Fig. 4. Comparative illustration of mean ISQ values
Fig. 4. Comparative illustration of mean ISQ values
Fig. 3. Implants were placed after application of CGF membrane
Fig. 3. Implants were placed after application of CGF membrane
Fig. 2. CGF membrane was applied in study group implant sockets
Fig. 2. CGF membrane was applied in study group implant sockets
Fig. 1. CGF was obtained after centrifugation
Fig. 1. CGF was obtained after centrifugation
Control group
Study group
Immediate–1st week
−2.25 ± 1.713
1.40 ± 1.847
Immediate–4th week
−2.30 ± 2.774
0.60 ± 2.798
1st Week–4th week
−0.05 ± 1.572
−0.80 ± 2.215
Table 3 Mean ISQ value changes between study and control groups
Control group
Study group
Immediate
75.75 ± 5.552
78.00 ± 2.828
1st week
73.50 ± 5.226
79.40 ± 2.604
4th week
73.45 ± 5.680
78.60 ± 3.136
Table 2 Mean ISQ values in the study and control groups
Case no.
Age
Sex
Group
Implant number
1
20
F
Study
1
2
28
M
Control
3
3
35
F
Study
4
4
32
F
Study
4
5
60
M
Control
5
6
64
F
Study
5
7
52
F
Study
5
8
34
M
Study
1
9
45
F
Control
3
10
48
F
Control
2
11
42
M
Control
3
12
68
F
Control
4
Table 1 Demographic data of patien...
Pirpir, C., Yilmaz, O., Candirli, C. et al. Evaluation of effectiveness of concentrated growth factor on osseointegration. Int J Implant Dent 3, 7 (2017). https://doi.org/10.1186/s40729-017-0069-3
Download citation
Received: 16 December 2016
Accepted: 16 February 2017
Published: 03 March 2017
DOI: https://doi.org/10.1186/s40729-017-0069-3
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Karadeniz Technical University, Trabzon, Turkey
Cagasan Pirpir, Onur Yilmaz, Celal Candirli & Emre Balaban
You can also search for this author in PubMed Google Scholar
You can also search for this author in PubMed Google Scholar
You can also search for this author in PubMed Google Scholar
You can also search for this a...
Prakash S, Thakur A. Platelet concentrates: past, present and future. J Maxillofac Oral Surg. 2011;10(1):45–9.
Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scari G, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech. 2011;74(8):772–7.
Ademokun JA, Chapman C, Dunn J, Lander D, Mair K, Proctor SJ, et al...
Huwiler MA, Pjetursson BE, Bosshardt DD, Salvi GE, Lang NP. Resonance frequency analysis in relation to jawbone characteristics and during early healing of implant installation. Clin Oral Implants Res. 2007;18(3):275–80.
Kroese-Deutman HC, Vehof JW, Spauwen PH, Stoelinga PJ, Jansen JA. Orthotopic bone formation in titanium fiber mesh loaded with platelet-rich plasma and placed in segmental defe...
Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci. 2008;13:3532–48.
Anitua E, Sanchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, et al. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009;42(2):162–70.
He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and ...
Raghavendra S, Wood MC, Taylor TD. Early wound healing around endosseous implants: a review of the literature. Int J Oral Maxillofac Implants. 2005;20(3):425–31.
Oncu E, Bayram B, Kantarci A, Gulsever S, Alaaddinoglu EE. Positive effect of platelet rich fibrin on osseointegration. Med Oral Patol Oral Cir Bucal. 2016;21(5):e601–7.
Anitua E. Plasma rich in growth factors: preliminary results o...
Bone morphogenetic protein
Concentrated growth factor
Computed tomography
Insulin-like growth factor
Platelet-derived growth factor
Platelet-rich fibrin
Platelet-rich plasma
Resonance frequency analysis
Transforming growth factor-β1
Transforming growth factor-β2
Vascular endothelial growth factor
Considering this data, it appears that application of CGF enhanced stability of implants and accelerated osseointegration in the early period. CGF has positive effects on the ISQ value at the first week and fourth week. Further laboratory studies are needed to demonstrate the positive effects of blood products on the osseointegration process at the histopathological level.
In a study by Monov et al. using PRP around the implant, a higher stability value was obtained in the study group during the early recovery period (6 weeks) although difference between the groups was not statistically significant [23]. Kim et al. reported in a study that there was a statistically significant increase in bone-implant contact with PRP administration in the vicinity of the implant [...
