Figure 6. Control group. Some implant thread areas were not covered by bone layer (magnification × 25—toluidine blue)
Figure 6. Control group. Some implant thread areas were not covered by bone layer (magnification × 25—toluidine blue)
Figure 5. Control group. Implants belonging to the control group showed some small surface areas not contacted with bone (magnification × 25—toluidine blue)
Figure 5. Control group. Implants belonging to the control group showed some small surface areas not contacted with bone (magnification × 25—toluidine blue)
Figure 4. Control group. No bone condensation was possible with traditional burs and standard implant (magnification × 25—toluidine blue)
Figure 4. Control group. No bone condensation was possible with traditional burs and standard implant (magnification × 25—toluidine blue)
Figure 3. Test group. The present histological photo showed a continuous thin layer of newly formed bone along the neck area of the implant (magnification × 25—toluidine blue)
Figure 3. Test group. The present histological photo showed a continuous thin layer of newly formed bone along the neck area of the implant (magnification × 25—toluidine blue)
Figure 2. Test group. Implants in the test group showed an extremely high percentage of bone directly contacted to implant surface (magnification × 25—toluidine blue)
Figure 2. Test group. Implants in the test group showed an extremely high percentage of bone directly contacted to implant surface (magnification × 25—toluidine blue)
Figure 1. Test group. The implant achieved a high osseointegration degree. The newly formed bone appeared well interconnected with the pre-existing trabeculae. The “corticalization” phenomenon is evident: the bone appears densified around a titanium implant (magnification × 8—toluidine blue)
Figure 1. Test group. The implant achieved a high osseointegration degree. The newly formed b...
BIC%P < 0.05BV%P < 0.05VamP < 0.05Reverse torqueP > 0.05 NsISQP < 0.05Table 3 Statistical comparison (T test) of examined parameters between the test and control groups. The histomorphometric analysis demonstrated significant differences in BIC% and %BV values between the two implant groups
Implant typeBIC%BV%Vam (μm) ± SDReverse torque (N/cm) ± SDISQ value ± SDTest group70.91 ± 7.9541.83 ± 6.3082.6 ± 23.2798.2 ± 16.8163.5 ± 1.30Control group49.33 ± 10.7329.61 ± 5.0560.5 ± 16.5898.8 ± 24.4059.4 ± 1.39Table 2 Mean values of histomorphometric parameters (%BIC and %BV) and biomechanical values (VAM, reverse torque, and ISQ) of each implant group
Basal %BV 26.17 ± 2.35Test groupControl group 41.83 ± 6.30*29.61 ± 5.05Table 1 Basal bone volume percentage (basal %BV) was compared to %BV around implants after 2 months of healing in both groups. %BV in the test group was significantly higher than basal %BV (P < 0.05)
Trisi, P., Falco, A. & Berardini, M. Single-drill implant induces bone corticalization during submerged healing: an in vivo pilot study. Int J Implant Dent 6, 2 (2020). https://doi.org/10.1186/s40729-019-0198-y
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Received: 30 August 2019
Accepted: 04 December 2019
Published: 15 January 2020
DOI: https://doi.org/10.1186/s40729-019-0198-y
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
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The Ethics Committee for Animal Research of the Veterinary School of the University of Teramo (Teramo, Italy) approved the study protocol with the protocol number 8110.
The Ethics Committee for Animal Research of the Veterinary School of the University of Teramo (Teramo, Italy) approved the study protocol with the protocol number 8110.
The authors declare that they have no competing interests.
Biomaterial Clinical and Histological Research Association, Private Practice, Via Galilei 8, 65122, Pescara, Italy
Paolo Trisi, Antonello Falco & Marco Berardini
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PT contributed to the study design, animal s...
No grants were received for the present study.
The authors wish to thank Cortex® Dental Implants (Shlomi, Israel) and NoDrill® (Milano, Italy) for providing the implants used in the present study.
Gehrke SA, Bettach R, Aramburú Júnior JS, Prados-Frutos JC, Del Fabbro M, Shibli JA. Peri-Implant Bone Behavior after Single Drill versus Multiple Sequence for Osteotomy Drill. Biomed Res Int. 2018;11:2018.
Möhlhenrich SC, Abouridouane M, Heussen N, Hölzle F, Klocke F, Modabber A. Thermal evaluation by infrared measurement of implant site preparation between single and gradual drilling in art...
Summers RB. A new concept in maxillary implant surgery: the osteotome technique. Compendium. 1994;15:152–6.
Büchter A, Kleinheinz J, Wiesmann HP, et al. Biological and biomechanical evaluation of bone remodelling and implant stability after using an osteotome technique. Clin Oral Implants Res. 2005;16:1–8.
Stavropoulos A, Nyengaard JR, Lang NP, et al. Immediate loading of single SLA implant...
Albrektsson T, Brånemark PI, Hansson HA, et al. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52(2):155–70.
Molly L. Bone density and primary stability in implant therapy. Clin Oral Implants Res. 2006;2:124–35.
Chong L, Khocht A, Suzuki JB, et al. Effect of implant design on initial stability of ...
All data and materials are available from the corresponding author in Pescara, Italy.
The hypothesis was accepted. Compressing implants with single-drill bone preparation demonstrated many clinical and histological advantages with respect with to standard implant drilling procedures and classical implant shape and design in low-density bone type. It is possible to summarize the advantages of this technique as follows: higher bone to implant contact percentage than the control group...
The comparison between the basal %BV and %BV in the test group revealed that these innovative implants were able to increase in a significant way the peri-implant bone density with respect to starting host bone density. This increased peri-implant bone density extended from about 0.5–0.7 mm beyond the implant perimeter causing an osseocorticalization around the fixture profile.
A recent study [...
Results from the present study clearly show that it is possible to insert an implant using a one-step concept for the surgical preparation of the bone bed in cancellous bone.
Guazzi et al. [24], comparing the clinical outcome of implants inserted in sites prepared with a simplified protocol consisting of one large single drill versus multiple conventional drilling steps, demonstrated less surgica...
No implant failure was observed after 2 months of healing. The clinical examination, done immediately after the bone block retrieval, showed no crestal bone resorption. No bone defects around implants, such as fenestration or dehiscence, were detected. The host bone density expressed in bone volume percentage (basal %BV) was 26.17 ± 2.35. This low value of BV% is common in soft bone, according to...
Specimens were immediately fixed in 10% neutral buffered formalin and processed for histologic analysis. After dehydration, samples were infiltrated with a methyl-methacrylate resin from a starting solution 50% ethanol/resin and subsequently 100% resin, with each step lasting 24 h. After polymerization, the blocks were sectioned and then ground down to about 40 μm. Toluidine blue staining was use...
After implant insertion, cover screws were secured and the surgical wounds were closed by a resorbable periosteal-muscular inner suture, followed by an external cutaneous 2-0 silk suture.
Each animal underwent systemic antibiotic therapy for 5 days with 8 ml long-acting Clamoxil (Pfizer Limited, Sandwich, USA). After surgery, animals received appropriate veterinary care and were allowed free acce...
The Ethics Committee for Animal Research of the Veterinary School of the University of Teramo (Teramo, Italy) approved the study protocol, which followed the guidelines established by the European Union Council Directive of February 2013 (R.D.53/2013).
Two female sheep, 4–5 years old, were included in the study. Clinical examination determined that all animals were in good general health. Exclu...
The aim of the present paper is to evaluate a reduced implant site preparation technique to preserve bone bulk and enhance primary stability using a new conical self-tapping implant in cancellous type IV bone. A histologic, histomorphometric, and biomechanical comparative analysis was conducted in low-density bone of the sheep’s iliac crest. The hypothesis to test is if undersized preparation an...
It is well documented that implant initial bone fixation, known as primary implant stability, represents the pre-requisite to achieve a successful long-term osseointegration [1].
Many studies demonstrated that the implant primary stability is strictly influenced by host bone density [2], fixture geometry [3, 4], and surgical technique used for preparing bone implant bed [5]. Other studies [6, 7] ...
The aim of the present paper is to evaluate a simplified implant site preparation technique to preserve bone bulk and enhance osseointegration using a new conical self-tapping implant in cancellous bone.
Ten Expander® 3.8 × 10 mm implants (NoDrill®, Milano, Italy) were inserted in the right side (test group) of sheep’s iliac crest using only the pilot drill 1.8 mm in diameter. Ten 3.8 × 10 ...
Fig. 6. Optic microscope photo (× 9 magnification) after 30 days of implantation. Left side: machined implant (group C). Central photo: sandblasted and acid-etched implant (group A). Right side: laser-treated implant
Fig. 6. Optic microscope photo (× 9 magnification) after 30 days of implantation. Left side: machined implant (group C). Central photo: sandblasted and acid-etched implant ...
Fig. 5. Optic microscope photo (× 9 magnification) after 15 days of implantation. Left side: machined implant (group C). Central photo: sandblasted and acid-etched implant (group A). Right side: laser-treated implant
Fig. 5. Optic microscope photo (× 9 magnification) after 15 days of implantation. Left side: machined implant (group C). Central photo: sandblasted and acid-etched implant ...
Fig. 4. Exemplificative photo of implant placement in sheep iliac crest (left side). All implant groups were inserted in the same bone host
Fig. 4. Exemplificative photo of implant placement in sheep iliac crest (left side). All implant groups were inserted in the same bone host
Fig. 3. Scanning electron microscopy picture of group C implant surface
Fig. 3. Scanning electron microscopy picture of group C implant surface
Fig. 2. Scanning electron microscopy picture of group B implant surface
Fig. 2. Scanning electron microscopy picture of group B implant surface
Fig. 1. Scanning electron microscopy picture of group A implant surface
Fig. 1. Scanning electron microscopy picture of group A implant surface
Group
BIC% (mean ± SD)
A
50.31 ± 13.44
B
56.53 ± 13.62
C
20.54 ± 11.06
Table 3 Mean BIC% value of each group after 30 days of healing
Group
BIC% (mean ± SD)
A
39.08 ± 15.85
B
37.35 ± 15.76
C
25.28 ± 8.97
Table 2 Mean BIC% value of each group after 15 days of healing
Group A implantsGroup B implantsGroup C implantsScrew pitch1.25 mm0.6 mm0.6 mmSmooth neck2.8 mm0.25 mm0.25 mmSurface treatmentLarge grit-blasted and acid-etched SLA surface, processed to a high degree of hydrophilicity (SLActive®)Laser surface characterized by a series of 20 μm diameter holes (7–10 μm deep) every 10 μm (Syntegra®)Machined surfaceSurface roughness (Ra)1.5...
De Tullio, I., Berardini, M., Di Iorio, D. et al. Comparative evaluation among laser-treated, machined, and sandblasted/acid-etched implant surfaces: an in vivo histologic analysis on sheep. Int J Implant Dent 6, 7 (2020). https://doi.org/10.1186/s40729-019-0204-4
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Received: 30 August 2019
Accepted: 24 December 2019
Published: 19 February 2020
DOI: https://doi.org/10.1186/s40...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The Ethics Committee for Animal Research of the Veterinary School of the University of Teramo (Teramo, Italy) approved the study protocol, according to the guidelines established by the European Union Council Directive of February 2013 (R.D.53/2013) (protocol number 3809).
The Ethics Committee for Animal Research of the Veterinary School of the University of Teramo (Teramo, Italy) approved the st...
Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy
I. De Tullio, F. Perfetti & G. Perfetti
Pescara, Italy
M. Berardini
Foggia, Italy
D. Di Iorio
You can also search for this author in PubMed Google Scholar
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You can also search for this author in PubMed Google Scholar
You c...
No grants were received for the present study.
The authors wish to thank the company Geass s.r.l. for providing implants used in the present study.
Piattelli A, Manzon L, Scarano A, Paolantonio M, Piattelli M. Histologic and histomorphometric analysis of the bone response to machined and sandblasted titanium implants: an experimental study in rabbits. Int J Oral Maxillofac Implants. 1998;13:805–10.
Lee JT, Cho SA. Biomechanical evaluation of laser-etched Ti implant surfaces vs. chemically modified SLA Ti implant surfaces: Removal torque an...
Gaggl A, Schultes G, Muller WD, Karcher H. Scanning electron microscopical analysis of laser-treated titanium implant surfaces. A comparative study. Biomaterials. 2000;21(10):1067–73.
Bonsignore LA, Colbrunn RW, Tatro JM, Messerschmitt PJ, Hernandez CJ, Goldberg VM, Stewart MC, Greenfield EM. Surface contaminants inhibit osseointegration in a novel murine model. Bone. 2011;49(5):923–30.
Peng...
Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52(2):155–70.
Puleo DA, Nanci A. Understanding and controlling the bone-implant interface. Biomaterials. 1999;20(23-24):2311–21.
Huang MS, Chen LK, Ou KL, et al. Rapid osseointegration of titanium...
All data and materials are available at University Chieti-Pescara, Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy.
Results from the present in vivo analysis revealed that both sandblasted and acid-etched titanium implants and laser-treated titanium implants, compared to the machined ones, have higher values of osseointegration in less healing time.
Indeed, both groups A and B at 15 days had higher values of the BIC% if compared to group C and were able to significantly increase their BIC% in the passage fro...
Data showed by the present study suggest that laser and sandblasted and acid-etched surface treatments could enhance the osteogenic bone formation by “contact,” already observed by other authors [20, 21].
Another interesting emerging datum is the observation of BIC% changes between 15 and 30 days: it is possible to assume that between the fifteenth and the thirtieth day, most part of the pe...
In the present study, the iliac crest of the sheep was chosen as a model because the site is characterized by a cancellous bone rich in marrow spaces, similar for quality to D4 density. This bone model appears superimposable to postero-lateral sectors of the human upper jaw that often represents a hard challenge for implant osseointegration due to low bone density.
Bone quality, in fact, is a key...
All implants resulted clinically integrated and stable into the bone tissue. No signs of tissue inflammation or infection were detected.
At low magnification, all the samples appeared surrounded by new tissue. The distinction between native tissue and newly formed bone was not clear, likely due to the fact that the latter is still in an initial forming phase. In the machined samples (group C) bon...
Measurement of the total length of the left half of the fixture;
Measurement of the contact area between bone and implant in the left half of the fixture;
Measurement of the total length of the right half of the fixture; and
Measurement of the contact area between bone and implant in the right half of the fixture.
Afterwards, the sum of parameters A and C represented the total length of the wh...
Implant drilling procedures were carried out using the drill sequence recommended by the manufacturer. The drill speed was set at 700 rpm under continuous sterile saline solution irrigation (stored at + 4 °C).
Implants were inserted with an insertion torque peak between 28 and 34 Ncm. Each animal received three implants of each group.
The suture of deep muscle planes was performed with poly...
The Ethics Committee for Animal Research of the Veterinary School of the University of Teramo (Teramo, Italy) approved the study protocol, which followed guidelines established by the European Union Council Directive of February 2013 (R.D.53/2013).
A total of 36 implants were used in the present study. Implants had different macro-geometries and surfaces and they were divided into three groups of...
In addition, some animal studies [15, 16] found an increased removal torque in laser processed implants compared to machined surface implants inserted.
The aim of the present paper was to evaluate the osseointegration process, in terms of bone to implant contact percentage (BIC%), of three different implants surface (machined, sandblasted and acid-etched, and laser-treated) both after 15 and 30...
Dental implant surfaces represent one of the key factors that could influence the osseointegration processes [1]. Puleo et al. [2] confirmed that the surface topography, as well as the chemical nature and the implant macro and micro geometry, is involved in creating a clinical and histological efficient bone-implant interface. It was demonstrated that different superficial treatments could affect ...
The aim of the present in vivo analysis was to evaluate the osseointegration process of titanium implants with three different surfaces (machined, sandblasted and acid-etched, and laser-treated) after 15 and 30 days of healing period.
Thirty-six implants with different surfaces were placed in the iliac crest of four Bergamasca sheep. The implant surfaces tested were sandblasted and acid-etched ...
Fig. 4. Micro-CT images indicate maxillary fist molar site will be able to provide a substantial cancellous bone to support a dental implant. a Sagittal plane. b Frontal plane
Fig. 4. Micro-CT images indicate maxillary fist molar site will be able to provide a substantial cancellous bone to support a dental implant. a Sagittal plane. b Frontal plane
Fig. 3. a–c Micro-CT frontal planes indicate the location of implant. d, e Micro-CT sagittal plane. f, g Micro-CT transverse plane. h Micro-CT 3D constructed image indicates osseointegration around the implant fixture
Fig. 3. a–c Micro-CT frontal planes indicate the location of implant. d, e Micro-CT sagittal plane. f, g Micro-CT transverse plane. h Micro-CT 3D constructed image indicates...
Fig. 2. Implantation of two implants at maxillary diastemata per rat. a Surgery implantation. b X-ray periapical picture after surgery. c Seven weeks after implantion
Fig. 2. Implantation of two implants at maxillary diastemata per rat. a Surgery implantation. b X-ray periapical picture after surgery. c Seven weeks after implantion
Fig. 1. a) Time course of the experiment. b) Curve of the rat body weight change. c) Implant survival after 7 weeks of implantation. Implant success and failure rate is analyzed by using Clopper-Pearson’s exact method at 95% confidence interval. Our experiment data indicate that the true success rate of implantation in maxillary natural diastema in rat is less than 38.4% at a confident level o...
None
Table 1 Rat body weight during the experiment
Yue, G., Edani, H., Sullivan, A. et al. Is maxillary diastema an appropriate site for implantation in rats?. Int J Implant Dent 6, 8 (2020). https://doi.org/10.1186/s40729-019-0203-5
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Received: 29 August 2019
Accepted: 24 December 2019
Published: 26 February 2020
DOI: https://doi.org/10.1186/s40729-019-0203-5
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
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Animals were maintained and experiments were performed according to a protocol that was approved by the Rutgers Institutional Animal Care and Use Committee (IACUC).
On behalf of all the authors, corresponding author of the current manuscript hereby declares that the abovementioned manuscript which is submitted for publication is NOT under consideration elsewhere.
The authors hereby declare that ...
Correspondence to Mohammad Ali Saghiri.
Department of Periodontics, Rutgers School of Dental Medicine, Newark, NJ, USA
Gang Yue, Husham Edani & Andrew Sullivan
The Office of Institutional Assessment, Rutgers School of Dental Medicine, Newark, NJ, USA
Shuying Jiang
Department of Restorative Dentistry, Rutgers School of Dental Medicine, Newark, NJ, 07103, USA
Hamed Kazerani & Mohammad Ali Saghiri
Department of Endodontics, Univ...
This publication is made possible due to the generosity and support from senior faculties of the Department of Periodontics, RSDM. They are Dr. Howard Drew, vice chairman of Department of Periodontics, Dr. Emil Cappetta, Director of Postgraduate Program, and Dr. Joel Pascuzzi, Director of the Undergraduate Periodontal Program. Particularly, Dr. Michael Conte, Senior Associate Dean for the Office o...
Inouye KAS, Bisch FC, Elsalanty ME, Zakhary I, Khashaba RM, Borke JL. Effect of metformin on periimplant wound healing in a rat model of type 2 diabetes. Implant Dent. 2014;23:319–27.
Lin Z, Rios HF, Volk SL, Sugai JV, Jin Q, Giannobile WV. Gene expression dynamics during bone healing and osseointegration. J Periodontol. 2011;82:1007–17.
Scala A, Lang NP, Schweikert MT, de Oliveira JA, Range...
Gutwald R, Haberstroh J, Stricker A, Rüther E, Otto F, Xavier SP, et al. Influence of rhBMP-2 on bone formation and osseointegration in different implant systems after sinus-floor elevation. An in vivo study on sheep. J Craniomaxillofac Surg. 2010;38:571–9.
Assenza B, Scarano A, Perrotti V, Vozza I, Quaranta A, Quaranta M, et al. Peri-implant bone reactions around immediately loaded conical im...
Casap N, Nimri S, Ziv E, Sela J, Samuni Y. Type 2 diabetes has minimal effect on osseointegration of titanium implants in Psammomys obesus. Clin Oral Implants Res. 2008;19:458–64.
Hashiguchi C, Kawamoto S-I, Kasai T, Nishi Y, Nagaoka E. Influence of an antidiabetic drug on biomechanical and histological parameters around implants in type 2 diabetic rats. Implant Dent. 2014;23:264–9.
Lioubavi...
Grand View Research, Dental implants market size, share & trends analysis report by product (titanium implants, zirconium implants), by region (North America, Europe, Asia Pacific, Latin America, MEA), and segment forecasts, 2018 – 2024. 2018.
Eke PI, Dye B, Wei L, Thornton-Evans G, Genco R. Prevalence of periodontitis in adults in the United States: 2009 and 2010. J Dent Res. 2012;91:914–20....
According to the results of the present study, the authors have concluded the following outcomes:
Current study indicates that maxillary nature diastema could be a site to place implant, but it has a low successful rate. Data indicate that the true success rate of implantation in maxillary natural diastema in rat is less than 38.4% at a confident level of 95%. Therefore, it is not an appropriate ...
The current investigation followed the protocol depicted in the article by Freire et al. [15] and tried to modify the procedure of induction of peri-implantitis. Freire and coworkers were precoating the implant with bacteria to induce the inflammation. Our design is to induce the peri-implantitis after ossointegration of the implant. However, the implant survival rate is one per 12 of implant or o...
Upon a comprehensive literature search, there are articles reported to place implants at maxillary first molar area. However, for variant reasons, these models are not clinical comparable. First, animal sizes are too small to have enough bone to support implant, i.e., Koutouzis et al. reported their experiment on rat model [31]. They placed diameter 1.5 mm × 2 mm length implants in approximat...
To explore the effective treatment for patients with severe systemic diseases and peri-implantitis, animal models are the most crucial subjects to help investigators to reveal the mechanisms underlying these disorders. Murine models both mice and rats are the most commonly used animal models in research because of their lower cost, biological relevance to human being, and available of genetic muta...
