Database Syst Rev. 2014;17:CD008397. Jungner M, Cricchio G, Salata LA, Sennerby L, Lundqvist C, Hultcrantz M, et al. On the early mechanisms of bone formation after maxillary sinus membrane elevation: an experimental histological and immunohistochemical study. ...

Conclusions : β-TCP/HA with or without enamel mat...

The present study showed that maxillary sinus floor augmentation with BC resulted in adequate amounts of new bone formation allowing successful implant installation, while adding EMD did not have a significant effect.

Discussion : β-TCP/HA with or without enamel matr...

Nevertheless, the amount of bone generated with BC or BC + EMD herein was adequate to support successful implant placement and osseointegration of implants. In fact, more or less similar amounts of bone formation have been reported in studies evaluating human sinus biopsies after grafting with a variety of biomaterials (bone formation ranging approximately from 30 to 50%) [19]. On the other ha...

Discussion : β-TCP/HA with or without enamel matr...

The present study compared the histological and histomorphometrical outcome of healing after maxillary sinus floor augmentation with BC with or without EMD, based on human biopsies. The results showed that addition of EMD did not enhance the outcome of healing, neither in terms of quality nor quantity of new bone. Nevertheless, the amount of bone generated after maxillary sinus floor augmentation ...

Results : β-TCP/HA with or without enamel matrix ...

All ten patients showed uneventful healing after the sinus floor augmentation procedure as well as after dental implant placement, with no overt postoperative inflammation or infection. Consistently, in all ten patients, no significant jiggling of the drill was noticed during biopsy harvesting, while subjective drilling resistance during implant placement was similar in both groups and all implant...

Methods : β-TCP/HA with or without enamel matrix ...

The data for each tissue component from the three histological sections were averaged to represent the biopsy. Commercially available software (GraphPad Prism 5.0 for Windows, GraphPad Software Inc., USA) was utilized for statistical comparisons between groups and for drawing the graphics. The assumption of normality was checked using D’Agostino & Pearson omnibus test. The data for each evaluate...

Methods : β-TCP/HA with or without enamel matrix ...

Six months after grafting, another CBCT examination was carried out for implant planning. In the sequence, following the previously described antiseptic and anesthetic procedures, two implants with a sand-blasted and acid etching surface were installed in each of the grafted sinuses, i.e., 40 implants in total (32—Neoporous, Neodent, Curitiba, Paraná, Brazil; 8—SLA, Straumann, Basel, Switzerl...

Methods : β-TCP/HA with or without enamel matrix ...

This research project was approved by the Ethics Committee of the School of Dentistry and Dental Research Center São Leopoldo Mandic, Brazil, under the protocol 2010/0360. Ten consecutive patients (age range 35–75 years) with the need of bilateral maxillary sinus floor augmentation prior to the placement of four dental implants (two in each side of posterior maxilla) were selected for the stu...

Background : β-TCP/HA with or without enamel matr...

The aim of the present study was to compare histomorphometrically the outcome of maxillary sinus floor augmentation with β-TCP/HA with or without enamel matrix proteins (BC + EMD and EMD, respectively) in humans.

Background : β-TCP/HA with or without enamel matr...

Reconstruction of the edentulous and severely atrophied posterior maxilla is often performed by means of maxillary sinus floor augmentation in combination with dental implants [1, 2]. Various bone graft materials are typically used for enhancing bone formation within the sinus cavity; autogenous bone (AB) is considered as the gold standard due to its osteogenic, osteoinductive, and osteoconductive...

Abstract : β-TCP/HA with or without enamel matrix...

It is still unclear whether enamel matrix proteins (EMD) as adjunct to bone grafting enhance bone healing. This study compared histomorphometrically maxillary sinus floor augmentation (MSFA) with β-TCP/HA in combination with or without EMD in humans. In ten systemically healthy patients needing bilateral MSFA, one side was randomly treated using β-TCP/HA mixed with EMD (BC + EMD) and the ot...

About this article : β-TCP/HA with or without ena...

Nery, J.C., Pereira, L.A.V.D., Guimarães, G.F. et al. β-TCP/HA with or without enamel matrix proteins for maxillary sinus floor augmentation: a histomorphometric analysis of human biopsies. Int J Implant Dent 3, 18 (2017). https://doi.org/10.1186/s40729-017-0080-8 Download citation Received: 08 December 2016 Accepted: 22 April 2017 Published: 04 May 2017 DOI: https://do...

Rights and permissions : β-TCP/HA with or without...

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...

Author information : β-TCP/HA with or without ena...

You can also search for this author in PubMed Google Scholar Correspondence to James Carlos Nery.

Author information : β-TCP/HA with or without ena...

Department of Implantology, São Leopoldo Mandic Research Center, Brasília, DF, Brazil James Carlos Nery, George Furtado Guimarães & Fabiana Mantovani Gomes França Department of Biochemistry and Tissue Biology, UNICAMP – State University of Campinas, Institute of Biology, Campinas, São Paulo, Brazil Luís Antônio Violin Dias Pereira Department of Periodontology, UNESP – Univ. Estad...

