Fig. 4. Micro-CT images indicate maxillary fist molar site will be able to provide a substantial cancellous bone to support a dental implant. a Sagittal plane. b Frontal plane
Fig. 4. Micro-CT images indicate maxillary fist molar site will be able to provide a substantial cancellous bone to support a dental implant. a Sagittal plane. b Frontal plane
Fig. 3. a–c Micro-CT frontal planes indicate the location of implant. d, e Micro-CT sagittal plane. f, g Micro-CT transverse plane. h Micro-CT 3D constructed image indicates osseointegration around the implant fixture
Fig. 3. a–c Micro-CT frontal planes indicate the location of implant. d, e Micro-CT sagittal plane. f, g Micro-CT transverse plane. h Micro-CT 3D constructed image indicates...
Fig. 2. Implantation of two implants at maxillary diastemata per rat. a Surgery implantation. b X-ray periapical picture after surgery. c Seven weeks after implantion
Fig. 2. Implantation of two implants at maxillary diastemata per rat. a Surgery implantation. b X-ray periapical picture after surgery. c Seven weeks after implantion
Fig. 1. a) Time course of the experiment. b) Curve of the rat body weight change. c) Implant survival after 7 weeks of implantation. Implant success and failure rate is analyzed by using Clopper-Pearson’s exact method at 95% confidence interval. Our experiment data indicate that the true success rate of implantation in maxillary natural diastema in rat is less than 38.4% at a confident level o...
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Table 1 Rat body weight during the experiment
Yue, G., Edani, H., Sullivan, A. et al. Is maxillary diastema an appropriate site for implantation in rats?. Int J Implant Dent 6, 8 (2020). https://doi.org/10.1186/s40729-019-0203-5
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Received: 29 August 2019
Accepted: 24 December 2019
Published: 26 February 2020
DOI: https://doi.org/10.1186/s40729-019-0203-5
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Animals were maintained and experiments were performed according to a protocol that was approved by the Rutgers Institutional Animal Care and Use Committee (IACUC).
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Correspondence to Mohammad Ali Saghiri.
Department of Periodontics, Rutgers School of Dental Medicine, Newark, NJ, USA
Gang Yue, Husham Edani & Andrew Sullivan
The Office of Institutional Assessment, Rutgers School of Dental Medicine, Newark, NJ, USA
Shuying Jiang
Department of Restorative Dentistry, Rutgers School of Dental Medicine, Newark, NJ, 07103, USA
Hamed Kazerani & Mohammad Ali Saghiri
Department of Endodontics, Univ...
This publication is made possible due to the generosity and support from senior faculties of the Department of Periodontics, RSDM. They are Dr. Howard Drew, vice chairman of Department of Periodontics, Dr. Emil Cappetta, Director of Postgraduate Program, and Dr. Joel Pascuzzi, Director of the Undergraduate Periodontal Program. Particularly, Dr. Michael Conte, Senior Associate Dean for the Office o...
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According to the results of the present study, the authors have concluded the following outcomes:
Current study indicates that maxillary nature diastema could be a site to place implant, but it has a low successful rate. Data indicate that the true success rate of implantation in maxillary natural diastema in rat is less than 38.4% at a confident level of 95%. Therefore, it is not an appropriate ...
The current investigation followed the protocol depicted in the article by Freire et al. [15] and tried to modify the procedure of induction of peri-implantitis. Freire and coworkers were precoating the implant with bacteria to induce the inflammation. Our design is to induce the peri-implantitis after ossointegration of the implant. However, the implant survival rate is one per 12 of implant or o...
Upon a comprehensive literature search, there are articles reported to place implants at maxillary first molar area. However, for variant reasons, these models are not clinical comparable. First, animal sizes are too small to have enough bone to support implant, i.e., Koutouzis et al. reported their experiment on rat model [31]. They placed diameter 1.5 mm × 2 mm length implants in approximat...
To explore the effective treatment for patients with severe systemic diseases and peri-implantitis, animal models are the most crucial subjects to help investigators to reveal the mechanisms underlying these disorders. Murine models both mice and rats are the most commonly used animal models in research because of their lower cost, biological relevance to human being, and available of genetic muta...
Under anesthesia, two implants were placed in maxillary diastemata in each rat (Fig. 2a). After implantation before the animal awakened, an X-ray was taken extraorally with a digital perioapical digital film. The X-ray indicates two implants were successfully placed in maxillary diastemata in one rat (Fig. 2b).
When rats arrived at animal facility, animals were stabilized for synchronizing. At da...
Baseline of osseointegration and induction of periodontitis
Seven weeks after the implantation
-Group (1): 2 rats will be sacrificed and osteointegration and inflammatory markers will be examined.
-Group (2): 2 rats will receive suture ligature at the cervical part of each implant.
-Group (3): 2 rats will receive no ligature as a control.
All the procedures will be performed when rats are und...
Titanium bone screw with machined surface 1.2 × 4.5 mm (screw head 1.5 mm, fixture 3 mm) was purchased from ACS Surgical Supply (Brockton, MA) that was used as implant by Freire and coworkers [15].
Six Sprague-Dawley, male, 400–450 g in which the body weight is based on reported article [15]. To achieve a stable implantation, the thickness of alveolar bone is crucial. Therefore, body wei...
To create a clinically compatible rat model for implantation, we have done a comprehensive literature review of rat dental implant models. Implants placed out of oral cavity such as the femur [9,10,11] and the tibia [12, 13], or not on the ridge of alveolar bone, i.e., the ramus of mandibular [14] is not considered in the present experiment because these implantations are not clinically comparable...
Implantology or implant dentistry is a fast-growing industry. It is reported that the global dental implant market was valued at $ 3.77 billion in 2016 growing at a compound annual growth rate (CAGR) of 7.7% over the forecast period (2018–2024) [1]. The USA holds a substantial market share due to the growing demand of dental implant treatment (Grand View Research, 2018, Figs 1 and 2). The 2009 a...
Current study indicates that maxillary nature diastema could be a site to place implant, but it has a low successful rate. Data indicate that the true success rate of implantation in maxillary natural diastema in rat is less than 38.4% at a confident level of 95%. Therefore, it is not an appropriate site for dental implant experiment. Moreover, it may be able to form certain osseointegration, but ...
Implantology or implant dentistry is growing fast during last four decades. Facing the growing demand of implant treatment, there are extreme challenges to clinicians and researchers. First is peri-implantitis with remarkable prevalence. Though investigators have revealed that the etiology of the peri-implant infection is similar to periodontitis, clinically there is no effective treatment. Second...
Current study indicates that maxillary nature diastema could be a site to place implant, but it has a low successful rate. Data indicate that the true success rate of implantation in maxillary natural diastema in rat is less than 38.4% at a confident level of 95%. Therefore, it is not an appropriate site for dental implant experiment. Moreover, it may be able to form certain osseointegration, but ...
Implantology or implant dentistry is growing fast during last four decades. Facing the growing demand of implant treatment, there are extreme challenges to clinicians and researchers. First is peri-implantitis with remarkable prevalence. Though investigators have revealed that the etiology of the peri-implant infection is similar to periodontitis, clinically there is no effective treatment. Second...