Under anesthesia, two implants were placed in maxillary diastemata in each rat (Fig. 2a). After implantation before the animal awakened, an X-ray was taken extraorally with a digital perioapical digital film. The X-ray indicates two implants were successfully placed in maxillary diastemata in one rat (Fig. 2b).
When rats arrived at animal facility, animals were stabilized for synchronizing. At da...
Baseline of osseointegration and induction of periodontitis
Seven weeks after the implantation
-Group (1): 2 rats will be sacrificed and osteointegration and inflammatory markers will be examined.
-Group (2): 2 rats will receive suture ligature at the cervical part of each implant.
-Group (3): 2 rats will receive no ligature as a control.
All the procedures will be performed when rats are und...
Titanium bone screw with machined surface 1.2 × 4.5 mm (screw head 1.5 mm, fixture 3 mm) was purchased from ACS Surgical Supply (Brockton, MA) that was used as implant by Freire and coworkers [15].
Six Sprague-Dawley, male, 400–450 g in which the body weight is based on reported article [15]. To achieve a stable implantation, the thickness of alveolar bone is crucial. Therefore, body wei...
To create a clinically compatible rat model for implantation, we have done a comprehensive literature review of rat dental implant models. Implants placed out of oral cavity such as the femur [9,10,11] and the tibia [12, 13], or not on the ridge of alveolar bone, i.e., the ramus of mandibular [14] is not considered in the present experiment because these implantations are not clinically comparable...
Implantology or implant dentistry is a fast-growing industry. It is reported that the global dental implant market was valued at $ 3.77 billion in 2016 growing at a compound annual growth rate (CAGR) of 7.7% over the forecast period (2018–2024) [1]. The USA holds a substantial market share due to the growing demand of dental implant treatment (Grand View Research, 2018, Figs 1 and 2). The 2009 a...
Current study indicates that maxillary nature diastema could be a site to place implant, but it has a low successful rate. Data indicate that the true success rate of implantation in maxillary natural diastema in rat is less than 38.4% at a confident level of 95%. Therefore, it is not an appropriate site for dental implant experiment. Moreover, it may be able to form certain osseointegration, but ...
Implantology or implant dentistry is growing fast during last four decades. Facing the growing demand of implant treatment, there are extreme challenges to clinicians and researchers. First is peri-implantitis with remarkable prevalence. Though investigators have revealed that the etiology of the peri-implant infection is similar to periodontitis, clinically there is no effective treatment. Second...
Fig. 6. Optic microscope photo (× 9 magnification) after 30 days of implantation. Left side: machined implant (group C). Central photo: sandblasted and acid-etched implant (group A). Right side: laser-treated implant
Fig. 6. Optic microscope photo (× 9 magnification) after 30 days of implantation. Left side: machined implant (group C). Central photo: sandblasted and acid-etched implant ...
Fig. 5. Optic microscope photo (× 9 magnification) after 15 days of implantation. Left side: machined implant (group C). Central photo: sandblasted and acid-etched implant (group A). Right side: laser-treated implant
Fig. 5. Optic microscope photo (× 9 magnification) after 15 days of implantation. Left side: machined implant (group C). Central photo: sandblasted and acid-etched implant ...
Fig. 4. Exemplificative photo of implant placement in sheep iliac crest (left side). All implant groups were inserted in the same bone host
Fig. 4. Exemplificative photo of implant placement in sheep iliac crest (left side). All implant groups were inserted in the same bone host
Fig. 3. Scanning electron microscopy picture of group C implant surface
Fig. 3. Scanning electron microscopy picture of group C implant surface
Fig. 2. Scanning electron microscopy picture of group B implant surface
Fig. 2. Scanning electron microscopy picture of group B implant surface
Fig. 1. Scanning electron microscopy picture of group A implant surface
Fig. 1. Scanning electron microscopy picture of group A implant surface
GroupBIC% (mean ± SD)A50.31 ± 13.44B56.53 ± 13.62C20.54 ± 11.06Table 3 Mean BIC% value of each group after 30 days of healing
Group
BIC% (mean ± SD)
A
39.08 ± 15.85
B
37.35 ± 15.76
C
25.28 ± 8.97
Table 2 Mean BIC% value of each group after 15 days of healing
Group A implantsGroup B implantsGroup C implantsScrew pitch1.25 mm0.6 mm0.6 mmSmooth neck2.8 mm0.25 mm0.25 mmSurface treatmentLarge grit-blasted and acid-etched SLA surface, processed to a high degree of hydrophilicity (SLActive®)Laser surface characterized by a series of 20 μm diameter holes (7–10 μm deep) every 10 μm (Syntegra®)Machined surfaceSurface roughness (Ra)1.5...
De Tullio, I., Berardini, M., Di Iorio, D. et al. Comparative evaluation among laser-treated, machined, and sandblasted/acid-etched implant surfaces: an in vivo histologic analysis on sheep.
Int J Implant Dent 6, 7 (2020). https://doi.org/10.1186/s40729-019-0204-4
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Received: 30 August 2019
Accepted: 24 December 2019
Published: 19 February 2020
DOI: https:...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
The Ethics Committee for Animal Research of the Veterinary School of the University of Teramo (Teramo, Italy) approved the study protocol, according to the guidelines established by the European Union Council Directive of February 2013 (R.D.53/2013) (protocol number 3809).
The Ethics Committee for Animal Research of the Veterinary School of the University of Teramo (Teramo, Italy) approved the st...
Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy
I. De Tullio, F. Perfetti & G. Perfetti
Pescara, Italy
M. Berardini
Foggia, Italy
D. Di Iorio
You can also search for this author in PubMed Google Scholar
You can also search for this author in PubMed Google Scholar
You can also search for this author in PubMed Google Scholar
You c...
No grants were received for the present study.
The authors wish to thank the company Geass s.r.l. for providing implants used in the present study.
Piattelli A, Manzon L, Scarano A, Paolantonio M, Piattelli M. Histologic and histomorphometric analysis of the bone response to machined and sandblasted titanium implants: an experimental study in rabbits. Int J Oral Maxillofac Implants. 1998;13:805–10.
Lee JT, Cho SA. Biomechanical evaluation of laser-etched Ti implant surfaces vs. chemically modified SLA Ti implant surfaces: Removal torque an...
Gaggl A, Schultes G, Muller WD, Karcher H. Scanning electron microscopical analysis of laser-treated titanium implant surfaces. A comparative study. Biomaterials. 2000;21(10):1067–73.
Bonsignore LA, Colbrunn RW, Tatro JM, Messerschmitt PJ, Hernandez CJ, Goldberg VM, Stewart MC, Greenfield EM. Surface contaminants inhibit osseointegration in a novel murine model. Bone. 2011;49(5):923–30.
Peng...
Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52(2):155–70.
Puleo DA, Nanci A. Understanding and controlling the bone-implant interface. Biomaterials. 1999;20(23-24):2311–21.
Huang MS, Chen LK, Ou KL, et al. Rapid osseointegration of titanium...
All data and materials are available at University Chieti-Pescara, Department of Medical, Oral and Biotechnological Sciences, University of Chieti-Pescara, Chieti, Italy.
Results from the present in vivo analysis revealed that both sandblasted and acid-etched titanium implants and laser-treated titanium implants, compared to the machined ones, have higher values of osseointegration in less healing time.
Indeed, both groups A and B at 15 days had higher values of the BIC% if compared to group C and were able to significantly increase their BIC% in the passage fro...
Data showed by the present study suggest that laser and sandblasted and acid-etched surface treatments could enhance the osteogenic bone formation by “contact,” already observed by other authors [20, 21].
Another interesting emerging datum is the observation of BIC% changes between 15 and 30 days: it is possible to assume that between the fifteenth and the thirtieth day, most part of the pe...
In the present study, the iliac crest of the sheep was chosen as a model because the site is characterized by a cancellous bone rich in marrow spaces, similar for quality to D4 density. This bone model appears superimposable to postero-lateral sectors of the human upper jaw that often represents a hard challenge for implant osseointegration due to low bone density.
Bone quality, in fact, is a key...
All implants resulted clinically integrated and stable into the bone tissue. No signs of tissue inflammation or infection were detected.
At low magnification, all the samples appeared surrounded by new tissue. The distinction between native tissue and newly formed bone was not clear, likely due to the fact that the latter is still in an initial forming phase. In the machined samples (group C) bon...
Measurement of the total length of the left half of the fixture;
Measurement of the contact area between bone and implant in the left half of the fixture;
Measurement of the total length of the right half of the fixture; and
Measurement of the contact area between bone and implant in the right half of the fixture.
Afterwards, the sum of parameters A and C represented the total length of the wh...
Implant drilling procedures were carried out using the drill sequence recommended by the manufacturer. The drill speed was set at 700 rpm under continuous sterile saline solution irrigation (stored at + 4 °C).
Implants were inserted with an insertion torque peak between 28 and 34 Ncm. Each animal received three implants of each group.
The suture of deep muscle planes was performed with poly...
The Ethics Committee for Animal Research of the Veterinary School of the University of Teramo (Teramo, Italy) approved the study protocol, which followed guidelines established by the European Union Council Directive of February 2013 (R.D.53/2013).
A total of 36 implants were used in the present study. Implants had different macro-geometries and surfaces and they were divided into three groups of...
In addition, some animal studies [15, 16] found an increased removal torque in laser processed implants compared to machined surface implants inserted.
The aim of the present paper was to evaluate the osseointegration process, in terms of bone to implant contact percentage (BIC%), of three different implants surface (machined, sandblasted and acid-etched, and laser-treated) both after 15 and 30...
Dental implant surfaces represent one of the key factors that could influence the osseointegration processes [1]. Puleo et al. [2] confirmed that the surface topography, as well as the chemical nature and the implant macro and micro geometry, is involved in creating a clinical and histological efficient bone-implant interface. It was demonstrated that different superficial treatments could affect ...
The aim of the present in vivo analysis was to evaluate the osseointegration process of titanium implants with three different surfaces (machined, sandblasted and acid-etched, and laser-treated) after 15 and 30 days of healing period.
Thirty-six implants with different surfaces were placed in the iliac crest of four Bergamasca sheep. The implant surfaces tested were sandblasted and acid-etched ...
Current study indicates that maxillary nature diastema could be a site to place implant, but it has a low successful rate. Data indicate that the true success rate of implantation in maxillary natural diastema in rat is less than 38.4% at a confident level of 95%. Therefore, it is not an appropriate site for dental implant experiment. Moreover, it may be able to form certain osseointegration, but ...
Implantology or implant dentistry is growing fast during last four decades. Facing the growing demand of implant treatment, there are extreme challenges to clinicians and researchers. First is peri-implantitis with remarkable prevalence. Though investigators have revealed that the etiology of the peri-implant infection is similar to periodontitis, clinically there is no effective treatment. Second...
Figure 2. poietic stem cells; MP, macrophages; OC, osteoclasts.
Figure 2. Summary of biological processes identified via gene expression during early peri-implant bone healing. CKs, cytokines; GFs, growth factors; EPC, endothelial progenitor cells; EC, endothelial cells; MSC, mesenchymal stem cells; OB, osteoblasts; ECM, extracellular matrix; HSC, haematopoietic stem cells; MP, macrophages; O...
Figure 1. Flowchart for study selection (
Figure 1. Flowchart for study selection ( n = number of studies).
Process
Upregulated genes
Category (gene code)
Inflammation/immune response
Pro-inflammatory cytokines
Tumor necrosis factor (TNF-a, TNFSF9)
Interleukin (IL-6, IL-2, IL-1 F9, IL-23A, ...
Study
Ivanovski et al. [
34
]
Donos et al. [
35
]
Bryington et al. [
36
]
Thalji et al. [
37
]
Design
9 patients; 9 implants placed
18 patients; 18 implants placed
10 patients;...
Category
Ivanovski et al. [ 34 ]
Donos et al. 2011 [ 35 ]
Bryington et al. [ 36 ]
Thalji et al. [ 37 ]
Study design
Comparison
None (only SLActive)
SLA vs. SLActive
TiOBlast vs. Osseospeed
TiOBlast vs. Osseospeed
Setting
University
University
University
University
Population, inclusion criteria
9 healthy volunteers with no mandibular thi...
Methodology
Ivanovski et al. [
34
]
Donos et al. [
35
]
Bryington et al. [
36
]
Thalji et al. [
37
]
Tissue harvesting
Tissue attached to implant carefully removed with a curette, preexisting hard tissue discarded
Tissue attached to ...
Shanbhag, S., Shanbhag, V. & Stavropoulos, A. Genomic analyses of early peri-implant bone healing in humans: a systematic review. Int J Implant Dent 1, 5 (2015). https://doi.org/10.1186/s40729-015-0006-2
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Received: 14 November 2014
Accepted: 27 January 2015
Published: 01 March 2015
DOI: https://doi.org/10.1186/s40729-015-0006-2
The authors declare that they have no competing interests.
SS conceived and carried out the study and drafted the manuscript. VS and AS participated in carrying out the study and drafting the manuscript. All authors read and approved the final manuscript.
Department of Periodontology, Faculty of Odontology, Malmö University, Carl Gustafs väg 34, 214 21, Malmö, Sweden
Siddharth Shanbhag & Andreas Stavropoulos
Centre for Oral Rehabilitation & Implant Dentistry, 1 Laxmi Niwas, 87 Bajaj Road, Vile Parle West, Mumbai, 400056, India
Siddharth Shanbhag & Vivek Shanbhag
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Donos N, Retzepi M, Wall I, Hamlet S, Ivanovski S. In vivo gene expression profile of guided bone regeneration associated with a microrough titanium surface. Clin Oral Implants Res. 2011;22(4):390–8. doi:10.1111/j.1600-0501.2010.02105.x.
Skaper SD. The neurotrophin family of neurotrophic factors: an overview. Methods Mol Biol. 2012;846:1–12. doi:10.1007/978-1-61779-536-7_1.
Vaillant AR, Mazz...
Nucera S, Biziato D, De Palma M. The interplay between macrophages and angiogenesis in development, tissue injury and regeneration. Int J Dev Biol. 2011;55(4–5):495–503. doi:10.1387/ijdb.103227sn.
Ziebart T, Schnell A, Walter C, Kämmerer PW, Pabst A, Lehmann KM, et al. Interactions between endothelial progenitor cells (EPC) and titanium implant surfaces. Clin Oral Investig. 2013;17(1):301–...
Rocci M, Rocci A, Martignoni M, Albrektsson T, Barlattani A, Gargari M. Comparing the TiOblast and Osseospeed surfaces. Histomorphometric and histological analysis in humans. Oral Implantol (Rome). 2008;1(1):34–42.
Qin C, Baba O, Butler WT. Post-translational modifications of sibling proteins and their roles in osteogenesis and dentinogenesis. Crit Rev Oral Biol Med. 2004;15(3):126–36.
Vlaci...
Chehroudi B, Ghrebi S, Murakami H, Waterfield JD, Owen G, Brunette DM. Bone formation on rough, but not polished, subcutaneously implanted Ti surfaces is preceded by macrophage accumulation. J Biomed Mater Res A. 2010;93(2):724–37. doi:10.1002/jbm.a.32587.
Heng BC, Cao T, Stanton LW, Robson P, Olsen B. Strategies for directing the differentiation of stem cells into the osteogenic lineage in vit...
Nishimura I. Genetic networks in osseointegration. J Dent Res. 2013;92(12 Suppl):109S–18. doi:10.1177/0022034513504928.
Higgins JPT, Green S, editors. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [updated March 2011]. The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org; 2011.
Tarca AL, Romero R, Draghici S. Analysis of microarray experiments of...
Lin Z, Rios HF, Volk SL, Sugai JV, Jin Q, Giannobile WV. Gene expression dynamics during bone healing and osseointegration. J Periodontol. 2011;82(7):1007–17. doi:10.1902/jop.2010.100577.
Ai-Aql ZS, Alagl AS, Graves DT, Gerstenfeld LC, Einhorn TA. Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res. 2008;87(2):107–18.
Albrektsson T...
Setzer FC, Kim S. Comparison of long-term survival of implants and endodontically treated teeth. J Dent Res. 2014;93(1):19–26. doi:10.1177/0022034513504782.
Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52(2):155–70.
Berglundh T, Abrahamsson ...
Based on limited evidence of gene expression data from four studies involving 43 patients, the following remarks can be made:
Early peri-implant healing (2 weeks) involves a sequence of biological events which are similar to those observed in other bone wound healing scenarios (fractures, extraction-sockets).
Osseointegration depends on osteogenesis at the implant interface, but other simultane...
It can be hypothesized that peri-implant neurogenesis is one of the underlying mechanisms governing the phenomenon of osseoperception, defined as the tactile sensibility of osseointegrated implants to occlusal forces induced via activation of nerve endings and/or receptors in the peri-implant environment [82,83]. Moreover, recent evidence suggests that implant surface properties may influence the ...
In the present review, a significant simultaneous upregulation of several angiogenesis-related genes was identified at day 7 in all included studies. Pro-angiogenic factors (ANXA2, EPAS-1) were upregulated at TiOBlast and Osseospeed surfaces at day 7 [37]. Genes associated with VEGF and P13K-AKT signaling pathways were upregulated at SLActive (but not SLA) surfaces on day 7 and continued to be upr...
Furthermore, genes associated with collagen fibril formation/organization (heat-shock protein-47 (HSP-47), pro-collagen C-endopeptidase enhancer (PCOLCE), small leucine-rich proteoglycans (SLRP)) and post-translational modification (pro-collagen lysyl-hydroxylases (PLOD1, PLOD2, PLOD3) and lysyl-oxidase (LOX)) were upregulated on Osseospeed and TiOBlast surfaces [37]. Collagen comprises approximat...
The key signaling pathways, via which GFs guide osteogenic cell differentiation, are the TGF-β/BMP- and Wnt-mediated pathways [19,47]. While the BMP pathway ensures differentiation of MSCs into osteo-chondro-progenitors (OCPs), the Wnt pathway is essential for subsequent osteoblastic commitment, i.e., Wnt acts ‘downstream’ of BMP to ensure that OCPs differentiate into osteoblasts and not chon...
Cells along the osteogenic differentiation pathway may be artificially categorized as (1) undifferentiated MSCs, (2) osteo-chondro-progenitor cells, (3) pre-osteoblasts, and (4) osteoblasts; although in reality, a developmental continuum without distinct boundaries may exist [43]. While pre-differentiated osteoblasts in the marrow compartment only play a minor role in bone wound healing, a more pr...
Thus, high risk of bias should be considered when interpreting the results, due to the above methodological limitations and the overall limited information (four studies) available.
Conventional implant surgery involves osteotomy preparation and insertion of the implant into the alveolar bone. The immediate local effects of this procedure, functionally relevant to subsequent healing processes, ar...
The included studies basically report on commercially available implants from two major manufacturers and involve comparisons of different implant surface technologies in regard with topography and/or chemistry modifications within each implant system. Various analyses were performed in the included studies; however, an attempt has been made to synthesize the various findings and discuss them here...
Both reviewers independently extracted data from the full texts of included articles using specially designed forms. Data on author(s), study design, implant type/surface, any additional procedures performed, number of patients (in each group), presence of a control group, procedure and time of implant retrieval, methods of gene expression analysis, and main results, were extracted. Descriptive su...
A study protocol for a systematic qualitative literature review was developed based on recommended methods [29]. The focused question was ‘what biological processes are reflected by gene expression analyses in peri-implant tissues of humans during the early stages (up to 4 weeks) of healing?’
All studies, controlled (using different implants) or uncontrolled, reporting gene expression analys...
Recent in vitro [24] and preclinical in vivo [25] studies have focused on the early molecular biological responses to various titanium implant surfaces. Understanding these early responses is essential for efforts aiming to accelerate and enhance the process of osseointegration [26]. Upregulation or downregulation of specific genes in peri-implant tissues identified by analyses of genetic material...
Osseointegrated oral implants are an integral part of modern reconstructive dentistry and are associated with favorable long-term therapeutic outcomes [1]. Osseointegration was originally defined as the direct contact between vital bone and a load-bearing implant observed at the light microscopic, i.e., histological, level [2]. Morphogenesis of implant osseointegration has been assessed in several...
The objective of the study was to systematically review the literature for studies reporting gene expression analyses (GEA) of the biological processes involved in early human peri-implant bone healing.
Electronic databases (MEDLINE, EMBASE) were searched in duplicate. Controlled and uncontrolled studies reporting GEA of human peri-implant tissues - including ≥5 patients and ≥2 time points - ...
SBP (mmHg)
DBP (mmHg)
PR (bpm)
RPP (bpm × mmHg)
Normotensive patients (N = 410)
On arrival at the office
133.0 ± 18.4
76.4 ± 12.5
79.2 ± 13...
SBP (>160 mmHg)
RPP (>12,000 bpm × mmHg)
Normotensive group (N = 410)
On arrival at the office
41 (10.0%)
111 (27.1%)
Prior to sedation
...
Normotensive group
Hypertensive group
p
value
Number (male: female)
410 (127: 283)
106 (37: 69)
0.170
Age (year mean ± SD)
...
Kimura, M., Takasugi, Y., Hanano, S. et al. Efficacy of intravenous sedation and oral nifedipine in dental implant patients with preoperative hypertension - a retrospective study of 516 cases. Int J Implant Dent 1, 6 (2015). https://doi.org/10.1186/s40729-015-0004-4
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Received: 08 October 2014
Accepted: 14 January 2015
Published: 18 March 2015
DOI: https://doi.org/10.1186/s407...
Motoshi Kimura, Yoshihiro Takasugi, Shigeyoshi Hanano, Katsuyuki Terabe and Yuko Kimura declare that they have no competing interests.
YT and MK designed the study; MK, SH, and KT performed the surgeries; YT performed the intravenous sedation. YT, MK, and YK collected and analyzed the data; MK wrote the manuscript. YT revised the manuscript. All authors read and approved the final manuscript.