Introduced in 1998 by Marx, PRP is used in oral and maxillofacial surgeries to speed up the recovery of grafts in bone-grafted areas [14, 26–30]. Although many studies have shown that platelet-rich plasma affects bone healing positively, the results of some other studies suggest otherwise [31, 32].
In recent years, the platelet-rich fibrin (PRF) was described by Choukroun as a second-generation...
Implant stability is one of the important parameters that assess the loading time and dental implant success. Investigators have recommended that implants with ISQ
The study includes 12 patients (5 males, 7 females). Patients participating in the study are between 20–68 years of age and the mean age is 44 years. A total of 40 implants were placed, 20 of these were included in the study group (50%), and the other 20 were included in the control group (50%). Twenty-one implants were placed in type 2 bone, 19 implants in type 3 bone (Table 1). The distribu...
Independent sample t test was applied between the two groups by taking the differences between the data obtained in these periods. Two-way ANOVA and Fisher’s LSD test was used for evaluating the associations among group and insertion torque.
A value of p
All surgical procedures were performed under local anesthesia by the same surgeon. A full-thickness mucoperiosteal flap was removed by incision on the alveolar crest. Implant cavities were prepared according to the surgical protocol of the Bego Semados implant system (BEGO Implant Systems GmbH & Co. KG, Bremen, Germany). The final osteotomy diameters were the same as the placed implants. In the st...
This study was conducted in compliance with the principles of the Declaration of Helsinki, and approval of the ethics committee required for the study was obtained from the Ethics Committee of the Karadeniz Technical University (2015/21). The procedures to be performed were explained in detail and patients signed the consent forms. The study was carried out on individuals who applied to Karadeniz ...
That the implant has sufficient stability after placement is important for providing the necessary bone formation around the implant and for the optimal distribution of functional forces at the implant-bone interface during healing [15–17].
It can be said that resonance frequency analysis (RFA) is a very important tool for tracking the osseointegration process [18, 19]. RFA is a technique that ...
Osseointegration of dental implants is important for long-term success and stability. There is no standardization in terms of the time of osseointegration and the timing of prosthetic loading. This process varies between 0–6 months [1]. Various strategies are being explored to shorten this period. Changes in implant surface properties and design have increased primer stability and helped the pe...
Growth factor-containing products have been reported to increase implant stability and accelerate osseointegration. Concentrated growth factor (CGF) can be used for this purpose with the growth factors it contains. The aim of this study is to assess the effect of CGF on implant stability and osseointegration.
Twelve patients with maxillary anterior toothless were included in the study. Implant ca...
Fig. 4. Comparative illustration of mean ISQ values
Fig. 4. Comparative illustration of mean ISQ values
Fig. 3. Implants were placed after application of CGF membrane
Fig. 3. Implants were placed after application of CGF membrane
Fig. 2. CGF membrane was applied in study group implant sockets
Fig. 2. CGF membrane was applied in study group implant sockets
Fig. 1. CGF was obtained after centrifugation
Fig. 1. CGF was obtained after centrifugation
Control group
Study group
Immediate–1st week
−2.25 ± 1.713
1.40 ± 1.847
Immediate–4th wee...
Control group
Study group
Immediate
75.75 ± 5.552
78.00 ± 2.828
1st week
...
Case no.
Age
Sex
Group
Implant number
1
20
...
Pirpir, C., Yilmaz, O., Candirli, C. et al. Evaluation of effectiveness of concentrated growth factor on osseointegration.
Int J Implant Dent 3, 7 (2017). https://doi.org/10.1186/s40729-017-0069-3
Download citation
Received: 16 December 2016
Accepted: 16 February 2017
Published: 03 March 2017
DOI: https://doi.org/10.1186/s40729-017-0069-3
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Karadeniz Technical University, Trabzon, Turkey
Cagasan Pirpir, Onur Yilmaz, Celal Candirli & Emre Balaban
You can also search for this author in
PubMed Google Scholar
You can also search for this author in
PubMed Google Scholar
You can also search for this author in
...
Prakash S, Thakur A. Platelet concentrates: past, present and future. J Maxillofac Oral Surg. 2011;10(1):45–9.
Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scari G, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech. 2011;74(8):772–7.