References : β-TCP/HA with or without enamel matr...

Wikesjo UM, Sorensen RG, Kinoshita A, Wozney JM. RhBMP-2/alphaBSM induces significant vertical alveolar ridge augmentation and dental implant osseointegration. Clin Implant Dent Relat Res. 2002;4:174–82. Carinci F, Brunelli G, Franco M, Viscioni A, Rigo L, Guidi R, et al. A retrospective study on 287 implants installed in resorbed maxillae grafted with fresh frozen allogenous bone. Clin Implant...

References : β-TCP/HA with or without enamel matr...

Miron RJ, Sculean A, Cochran DL, Froum S, Zucchelli G, Nemcovsky C, et al. Twenty years of enamel matrix derivative: the past, the present and the future. J Clin Periodontol. 2016;43:668–83. Sculean A, Nikolidakis D, Nikou G, Ivanovic A, Chapple IL, Stavropoulos A. Biomaterials for promoting periodontal regeneration in human intrabony defects: a systematic review. Periodontol 2000. 2015;68:182...

References : β-TCP/HA with or without enamel matr...

Esposito M, Felice P, Worthington HV. Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus. Cochrane Database Syst Rev. 2014;17:CD008397. Jungner M, Cricchio G, Salata LA, Sennerby L, Lundqvist C, Hultcrantz M, et al. On the early mechanisms of bone formation after maxillary sinus membrane elevation: an experimental histological and immunohistochemical study. ...

Conclusions : β-TCP/HA with or without enamel mat...

The present study showed that maxillary sinus floor augmentation with BC resulted in adequate amounts of new bone formation allowing successful implant installation, while adding EMD did not have a significant effect.

Discussion : β-TCP/HA with or without enamel matr...

Nevertheless, the amount of bone generated with BC or BC + EMD herein was adequate to support successful implant placement and osseointegration of implants. In fact, more or less similar amounts of bone formation have been reported in studies evaluating human sinus biopsies after grafting with a variety of biomaterials (bone formation ranging approximately from 30 to 50%) [19]. On the other ha...

Discussion : β-TCP/HA with or without enamel matr...

The present study compared the histological and histomorphometrical outcome of healing after maxillary sinus floor augmentation with BC with or without EMD, based on human biopsies. The results showed that addition of EMD did not enhance the outcome of healing, neither in terms of quality nor quantity of new bone. Nevertheless, the amount of bone generated after maxillary sinus floor augmentation ...

Results : β-TCP/HA with or without enamel matrix ...

All ten patients showed uneventful healing after the sinus floor augmentation procedure as well as after dental implant placement, with no overt postoperative inflammation or infection. Consistently, in all ten patients, no significant jiggling of the drill was noticed during biopsy harvesting, while subjective drilling resistance during implant placement was similar in both groups and all implant...

Methods : β-TCP/HA with or without enamel matrix ...

The data for each tissue component from the three histological sections were averaged to represent the biopsy. Commercially available software (GraphPad Prism 5.0 for Windows, GraphPad Software Inc., USA) was utilized for statistical comparisons between groups and for drawing the graphics. The assumption of normality was checked using D’Agostino & Pearson omnibus test. The data for each evaluate...

Methods : β-TCP/HA with or without enamel matrix ...

Six months after grafting, another CBCT examination was carried out for implant planning. In the sequence, following the previously described antiseptic and anesthetic procedures, two implants with a sand-blasted and acid etching surface were installed in each of the grafted sinuses, i.e., 40 implants in total (32—Neoporous, Neodent, Curitiba, Paraná, Brazil; 8—SLA, Straumann, Basel, Switzerl...

Methods : β-TCP/HA with or without enamel matrix ...

This research project was approved by the Ethics Committee of the School of Dentistry and Dental Research Center São Leopoldo Mandic, Brazil, under the protocol 2010/0360. Ten consecutive patients (age range 35–75 years) with the need of bilateral maxillary sinus floor augmentation prior to the placement of four dental implants (two in each side of posterior maxilla) were selected for the stu...

Background : β-TCP/HA with or without enamel matr...

The aim of the present study was to compare histomorphometrically the outcome of maxillary sinus floor augmentation with β-TCP/HA with or without enamel matrix proteins (BC + EMD and EMD, respectively) in humans.

Background : β-TCP/HA with or without enamel matr...

Reconstruction of the edentulous and severely atrophied posterior maxilla is often performed by means of maxillary sinus floor augmentation in combination with dental implants [1, 2]. Various bone graft materials are typically used for enhancing bone formation within the sinus cavity; autogenous bone (AB) is considered as the gold standard due to its osteogenic, osteoinductive, and osteoconductive...

Abstract : β-TCP/HA with or without enamel matrix...

It is still unclear whether enamel matrix proteins (EMD) as adjunct to bone grafting enhance bone healing. This study compared histomorphometrically maxillary sinus floor augmentation (MSFA) with β-TCP/HA in combination with or without EMD in humans. In ten systemically healthy patients needing bilateral MSFA, one side was randomly treated using β-TCP/HA mixed with EMD (BC + EMD) and the ot...