Hanano Dental Clinic, 4-2-3 Yamanoue, Hirakata, Osaka, 573-0047, Japan
Motoshi Kimura & Shigeyoshi Hanano
Department of Anesthesiology, Kinki University Faculty of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, 589-8511, Japan
Yoshihiro Takasugi
Terabe Dental Clinic, 4-249 Sakae-cho, Tsu, Mie, 514-0004, Japan
Katsuyuki Terabe
First Department of Internal Medicine, Osaka Medical College...
Abraham-Inpijn L, Borgmeijer-Hoelen A, Gortzak RAT. Changes in blood pressure, heart rate, and electrocardiogram during dental treatment with use of local anesthesia. J Am Dent Assoc. 1988;116:531–6.
Brand HS, Gortzak RA, Palmer-Bouva CC, Abraham RE, Abraham-Inpijn L. Cardiovascular and neuroendocrine responses during acute stress induced by different types of dental treatment. Int Dent J. 1995...
Little JW. The impact on dentistry of recent advances in the management of hypertension. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;90:591–9.
Aubertin MA. The hypertensive patient in dental practice: updated recommendations for classification, prevention, monitoring, and dental management. Gen Dent. 2004;52:544–52.
Vaughan CJ, Delanty N. Hypertensive emergencies. Lancet. 2000;356...
Systolic blood pressure
Diastolic blood pressure
Pulse rate
Rate pressure product
Electrocardiogram
Percutaneous oxygen saturation
Analysis of variance
Immediate-release
In this study, we showed that the stable hemodynamic was obtained by performing intravenous sedation and oral administration of nifedipine for patients with hypertension. It is important not only to understand the systemic management of the patient but also to obtain stabled hemodynamic by performing intravenous sedation and oral administration of nifedipine for patients with hypertension in order...
Implant surgery is performed in patients with a wide age range, including elderly patients with hypertension. Dentists or oral surgeons often encounter hypertensive patients who are undiagnosed or noncompliant. Among Japanese over the age of 30, 60% of men and 44.6% of women suffer from high blood pressure, and 33.8% of men and 25.6% of women with a history of hypertension have not been managed me...
For patients with stage 2 hypertension before operation, it is difficult to maintain the recommended blood pressure during surgery using only intravenous sedation, and it is necessary to decrease blood pressure by antihypertensive drugs. In this study, the blood pressure of patients with sustained hypertension was reduced to stage I hypertension about 30 min after administration of oral nifedipin...
In 44 (8.5%) of the 516 implant surgery cases, oral nifedipine had to be administered, since preoperative SBP was higher than 160 mmHg in these patients. Within 30 min of administration of nifedipine, SBP of hypertensive patients decreased to a similar range as that of hypertensive patients who did not need administration of oral nifedipine. Intravenous sedation after nifedipine administration t...
In patients with oral nifedipine in the hypertensive group, the PR value slightly increased prior to initiation of intravenous sedation (p = 0.224) and then significantly decreased until completion of the operation (p 160 mmHg during and at completion of operation showed maximum SBP of 180 mmHg in the normotensive group, 190 mmHg on the hypertensive group without preoperative oral nifedip...
Patient demographics and clinical characteristics are summarized in Table 1. There were significant differences in age (p
This study protocol was approved by the ethics committee of Japanese Dental Society of Anesthesiology (No. 2015–4).
Following confirmation of a sufficient anesthetic effect, intravenous sedation with continuous infusion of propofol 1 to 2 mg/kg/h and midazolam 20 to 40 μg/kg bolus together with inhalation of oxygen 3 L/min via nasal cannula was initiated. After confirming Verrill sign, implant surgery was initiated. During operation, the propofol dose was adjusted to maintain the optimum conscious sedative ...
A retrospective review of the clinical records was conducted for 336 patients who received dental implant-related surgeries combined with intravenous sedation between January 2008 and February 2012 at our outpatient dental offices. Among the patients, 125 patients received multiple surgeries during the observation period: 4 patients underwent surgery five times, 7 patients four times, 29 patients ...
Osseointegrated dental implants were introduced in Japan in 1983, and the procedures are now performed very frequently. Dental implants are placed in a wide age range of patients, including elderly patients with hypertension. Patients with very high blood pressure are at great risk for acute medical problems when undergoing stressful dental procedures, such as oral surgery, periodontal surgery, an...
To examine the effects of intravenous sedation and oral nifedipine on blood pressure and pulse rate in patients with perioperative high blood pressure undergoing implant surgery, the clinical records of dental implant patients managed by intravenous sedation at our outpatient dental offices were retrospectively evaluated.
A total of 516 clinical charts were evaluated. The subjects were divided in...
Fig. 7. The epithesis allows both prompt inspection of the resection site and makes daily care easier
Fig. 7. The epithesis allows both prompt inspection of the resection site and makes daily care easier
Fig. 6. Frontal view of the patient after superior overdenture and nasal prosthesis delivery
Fig. 6. Frontal view of the patient after superior overdenture and nasal prosthesis delivery
Fig. 5. The intraoral bar crossing the palatal defect arising the nasal understructure
Fig. 5. The intraoral bar crossing the palatal defect arising the nasal understructure
Fig. 4. A front view of the bar with the intraoral portion and the metal extension for epithesis attachment
Fig. 4. A front view of the bar with the intraoral portion and the metal extension for epithesis attachment
Fig. 3. Postoperative panorex showing the symmetric distribution of the fixtures
Fig. 3. Postoperative panorex showing the symmetric distribution of the fixtures
Fig. 2. The healing abutments positioned onto fixtures and the oronasal communication
Fig. 2. The healing abutments positioned onto fixtures and the oronasal communication
Fig. 1. Intraoperative view of the zygoma implants placed in the residual maxilla
Fig. 1. Intraoperative view of the zygoma implants placed in the residual maxilla
Trevisiol, L., Procacci, P., D’Agostino, A. et al. Rehabilitation of a complex midfacial defect by means of a zygoma-implant-supported prosthesis and nasal epithesis: a novel technique.
Int J Implant Dent 2, 7 (2016). https://doi.org/10.1186/s40729-016-0043-5
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Received: 22 July 2015
Accepted: 23 March 2016
Published: 01 April 2016
DOI: https://doi.org/1...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Francesca Ferrari, Pasquale Procacci, Lorenzo Trevisiol, Pier Francesco Nocini, Daniele De Santis and Antonio D’Agostino declare that they have no competing interests.
FF was involved in revising the manuscript critically. PP was involved in drafting the manuscript. LT is another surgeon that belongs to surgery equipment. PFN, head professor and surgeon, operated the patient. DDeS was involved ...
Department of Surgery, Section of Oral and Maxillofacial Surgery, University of Verona, Policlinico “Giovanni Battista Rossi”, Piazzale Ludovico Antonio Scuro, 10, 37134, Verona, Italy
Lorenzo Trevisiol, Pasquale Procacci, Antonio D’Agostino, Francesca Ferrari, Daniele De Santis & Pier Francesco Nocini
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Karakoca S, Aydin C, Handan Y, Bal BT. Retrospective study of treatment outcomes with implant- retained extraoral prostheses: survival rates and prosthetic complications. J Prosthet Dent. 2010;103:118–26.
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Parel SM, Branemark PI, Ohrnell LO, Svensson B. Remote implant anchorage for the rehabilitation of maxillary defects. J Prosthet Dent. 2001;86:377–81.
Bowden JR, Flood TR, Downie IP. Zygomaticus implants for retention of nasal prostheses after rhinectomy. Br J Oral Maxillofac Surg. 2006;44:54–6.
D’Agostino A, Procacci P, Ferrari F, Trevisiol L, Nocini PF. Zygoma implant-supported prostheti...
Written informed consent was obtained from the patient for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
Implant-supported prosthesis is a valid method to restore resected oral and head cancer patients and offers a good chance to social reintegration. The aesthetic result and facial camouflage are more achievable by means of dentures and epithesis than with several reconstructive interventions. Furthermore, due to the high risk of recurrences, it is sometime mandatory to keep the defect inspectionabl...
Rethinking globally of the possible indications to the adoption of this technique and its advantages compared to reconstructive microsurgery, the use of zygoma-implant-supported prosthesis may be suitable for patients whose systemic conditions are poor. The duration of surgery and of the postoperative recovery would be remarkably shortened avoiding the complications related to the harvesting of a ...
As far as prosthetic design is concerned, it is mandatory to avoid or, if not possible, limit as much as possible distal cantilever: given the absence of the premaxilla, an anterior cantilever is already present. Implant splintage is recommended [1, 8], and the bar design must respect technical data (implant-to-implant distance, cross-arch stabilization avoiding to cover oronasal communication and...
Patients with advanced orofacial cancer may require extensive surgical resection; the wider and more evident is the amputated region, the more this condition is generating inability for patients [6]. Visible head site mutilation and functional impairment in speech prevent social reintegration, and abnormal self-perception leads patients to depression [6].
Even if modern surgery offers many techni...
Cortical steroids were administered for the first two postoperative days. A postoperative 10-day cycle of antibiotic therapy (amoxicillin 1000 mg TID) was administered. Analgesics were administered as required. Sutures were removed 15 days after surgery. A soft diet was recommended for the first 2 weeks.
Three months afterwards, healing abutments were connected (Fig. 2) [4].
Approximately 4...
The patient, a male 46 years old at the time of our visit, underwent surgical resection of nasal pyramid and premaxilla including the whole upper jaw teeth sparing nasal bones. When the patient came to our clinic, apart from the defect resulting from the resection, he presented with a retraction scar crossing the upper lip from the floor of the nasal defect through the filtrum. The surgical resec...
The use of zygoma implants in the rehabilitation of patients who underwent surgical resection for oral cancer has been widely described [1–3]. There are several possibilities that can be considered when evaluating the possibility of surgical reconstruction after the first cancer resection, such as microvascular free flaps or rotation flaps, but it is sometimes necessary to monitor the healing pr...
Several authors have described zygoma implants as a reliable surgical option to rehabilitate severe maxillary defects in case of extreme atrophy or oncological resections. The aim of this study is to report a new technical approach to the rehabilitation of a complex oronasal defect by means of a zygoma-implant-supported full-arch dental prosthesis combined with a nasal epithesis.
The patient pres...
Fig. 4. Effects of PRP, PRGF, A-PRF, and CGF on the proliferation of human periosteal cells. Cells were treated with PRP preparations, PRGF preparations, A-PRF extracts, or CGF extracts at the indicated doses for 48 h in 1 % FBS-containing medium. *P
Fig. 3. Concentrations of the pro-inflammatory cytokines (IL-1β, IL-6) in PRP, PRGF, A-PRF, and CGF preparations (n = 20)
Fig. 3. Concentrations of the pro-inflammatory cytokines (IL-1β, IL-6) in PRP, PRGF, A-PRF, and CGF preparations (n = 20)
Preparation type
Models
Rotor
Radius
(mm)
Rotational speed
...
Masuki, H., Okudera, T., Watanebe, T. et al. Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF).
Int J Implant Dent 2, 19 (2016). https://doi.org/10.1186/s40729-016-0052-4
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Received: 21 June 2016
Accepted: 18 Au...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
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Correspondence to
Tomoyuki Kawase.
Tokyo Plastic Dental Society, Kita-ku, Tokyo, Japan
Hideo Masuki, Toshimitsu Okudera, Taisuke Watanebe, Masashi Suzuki, Kazuhiko Nishiyama & Hajime Okudera
Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan
Koh Nakata
Department of Dentistry, National Yang-Ming University, Taipei, Taiwan
Chen-Yao Su
Division of Oral Bioengineering, Instit...
Kobayashi M, Kawase T, Okuda K, Wolff LF, Yoshie H. In vitro immunological and biological evaluations of the angiogenic potential of platelet-rich fibrin preparations: a standardized comparison with PRP preparations. Int J Implant Dent. 2015;1:31.
Sonnenschein SK, Meyle J. Local inflammatory reactions in patients with diabetes and periodontitis. Periodontol 2000. 2015;69:221–54.
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Clipet F, Tricot S, Alno N, Massot M, Solhi H, Cathelineau G, Perez F, De Mello G, Pellen-Mussi P. In vitro effects of Choukroun’s platelet-rich fibrin conditioned medium on 3 different cell lines implicated in dental implantology. Implant Dent. 2012;21:51–6.
Gassling VL, Acil Y, Springer IN, Hubert N, Wiltfang J. Platelet-rich plasma and platelet-rich fibrin in human cell culture. Oral Surg ...
Kawase T. Platelet-rich plasma and its derivatives as promising bioactive materials for regenerative medicine: basic principles and concepts underlying recent advances. Odontology. 2015;103:126–35.
Anitua E. The use of plasma-rich growth factors (PRGF) in oral surgery. Pract Proced Aesthet Dent. 2001;13:487–93.
Choukroun J. Advanced PRF, &i-PRF: platelet concentrates or blood concentrates? J...
Acid citrate dextrose solution
Analysis of variance
Advanced platelet-rich fibrin
A-PRF extract
Concentrated growth factors
CGF extract
Enzyme-linked immunosorbent assay
Interleukin-1β
Interleukin-6
Platelet-derived growth factor-BB
Platelet
Plasma rich in growth factors
Platelet-rich plasma
Red blood cell
Transforming growth factor-β1
Vascular endothelial growth factor
White blo...
The present study clearly demonstrated that both A-PRF and CGF preparations contained significant amounts of growth factors, which makes us to believe that A-PRF and CGF preparations would not only function as a scaffolding material but also as a reservoir to deliver certain growth factors at the site of application. Accordingly, it is expected that these two preparations are more potently capable...
In the previous study [12], we found that PRP and A-PRF preparations exert distinguishable actions on periosteal cell proliferation. Because both IL-1β and IL-6 are known to be produced by WBCs [23], and because WBCs are not included in PRGF preparations, we thought that the bi-phasic effects of PRP preparations may be attributed to WBCs. Furthermore, if WBCs are highly concentrated in A-PRF, it ...
Although the growth factor contents in PRF and CGF preparations and their bioactivities have been demonstrated in in vitro studies by several independent groups [8–11, 13–20], many clinicians still believe that the regenerative effects of PRF/CGF are solely due to fibrin clots. We speculate that this discrepancy may be caused by two major factors. First, the initial report on PRF by Choukroun ...
Numbers of platelets in PRP and PRGF preparations are shown in Fig. 1 (upper panel). Platelets were significantly concentrated both in the PRP and PRGF preparations, and the concentration rate of PRP preparations was substantially higher than that of PRGF preparations (8.79-fold vs. 2.84-fold). Numbers of platelets in A-PRF and CGF preparations calculated by the indirect subtraction method are al...
Because alveolar periosteum is closely contributed to periodontal skeletal tissue regeneration, we used human alveolar bone-derived periosteal cells for evaluation of efficacy of the PRP derivatives. The periosteal cells were obtained and expanded as described below. With informed consent, human periosteum tissue segments were aseptically dissected from the periodontal tissues of the healthy bucca...
As described previously [7, 9], blood samples (~9.5 mL) collected without anticoagulants using vacuum plain glass tubes (A-PRF+: Jiangxi Fenglin Medical Technology Co. Ltd, Fengcheng, China) or conventional vacuum plain glass tube (Plain BD Vacutainer Tube; Becton, Dickinson and Company, Franklin Lakes, NJ, USA) from the same donors were immediately centrifuged by an A-PRF centrifugation system (...
Based on their characteristics and fractionation, the differences among PRP and PRP derivatives are concisely described in our previous article [1].
As previously described [5, 6], blood samples (11.5 mL) were collected using syringes or vacuum blood collection tubes equipped with 18G needles from seven non-smoking, healthy, middle-aged, male volunteers (37 to 68 years old) three times with a 2...
Platelet-rich plasma (PRP) was originally demonstrated to be effective in the operation of alveolar ridge augmentation and immediately spread to the fields of periodontal and oral maxillofacial surgery [1]. This clinical application was endorsed by evidence that several major growth factors are contained at high levels in PRP preparations. However, for some reasons, such as low handling efficiency...
The development of platelet-rich fibrin (PRF) drastically simplified the preparation procedure of platelet-concentrated biomaterials, such as platelet-rich plasma (PRP), and facilitated their clinical application. PRF’s clinical effectiveness has often been demonstrated in pre-clinical and clinical studies; however, it is still controversial whether growth factors are significantly concentrated ...
Patient
Implant region
(FDI)
Implant parameters
Dimensions of implant
Diameter [mm]/length [mm]
...
Fretwurst, T., Grunert, S., Woelber, J.P. et al. Vitamin D deficiency in early implant failure: two case reports. Int J Implant Dent 2, 24 (2016). https://doi.org/10.1186/s40729-016-0056-0
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Received: 04 August 2016
Accepted: 16 November 2016
Published: 25 November 2016
DOI: https://doi.org/10.1186/s40729-016-0056-0
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Department of Oral- and Craniomaxillofacial Surgery, Center for Dental Medicine, University Medical Center Freiburg, Hugstetter Straße 55, Freiburg, D-79106, Germany
Tobias Fretwurst, Sebastian Grunert, Katja Nelson & Wiebke Semper-Hogg
Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, USA
Tobias Fretwurst
Department of Operative Dentistr...
We would like to thank Dr. John Nelson for his resourceful and constructive ideas.
The authors Tobias Fretwurst, Sebastian Grunert, Johan Woelber, Katja Nelson, and Wiebke Semper-Hogg declare no conflicts of interest with respect to the research, authorship, and/or publication of this article.
The authors Tobias Fretwurst, Sebastian Grunert, Johan Woelber, Katja Nelson, and Wiebke Semper-Hogg do...
Di Rosa M, Malaguarnera M, Nicoletti F, Malaguarnera L. Vitamin D3: a helpful immuno-modulator. Immunology. 2011;134(2):123–39.
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Kikuta J, Kawamura S, Okiji F, Shirazaki M, Sakai S, Saito H, Ishii M. Sphingosine-1-phosphate-mediated osteoclast precursor monocyte migration is a critical point of control in antibone-resorptive action of active vitamin D. Proc Natl Acad Sci U S A. 2013;110(17):7009–13.
Hewison M, Freeman L, Hughes SV, Evans KN, Bland R, Eliopoulos AG, Kilby MD, Moss PA, Chakraverty R. Differential regulatio...
Hong HH, Chou TA, Yang JC, Chang CJ. The potential effects of cholecalciferol on bone regeneration in dogs. Clin Oral Implants Res. 2012;23(10):1187–92.
Hong HH, Yen TH, Hong A, Chou TA. Association of vitamin D3 with alveolar bone regeneration in dogs. J Cell Mol Med. 2015;19(6):1208–17.
Schulze-Späte U, Dietrich T, Wu C, Wang K, Hasturk H, Dibart S. Systemic vitamin D supplementation and ...
Gallagher JC, Sai AJ. Vitamin D insufficiency, deficiency, and bone health. J Clin Endocrinol Metab. 2010;95(6):2630–3.
Ning Z, Song S, Miao L, Zhang P, Wang X, Liu J, Hu Y, Xu Y, Zhao T, Liang Y, Wang Q, Liu L, Zhang J, Hu L, Huo M, Zhou Q. High prevalence of vitamin D deficiency in urban health checkup population. Clin Nutr. 2016;35(4):859–63.
Spiro A, Buttriss JL. Vitamin D: an overview o...
Maier GS, Horas K, Seeger JB, Roth KE, Kurth AA, Maus U. Is there an association between periprosthetic joint infection and low vitamin D levels? Int Orthop. 2014;38(7):1499–504.
Alvim-Pereira F, Montes CC, Thomé G, Olandoski M, Trevilatto PC. Analysis of association of clinical aspects and vitamin D receptor gene polymorphism with dental implant loss. Clin Oral Implants Res. 2008;19(8):786–...
Esposito M, Thomsen P, Ericson LE, Lekholm U. Histopathologic observations on early oral implant failures. Int J Oral Maxillofac Implants. 1999;14:798–810.
Olmedo-Gaya MV, Manzano-Moreno FJ, Cañaveral-Cavero E, de Dios Luna-Del Castillo J, Vallecillo-Capilla M. Risk factors associated with early implant failure: a 5-year retrospective clinical study. J Prosthet Dent. 2016;115(2):150–5.
Wenn...
To overcome the shortcomings of this case reports, prospective, multicenter, and controlled studies must follow to affirm a potential relationship between vitamin D deficiency, osteoimmunology, and the early failure of dental implants. Currently, a general recommendation for a standardized vitamin D screening in dental implantology cannot be stated due to lack of evidence.
Nevertheless, the vitamin D deficiency prevalence in the European population indicates that a vitamin D deficiency is probably not a sole causative factor for early implant failure; otherwise, the early implant failure rate would be significantly higher. However, a synergistic effect with other factors is conceivable. Some authors stated that implant osseointegration is not simply a wound healing ...
Local and systemic factors can affect the survival rate of dental implants [30–33]. The causes of early implant failure are not fully clarified and an association between vitamin D and dental implant osseointegration has not been investigated properly [8, 13–16]. Some recent animal studies in rodents demonstrated a relationship between vitamin D supplementation and an increased bone to implant...
In this 51-year-old male patient, no grafting procedure was performed as vertical and horizontal alveolar ridge dimension was adequate for implant placement. The implant placement in regions 36 and 37 was performed as guided surgery (Fig. 2a, Table 1). The implant placement was uneventful and the bone appeared clinically healthy. A cortical bone profiling was performed during implant placement. ...
The medical history of this 48-year-old male patient showed a high blood pressure; otherwise, the patient was healthy. A successfully completed periodontal therapy was done before implant therapy. The patient demonstrated stable marginal bone levels. Autologous retromolar bone grafting using local anesthesia was performed in the left mandible (see Fig. 1a). This patient received a postoperative o...