Ademokun JA, Chapman C, Dunn J, Lander D, Mair K, Proctor SJ, et al...
Huwiler MA, Pjetursson BE, Bosshardt DD, Salvi GE, Lang NP. Resonance frequency analysis in relation to jawbone characteristics and during early healing of implant installation. Clin Oral Implants Res. 2007;18(3):275–80.
Kroese-Deutman HC, Vehof JW, Spauwen PH, Stoelinga PJ, Jansen JA. Orthotopic bone formation in titanium fiber mesh loaded with platelet-rich plasma and placed in segmental defe...
Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci. 2008;13:3532–48.
Anitua E, Sanchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, et al. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009;42(2):162–70.
He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and ...
Raghavendra S, Wood MC, Taylor TD. Early wound healing around endosseous implants: a review of the literature. Int J Oral Maxillofac Implants. 2005;20(3):425–31.
Oncu E, Bayram B, Kantarci A, Gulsever S, Alaaddinoglu EE. Positive effect of platelet rich fibrin on osseointegration. Med Oral Patol Oral Cir Bucal. 2016;21(5):e601–7.
Anitua E. Plasma rich in growth factors: preliminary results o...
Bone morphogenetic protein
Concentrated growth factor
Computed tomography
Insulin-like growth factor
Platelet-derived growth factor
Platelet-rich fibrin
Platelet-rich plasma
Resonance frequency analysis
Transforming growth factor-β1
Transforming growth factor-β2
Vascular endothelial growth factor
Considering this data, it appears that application of CGF enhanced stability of implants and accelerated osseointegration in the early period. CGF has positive effects on the ISQ value at the first week and fourth week. Further laboratory studies are needed to demonstrate the positive effects of blood products on the osseointegration process at the histopathological level.
In a study by Monov et al. using PRP around the implant, a higher stability value was obtained in the study group during the early recovery period (6 weeks) although difference between the groups was not statistically significant [23]. Kim et al. reported in a study that there was a statistically significant increase in bone-implant contact with PRP administration in the vicinity of the implant [...
Introduced in 1998 by Marx, PRP is used in oral and maxillofacial surgeries to speed up the recovery of grafts in bone-grafted areas [14, 26–30]. Although many studies have shown that platelet-rich plasma affects bone healing positively, the results of some other studies suggest otherwise [31, 32].
In recent years, the platelet-rich fibrin (PRF) was described by Choukroun as a second-generation...
Implant stability is one of the important parameters that assess the loading time and dental implant success. Investigators have recommended that implants with ISQ
The study includes 12 patients (5 males, 7 females). Patients participating in the study are between 20–68 years of age and the mean age is 44 years. A total of 40 implants were placed, 20 of these were included in the study group (50%), and the other 20 were included in the control group (50%). Twenty-one implants were placed in type 2 bone, 19 implants in type 3 bone (Table 1). The distribu...
Independent sample t test was applied between the two groups by taking the differences between the data obtained in these periods. Two-way ANOVA and Fisher’s LSD test was used for evaluating the associations among group and insertion torque.
A value of p
All surgical procedures were performed under local anesthesia by the same surgeon. A full-thickness mucoperiosteal flap was removed by incision on the alveolar crest. Implant cavities were prepared according to the surgical protocol of the Bego Semados implant system (BEGO Implant Systems GmbH & Co. KG, Bremen, Germany). The final osteotomy diameters were the same as the placed implants. In the st...
This study was conducted in compliance with the principles of the Declaration of Helsinki, and approval of the ethics committee required for the study was obtained from the Ethics Committee of the Karadeniz Technical University (2015/21). The procedures to be performed were explained in detail and patients signed the consent forms. The study was carried out on individuals who applied to Karadeniz ...
That the implant has sufficient stability after placement is important for providing the necessary bone formation around the implant and for the optimal distribution of functional forces at the implant-bone interface during healing [15–17].
It can be said that resonance frequency analysis (RFA) is a very important tool for tracking the osseointegration process [18, 19]. RFA is a technique that ...
Osseointegration of dental implants is important for long-term success and stability. There is no standardization in terms of the time of osseointegration and the timing of prosthetic loading. This process varies between 0–6 months [1]. Various strategies are being explored to shorten this period. Changes in implant surface properties and design have increased primer stability and helped the pe...