Patients treated consecutively in one center (Department of Oral- and Craniomaxillofacial Surgery, University Medical Center Freiburg). None of the patients showed systemic disease. Both patients did not take regular medication and were negative for alcohol, nicotine, and drug use. Bothe male patients (48 and 51 years of age) were not immunosuppressed, irradiated or received chemotherapy. Written...
Long-term stable osseointegrated implants are the primary goal in dental implantology. Although dental implants have proven clinical reliable in the long term, the failure of implants at a very early stage of osseointegration has been described [1, 2]. The pursuit to identify the mechanisms leading to early implant failure is ongoing to date and include the following: tobacco usage, diabetes, wear...
An association between vitamin D deficiency and early dental implant failure is not properly verified, but its role in osteoimmunology is discussed. This article illustrates two case reports with vitamin D deficiency and early implant failure. Prior to implant placement, the first patient received crestal bone grafting with autologous material. Both patients received dental implants from different...
Fig. 4. Kaplan-Meier implant survival curves for bone and bone substitutes
Fig. 4. Kaplan-Meier implant survival curves for bone and bone substitutes
Fig. 3. Kaplan-Meier survival curves for membrane types
Fig. 3. Kaplan-Meier survival curves for membrane types
Fig. 2. Kaplan-Meier implant survival curves for augmentation procedures
Fig. 2. Kaplan-Meier implant survival curves for augmentation procedures
Fig. 8. There were moderately significant and positive correlations between the ALP levels and OC levels at all measurements from week 1 to week 12. The OC levels in pg/μg protein were associated with the ALP levels in nM/μg protein at the implant site (a), control site (b), and pooled samples of the control and implant sites (c)
Fig. 8. There were moderately significant and positive correl...
Fig. 7. Comparison between the trend of the biomarker levels and the trend of the ISQ values over time
Fig. 7. Comparison between the trend of the biomarker levels and the trend of the ISQ values over time
Fig. 6. There were weakly significant and positive correlations between the ALP or OC levels and ISQ values at all measurements from week 1 to week 12. At the implant site, the ALP levels in nM/μg protein (a) or the OC levels in pg/μg protein (b) were associated with ISQ values
Fig. 6. There were weakly significant and positive correlations between the ALP or OC levels and ISQ values at all...
Fig. 5. Change in the median values of the OC level over time. In the test group, the OC level continuously increased with time. There was a statistically significant increase in the OC level at 6, 8, 10, and 12 weeks when compared with 1 week (P
Fig. 4. Change in the median values of the ALP level over time. In the test group, the ALP level decreased at 1–4 weeks and then increased at 6, 8, 10, and 12 weeks. There was no statistically significant difference in the ALP level in either the control or the test groups at any measurement
Fig. 4. Change in the median values of the ALP level over time. In the test group, the ALP level d...
Fig. 3. Change in the median values of the GCF (control group) and PICF (test group) volume over time. In the test group, the PICF volume continuously decreased with time (a). There were no significant differences in the median values of the crevicular fluid volume in either the control group or the test groups at any measurement (b)
Fig. 3. Change in the median values of the GCF (control gro...
Fig. 2. Change in the mean ISQ values over time. There was a statistically significant decrease in the mean ISQ values between 1 and 3 weeks (P
Fig. 1. Timeline of the clinical study. I—implant site, T—contralateral posterior mandibular nonsurgical tooth
Fig. 1. Timeline of the clinical study. I—implant site, T—contralateral posterior mandibular nonsurgical tooth
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks
8 weeks
10 weeks
12 weeks
Median (interquartile range)
ALP level
(nM/μg protein)
Tooth (control)
175 (215)
203 (308)
148 (269)
143 (112)
266 (427)
145 (96)
181 (148)
191 (263)
107 (128)
Implant (test)
230 (238)
139 (139)
157 (293)
108 (134)
166 (434)
179 (251)
147 (...
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks
8 weeks
10 weeks
12 weeks
Median (interquartile range)
CF volume (μl)
Tooth (control)
0.20 (0.23)
0.26 (0.25)
0.19 (0.20)
0.19 (0.50)
0.17 (0.33)
0.18 (0.08)
0.13 (0.24)
0.23 (0.42)
0.20 (0.17)
Implant (test)
0.26 (0.30)
0.25 (0.41)
0.16 (0.21)
0.17 (0.19)
0.18 (0.33)
0.13 (0.14)
...
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks...
Patient no.
Age
Sex
Positiona
Bone qualityb
1
34
...
Inclusion criteria
Exclusion criteria
Patients aged 25–65 years
Presence of periodontal disease or periapical lesions
Ability to participat...
Tirachaimongkol, C., Pothacharoen, P., Reichart, P.A. et al. Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study.
Int J Implant Dent 2, 27 (2016). https://doi.org/10.1186/s40729-016-0058-y
Download citation
Received: 14 September 2016
Accepted: 18 November 2016
Published: 08 December 2016
DOI...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Center of Excellence for Dental Implantology, Faculty of Dentistry, Chiang Mai University, Suthep sub-district, A. Muang, Chiang Mai, 50200, Thailand
Choknapa Tirachaimongkol & Pathawee Khongkhunthian
Department of Biochemistry, Faculty of Medicine, Thailand Excellence Center for Tissue Engineering and Stem Cells, Chiang Mai, Thailand
Peraphan Pothacharoen
Department of Oral Medicine, Dental...
The authors acknowledge Mrs. Yupaporn Kiatsakulcharoen and Miss Kamolwan Mangkalad, the Center of Excellent for Dental Implantology, Chiang Mai University for clinical assistance, Mr. Aitthiphon Chongchai, the Department of Biochemistry, Faculty of Medicine Chiang Mai University for laboratory assistance, Dr.Thanapat Sastraruji, Faculty of Dentistry, Chiang Mai University for statistical consultat...
Lekholm U, Zarb G, Albrektsson T. Tissue integrated prostheses. Patient selection and preparation. Chicago: Quintessence Publishing Co Inc; 1985. p. 199–209.
Download references
Berglundh T, Abrahamsson I, Lang NP, Lindhe J. De novo alveolar bone formation adjacent to endosseous implants. Clin Oral Implants Res. 2003;3:251–62.
Emecen-Huja P, Eubank TD, Shapiro V, Yildiz V, Tatakis DN, Leblebicioglu B. Peri-implant versus periodontal wound healing. J Clin Periodontol. 2013;40:816–24.
Chapple LLC, Socransky SS, Dibart S, Glenwright DH, Matthews JB. Chemiluminescent as...
Bischof M, Nedir R, Szmukler-Moncler S, Bernard JP, Samson J. Implant stability measurement of delayed and immediately loaded implants during healing. Clin Oral Implants Res. 2004;5:529–39.
Sim CPC, Lang NP. Factors influencing resonance frequency analysis assessed by Osstell mentor during implant tissue integration: I. Instrument positioning, bone structure, implant length. Clin Oral Implants ...
Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52:155–70.
Khongkhunthian P. Implant features. In: Khongkhunthian P, editor. PW Plus Thai Dental Implant. Bangkok: STZ Mospace design; 2015. p. 12.
Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, ...
Within the limitations of this study and cautious interpretation due to small number of implants/patients, the ISQ values were weakly correlated with both ALP and OC molecules in PICF during the healing period. The results also show that osteocalcin may be used as a biological marker for monitoring implant healing at 6, 8, 10, and 12 weeks after implant placement. The ISQ values showed high stabi...
Vogel and Marcotte [33] suggested that the correlation between mRNA and protein quantities is approximately 40%. As there are many mechanisms between transcription and translation, especially in human cell and protein stability, at the gene expression level, the transcription data is beneficial in making decisions about molecular candidates for future studies at the protein level. The colorimetric...
The main sources of ALP in GCF are neutrophils, bacteria within dental plaque, fibroblasts, and osteoblasts [28]. Plagnat et al. [29] suggested that longitudinal monitoring of ALP in PICF might confirm its possible use as a marker of implant failure. Considering the change in the median values of the ALP level over time, in the test group, the ALP level decreased at 1–4 weeks and then increased...
At the implant site, the OC level continuously increased with time. According to the Friedman followed by Wilcoxon signed-rank tests, there was statistically significant increase in the OC level at 6, 8, 10, and 12 weeks when compared with 1 week (P
Ten patients, seven females, and three males, aged 42.4 ± 11.99 years (range, 28 to 64 years), with either a first mandibular or second mandibular molar edentulous area, who required a single nonsubmerged implant participated in this study, as shown in Table 2. The implants used for all patients were 10 mm long and 5 mm in diameter. All patients completed the follow-up. None of the impla...
Data were analyzed by using SPSS 17.0 software (SPSS Inc., Chicago, IL, USA). Repeated measures analysis of variance was performed to evaluate the change in the ISQ values at each measurement. The independent samples t test was used to investigate the differences in implant stability in the patients’ gender and bone quality. The Friedman test, followed by the Wilcoxon signed-rank test, was used ...
The level of OC was measured by using commercially available ELISA kits (Human Osteocalcin Quantikine ELISA Kit, R&D Systems, Inc., Minneapolis, MN, USA) according to the manufacturer’s instructions. A 100 μl volume of Assay Diluent RD1-117 (R&D Systems) was added into each well of the microplate and then 50 μl of standard (0–64 ng/ml) or sample was added to each well. The microplate was ...
To observe the level of two bone formation biomarkers (alkaline phosphatase and osteocalcin) during the osseointegration period compared with control group using GCF from the first molar of the contralateral side of implant position, the sample collection of GCF was performed before the surgical procedure, immediately after the surgical operation and after 1, 2, 3, 4, 6, 8, 10, and 12 weeks. The ...
The study is a prospective clinical study during the 3-month healing period of implant. The study was approved by the Human Experimentation Committee, Faculty of Dentistry, Chiang Mai University. The study outline is shown in Fig. 1.
Ten patients, who were partially edentulous in the mandibular posterior region for whom a single nonsubmerged implant was planned, participated in this study. All o...
Osteocalcin (OC) is the most plentiful noncollagenous protein of the bone matrix. It is secreted from odontoblasts, osteocytes, and osteoblasts, in order to bind hydroxyapatite and calcium during matrix mineralization [7]. It is one of the serological markers in the bone formation process. Numerous studies have shown increased OC levels in bone formation. However, increased OC level relates more t...
Dental implants have shown a high success rate for rehabilitation of edentulous patients if certain conditions are met during treatment. Nevertheless, the risk of failure remains difficult to predict. The achievement of osseointegration depends on many factors, such as a suitable host, biocompatible materials, careful surgery, and an appropriate healing time [1].
The primary stability comes from ...
The purposes of this study were to examine the correlation between the stability of dental implants and bone formation markers during the healing period and to monitor the stability of dental implants using the resonance frequency analysis (RFA) method. The null hypothesis of the study is no correlation between the stability of dental implant and bone formation markers.
The study is a prospective...
Fig. 8. There were moderately significant and positive correlations between the ALP levels and OC levels at all measurements from week 1 to week 12. The OC levels in pg/μg protein were associated with the ALP levels in nM/μg protein at the implant site (a), control site (b), and pooled samples of the control and implant sites (c)
Fig. 8. There were moderately significant and positive correl...
Fig. 7. Comparison between the trend of the biomarker levels and the trend of the ISQ values over time
Fig. 7. Comparison between the trend of the biomarker levels and the trend of the ISQ values over time
Fig. 6. There were weakly significant and positive correlations between the ALP or OC levels and ISQ values at all measurements from week 1 to week 12. At the implant site, the ALP levels in nM/μg protein (a) or the OC levels in pg/μg protein (b) were associated with ISQ values
Fig. 6. There were weakly significant and positive correlations between the ALP or OC levels and ISQ values at all...
Fig. 5. Change in the median values of the OC level over time. In the test group, the OC level continuously increased with time. There was a statistically significant increase in the OC level at 6, 8, 10, and 12 weeks when compared with 1 week (P
Fig. 4. Change in the median values of the ALP level over time. In the test group, the ALP level decreased at 1–4 weeks and then increased at 6, 8, 10, and 12 weeks. There was no statistically significant difference in the ALP level in either the control or the test groups at any measurement
Fig. 4. Change in the median values of the ALP level over time. In the test group, the ALP level d...
Fig. 3. Change in the median values of the GCF (control group) and PICF (test group) volume over time. In the test group, the PICF volume continuously decreased with time (a). There were no significant differences in the median values of the crevicular fluid volume in either the control group or the test groups at any measurement (b)
Fig. 3. Change in the median values of the GCF (control gro...
Fig. 2. Change in the mean ISQ values over time. There was a statistically significant decrease in the mean ISQ values between 1 and 3 weeks (P
Fig. 1. Timeline of the clinical study. I—implant site, T—contralateral posterior mandibular nonsurgical tooth
Fig. 1. Timeline of the clinical study. I—implant site, T—contralateral posterior mandibular nonsurgical tooth
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks
8 weeks
10 weeks
12 weeks
Median (interquartile range)
ALP level
(nM/μg protein)
Tooth (control)
175 (215)
203 (308)
148 (269)
143 (112)
266 (427)
145 (96)
181 (148)
191 (263)
107 (128)
Implant (test)
230 (238)
139 (139)
157 (293)
108 (134)
166 (434)
179 (251)
147 (...
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks
8 weeks
10 weeks
12 weeks
Median (interquartile range)
CF volume (μl)
Tooth (control)
0.20 (0.23)
0.26 (0.25)
0.19 (0.20)
0.19 (0.50)
0.17 (0.33)
0.18 (0.08)
0.13 (0.24)
0.23 (0.42)
0.20 (0.17)
Implant (test)
0.26 (0.30)
0.25 (0.41)
0.16 (0.21)
0.17 (0.19)
0.18 (0.33)
0.13 (0.14)
...
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks...
Patient no.
Age
Sex
Positiona
Bone qualityb
1
34
Female
46
3
2
38
Female
36
3
3
43
Female
37
3
4
64
Male
46
2
5
30
Female
47
3
6
48
Female
36
2
7
57
Male
36
3
8
28
Female
46
3
9
33
Male
46
2
10
49
Female
46
3
Table 2 Profile of patients
Inclusion criteria
Exclusion criteria
Patients aged 25–65 years
Presence of periodontal disease or periapical lesions
Ability to participat...
Tirachaimongkol, C., Pothacharoen, P., Reichart, P.A. et al. Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study. Int J Implant Dent 2, 27 (2016). https://doi.org/10.1186/s40729-016-0058-y
Download citation
Received: 14 September 2016
Accepted: 18 November 2016
Published: 08 December 2016
DOI: https://doi.org/10....
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Center of Excellence for Dental Implantology, Faculty of Dentistry, Chiang Mai University, Suthep sub-district, A. Muang, Chiang Mai, 50200, Thailand
Choknapa Tirachaimongkol & Pathawee Khongkhunthian
Department of Biochemistry, Faculty of Medicine, Thailand Excellence Center for Tissue Engineering and Stem Cells, Chiang Mai, Thailand
Peraphan Pothacharoen
Department of Oral Medicine, Dental...
The authors acknowledge Mrs. Yupaporn Kiatsakulcharoen and Miss Kamolwan Mangkalad, the Center of Excellent for Dental Implantology, Chiang Mai University for clinical assistance, Mr. Aitthiphon Chongchai, the Department of Biochemistry, Faculty of Medicine Chiang Mai University for laboratory assistance, Dr.Thanapat Sastraruji, Faculty of Dentistry, Chiang Mai University for statistical consultat...
Lekholm U, Zarb G, Albrektsson T. Tissue integrated prostheses. Patient selection and preparation. Chicago: Quintessence Publishing Co Inc; 1985. p. 199–209.
Download references
Berglundh T, Abrahamsson I, Lang NP, Lindhe J. De novo alveolar bone formation adjacent to endosseous implants. Clin Oral Implants Res. 2003;3:251–62.
Emecen-Huja P, Eubank TD, Shapiro V, Yildiz V, Tatakis DN, Leblebicioglu B. Peri-implant versus periodontal wound healing. J Clin Periodontol. 2013;40:816–24.
Chapple LLC, Socransky SS, Dibart S, Glenwright DH, Matthews JB. Chemiluminescent as...
Bischof M, Nedir R, Szmukler-Moncler S, Bernard JP, Samson J. Implant stability measurement of delayed and immediately loaded implants during healing. Clin Oral Implants Res. 2004;5:529–39.
Sim CPC, Lang NP. Factors influencing resonance frequency analysis assessed by Osstell mentor during implant tissue integration: I. Instrument positioning, bone structure, implant length. Clin Oral Implants ...
Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52:155–70.
Khongkhunthian P. Implant features. In: Khongkhunthian P, editor. PW Plus Thai Dental Implant. Bangkok: STZ Mospace design; 2015. p. 12.
Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, ...
Within the limitations of this study and cautious interpretation due to small number of implants/patients, the ISQ values were weakly correlated with both ALP and OC molecules in PICF during the healing period. The results also show that osteocalcin may be used as a biological marker for monitoring implant healing at 6, 8, 10, and 12 weeks after implant placement. The ISQ values showed high stabi...
Vogel and Marcotte [33] suggested that the correlation between mRNA and protein quantities is approximately 40%. As there are many mechanisms between transcription and translation, especially in human cell and protein stability, at the gene expression level, the transcription data is beneficial in making decisions about molecular candidates for future studies at the protein level. The colorimetric...
The main sources of ALP in GCF are neutrophils, bacteria within dental plaque, fibroblasts, and osteoblasts [28]. Plagnat et al. [29] suggested that longitudinal monitoring of ALP in PICF might confirm its possible use as a marker of implant failure. Considering the change in the median values of the ALP level over time, in the test group, the ALP level decreased at 1–4 weeks and then increased...
The results of this study show that, at the time of implantation, the ISQ values ranged between 67.5 and 83. The mean initial ISQ value was 77.0 ± 1.32. These findings are in harmony with those of previous studies [16, 18]. Tallarico et al. (2011) reported that the macro-design of dental implant affects the primary anchorage [16]. They suggested that the high initial ISQ value is a factor in ...
At the implant site, the OC level continuously increased with time. According to the Friedman followed by Wilcoxon signed-rank tests, there was statistically significant increase in the OC level at 6, 8, 10, and 12 weeks when compared with 1 week (P
Ten patients, seven females, and three males, aged 42.4 ± 11.99 years (range, 28 to 64 years), with either a first mandibular or second mandibular molar edentulous area, who required a single nonsubmerged implant participated in this study, as shown in Table 2. The implants used for all patients were 10 mm long and 5 mm in diameter. All patients completed the follow-up. None of the impla...
Data were analyzed by using SPSS 17.0 software (SPSS Inc., Chicago, IL, USA). Repeated measures analysis of variance was performed to evaluate the change in the ISQ values at each measurement. The independent samples t test was used to investigate the differences in implant stability in the patients’ gender and bone quality. The Friedman test, followed by the Wilcoxon signed-rank test, was used ...
The level of OC was measured by using commercially available ELISA kits (Human Osteocalcin Quantikine ELISA Kit, R&D Systems, Inc., Minneapolis, MN, USA) according to the manufacturer’s instructions. A 100 μl volume of Assay Diluent RD1-117 (R&D Systems) was added into each well of the microplate and then 50 μl of standard (0–64 ng/ml) or sample was added to each well. The microplate was ...
To observe the level of two bone formation biomarkers (alkaline phosphatase and osteocalcin) during the osseointegration period compared with control group using GCF from the first molar of the contralateral side of implant position, the sample collection of GCF was performed before the surgical procedure, immediately after the surgical operation and after 1, 2, 3, 4, 6, 8, 10, and 12 weeks. The ...
The study is a prospective clinical study during the 3-month healing period of implant. The study was approved by the Human Experimentation Committee, Faculty of Dentistry, Chiang Mai University. The study outline is shown in Fig. 1.
Ten patients, who were partially edentulous in the mandibular posterior region for whom a single nonsubmerged implant was planned, participated in this study. All o...
Osteocalcin (OC) is the most plentiful noncollagenous protein of the bone matrix. It is secreted from odontoblasts, osteocytes, and osteoblasts, in order to bind hydroxyapatite and calcium during matrix mineralization [7]. It is one of the serological markers in the bone formation process. Numerous studies have shown increased OC levels in bone formation. However, increased OC level relates more t...
Dental implants have shown a high success rate for rehabilitation of edentulous patients if certain conditions are met during treatment. Nevertheless, the risk of failure remains difficult to predict. The achievement of osseointegration depends on many factors, such as a suitable host, biocompatible materials, careful surgery, and an appropriate healing time [1].
The primary stability comes from ...
The purposes of this study were to examine the correlation between the stability of dental implants and bone formation markers during the healing period and to monitor the stability of dental implants using the resonance frequency analysis (RFA) method. The null hypothesis of the study is no correlation between the stability of dental implant and bone formation markers.
The study is a prospective...
Fig. 7. Orthopantomograph 2 years after implant placement
Fig. 6. Clinical picture 2 years after implant placement
Fig. 6. Clinical picture 2 years after implant placement
Fig. 5. Occlusal view of implants after vertical repositioning of the dental alveolus segment showing proper mesiodistal space and buccolingual spacing
Fig. 5. Occlusal view of implants after vertical repositioning of the dental alveolus segment showing proper mesiodistal space and buccolingual spacing
Fig. 4. Vertical repositioning of dental alveolus segment with placement of dental implants
Fig. 4. Vertical repositioning of dental alveolus segment with placement of dental implants
Fig. 3. Direct sinus lift with implant osteotomy preparation
Fig. 3. Direct sinus lift with implant osteotomy preparation
Fig. 2. Marked incision site for surgical access
Fig. 2. Marked incision site for surgical access
Fig. 1. Edentulous site with supra-eruption of opposing dentition
Fig. 1. Edentulous site with supra-eruption of opposing dentition
Tsegga, T., Wright, T. Maxillary segmental osteoperiosteal flap with simultaneous placement of dental implants: case report of a novel technique. Int J Implant Dent 3, 2 (2017). https://doi.org/10.1186/s40729-017-0067-5
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Received: 06 December 2016
Accepted: 13 January 2017
Published: 19 January 2017
DOI: https://doi.org/10.1186/s40729-017-0067-5
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Department of Oral & Maxillofacial Surgery, San Antonio Military Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, 78234, TX, USA
Tibebu Tsegga & Thomas Wright
Department of Oral & Maxilofacial Surgery, Wilford Hall Ambulatory Surgical Center, 2200 Bergquist Dr, Suite 1, Lackland AFB, TX, 78236, USA
Tibebu Tsegga & Thomas Wright
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Irinakis T. Efficacy of injectable demineralized bone matrix as graft material during sinus elevation surgery with simultaneous implant placement in the posterior maxilla: clinical evaluation of 49 sinuses. J Oral and Maxillofac Surg. 2011;69:134–41.
Chiapasoo M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants. 2009;24:237–69.
Jenson...
This case highlights the evolving variations in dentoalveolar augmentation with an emphasis on concomitant implant placement. In the most traditional sense, a vertical osteoperiosteal flap technique would be bound with a stable basal bone that can be used to anchor simultaneous dental implant placement. Further refinement should consider minimizing crestal reflection and overall labial bone resorp...
A critical appraisal of the gingival architecture in the final end point of this case demonstrates some radiolucency through the soft tissue outlining the platform of the Nobel Biocare TiUnite implant. This would lead us to believe that either the transmucosal bone level placement attempt was inaccurate or excessive reflection of the labial tissue has caused some degree of resorption. This is anot...
A suitable alternative surgical management of this particular case might have been to simply perform an alveoloplasty to produce the desired inter-occlusal clearance and proceed with placement of implant and simultaneous direct sinus lift. That would have left more of the apical portion of the implant within the grafted sinus and possibly modified the location of keratinized band of tissue. The lo...
A 35-year-old female with a 10-year history of partial acquired edentulism at site numbers 3 and 4 presented to our clinic for dental implant evaluation. Preoperative clinical examination revealed a reproducible intercuspation, well-delineated band of keratinized tissue, and decreased inter-occlusal clearance to allow for optimal dimension of prosthetic crowns (Fig. 1). Radiographs demonstrated e...
Obtaining proper occlusal clearance to allow for a single unit crown restoration is a fundamental prerequisite for dental implant restoration. Long-standing edentulous sites are often fraught with disuse atrophy and unopposed supra-eruption of the opposing dentition. In the posterior maxillae/mandible, there are vital structures that have to be mobilized in order to allow space for either bone tra...
Dental restorative space from the opposing dentition requires adequate distance for restorative material for an acceptable restoration. Typically, long-standing edentulous alveolar ridges will have vertical and or horizontal defects that require alveolar ridge augmentation for ideal dental implant restorations. Along with these defects, one will see the opposing dentition supra erupt which can obl...
Fig. 5. Periapical X ray after 1 year of follow-up, the bone was stable and no sign of peri-implantitis was shown
Fig. 5. Periapical X ray after 1 year of follow-up, the bone was stable and no sign of peri-implantitis was shown
Fig. 4. Follow-up after 1 year, no radiographic sign was appreciating and the osseointegration was satisfactory
Fig. 4. Follow-up after 1 year, no radiographic sign was appreciating and the osseointegration was satisfactory
Fig. 3. Final restaurations: The parallelism of the implants is achieved by carving the non-submerged part a occlusal view and b lingual view
Fig. 3. Final restaurations: The parallelism of the implants is achieved by carving the non-submerged part a occlusal view and b lingual view
Fig. 2. Flapless surgical technique, atraumatic surgical procedure for zirconium implants using the circular scalpel (a)–sharp, clean cut without bleeding (b)
Fig. 2. Flapless surgical technique, atraumatic surgical procedure for zirconium implants using the circular scalpel (a)–sharp, clean cut without bleeding (b)
Fig. 1. Diagnostic radiographic exploration previous to treatment
Fig. 1. Diagnostic radiographic exploration previous to treatment
Parmigiani-Izquierdo, J.M., Cabaña-Muñoz, M.E., Merino, J.J. et al. Zirconia implants and peek restorations for the replacement of upper molars. Int J Implant Dent 3, 5 (2017). https://doi.org/10.1186/s40729-016-0062-2
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Received: 13 October 2016
Accepted: 22 December 2016
Published: 20 February 2017
DOI: https://doi.org/10.1186/s40729-016-0062-2
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Periodontics Unit, Faculty of Medicine and Dentistry, University of Murcia (Spain), Murcia, Spain
Arturo Sánchez-Pérez
Clínica CIROM, Murcia, 30001, Spain
José María Parmigiani-Izquierdo, María Eugenia Cabaña-Muñoz & José Joaquín Merino
Clínica Odontologíca Universitaria, Hospital Morales Meseguer, 2ª planta, C/ Marqués de los Vélez s/n, Murcia, 30008, Spain
Arturo Sánchez-...
Bormann K-H, Gellrich N-C, Kniha H, Dard M, Wieland M, Gahlert M. Biomechanical evaluation of a microstructured zirconia implant by a removal torque comparison with a standard Ti-SLA implant. Clin oral implants res. 2012;23:1210–6.
Oliva J, Oliva X, Oliva JD. One-year follow-up of first consecutive 100 zirconia dental implants in humans: a comparison of 2 different rough surfaces. Int j oral ma...
Brånemark PI, Hansson BO, Adell R, Breine U, Lindström J, Hallén O, et al. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand j plast reconstr surg suppl. 1977;16:1–132.
Parmigiani-Izquierdo JM. TécnicaAtraumática en Implantología. Rev esp odontoestomatológica implant. 11:30–5.
Parmigiani-Izquierdo JM, Sánchez-Pérez A, Cabaña-Mu...
Zirconia implants with PEEK restorations can be considered a good alternative for replacing natural teeth. Their biocompatibility and biostability make them a promising material for those patients who suffer from allergies and sensitivity to metal alloys.
PEEK restorations are a valid and alternative recommendation when using zirconia implants because of their cushioning effect and elastic modulu...
In addition to PEEK, new coatings based on PMMA or composite materials (Anaxblent®Anaxdent®, Nexco®Ivoclar®, Solidex®Shofu®, Novo.lign®Bredent®, etc.) which incorporate ceramic fillings have been developed. Due to their molecular structure, these materials have excellent density and homogeneity [24]. The micro filling integrated into the polymer matrix increases abrasion resistance, at the...
In terms of the load-cushioning capacity of the prosthetic elements, the use of PEEK as a prosthetic structure on implants has increased in recent years [14]. PEEK is a high-density thermoplastic polymer with a linear aromatic semi-crystalline structure that has exceptional physical and chemical properties as regards toughness, hardness and elasticity. Also, its low molecular weight, combined with...
Fifteen days after surgery, the appearance of the soft tissue was excellent, with no signs of inflammation in the mucosa. The patient mentioned the absence of bleeding and pain during the post-operation period. At the same time, we made a clinical and radiological evaluation. Three months after surgery, the stumps of the implants were carved to improve their parallelism with a special diamond dril...
A patient who is a 45-year-old woman and non-smoker has no medical record of interest. The patient complained of pain in the right second upper molar. She said that she felt intense pain while chewing. The pain was accentuated with occlusion and while chewing, making normal functioning impossible. The patient mentioned the absence of piece 16, which had been extracted 8 years previously.
Clinica...
In the field of implant dentistry, the most widely used implants over the past 40 years are those manufactured from titanium [1], which are still the most popular.
The recent demands for materials without metal alloys in dentistry, together with the increased sensitivity and allergies of some patients, have promoted the development of new materials.
An example of this is zirconia-based dental i...
One of the disadvantages of the zirconia implants is the lack of elasticity, which is increased with the use of ceramic or zirconia crowns. The consequences that could result from this lack of elasticity have led to the search for new materials with improved mechanical properties.
A patient who is a 45-year-old woman, non-smoker and has no medical record of interest with a longitudinal fracture i...
Fig. 4. Comparative illustration of mean ISQ values
Fig. 4. Comparative illustration of mean ISQ values
Fig. 3. Implants were placed after application of CGF membrane
Fig. 3. Implants were placed after application of CGF membrane
Fig. 2. CGF membrane was applied in study group implant sockets
Fig. 2. CGF membrane was applied in study group implant sockets
Fig. 1. CGF was obtained after centrifugation
Fig. 1. CGF was obtained after centrifugation
Control group
Study group
Immediate–1st week
−2.25 ± 1.713
1.40 ± 1.847
Immediate–4th week
−2.30 ± 2.774
0.60 ± 2.798
1st Week–4th week
−0.05 ± 1.572
−0.80 ± 2.215
Table 3 Mean ISQ value changes between study and control groups
Control group
Study group
Immediate
75.75 ± 5.552
78.00 ± 2.828
1st week
73.50 ± 5.226
79.40 ± 2.604
4th week
73.45 ± 5.680
78.60 ± 3.136
Table 2 Mean ISQ values in the study and control groups
Case no.
Age
Sex
Group
Implant number
1
20
F
Study
1
2
28
M
Control
3
3
35
F
Study
4
4
32
F
Study
4
5
60
M
Control
5
6
64
F
Study
5
7
52
F
Study
5
8
34
M
Study
1
9
45
F
Control
3
10
48
F
Control
2
11
42
M
Control
3
12
68
F
Control
4
Table 1 Demographic data of patien...
Pirpir, C., Yilmaz, O., Candirli, C. et al. Evaluation of effectiveness of concentrated growth factor on osseointegration. Int J Implant Dent 3, 7 (2017). https://doi.org/10.1186/s40729-017-0069-3
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Received: 16 December 2016
Accepted: 16 February 2017
Published: 03 March 2017
DOI: https://doi.org/10.1186/s40729-017-0069-3
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Karadeniz Technical University, Trabzon, Turkey
Cagasan Pirpir, Onur Yilmaz, Celal Candirli & Emre Balaban
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You can also search for this author in PubMed Google Scholar
You can also search for this author in PubMed Google Scholar
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Prakash S, Thakur A. Platelet concentrates: past, present and future. J Maxillofac Oral Surg. 2011;10(1):45–9.
Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scari G, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech. 2011;74(8):772–7.
Ademokun JA, Chapman C, Dunn J, Lander D, Mair K, Proctor SJ, et al...
Huwiler MA, Pjetursson BE, Bosshardt DD, Salvi GE, Lang NP. Resonance frequency analysis in relation to jawbone characteristics and during early healing of implant installation. Clin Oral Implants Res. 2007;18(3):275–80.
Kroese-Deutman HC, Vehof JW, Spauwen PH, Stoelinga PJ, Jansen JA. Orthotopic bone formation in titanium fiber mesh loaded with platelet-rich plasma and placed in segmental defe...
Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci. 2008;13:3532–48.
Anitua E, Sanchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, et al. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009;42(2):162–70.
He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and ...
Raghavendra S, Wood MC, Taylor TD. Early wound healing around endosseous implants: a review of the literature. Int J Oral Maxillofac Implants. 2005;20(3):425–31.
Oncu E, Bayram B, Kantarci A, Gulsever S, Alaaddinoglu EE. Positive effect of platelet rich fibrin on osseointegration. Med Oral Patol Oral Cir Bucal. 2016;21(5):e601–7.
Anitua E. Plasma rich in growth factors: preliminary results o...
Bone morphogenetic protein
Concentrated growth factor
Computed tomography
Insulin-like growth factor
Platelet-derived growth factor
Platelet-rich fibrin
Platelet-rich plasma
Resonance frequency analysis
Transforming growth factor-β1
Transforming growth factor-β2
Vascular endothelial growth factor
Considering this data, it appears that application of CGF enhanced stability of implants and accelerated osseointegration in the early period. CGF has positive effects on the ISQ value at the first week and fourth week. Further laboratory studies are needed to demonstrate the positive effects of blood products on the osseointegration process at the histopathological level.
In a study by Monov et al. using PRP around the implant, a higher stability value was obtained in the study group during the early recovery period (6 weeks) although difference between the groups was not statistically significant [23]. Kim et al. reported in a study that there was a statistically significant increase in bone-implant contact with PRP administration in the vicinity of the implant [...
Introduced in 1998 by Marx, PRP is used in oral and maxillofacial surgeries to speed up the recovery of grafts in bone-grafted areas [14, 26–30]. Although many studies have shown that platelet-rich plasma affects bone healing positively, the results of some other studies suggest otherwise [31, 32].
In recent years, the platelet-rich fibrin (PRF) was described by Choukroun as a second-generation...
Implant stability is one of the important parameters that assess the loading time and dental implant success. Investigators have recommended that implants with ISQ
The study includes 12 patients (5 males, 7 females). Patients participating in the study are between 20–68 years of age and the mean age is 44 years. A total of 40 implants were placed, 20 of these were included in the study group (50%), and the other 20 were included in the control group (50%). Twenty-one implants were placed in type 2 bone, 19 implants in type 3 bone (Table 1). The distribu...
Independent sample t test was applied between the two groups by taking the differences between the data obtained in these periods. Two-way ANOVA and Fisher’s LSD test was used for evaluating the associations among group and insertion torque.
A value of p
All surgical procedures were performed under local anesthesia by the same surgeon. A full-thickness mucoperiosteal flap was removed by incision on the alveolar crest. Implant cavities were prepared according to the surgical protocol of the Bego Semados implant system (BEGO Implant Systems GmbH & Co. KG, Bremen, Germany). The final osteotomy diameters were the same as the placed implants. In the st...
This study was conducted in compliance with the principles of the Declaration of Helsinki, and approval of the ethics committee required for the study was obtained from the Ethics Committee of the Karadeniz Technical University (2015/21). The procedures to be performed were explained in detail and patients signed the consent forms. The study was carried out on individuals who applied to Karadeniz ...
That the implant has sufficient stability after placement is important for providing the necessary bone formation around the implant and for the optimal distribution of functional forces at the implant-bone interface during healing [15–17].
It can be said that resonance frequency analysis (RFA) is a very important tool for tracking the osseointegration process [18, 19]. RFA is a technique that ...
Osseointegration of dental implants is important for long-term success and stability. There is no standardization in terms of the time of osseointegration and the timing of prosthetic loading. This process varies between 0–6 months [1]. Various strategies are being explored to shorten this period. Changes in implant surface properties and design have increased primer stability and helped the pe...
Growth factor-containing products have been reported to increase implant stability and accelerate osseointegration. Concentrated growth factor (CGF) can be used for this purpose with the growth factors it contains. The aim of this study is to assess the effect of CGF on implant stability and osseointegration.
Twelve patients with maxillary anterior toothless were included in the study. Implant ca...
Fig. 12. Facial photograph views at 22-month follow-up
Fig. 12. Facial photograph views at 22-month follow-up
Fig. 11. Facial radiograph at 22-month follow-up
Fig. 11. Facial radiograph at 22-month follow-up
Fig. 10. Full facial view of definitive implant-retained obturator at initial fitting (April 2014)
Fig. 10. Full facial view of definitive implant-retained obturator at initial fitting (April 2014)
Fig. 9. Palatal view of definitive implant-retained obturator at initial fitting (April 2014)
Fig. 9. Palatal view of definitive implant-retained obturator at initial fitting (April 2014)
Fig. 8. Anterior view of definitive obturator prosthesis in occlusion
Fig. 8. Anterior view of definitive obturator prosthesis in occlusion
Fig. 7. Smile view of definitive implant-retained obturator at initial fitting (April 2014)
Fig. 7. Smile view of definitive implant-retained obturator at initial fitting (April 2014)
Fig. 6. Intaglio surface of definitive acrylic obturator with bar attachments in place. Note the absence of any other retaining clasps and the simple nature of this prosthesis
Fig. 6. Intaglio surface of definitive acrylic obturator with bar attachments in place. Note the absence of any other retaining clasps and the simple nature of this prosthesis
Fig. 5. Zygomatic implant bar utilising Rhein attachments for retention
Fig. 5. Zygomatic implant bar utilising Rhein attachments for retention
Fig. 4. Twelve-week review post-surgery prior to definitive impressions for the implant-supported prosthesis
Fig. 4. Twelve-week review post-surgery prior to definitive impressions for the implant-supported prosthesis
Fig. 3. Low-level right-sided maxillectomy with the insertion of two zygomatic oncology implants at time of surgery
Fig. 3. Low-level right-sided maxillectomy with the insertion of two zygomatic oncology implants at time of surgery
Fig. 2. Palatal swelling (post-biopsy) between upper right first and second premolar teeth
Fig. 2. Palatal swelling (post-biopsy) between upper right first and second premolar teeth
Fig. 1. Zygomatic oncology implant with cleansable polished surface for intra-oral component
Fig. 1. Zygomatic oncology implant with cleansable polished surface for intra-oral component
Dattani, A., Richardson, D. & Butterworth, C.J. A novel report on the use of an oncology zygomatic implant-retained maxillary obturator in a paediatric patient. Int J Implant Dent 3, 9 (2017). https://doi.org/10.1186/s40729-017-0073-7
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Received: 24 November 2016
Accepted: 26 February 2017
Published: 28 March 2017
DOI: https://doi.org/10.1186/s40729-017-0073-7
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Oral and Maxillofacial Surgery, Regional Maxillofacial Unit, University Hospital Aintree, Liverpool, UK
Amit Dattani
Maxillofacial Surgery, Regional Craniofacial Unit, Alder Hey Children’s Hospital, Liverpool, UK
David Richardson
Maxillofacial Prosthodontics, Regional Maxillofacial Unit, University Hospital Aintree, Longmoor Lane, Liverpool, L9 7AL, UK
Chris J. Butterworth
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Brown JS, Shaw RJ. Reconstruction of the maxilla and midface: introducing a new classification. Lancet Oncol. 2010;11(10):1001–8.
Breeze J, Rennie A, Morrison A, Dawson D, Tipper J, Rehman K, et al. Health-related quality of life after maxillectomy: obturator rehabilitation compared with flap reconstruction. Br J Oral Maxillofac Surg. 2016;54(8):857–62.
Kim SM, Park MW, Cho YA, Myoung H, Lee...
The use of zygomatic implants to supplement the stability and retention of the maxillary obturator in this case has improved the function of the prosthesis and provided for a very high-quality rehabilitation for the patient reported with no evidence of disruption to facial growth in the 22 months following surgery.
The use of modified zygomatic implants (Fig. 1) allows improved hygiene by the patient of the implants within the maxillary defect. The threaded portion of the implants is fully engaged into the bone with only the smooth portion protruding into the defect. Clearly this ongoing hygiene by the patient is of utmost importance in preventing peri-implant soft and hard tissue changes, but the implant d...
The difficulty of restoration with a maxillary obturator prosthesis depends on the extent of the surgical resection, with the acceptance that resections with an increasing horizontal component provide a much greater prosthodontic challenge. The number of remaining teeth is a key component in conventional obturator design [9] with the remaining dentition being used exclusively to retain the prosthe...
The paediatric population rarely suffer malignant disease of the oral cavity requiring any form of maxillectomy, and there is little published evidence around the rehabilitation and restorative management of children undergoing such procedures. The seemingly most common approach for a limited low-level maxillary resection in a child would be to consider resection and simple prosthetic obturation a...
Four weeks later, the patient was returned to the operating room for removal and modification of the obturator. The cavity was healing well, and both implants were firm with no evidence of infection. The initial obturator was modified with the application of a soft lining material and the patient subsequently discharged with instructions on the insertion and removal of the obturator.
At the 12-we...
A medically fit and well 13-year 11-month-old male was referred to the oral and maxillofacial surgery department at Alder Hey Children’s Hospital in Liverpool in regard to an intra-oral swelling of the right palatal region (Fig. 2). An incisional biopsy was initially reported as a pleomorphic adenoma of the premolar region. Subsequently, a CT scan showed no significant bony abnormality, and a w...
The characteristics of a good obturator will improve swallowing, speech function, minimise nasal fluid leakage from the antrum and nasal spaces, restore facial aesthetics including the teeth and facilitate masticatory function and speech. A surgical obturator can be provided at the time of surgery to facilitate function and haemostasis in the immediate post-operative period, and this can subsequen...
Maxillary defects of acquired [1] or congenital origin produce a communication between the oral and nasal cavities sometimes via an opening into the maxillary antrum and by direct communication into the nose. This in turn can result in masticatory compromise, swallowing and speech impairment, nasal fluid regurgitation and aesthetic concerns. The management of the maxillectomy patient is a complex ...
This report details the use of zygomatic oncology osseointegrated implants to support and retain a maxillary obturator in a 13-year-old male patient who underwent a right-sided hemi-maxillectomy (Brown Class 2b) (Brown and Shaw, Lancet Oncol 11:1001–8, 2010) for a myxoid spindle cell carcinoma. At the time of maxillary resection, two zygomatic oncology implants were inserted into the right zygom...
Fig. 6. a Panoramic radiograph 16 months after the sequestrectomy. b Sagittal CT view. c Coronal CT view. d 3D CT view
Fig. 5. tograph 5 months after the sequestrectomy.
Fig. 5. a Extraoral photograph 5 months after the sequestrectomy. b Intraoral photograph 5 months after the sequestrectomy.
Fig. 4. y. c Removal of the dental implant with a specimen of the necrotic bone
Fig. 4. a Preoperative intraoral photograph. b Intraoperative photograph of the sequestrectomy. c Removal of the dental implant with a specimen of the necrotic bone
Fig. 3.