Growth factor-containing products have been reported to increase implant stability and accelerate osseointegration. Concentrated growth factor (CGF) can be used for this purpose with the growth factors it contains. The aim of this study is to assess the effect of CGF on implant stability and osseointegration.
Twelve patients with maxillary anterior toothless were included in the study. Implant ca...
Figure 7. Post-operative occlusal photograph of the maxilla
Figure 6. Post-operative lateral view of the right maxillary arch
Figure 5. Post-operative lateral view of the left maxillary arch
Figure 4. Post-operative frontal view with teeth in occlusion
Date
Site number
Implant diameter (mm)
Implant length (mm)
Immediate load
Bone graft augmentation
3/26/14
12
4.3
10
Yes
Allograft
3/26/14
14
4.3
10
Yes
None
11/10/14
10
3.5
13
Yes
Allograft
3/5/15
7
3.5
13
Yes
Allograft
4/19/16
11
4.3
11.5
Yes
None
2/22/17
3
4.3
10
Yes
Allograft
2/22/17
4
5.0
10
Yes
Allograft
...
Figure 1. Characteristic blue sclerae
Table 1 Osteogenesis imperfecta classifications
Type
Inheritance
Gene
Locus
Clinical features
OMIM
I
AD
COL1A1 or COL1A2
17q21.33 or 7q21.3
Variable bone fragility, moderate bone deformity, blue sclerae, possible dentinogenesis imperfecta
166,200
II
AD
COL1A1 or COL1A2
17q21.33 or 7q21.3
Perinatally lethal
166,210
III
AD
COL1A1 or COL1A2
17q21....
References
Sillence DO, Senn A, Danks DM. Genetic heterogeneity in osteogenesis imperfecta. J Med Genet. 1979;16:101–16.
Orioli IM, Castilla EE, Barbosa-Neto JG. The birth prevalence rates for the skeletal dysplasias. J Med Genet. 1986;23:328–32.
Stevenson DA, Carey JC, Byrne JL, Srisukhumbowornchai S, Feldkamp ML. Analysis of skeletal dysplasias in the Utah population. Am J Med Genet...
Discussion
The vast majority of published articles regarding OI type I revolve around fractures of the long bones and treatment strategies. An extensive literature search for manuscripts detailing the implant therapy for patients diagnosed with OI produced a marginal amount of literature (Table 3). Our case posits that oral restoration is attainable without implant failure for OI type I patien...
Surgical technique
The patient underwent implant therapy in stages under general anesthesia with immediate load protocol. Intravenous access was obtained, and the patient was anesthetized under general anesthesia by our anesthesiologist. Carpules of 2% lidocaine with 1:100,000 epinephrine, 4% articaine hydrochloride with 1:100,000 epinephrine (Septocaine), and 0.5% bupivacaine hydrochloride w...
Case presentation
Evaluation
A 53-year-old male diagnosed with OI type I was referred to our clinic for extraction of the remaining maxillary teeth and evaluation for full arch immediate load hybrid prosthesis. His clinical history included osteogenesis type 1, bipolar disorder, alopecia, and hypothyroidism. The patient presented with normal stature, measuring 170.18 cm and weighing 81.65 kg...
Introduction
Osteogenesis imperfecta (OI), colloquially known as “brittle bone disease,” is a broad term for a group of congenital disorders affecting the connective tissue resulting in a susceptibility to fractures. In 1979, Sillence et al. conducted an epidemiological and genetic study of OI patients [1]. These patients were grouped according to four distinct syndromes: (1) dominantly inh...
Implant therapy for a patient with osteogenesis imperfecta type I: review of literature with a case report
Abstract
Bone fragility and skeletal irregularities are the characteristic features of osteogenesis imperfecta (OI). Many patients with OI have weakened maxillary and mandibular bone, leading to poor oral hygiene and subsequent loss of teeth. Improvements in implant therapy have allowed f...
IstilahIstilah "Osteogenesis" berasal dari kata dalam bahasa Yunani, yaitu kata "ostō" (οστο) yang berarti tulang dan kata "genesē" (γενεση) yang berarti kejadian atau penciptaan. Istilah ini merujuk pada proses pembentukan tulang. Istilah ini bersinonim dengan sebutan "Pembentukan Tulang."Istilah "osteogenesis" agak dekat dengan istilah "osifikasi" dan "mineralisasi". Istilah "os...