Fig. 3. a Panoramic radiograph showing the sequestrum separation after 5 months of teriparatide therapy (arrows). b Sagittal CT view. c Coronal CT view
molar (arrow). b Sagittal CT view. c Coronal CT view
Fig. 2. a Panoramic radiograph showing marked alveolar bone resorption surrounding the dental implant replacing the right mandibular first molar (arrow). b Sagittal CT view. c Coronal CT view
Fig. 1. al implants associated with mucosal inflammation and a purulent discharge
Fig. 1. a Extraoral photograph showing an extraoral fistula in the right mandibular region. b Intraoral photograph showing an intraoral fistula on the lingual side of the distal dental implants associated with mucosal inflammation and a purulent discharge
Zushi, Y., Takaoka, K., Tamaoka, J. et al. Treatment with teriparatide for advanced bisphosphonate-related osteonecrosis of the jaw around dental implants: a case report. Int J Implant Dent 3, 11 (2017). https://doi.org/10.1186/s40729-017-0074-6
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Received: 06 December 2016
Accepted: 12 February 2017
Published: 30 March 2017
DOI: https://doi.org/10.1186/s40729-017-0074-6
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan
Yusuke Zushi, Kazuki Takaoka, Joji Tamaoka, Miho Ueta, Kazuma Noguchi & Hiromitsu Kishimoto
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Stanton DC, Balasanian E. Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases. J Oral Maxillofac Surg. 2009;67:943–50.
Carlson ER, Basile JD. The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2009;67:85–95.
Wilde F, Heufelder M, Winter K, et al. The role of ...
Grant BT, Amenedo C, Freeman K, Kraut RA. Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases. J Oral Maxillofac Surg. 2008;66:223–30.
Goss A, Bartold M, Sambrook P, Hawker P. The nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in dental implant patients: a South Australian case series. J Oral Maxillofac Surg. 2010;68:33...
Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61:1115–7.
Marx RE, Sawatari J, Fortin M, et al. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws; risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005;63:1567.
Harper RP, Fung E. Resolution of...
We have reported a case of a severely osteoporotic elderly woman with BRONJ around her dental implants, who was treated successfully with teriparatide. Teriparatide therapy appeared to exert beneficial effects in this patient.
It is therefore important that all patients treated with oral BPs must be given a full explanation of the potential risks of implant failure and BRONJ development in the short and long term. Because the potential role of infection in implant failure and BRONJ occurrence is still debated, great attention should be paid to the long-term oral hygiene and plaque control of implant-prosthetic restorati...
We describe a case of a patient with a 6-year history of alendronate therapy, in which BRONJ developed around her dental implants. In this patient, the dental implants achieved successful osseointegration, and BRONJ occurred after the second surgery. Several factors could have played a role in the development of BRONJ in this patient. Glucocorticoid therapy is associated with an increased risk of ...
In November 2011, after a consultation with an osteoporosis expert at the Orthopedic Medicine Clinic of our hospital, alendronate therapy was stopped and subcutaneous teriparatide therapy at a dose of 20 μg per day was started. During the course of the teriparatide therapy, the patient continued to use 0.02% benzalkonium chloride solution for local irrigation.
In April 2012, after 5 months of ...
A 66-year-old woman was referred to the Oral and Maxillofacial Surgery Clinic at Hyogo College of Medicine Hospital, Japan, in September 2011, for an extraoral fistula and refractory pain of the right mandible associated with a purulent discharge and soft tissue swelling. The patient’s osteoporosis was diagnosed in 2005 and treated with 35 mg of alendronate weekly by the family doctor. The pati...
Oral bisphosphonates (BPs) are used to treat osteoporosis, Paget’s disease, and osteogenesis imperfecta. They are most widely used for treatment of osteoporosis. BP-related osteonecrosis of the jaw (BRONJ) was first reported by Marx in 2003 [1]. The risk of BRONJ in osteoporotic patients treated with BPs remains low compared with that of oncology patients [2]. Recent studies have indicated that ...
We report a case of a 66-year-old severely osteoporotic woman with bisphosphonate-related osteonecrosis of the jaw (BRONJ) around her dental implants, who was treated successfully with teriparatide and sequestrectomy of the mandible. After 5 months of teriparatide therapy, the sequestrum separation had progressed and a sequestrectomy was performed under general anesthesia. Five months after the o...
Fig. 2. a Panoramic radiography with area of interest (maxillary sinus) and b, c examples of corresponding images in cone beam computed tomography
Fig. 2. a Panoramic radiography with area of interest (maxillary sinus) and b, c examples of corresponding images in cone beam computed tomography
Fig. 1.
Fig. 1. a Panoramic radiography with area of interest (maxillary sinus) and b, c examples of corresponding images in cone beam computed tomography
Question
General practitioner (n = 2)
Junior maxillofacial surgeon (n = 2)
Senior maxillofacial surgeon (n = 3)
p value*
...
Additional incidental findings in panoramic radiography
Relative incidence (%) in relation to total number of therapy affecting findings
Retained third molar/follicular cyst
22
...
Number of cases
General practitioner (n = 2)
Junior maxillofacial surgeon (n = 2)
Senior maxillofacial surgeon (n = 3)
p value*
...
Question
General practitioner (n = 2)
Junior maxillofacial surgeon (n = 2)
Senior maxillofacial surgeon (n = 3)
p value*
...
Question
General practitioner (n = 2)
Junior maxillofacial surgeon (n = 2)
Senior maxillofacial surgeon (n = 3)
p value*
...
Dau, M., Marciak, P., Al-Nawas, B. et al. Evaluation of symptomatic maxillary sinus pathologies using panoramic radiography and cone beam computed tomography—influence of professional training.
Int J Implant Dent 3, 13 (2017). https://doi.org/10.1186/s40729-017-0075-5
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Received: 10 December 2016
Accepted: 12 March 2017
Published: 05 April 2017
DOI: http...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Department of Oral, Maxillofacial and Plastic Surgery, University Medical Center, Schillingallee 35, 18057, Rostock, Germany
Michael Dau, Bernhard Frerich & Peer Wolfgang Kämmerer
Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre, Mainz, Germany
Paul Marciak & Bial Al-Nawas
Private Dental Praxis Dr. Rossa, Ludwigshafen, Germany
Henning Staedt
Depa...
Quintero JC, et al. Craniofacial imaging in orthodontics: historical perspective, current status, and future developments. Angle Orthod. 1999;69(6):491–506.
Tadinada A, et al. Radiographic evaluation of the maxillary sinus prior to dental implant therapy: a comparison between two-dimensional and three-dimensional radiographic imaging. Imaging Sci Dent. 2015;45(3):169–74.
Ritter L, et al. Pre...
Rivis M, Valeanu AN. Giant maxillary cyst with intrasinusal evolution. Rom J Morphol Embryol. 2013;54(3 Suppl):889–92.
Yilmaz SY, Misirlioglu M, Adisen MZ. A diagnosis of maxillary sinus fracture with cone-beam CT: case report and literature review. Craniomaxillofac Trauma Reconstr. 2014;7(2):85–91.
Lana JP, et al. Anatomic variations and lesions of the maxillary sinus detected in cone beam ...
Gang TI, et al. The effect of radiographic imaging modalities and the observer’s experience on postoperative maxillary cyst assessment. Imaging Sci Dent. 2014;44(4):301–5.
Batra PS, et al. Computed tomography imaging practice patterns in adult chronic rhinosinusitis: survey of the American Academy of Otolaryngology-Head and Neck Surgery and American Rhinologic Society Membership. Int Forum Al...
Dragan E, et al. Maxillary sinus anatomic and pathologic CT findings in edentulous patients scheduled for sinus augmentation. Rev Med Chir Soc Med Nat Iasi. 2014;118(4):1114–21.
Raghav M, et al. Prevalence of incidental maxillary sinus pathologies in dental patients on cone-beam computed tomographic images. Contemp Clin Dent. 2014;5(3):361–5.
Lyros I, et al. An incidental finding on a diagno...
Depending on the observers’ clinical and radiological experience, PAN alone may not be sufficient for evaluation of pathologies of the maxillary sinus. On the contrary, significant benefits of sFOV-CBCT for diagnosing symptomatic maxillary sinus pathologies were reported. Having sFOV-CBCT seems to have added additional information and confidence in comparison to PAN alone. Nonetheless, also with...
The influence of clinical experience of evaluation of PAN [34] as well as the clinical experience and routine analysis of 3D radiographs (as assumed for maxillofacial surgeons when compared to those for general practitioners) strongly influence the diagnostic value of additional three-dimensional imaging. The number of incidental findings in CBCT in addition to those seen in PAN was not of major d...
In dentistry, PAN is a widely available, useful, and important diagnostic tool for diagnosis and general preoperative planning [32] with less radiation exposure then CBCT [21]. While most dentists have used it routinely successful for years and gained significant experience in doing so [33], there are certain limitations in dependence of the region to be examined [10]. The high number of “not vi...
This study focused on three different aspects in our analysis—PAN, PAN and CBCT, as well as the influence of the different clinical and radiological experience (examples in Figs. 1 and 2).
Panoramic radiography (PAN)
When assessing PAN, the ratings were significantly lower at “good visible and can be evaluated” (9.9%) compared to “visible but cannot be evaluated” (39.5%; p
The first question for PAN addressed the imaging quality in the clinical relevant area of interest (clinical data were given). Three answers were possible: 1 = good visibility and can be evaluated, 2 = visible but cannot be evaluated, and 3 = not visible. The second question asked for an additional need for CBCT scans. Three answers were possible: 1 = required, 2 = reasonable, and 3 = not required...
In an experimental diagnostic comparison, radiographic images of 15 female and 13 male patients were assessed. Patients’ radiographs were selected from the Department of Oral, Maxillofacial and Facial Plastic Surgery of the University Medical Centre of Mainz and Rostock, Germany. All patients have had referrals to the hospitals with symptomatic maxillary sinus pathologies and received PAN (Ortho...
In order to justify CBCT use for clinical examination and diagnosis of the maxillary sinus, the aim of this study was to compare the subjective quality rating of PAN and PAN together with a small field of view (sFOV) CBCT to evaluate symptomatic maxillary sinus by clinicians with different training and clinical experience.
Non-symptomatic abnormalities of the maxillary sinus such as mucosal thickening, retention cysts, and opacification are reported to occur in up to 74% of all cases [1–6]. For diagnosis of symptomatic pathologies of the maxillary sinus like retention cysts, polyps, and tumors, panoramic radiographies (PAN) are commonly used and widely available. In PAN, not every area of interest is accurately de...
A comparison of panoramic radiography (PAN) alone and PAN together with small field of view cone beam computed tomography (sFOV-CBCT) for diagnosis of symptomatic pathologies of the maxillary sinus was carried out by clinicians of different experience.
Corresponding radiographic images (PAN/sFOV-CBCT) of 28 patients with symptomatic maxillary sinus pathologies were chosen and analyzed by two gene...
Fig. 6. Micro CT scan images of the MDIs and Ankylos® embedded in rabbit bone 6 weeks post implantation
Fig. 6. Micro CT scan images of the MDIs and Ankylos® embedded in rabbit bone 6 weeks post implantation
Fig. 5. Histological section of standard implant in rabbit tibia stained with methylene blue and basic fuchsin
Fig. 5. Histological section of standard implant in rabbit tibia stained with methylene blue and basic fuchsin
Fig. 4. Histological section of mini dental implant in rabbit tibia stained with methylene blue and basic fuchsin
Fig. 4. Histological section of mini dental implant in rabbit tibia stained with methylene blue and basic fuchsin
Fig. 3. Histological sections being obtained with Leica SP 1600 saw microtome
Fig. 3. Histological sections being obtained with Leica SP 1600 saw microtome
Fig. 2. Leica SP 1600 saw microtome
Fig. 2. Leica SP 1600 saw microtome
Fig. 1. Radiograph showing implants in the rabbit tibia
Fig. 1. Radiograph showing implants in the rabbit tibia
BIC
3M™ ESPE™ MDIs
Ankylos® Friadent (Dentsply)
Median
58.5
57
Mean
57
56.5
Interquartile range
8
5.5
First quartile
53.25
53.75
Third quartile
61.25
59.25
Table 2 Descriptive statistics of the experimental and control group
Sample
3M™ESPE™ MDIs
Ankylos®
1.
67
54
2.
59
67
3.
54
45
4.
51
58
5.
47
57
6.
64
49
7.
50
54
8.
60
56
9.
56
60
10.
61
53
11.
62
59
12.
61
55
13.
59
59
14.
45
51
15.
58
59
16.
54
62
17.
66
62
18.
56
57
Table 1 Comparison of % BIC in both groups
Dhaliwal, J.S., Albuquerque, R.F., Murshed, M. et al. Osseointegration of standard and mini dental implants: a histomorphometric comparison. Int J Implant Dent 3, 15 (2017). https://doi.org/10.1186/s40729-017-0079-1
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Received: 22 February 2017
Accepted: 26 April 2017
Published: 01 May 2017
DOI: https://doi.org/10.1186/s40729-017-0079-1
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
This article was ammended to correct discrpencies in the Abstract. An erratum has also been published for this manuscript.
An erratum to this article is available at http://dx.doi.org/10.1186/s40729-017-0088-0.
Faculty of Dentistry, McGill University, 2001 McGill College Avenue, Suite 500, Montreal, Quebec, H3A 1G1, Canada
Jagjit S. Dhaliwal, Monzur Murshed & Jocelyne S. Feine
Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil
Rubens F. Albuquerque Jr
Department of Medicine, McGill University, Montreal, Quebec, Canada
Monzur Murshed
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Froum SJ, Simon H, Cho SC, Elian N, Rohrer MD, Tarnow DP. Histologic evaluation of bone-implant contact of immediately loaded transitional implants after 6 to 27 months. In...
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Siddiqui AA, Sosovicka M, Go...
Branemark PI, Adell R, Breine U, Hansson BO, Lindstrom J, Ohlsson A. Intra-osseous anchorage of dental prostheses. I. Experimental studies. Scand J Plast Reconstr Surg. 1969;3(2):81–100.
Boerrigter EM, Stegenga B, Raghoebar GM, Boering G. Patient satisfaction and chewing ability with implant-retained mandibular overdentures: a comparison with new complete dentures with or without preprosthetic ...
The results of this study show that MDIs as well as regular implants osseointegrate in rabbits.
Our study is also in concordance with the results of a removal torque study by Simon et al. [63] in immediately loaded “transitional endosseous implants” in humans. The percentage BIC for MDIs was similar to standard implants.
The surface topography also affects the BIC, Wennerberg et al. [32] measured and compared removal torque values on screw-shaped titanium implants with three surface typ...
The osseointegration potential of 3M™ESPE™ MDIs has not been studied. The MDI is a one-piece implant that simplifies the restorative phase resulting in a reduced cost for the patient. Titanium-aluminum-vanadium alloy (Ti 6Al-4V-ELI) is used for increased strength. The success of these implants led to its use in long-term fixed and removable dental prostheses [51]. Conventional implant treatmen...
On the whole, postoperative wound healing in all the rabbits was good. None of them exhibited any signs of wound infection or exposure. A total of 36 specimens were retrieved for histological examination.
All of the implants in both groups showed osseointegration and displayed a good amount of bone contact length (Figs. 4 and 5). No discernible differences were noticed between both the groups. T...
The saw blade has a thickness of 280 μm and a feed of 310 μm was selected to obtain the final section thickness of 30 μm. The knurled screw was used for the setting of the section thickness. The prepared section was finally removed from the saw blade. The specimens were prepared for histology by the method as described by Donath and Breuner [49].
Subsequently, the sections were stained with...
The specimens were dehydrated in the ascending graded ethanol solution and kept in a pre-filtration solution for 3 h at room temperature and then in the filtration solution at 4 °C for 17 h. The specimens were then embedded in a light curing resin Technovit 9100 NEW (Kulzer & Co., Wehrheim, Germany) polymerization system based on methyl methacrylate, specially developed for embedding mineraliz...
Expected length of the procedure was approximately 1 h. Following placement of the implants, the wound was sutured in layers. The underlying muscle, fascia, and dermal layers were sutured with the help of Vicryl (Polyglactin 910) suture with 3/8 circle reverse cutting needle. The skin was sutured to a primary closer with the same suture material.
Plain X-ray images of all the rabbit tibia were t...
A small longitudinal skin incision just distal to the tibia-femur joint was made. The tibia/femur head was exposed subperiosteally and an osteotomy performed with the delicately placed pilot drill over the entry point and lightly pumped up and down under copius saline irrigation just to enter the cortical bone for the MDIs. This was used for initial bone drilling to depth of 0.5 mm. The 3M™ESPE...
Nine clinically healthy New Zealand white rabbits weighing 3.5 kg and more were used for the study, and the animals were housed in the central animal house facility. The head of tibia/femur of the animals were used for the implantation of samples. Rabbits’ tibiae and femur have been widely used as an animal model by various other authors to study osseointegration of dental implants [36–45].
...
Despite the advantages of the mini dental implants, evidence on their efficacy and long-term success is lacking. The success of these implants will depend on their union with the surrounding bone. New implant systems entering into the market have to be studied with the help of animal models first, to demonstrate the osseointegration potential for their probable success in humans. There is a limite...
The term “osseointegration” was first introduced to explain the phenomenon for stable fixation of titanium to bone by Brånemark et al. in the 1960s [1]. Osseointegrated implants were introduced, a new era in oral rehabilitation began, and many studies were conducted [2, 3]. A success rate of over 90% has been reported [4, 5]. Further, a success rate of 81% in the maxillary bone and 91% in the...
Mini dental implants (MDIs) are becoming increasingly popular for rehabilitation of edentulous patients because of their several advantages. However, there is a lack of evidence on the osseointegration potential of the MDIs. The objective of the study was to histomorphometrically evaluate and compare bone apposition on the surface of MDIs and standard implants in a rabbit model.
Nine New Zealand ...
Fig. 3. Enzymatic degradability of A-PRF, CGF, and PPTF membranes. Each membrane disk (φ8 mm, 1 mm thick) was immersed in PBS containing trypsin and incubated in a CO2 incubator. N = 4. The asterisks represent significant differences (P
Fig. 2. Representative stress-strain curves for A-PRF and CGF membranes and mechanical properties (Young’s modulus, strain at break, and maximum stress) of A-PRF, CGF, and PPTF membranes. N = 3–9
Fig. 2. Representative stress-strain curves for A-PRF and CGF membranes and mechanical properties (Young’s modulus, strain at break, and maximum stress) of A-PRF, CGF, and PPTF membranes. N...
Fig. 1. Surface microstructures of A-PRF, CGF, and fibrin clots prepared by PPP + CaCl2 and PPTF (fibrin clots prepared by PPP and thrombin). Similar observations were obtained from other three independent blood samples. Scale bar = 10 μm. Note: the same magnification (×9000) was used in all the SEM images shown here
Fig. 1. Surface microstructures of A-PRF, CGF, and fibrin clots p...
A-PRF
CGF
PPTF
Centrifugal conditions
198 g × 8 min
692 g × 2 mina
...
Wet weight (g)
Dry weight (g)
Water content (%)
A-PRF
1.905 ± 0.416
0.043 ± 0.014*
...
Size (W × L mm)
Stretching (times longer)
Number
A-PRF
8.6 ± 1.2 × 27.5 ± 3.5
...
Isobe, K., Watanebe, T., Kawabata, H. et al. Mechanical and degradation properties of advanced platelet-rich fibrin (A-PRF), concentrated growth factors (CGF), and platelet-poor plasma-derived fibrin (PPTF).
Int J Implant Dent 3, 17 (2017). https://doi.org/10.1186/s40729-017-0081-7
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Received: 29 January 2017
Accepted: 25 April 2017
Published: 02 May 2017
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Correspondence to
Tomoyuki Kawa...
Tokyo Plastic Dental Society, Kita-ku, Tokyo, Japan
Kazushige Isobe, Taisuke Watanebe, Hideo Kawabata, Yutaka Kitamura, Toshimitsu Okudera & Hajime Okudera
Division of Dental Implantology, Niigata University Medical and Dental Hospital, Niigata, Japan
Kohya Uematsu
Division of Periodontology, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan
Kazuhiro Okuda
Bioscie...
Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost. 2005;3:1894–904.
Kawase T, Kamiya M, Kobayashi M, Tanaka T, Okuda K, Wolff LF, Yoshie H. The heat-compression technique for the conversion of platelet-rich fibrin preparation to a barrier membrane with a reduced rate of biodegradation. J Biomed Mater Res B Appl Biomater. 2015;103:825–31.
Hartshorne J, Gluckman H. A...
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:299–303.
Kawase T. Platelet-rich plasma and its derivatives as promising bioac...
Acid citrate dextrose solution
Advanced platelet-rich fibrin
Concentrated growth factors
Platelet-poor plasma-derived, thrombin-activated fibrin
Platelet-rich plasma
In the mechanical parameters and degradability we tested, CGF membranes were almost identical to A-PRF membranes. In contrast, PPTF membranes were mechanically weaker and highly degradable. Therefore, we conclude that all of these fibrin membranes are tough enough to serve as barrier membranes; however, we should pay attention to their degradability and choose an appropriate membrane type dependin...
Growth factor release is a key function of these fibrin clots for tissue regeneration. Our previous study [16] demonstrated that CGF membranes compressed by the stainless steel compression device contain significantly higher levels of growth factors even after releasing approximately 85% of exudate. Repeated rinsing with PBS failed to completely remove the growth factors from CGF membranes. The ri...
In this study, we found no apparent differences between A-PRF and CGF clot microstructures, especially in fibrin fiber thickness or crosslink density. However, in PPTF clots, which were prepared through direct conversion of fibrinogen by thrombin, fibrin fiber thickness and their crosslink density were substantially thinner and higher, respectively, than those of either A-PTF or CGF clots. This fi...
The main purpose of this study was to compare A-PRF with CGF preparations to find possible differences in mechanical properties. As shown in Table 1, the sizes of A-PRF clots compressed to membranes were 8.6 ± 1.2 mm (W) × 27.5 ± 3.5 mm (L) and very similar to those of CGF clots (8.4 ± 0.8 mm × 27.6 ± 2.5 mm). As reference, PPTF membranes were also prepared by ad...
After pipetting the digestion solution, 50 μL of the digestion solution was collected every 20 min and was stored at −20 °C until protein measurement. Protein levels, which can be considered primarily as levels of digested fibrin fiber, were then determined by a BCA protein assay kit (Takara Bio, Kusatsu, Japan). The protein levels at the time point when the initial fibrin disks were comple...
The mechanical properties of gel sheets were measured at a stretching speed of 1 mm/min with a desktop universal testing machine (EZ test; Shimadzu, Kyoto, Japan), of which maximum load cell capacity was 500 N under standard ambient conditions at 25 ± 3 °C and 50 ± 25% RH. The samples were gripped by clamps at each end (using slip-proof rubber sheets to prevent slippage) such that th...
Blood samples were collected from four non-smoking, healthy, male volunteers with ages ranging from 27 to 56 years. Although having lifestyle-related diseases and receiving medication, these donors had no hindrance in daily life. The study design and consent forms for all procedures performed with the study subjects were approved by the ethical committee for human subjects at Niigata University S...
In this study, we hypothesized that the mechanical properties of the fibrin membrane are closely related to its degradability. We compared these characteristics among A-PRF, CGF, and PPTF membranes through tensile and digestion tests.
Platelet-rich fibrin (PRF), a self-clotted preparation of platelet-concentrated, blood-derived biomaterials, is prepared solely by contact activation of intrinsic coagulation pathways through centrifugation without addition of coagulation factors [1, 2]. Therefore, the preparation protocol is drastically simplified, and the resulting clot can be handled easily with forceps. PRF is further modified...
Fibrin clot membranes prepared from advanced platelet-rich fibrin (A-PRF) or concentrated growth factors (CGF), despite their relatively rapid biodegradability, have been used as bioactive barrier membranes for alveolar bone tissue regeneration. As the membranes degrade, it is thought that the growth factors are gradually released. However, the mechanical and degradable properties of these membran...
Fig. 7 Second stage surgery of patient in Fig. 1. a Vestibular depth reduction after augmentation and implant placement. b Partial thickness and apical repositioned flap. c CMX healing and soft tissue dehiscence with CCXBB exposure. d Dehiscence healing after re-contouring and buccal emergency profile. e Buccal aspect of the final restoration. f Buccal ridge contour
Fig. 6 Immunohistochemical analysis of slices from the same sample with four different markers. a TRAP. b OPN. c ALP. d OSC
ple. a Ground section stained with Levai-Laczkó. b Tissue identification of the ROI. c Closer view a bone and CCXBB. d Closer view of b
Fig. 5. Histomorphometric analysis of the same sample. a Ground section stained with Levai-Laczkó. b Tissue identification of the ROI. c Closer view a arrow pointing a cement line between new mineralized bone and CCXBB. d Closer view of b
Fig. 4. Histological samples. a CCXBB control without implantation. b Histologic samples with acute inflammatory infiltration. c Histologic sample with limited remaining CCXBB and large bone ingrowth
Fig. 4. Histological samples. a CCXBB control without implantation. b Histologic samples with acute inflammatory infiltration. c Histologic sample with limited remaining CCXBB and large bone ingr...
Fig. 3. Re-entry procedure of patient in Fig. 1. a Buccal aspect of the augmented region. b Horizontal bone augmentation. c Screws and pins removal and bone trephine sampling. d Implants placement and buccal bone width from the implant shoulder. e Primary flap closure. f Implants submerged healing
Fig. 3. Re-entry procedure of patient in Fig. 1. a Buccal aspect of the augmented region. b Ho...
Fig. 2. Lateral bone augmentation of the alveolar crest (a) atrophic ridge. b Perforations and adaptation of the cortical layer. c Shaping, pre-wetting and fixation of CCXBB with titanium screws. d Horizontal contour and peripheral gap between CCXBB and bone layer. e Outlying DBBM filling. f CM stabilized with pins
Fig. 2. Lateral bone augmentation of the alveolar crest (a) atrophic ridge. b ...
Fig. 1. Study chart and follow-up visits
Fig. 1. Study chart and follow-up visits
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Ortiz-Vigón, A., Martinez-Villa, S., Suarez, I. et al. Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement.
Int J Implant Dent 3, 24 (2017). https://doi.org/10.1186/s40729-017-0087-1
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Received: 21 March 2017
Accepted: 12 June 2017
Published: 21 Ju...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
ETEP Research Group, Facultad de Odontología, Universidad Complutense de Madrid, Plaza Ramón y Cajal, 28040, Madrid, Spain
Alberto Ortiz-Vigón, Sergio Martinez-Villa, Iñaki Suarez, Fabio Vignoletti & Mariano Sanz
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We wish to acknowledge the dedication and scientific advise of Prof. Dr. Tord Berglundh on the histological analysis as well as the diligent work in processing the histological samples to Estela Maldonado for the immunohistochemistry and Asal Shikhan and Fernando Muñoz for the histomorphometry. The work of Esperanza Gross on the statistical analysis is highly acknowledged.
This study was partial...
Patti A, Gennari L, Merlotti D, Dotta F, Nuti R. Endocrine actions of osteocalcin. Int J Endocrinol. 2013;2013:846480.
Schwarz F, Herten M, Sager M, Wieland M, Dard M, Becker J. Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA titanium implants: preliminary results of a pilot study in dogs. Clin Oral Implants Res. 2...
Araujo MG, Linder E, Lindhe J. Bio-Oss collagen in the buccal gap at immediate implants: a 6-month study in the dog. Clin Oral Implants Res. 2011;22:1–8.
Chiapasco M, Colletti G, Coggiola A, Di Martino G, Anello T, Romeo E. Clinical outcome of the use of fresh frozen allogeneic bone grafts for the reconstruction of severely resorbed alveolar ridges: preliminary results of a prospective study. I...
Jeno L, Geza L. A simple differential staining method for semi-thin sections of ossifying cartilage and bone tissues embedded in epoxy resin. Mikroskopie. 1975;31:1–4.
Dias RR, Sehn FP, de Santana Santos T, Silva ER, Chaushu G, Xavier SP. Corticocancellous fresh-frozen allograft bone blocks for augmenting atrophied posterior mandibles in humans. Clin Oral Implants Res. 2016;27:39–46.
Nissan ...
Cremonini CC, Dumas M, Pannuti C, Lima LA, Cavalcanti MG. Assessment of the availability of bone volume for grafting in the donor retromolar region using computed tomography: a pilot study. Int J Oral Maxillofac Implants. 2010;25:374–8.
Nkenke E, Weisbach V, Winckler E, Kessler P, Schultze-Mosgau S, Wiltfang J, et al. Morbidity of harvesting of bone grafts from the iliac crest for preprosthetic...
Sanz M, Vignoletti F. Key aspects on the use of bone substitutes for bone regeneration of edentulous ridges. Dent Mater. 2015;31:640–7.
Benic GI, Hammerle CH. Horizontal bone augmentation by means of guided bone regeneration. Periodontology. 2014;66:13–40.
Beretta M, Cicciu M, Poli PP, Rancitelli D, Bassi G, Grossi GB, et al. A Retrospective Evaluation of 192 Implants Placed in Augmented Bon...
Alkaline phosphatase
Cone beam computed tomography
Collagen containing xenogeneic bone block
Native collagen membrane
Deproteinized bovine bone mineral
Etiology and Therapy of Periodontal Diseases
Osteopontin
Osteocalcine
Tartrate-resistant acid phosphatase
Within the limitations of this clinical study, we may conclude that the use of CCXBB in combination with DBBM particles and a native bilayer collagen membrane for staged lateral bone augmentation in severe atrophic alveolar crests achieved significant horizontal crestal width allowing for staged implant placement in most of the patients. Histological analysis and implant survival records indicate ...
The immune-histochemical results reported expression of osteopontin mainly at the border between mineralized vital bone (MVB) with CCXBB, what coincides with findings from previous reports [38,39,40]. Alkaline phosphatase (ALP) is considered as an early osteoblast differentiation marker [41]. ALP-positive cells were detectable, in all specimens on the periphery of MVB, associated to areas of new b...
When correlating the clinical results and the histological outcomes, there was a positive association between the presence of soft tissue dehiscence with CCXBB exposure and a diminished amount of new mineralized bone (p = 0.06). This lower amount of new bone within the xenogeneic graft suggests a lack of full graft integration and diminished vascular supply, what may have caused the soft tissu...
The purpose of this investigation was to evaluate histologically and immunohistochemically the behavior of CCXBB blocks when used for staged lateral bone augmentation in severe human horizontal residual bone defects. Six months after the regenerative intervention using the CCXBB blocks, the mean increase in bone width was 4.12 mm and hence, this outcome allowed for the placement of dental implant...
The results from the histomorphometric measurements are depicted in Table 2. Bone biopsies were composed by 21.37% (SD 7.36) of residual CCXBB, 26.90% (SD 12.21) of mineralized vital bone (MVB), 47.13% (SD 19.15) of non-mineralized tissue and 0.92% of DBBM (Fig. 5b). Biopsies from patients who lost their implants had a statistical significant lower amount of MVB (p = 0.01u) and a statistical...
Twenty-eight CCXBB blocks were placed in 15 patients that fulfilled the selection criteria (12 women and 3 men) with a mean age of 54.5 (SD 8.34).
The detailed clinical and radiographical outcomes have been reported previously [21]. In brief, one patient experienced pain and soft tissue dehiscence leading to removal of the graft material 3 days after the regenerative procedure. Another patient r...
For the immunohistochemical analysis, the semi-thin sections were incubated over night with primary antibodies at 4 °C (Santa Cruz Biotechnology Inc., Santa Cruz, Calif., USA). The antibody dilutions used were alkaline phosphatase (ALP) 1:100, osteopontin (OPN) 1:100, osteocalcin (OSC) 1:100, and tatrate resistant acid phosphatase (TRAP) 1:100.
The obtained semi-thin sections were evaluated wit...
Twenty-six weeks after the regenerative procedure the patient returned for the re-entry intervention for placement of dental implants. After raising full-thickness flaps, the augmented area was exposed and horizontal crestal width measurements were performed. Then, the surgeon evaluated the bone availability and if implant placement was considered possible, a core bone biopsy was harvested with th...
CCXBB (Bio-Graft® Geistlich Pharma) is a bone substitute material in a natural block form. The dimensions of the Bio-Graft block are 10 mm in height, 10 mm in length and 5 mm in width. It consists of a natural cancellous bone structure of hydroxyapatite and endogenous collagen type I and III, equine origin and is a class III medical device according to the Medical Device Directive 93/42 EECs...
The present manuscript reports the histological outcomes of a prospective single arm study evaluating the safety and clinical performance of CCXBB blocks when used as replacement bone grafts for lateral bone augmentation prior to staged implant placement. The results of the clinical and radiographic outcomes have been reported in a previous publication [21]. For correlation of the histological wit...
Different techniques and grafting materials have been used for the horizontal reconstruction of deficient alveolar processes before implant placement, resulting in different degrees of predictability and clinical outcomes [1]. Among the grafting materials, particulated xenogeneic materials have been extensively studied in both experimental and clinical studies and when combined with porcine-derive...
The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures.
In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed us...
Sagheb, K., Schiegnitz, E., Moergel, M. et al. Clinical outcome of alveolar ridge augmentation with individualized CAD-CAM-produced titanium mesh.
Int J Implant Dent 3, 36 (2017). https://doi.org/10.1186/s40729-017-0097-z
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Received: 15 March 2017
Accepted: 13 July 2017
Published: 26 July 2017
DOI: https://doi.org/10.1186/s40729-017-0097-z
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Keyvan Sagheb reports personal fees and grants from Dentsply, Geistlich, and Nobel Biocare outside the submitted work. Eik Schiegnitz reports personal fees and grants from Septodont, Dentsply, Geistlich, and Straumann outside the submitted work. Maximilian Moergel reports grants from Camlog outside the submitted work. Christian Walter reports grants and personal fees from Straumann outside the sub...
Correspondence to
E. Schiegnitz.
K. Sagheb and E. Schiegnitz contributed equally to this work.
Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany
K. Sagheb, E. Schiegnitz, M. Moergel, C. Walter, B. Al-Nawas & W. Wagner
Mediplus, Oral and Maxillofacial Surgery, Private Praxis, Mainz, Germany
C. Walter
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Ali S, Bakry SA, Abd-Elhakam H. Platelet-rich fibrin in maxillary sinus augmentation: a systematic review. The Journal of oral implantology. 2015;41(6):746–53. PubMed PMID: 25536095
Moraschini V, Barboza ES. Effect of autologous platelet concentrates for alveolar socket preservation: a systematic review. Int J Oral Maxillofac Surg. 2015;44(5):632–41. PubMed PMID: 25631334
Torres J, Tamimi F,...
Pieri F, Corinaldesi G, Fini M, Aldini NN, Giardino R, Marchetti C. Alveolar ridge augmentation with titanium mesh and a combination of autogenous bone and anorganic bovine bone: a 2-year prospective study. J Periodontol. 2008;79(11):2093–103. PubMed PMID: 18980518
Proussaefs P, Lozada J. Use of titanium mesh for staged localized alveolar ridge augmentation: clinical and histologic-histomorphom...
von Arx T, Kurt B. Implant placement and simultaneous peri-implant bone grafting using a micro titanium mesh for graft stabilization. Int J Periodontics Restorative Dent. 1998;18(2):117–27. PubMed PMID: 9663090
von Arx T, Kurt B. Implant placement and simultaneous ridge augmentation using autogenous bone and a micro titanium mesh: a prospective clinical study with 20 implants. Clin Oral Implant...
Moraschini V, Poubel LA, Ferreira VF, Barboza ES. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review. Int J Oral Maxillofac Surg. 2015;44(3):377–88. PubMed PMID: 25467739
Al-Nawas B, Kammerer PW, Morbach T, Ladwein C, Wegener J, Wagner W. Ten-year retrospective follow-up study of the TiO...
Within the limitations of this study, being retrospective and having no control group, the results show that individualized CAD-CAM-produced titanium meshes are a safe and predictable procedure for large vertical and horizontal ridge augmentations. The soft tissue covering remains one of the most critical steps using this technique. However, exposure of the mesh does not result in complete loss of...
The results showed that in all 21 augmented sites, a significant ridge augmentation was achieved, with a mean vertical augmentation of 6.5 ± 1.7 mm and a mean horizontal augmentation of 5.5 ± 1.9 mm. To our best knowledge, this is the first study investigating these parameters in individualized CAD-CAM-produced titanium meshes. For conventional titanium meshes, several studies were publish...
In our study, PRF membranes were additionally to collagen membranes used to cover the CAD-CAM mesh. The aim of this clinical approach was to improve and accelerate wound healing. The results with the low exposure rates and the sufficient augmentation heights indicated that these PRF membranes are a promising technique. However, due to low case number in the control group without a PRF membrane, de...
The vertical and horizontal regeneration of resorbed alveolar ridges remains a challenging surgical procedure, especially in the case of extensive bone atrophy. During the past years, different augmentation techniques have been proposed to restore an adequate bone volume. The aim of this study was to evaluate a technique for ridge augmentation in the maxilla and mandible using an individualized CA...
In the investigated time period, 17 patients received 21 TM augmentations. Fourteen of these patients were women and three men. Mean age at the time of augmentation was 37 ± 15 years (17–64 years). Twelve of the patients were non-smoker, and 5 patients were smoker. In 8 patients, a steady periodontal disease could be detected. Sixty-five percent (n = 11) of the patients presented a thin g...
Cone beam computed tomography (CBCT) of the treated sites was performed before augmentation procedure and 6 months postoperatively at time of reentry. Craniofacial bone and TM showed different radio-opacity, which allowed their easy differentiation on the scans after regulating the brightness and contrast. In our department, two different CBCTs were available (Accuitomo, J. Morita Corporation, Ja...
In a retrospective study, the clinical outcome of an individualized CAD-CAM-produced TM (Yxoss CBR®, Filderstadt, Germany) inserted by experienced surgeons in the Department of Oral and Maxillofacial Surgery of the University Medical Centre Mainz, Germany, between December 2014 and January 2017, was analyzed. Therefore, all patients with this CAD-CAM mesh augmentation and reentry operation for im...
The aim of this clinical study was to present the clinical outcome of individualized CAD-CAM-produced TM in combination with particulate autogenous bone mixed with deproteinized bovine bone mineral (DBBM) used to augment horizontal and/or vertical bony defects in both maxillary and mandibular arches, within a two-stage technique. Furthermore, gained horizontal and vertical bone height and the infl...
Dental implant placement is an effective treatment method for the replacement of lost teeth with high survival rates after long-term follow-up [1,2,3]. However, the long-term success and stability of implants in function are directly correlated with the quality and quantity of the available bone at the prospective implant site [4, 5]. Despite the development of various techniques and augmentation ...
The augmentation of the jaw has been and continues to be a sophisticated therapy in implantology. Modern CAD-CAM technologies lead to revival of old and established augmentation techniques such as the use of titanium mesh (TM) for bone augmentation. The aim of this retrospective study was to evaluate the clinical outcome of an individualized CAD-CAM-produced TM based on the CT/DVT-DICOM data of th...
Fig. 2. Clinical image of patient 4: a region 21 before implant placement. b, c Implant placement using the GBR procedure with a synthetic bone substitute material composed of HA + β-TCP
Fig. 2. Clinical image of patient 4: a region 21 before implant placement. b, c Implant placement using the GBR procedure with a synthetic bone substitute material composed of HA + β-TCP
Fig. 1. Schematic representation of the technical characteristics of the investigated C-Tech Esthetic Line implant system (provided by the manufacturer)
Fig. 1. Schematic representation of the technical characteristics of the investigated C-Tech Esthetic Line implant system (provided by the manufacturer)
Patient
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Lorenz, J., Lerner, H., Sader, R.A. et al. Investigation of peri-implant tissue conditions and peri-implant tissue stability in implants placed with simultaneous augmentation procedure: a 3-year retrospective follow-up analysis of a newly developed bone level implant system.
Int J Implant Dent 3, 41 (2017). https://doi.org/10.1186/s40729-017-0104-4
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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
This study was conducted in compliance with the principles of the Declaration of Helsinki, and the approval of the ethics committee required for the study was obtained from the Ethics Committee of the Medical Center of the Goethe University Frankfurt. The procedures to be performed were explained in detail, and the patients signed the consent form.
Jonas Lorenz, Henriette Lerner, Robert Sader, an...
Department for Oral, FORM-Lab, Cranio-Maxillofacial, and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Frankfurt am Main, Germany
Jonas Lorenz, Robert A. Sader & Shahram Ghanaati
HL-Dentclinic, Baden-Baden, Germany
Henriette Lerner
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Lerner H, Lorenz J, Sader R, Ghanaati S. Two-year retrospective study of periimplant health and periimplant bone stability after immediate implant placement of a newly developed bone level implant system—a first report. EDI Journal (European Association of Dental Implantologists, Teamwork Media); 2017; ahead of print.
Ghanaati S, Lorenz J, Obreja K, Choukroun J, Landes C, Sader R. Nanocrystalli...
Gurgel BC, Montenegro SC, Dantas PM, Pascoal AL, Lima KC, Calderon PD. Frequency of peri-implant diseases and associated factors. Clin Oral Implants Res. 2016; doi: 10.1111/clr.12944
Qian J, Wennerberg A, Albrektsson T. Reasons for marginal bone loss around oral implants. Clin Implant Dent Relat Res. 2012;14(6):792–807.
Berglundh T, Lindhe J, Ericsson I, Marinello C, Liljenberg B, Thomsen P....
β-tricalcium phosphate
Bleeding on probing
Fixed prosthetics
Guided bone regeneration
Hydroxyapatite
Multinucleated giant cells
Pink Esthetic Score
Removable prosthetics
In the present study, the implant and peri-implant hard- and soft-tissue stability was analyzed in a bone level implant system placed simultaneously with a GBR procedure 3 years after prosthetic loading. Peri-implant hard- and soft-tissue parameters such as width and thickness of peri-implant keratinized gingiva, probing depth, BOP, PES, peri-implant bone loss, and the presence of peri-implant os...
Comparing the present results to the aforementioned study with the same implant system on immediately placed implants, it seems that the GBR augmentation procedure has no influence on the long-term stability of the implants. In both studies with different placement modalities and protocols, comparable clinical and radiological results were achieved. This leads to the assumption that the investigat...
The tissue reaction, however, did not only differ in bone substitute materials of different origin but also in bone substitute materials of the same origin. In an in vivo trial, two xenogeneic bone substitute materials processed with different techniques were implanted subcutaneously in CD-1 mice for up to 60 days. Both bone substitute materials showed good integration within the peri-implant tis...
In the present retrospective study, C-Tech bone level implants placed simultaneously with a GBR procedure around the implant shoulder were investigated clinically and radiologically after at least 3 years of loading to assess peri-implant tissue conditions and document peri-implant tissue stability.
A total of 47 implants were placed in the upper (23 implants) and lower jaw (24 implants) of 20 p...
Investigation of the esthetic appearance via PES revealed a mean point score of 10.1 (ranging from 7 to 13) from a maximum of 14. The highest values and therefore acceptance were found in the alveolar process deficiency and the soft-tissue level, which can be interpreted as a benefit of the augmentation procedure around the implant shoulder.
Peri-implant bone loss calculated using the average bon...
Altogether, 47 implants were placed in the upper and lower jaws of a total of 20 patients. In all implants, lateral augmentation in a GBR process was performed simultaneously with implant placement due to reduced horizontal or vertical height of the alveolar crest. A total of 23 implants were placed in the upper jaw and 24 implants in the lower jaw. The implant diameter varied between 3.5 mm (32 ...
Investigation parameters:
Implant being in situ
Width and thickness of peri-implant keratinized gingiva
Pink Esthetic Score (PES)
Probing depth
BOP
Peri-implant bone loss
Presence of peri-implant osteolysis
In the present retrospective study, bone level implants (C-Tech Esthetic Line implants) were investigated clinically and radiologically. The bone level implant system has a Morse-locking conical implant-abutment connection with platform switching and an indexing hex that allows subcrestal implant placement and aims to prevent peri-implant bone loss. The surface of the implant system is manufacture...
In the present retrospective study, 47 dental implants (C-Tech Esthetic Line implants) from 20 patients (11 female, 9 male) with a mean age of 58.5 years (45–75 years) were analyzed clinically and radiologically. Implant placement and follow-up investigation was performed at the HL Dentclinic in Baden-Baden, Germany. The study was approved by the ethics commission of the medical department of ...
The aim of the present retrospective investigation was to assess clinically and radiologically peri-implant tissue conditions and document peri-implant tissue stability in C-Tech implants when placed simultaneously with a GBR augmentation procedure after at least 3 years of loading.
The ability of bone substitute materials to form a sufficient and stable implantation bed has been proven in numerous clinical trials; however, it is still to a certain degree unclear if the different tissue reactions have an impact on the establishment of a peri-implant infection, especially when these biomaterials are used for augmentations around the implant shoulder. Due to the two-stage desig...
The prevalence of peri-implantitis has grown in the past few years and has become a major issue in implant dentistry. Long-term stable and healthy soft- and hard-tissue conditions should be achieved in combination with esthetically and functionally satisfying results. However, the rising number of placed implants in the past decades has come with an increase in the prevalence of peri-implantitis [...
Guided bone regeneration (GBR) has been proven to be a reliable therapy to regenerate missing bone in cases of atrophy of the alveolar crest. The aim of the present retrospective analysis was to assess peri-implant tissue conditions and document peri-implant tissue stability in C-Tech implants when placed simultaneously with a GBR augmentation procedure.
A total of 47 implants, which were placed ...
Failure rate
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Mengel, R., Heim, T. & Thöne-Mühling, M. Mucositis, peri-implantitis, and survival and success rates of oxide-coated implants in patients treated for periodontitis 3- to 6-year results of a case-series study.
Int J Implant Dent 3, 48 (2017). https://doi.org/10.1186/s40729-017-0110-6
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Received: 29 August 2017
Accepted: 26 October 2017
Published: 28 Novemb...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
RM is a professor at the Department of Prosthetic Dentistry, School of Dental Medicine, Philipps-University, Marburg/Lahn, Germany. TH is a private practicioner in Gruben, Brandenburg, Germany. MT is a researcher at the Department of Prosthetic Dentistry, School of Dental Medicine, Philipps-University, Marburg/Lahn, Germany.
This clinical study was conducted in accordance with the World Medical A...
Department of Prosthetic Dentistry, School of Dental Medicine, Philipps-University, Marburg/Lahn, Germany
Reiner Mengel & Miriam Thöne-Mühling
Gruben, Brandenburg, Germany
Theresa Heim
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Swierkot K, Lottholz P, Flores-de-Jacoby L, Mengel R. Mucositis, peri-implantitis, implant success, and survival of implants in patients with treated generalized aggressive periodontitis: 3- to 16-year results of a prospective long-term cohort study. J Periodontol. 2012...
Jungner M, Lundqvist P, Lundgren S. A retrospective comparison of oxidized and turned implants with respect to implant survival, marginal bone level and peri-implant soft tissue conditions after at least 5 years in function. Clin Implant Dent Relat Res. 2014;16:230–7.
Rocci A, Rocci M, Rocci C, Scoccia A, Gargari M, Martignoni M, Gottlow J, Sennerby L. Immediate loading of Brånemark system TiU...
Esposito M, Ardebili Y, Worthington HV. Interventions for replacing missing teeth: different types of dental implants. Cochrane Database Sys Rev. 2014;7:CD003815.
Salata LA, Burgos PM, Rasmusson L, Novaes AB, Papalexiou V, Dahlin C, Sennerby L. Osseointegration of oxidized and turned implants in circumferential bone defects with and without adjunctive therapies: an experimental study on BMP-2 and...
The results of the present case series study should be interpreted in a critical light because of the small study population. However, it can be concluded that periodontally diseased subjects treated in a supportive periodontal therapy can be successfully rehabilitated with oxide-coated dental implants for a follow-up period of 3 to 6 years. The results suggest that implants in the maxilla and in...
These results from long-term clinical studies indicate that oxide-coated implants achieve equivalent survival rates and prevalence of mucositis and peri-implantitis when compared to implants with other surface characteristics. They support the assumption that the implant surface has little influence on the development of mucositis or peri-implantitis. This was subsequently confirmed in a Cochrane ...
The present study examines the success rates of oxide-coated implants in subjects with treated periodontal disease. Several long-term clinical studies on periodontally healthy subjects have revealed survival rates of 97.1 to 99.2% for oxide-coated implants [10, 24, 25]. The results of the present study show a comparable implant survival rate (96.2% in GAP and 97.1% in GCP subjects) for subjects wi...
The present study examines the success rates of oxide-coated implants in subjects with treated periodontal disease. Several long-term clinical studies on periodontally healthy subjects have revealed survival rates of 97.1 to 99.2% for oxide-coated implants [10, 24, 25]. The results of the present study show a comparable implant survival rate (96.2% in GAP and 97.1% in GCP subjects) for subjects wi...
The univariate analyses showed a significantly higher risk for peri-implantitis in GAP subjects (OR = 3.294 with p = 0.027) and at implants with bone quality grade 3 (OR = 21.200 with p = 0.000). However, these differences were not significant in multivariate analyses.
Both the uni- and multivariate patient-related analyses were non-significant.
The implant success rate was 77.9% for GCP...
All 29 subjects were examined over the period of 3 to 6 years (Table 2). For the duration of the observation period, all the remaining teeth were periodontally healthy, with PDs ≤ 3 mm and negative BOP. All subjects were non-smokers, had excellent oral hygiene, attended the follow-up examinations on a regular basis, and had no systemic disease.
In total, four implants (3.1%) were lost du...
Peri-implant mucositis was defined as PDs ≥ 5 mm with BOP and no bone loss after the first year of loading. Peri-implantitis was defined as PDs > 5 mm with or without BOP and an annual bone loss of > 0.2 mm after the first year of loading.
All technical and surgical complications (e.g., fracture of the abutment screw or superstructure, compromised wound healing) were recorded.
T...
All patients received a supportive periodontal therapy at the Dental School of Medicine, Philipps-University, Marburg, in the course of the observation period. The first clinical examination was 2 to 4 weeks before the non-retainable teeth were extracted. The periodontally healthy residual dentition and the implants were evaluated immediately after the superstructure was inserted. Subsequently, t...
Second-stage surgery was performed in the maxilla after 6 months and in the mandible after 3 months. Implant placement and second-stage surgery were performed by a single periodontist (R.M.).
About 4 weeks after the final abutments were placed, GCP subjects were rehabilitated with single crowns, implant-supported bridges, or removable superstructures, according to the Marburg double crown syst...
A total of 29 partially edentulous subjects were consecutively recruited from the Dental School of Medicine, Philipps-University, Marburg, Germany between April 2010 and April 2013 (Table 1). Subjects were excluded for the following reasons: history of systemic disease (e.g., cardiovascular diseases, diabetes mellitus, osteoporosis), pregnancy, untreated caries, current orthodontic treatment, con...
The aim of this long-term clinical study on partially edentulous subjects treated for periodontal disease was to evaluate the prevalence of mucositis and peri-implantitis and to determine the survival and success rates of dental implants with oxide-coated surfaces.
In recent years, a great number of different implant systems varying in materials, surface structure, and macroscopic design have been introduced to the dental market [1]. In studies using implants with modified surfaces, it was concluded that rough surfaces induce a stronger initial bone response, achieve stability more rapidly, and integrate more fully with extant bone [2,3,4,5,6]. Dental implan...
The aim of this case-series study is to evaluate the prevalence of mucositis, peri-implantitis, and survival and success rates of oxide-coated implants in subjects treated for periodontitis.
Twenty-four subjects treated for generalized chronic periodontitis (GCP) and five treated for generalized aggressive periodontitis (GAP) were orally rehabilitated with a total of 130 dental implants. Subjects...
Fig. 8. There were moderately significant and positive correlations between the ALP levels and OC levels at all measurements from week 1 to week 12. The OC levels in pg/μg protein were associated with the ALP levels in nM/μg protein at the implant site (a), control site (b), and pooled samples of the control and implant sites (c)
Fig. 8. There were moderately significant and positive correl...
Fig. 7. Comparison between the trend of the biomarker levels and the trend of the ISQ values over time
Fig. 7. Comparison between the trend of the biomarker levels and the trend of the ISQ values over time
Fig. 6. There were weakly significant and positive correlations between the ALP or OC levels and ISQ values at all measurements from week 1 to week 12. At the implant site, the ALP levels in nM/μg protein (a) or the OC levels in pg/μg protein (b) were associated with ISQ values
Fig. 6. There were weakly significant and positive correlations between the ALP or OC levels and ISQ values at all...
Fig. 5. Change in the median values of the OC level over time. In the test group, the OC level continuously increased with time. There was a statistically significant increase in the OC level at 6, 8, 10, and 12 weeks when compared with 1 week (P
Fig. 4. Change in the median values of the ALP level over time. In the test group, the ALP level decreased at 1–4 weeks and then increased at 6, 8, 10, and 12 weeks. There was no statistically significant difference in the ALP level in either the control or the test groups at any measurement
Fig. 4. Change in the median values of the ALP level over time. In the test group, the ALP level d...
Fig. 3. Change in the median values of the GCF (control group) and PICF (test group) volume over time. In the test group, the PICF volume continuously decreased with time (a). There were no significant differences in the median values of the crevicular fluid volume in either the control group or the test groups at any measurement (b)
Fig. 3. Change in the median values of the GCF (control gro...
Fig. 2. Change in the mean ISQ values over time. There was a statistically significant decrease in the mean ISQ values between 1 and 3 weeks (P
Fig. 1. Timeline of the clinical study. I—implant site, T—contralateral posterior mandibular nonsurgical tooth
Fig. 1. Timeline of the clinical study. I—implant site, T—contralateral posterior mandibular nonsurgical tooth
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks...
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks...
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks...
Patient no.
Age
Sex
Positiona
Bone qualityb
1
34
...
Inclusion criteria
Exclusion criteria
Patients aged 25–65 years
Presence of periodontal disease or periapical lesions
Ability to participat...
Tirachaimongkol, C., Pothacharoen, P., Reichart, P.A. et al. Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study.
Int J Implant Dent 2, 27 (2016). https://doi.org/10.1186/s40729-016-0058-y
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Received: 14 September 2016
Accepted: 18 November 2016
Published: 08 December 2016
DOI...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Center of Excellence for Dental Implantology, Faculty of Dentistry, Chiang Mai University, Suthep sub-district, A. Muang, Chiang Mai, 50200, Thailand
Choknapa Tirachaimongkol & Pathawee Khongkhunthian
Department of Biochemistry, Faculty of Medicine, Thailand Excellence Center for Tissue Engineering and Stem Cells, Chiang Mai, Thailand
Peraphan Pothacharoen
Department of Oral Medicine, Dental...
The authors acknowledge Mrs. Yupaporn Kiatsakulcharoen and Miss Kamolwan Mangkalad, the Center of Excellent for Dental Implantology, Chiang Mai University for clinical assistance, Mr. Aitthiphon Chongchai, the Department of Biochemistry, Faculty of Medicine Chiang Mai University for laboratory assistance, Dr.Thanapat Sastraruji, Faculty of Dentistry, Chiang Mai University for statistical consultat...
Lekholm U, Zarb G, Albrektsson T. Tissue integrated prostheses. Patient selection and preparation. Chicago: Quintessence Publishing Co Inc; 1985. p. 199–209.
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Berglundh T, Abrahamsson I, Lang NP, Lindhe J. De novo alveolar bone formation adjacent to endosseous implants. Clin Oral Implants Res. 2003;3:251–62.
Emecen-Huja P, Eubank TD, Shapiro V, Yildiz V, Tatakis DN, Leblebicioglu B. Peri-implant versus periodontal wound healing. J Clin Periodontol. 2013;40:816–24.
Chapple LLC, Socransky SS, Dibart S, Glenwright DH, Matthews JB. Chemiluminescent as...
Bischof M, Nedir R, Szmukler-Moncler S, Bernard JP, Samson J. Implant stability measurement of delayed and immediately loaded implants during healing. Clin Oral Implants Res. 2004;5:529–39.
Sim CPC, Lang NP. Factors influencing resonance frequency analysis assessed by Osstell mentor during implant tissue integration: I. Instrument positioning, bone structure, implant length. Clin Oral Implants ...
Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52:155–70.
Khongkhunthian P. Implant features. In: Khongkhunthian P, editor. PW Plus Thai Dental Implant. Bangkok: STZ Mospace design; 2015. p. 12.
Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, ...
Within the limitations of this study and cautious interpretation due to small number of implants/patients, the ISQ values were weakly correlated with both ALP and OC molecules in PICF during the healing period. The results also show that osteocalcin may be used as a biological marker for monitoring implant healing at 6, 8, 10, and 12 weeks after implant placement. The ISQ values showed high stabi...
Vogel and Marcotte [33] suggested that the correlation between mRNA and protein quantities is approximately 40%. As there are many mechanisms between transcription and translation, especially in human cell and protein stability, at the gene expression level, the transcription data is beneficial in making decisions about molecular candidates for future studies at the protein level. The colorimetric...
The main sources of ALP in GCF are neutrophils, bacteria within dental plaque, fibroblasts, and osteoblasts [28]. Plagnat et al. [29] suggested that longitudinal monitoring of ALP in PICF might confirm its possible use as a marker of implant failure. Considering the change in the median values of the ALP level over time, in the test group, the ALP level decreased at 1–4 weeks and then increased...
The results of this study show that, at the time of implantation, the ISQ values ranged between 67.5 and 83. The mean initial ISQ value was 77.0 ± 1.32. These findings are in harmony with those of previous studies [16, 18]. Tallarico et al. (2011) reported that the macro-design of dental implant affects the primary anchorage [16]. They suggested that the high initial ISQ value is a factor in ...
At the implant site, the OC level continuously increased with time. According to the Friedman followed by Wilcoxon signed-rank tests, there was statistically significant increase in the OC level at 6, 8, 10, and 12 weeks when compared with 1 week (P
Ten patients, seven females, and three males, aged 42.4 ± 11.99 years (range, 28 to 64 years), with either a first mandibular or second mandibular molar edentulous area, who required a single nonsubmerged implant participated in this study, as shown in Table 2. The implants used for all patients were 10 mm long and 5 mm in diameter. All patients completed the follow-up. None of the impla...
Data were analyzed by using SPSS 17.0 software (SPSS Inc., Chicago, IL, USA). Repeated measures analysis of variance was performed to evaluate the change in the ISQ values at each measurement. The independent samples t test was used to investigate the differences in implant stability in the patients’ gender and bone quality. The Friedman test, followed by the Wilcoxon signed-rank test, was used ...
The level of OC was measured by using commercially available ELISA kits (Human Osteocalcin Quantikine ELISA Kit, R&D Systems, Inc., Minneapolis, MN, USA) according to the manufacturer’s instructions. A 100 μl volume of Assay Diluent RD1-117 (R&D Systems) was added into each well of the microplate and then 50 μl of standard (0–64 ng/ml) or sample was added to each well. The microplate was ...
To observe the level of two bone formation biomarkers (alkaline phosphatase and osteocalcin) during the osseointegration period compared with control group using GCF from the first molar of the contralateral side of implant position, the sample collection of GCF was performed before the surgical procedure, immediately after the surgical operation and after 1, 2, 3, 4, 6, 8, 10, and 12 weeks. The ...
The study is a prospective clinical study during the 3-month healing period of implant. The study was approved by the Human Experimentation Committee, Faculty of Dentistry, Chiang Mai University. The study outline is shown in Fig. 1.
Ten patients, who were partially edentulous in the mandibular posterior region for whom a single nonsubmerged implant was planned, participated in this study. All o...
Osteocalcin (OC) is the most plentiful noncollagenous protein of the bone matrix. It is secreted from odontoblasts, osteocytes, and osteoblasts, in order to bind hydroxyapatite and calcium during matrix mineralization [7]. It is one of the serological markers in the bone formation process. Numerous studies have shown increased OC levels in bone formation. However, increased OC level relates more t...
Dental implants have shown a high success rate for rehabilitation of edentulous patients if certain conditions are met during treatment. Nevertheless, the risk of failure remains difficult to predict. The achievement of osseointegration depends on many factors, such as a suitable host, biocompatible materials, careful surgery, and an appropriate healing time [1].The primary stability comes from th...
Dental implants have shown a high success rate for rehabilitation of edentulous patients if certain conditions are met during treatment. Nevertheless, the risk of failure remains difficult to predict. The achievement of osseointegration depends on many factors, such as a suitable host, biocompatible materials, careful surgery, and an appropriate healing time [1].
The primary stability comes from ...
The purposes of this study were to examine the correlation between the stability of dental implants and bone formation markers during the healing period and to monitor the stability of dental implants using the resonance frequency analysis (RFA) method. The null hypothesis of the study is no correlation between the stability of dental implant and bone formation markers.
The study is a prospective...
Tsegga, T., Wright, T. Maxillary segmental osteoperiosteal flap with simultaneous placement of dental implants: case report of a novel technique.
Int J Implant Dent 3, 2 (2017). https://doi.org/10.1186/s40729-017-0067-5
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Received: 06 December 2016
Accepted: 13 January 2017
Published: 19 January 2017
DOI: https://doi.org/10.1186/s40729-017-0067-5
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Department of Oral & Maxillofacial Surgery, San Antonio Military Medical Center, 3551 Roger Brooke Dr., Ft. Sam Houston, 78234, TX, USA
Tibebu Tsegga & Thomas Wright
Department of Oral & Maxilofacial Surgery, Wilford Hall Ambulatory Surgical Center, 2200 Bergquist Dr, Suite 1, Lackland AFB, TX, 78236, USA
Tibebu Tsegga & Thomas Wright
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Irinakis T. Efficacy of injectable demineralized bone matrix as graft material during sinus elevation surgery with simultaneous implant placement in the posterior maxilla: clinical evaluation of 49 sinuses. J Oral and Maxillofac Surg. 2011;69:134–41.
Chiapasoo M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants. 2009;24:237–69.
Jenson...
This case highlights the evolving variations in dentoalveolar augmentation with an emphasis on concomitant implant placement. In the most traditional sense, a vertical osteoperiosteal flap technique would be bound with a stable basal bone that can be used to anchor simultaneous dental implant placement. Further refinement should consider minimizing crestal reflection and overall labial bone resorp...
A critical appraisal of the gingival architecture in the final end point of this case demonstrates some radiolucency through the soft tissue outlining the platform of the Nobel Biocare TiUnite implant. This would lead us to believe that either the transmucosal bone level placement attempt was inaccurate or excessive reflection of the labial tissue has caused some degree of resorption. This is anot...
A suitable alternative surgical management of this particular case might have been to simply perform an alveoloplasty to produce the desired inter-occlusal clearance and proceed with placement of implant and simultaneous direct sinus lift. That would have left more of the apical portion of the implant within the grafted sinus and possibly modified the location of keratinized band of tissue. The lo...
A 35-year-old female with a 10-year history of partial acquired edentulism at site numbers 3 and 4 presented to our clinic for dental implant evaluation. Preoperative clinical examination revealed a reproducible intercuspation, well-delineated band of keratinized tissue, and decreased inter-occlusal clearance to allow for optimal dimension of prosthetic crowns (Fig. 1). Radiographs demonstrated e...
Obtaining proper occlusal clearance to allow for a single unit crown restoration is a fundamental prerequisite for dental implant restoration. Long-standing edentulous sites are often fraught with disuse atrophy and unopposed supra-eruption of the opposing dentition. In the posterior maxillae/mandible, there are vital structures that have to be mobilized in order to allow space for either bone tra...
Dental restorative space from the opposing dentition requires adequate distance for restorative material for an acceptable restoration. Typically, long-standing edentulous alveolar ridges will have vertical and or horizontal defects that require alveolar ridge augmentation for ideal dental implant restorations. Along with these defects, one will see the opposing dentition supra erupt which can obl...
Parmigiani-Izquierdo, J.M., Cabaña-Muñoz, M.E., Merino, J.J. et al. Zirconia implants and peek restorations for the replacement of upper molars.
Int J Implant Dent 3, 5 (2017). https://doi.org/10.1186/s40729-016-0062-2
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Received: 13 October 2016
Accepted: 22 December 2016
Published: 20 February 2017
DOI: https://doi.org/10.1186/s40729-016-0062-2
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Periodontics Unit, Faculty of Medicine and Dentistry, University of Murcia (Spain), Murcia, Spain
Arturo Sánchez-Pérez
Clínica CIROM, Murcia, 30001, Spain
José María Parmigiani-Izquierdo, María Eugenia Cabaña-Muñoz & José Joaquín Merino
Clínica Odontologíca Universitaria, Hospital Morales Meseguer, 2ª planta, C/ Marqués de los Vélez s/n, Murcia, 30008, Spain
Arturo Sánchez-...
Bormann K-H, Gellrich N-C, Kniha H, Dard M, Wieland M, Gahlert M. Biomechanical evaluation of a microstructured zirconia implant by a removal torque comparison with a standard Ti-SLA implant. Clin oral implants res. 2012;23:1210–6.
Oliva J, Oliva X, Oliva JD. One-year follow-up of first consecutive 100 zirconia dental implants in humans: a comparison of 2 different rough surfaces. Int j oral ma...
Brånemark PI, Hansson BO, Adell R, Breine U, Lindström J, Hallén O, et al. Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period. Scand j plast reconstr surg suppl. 1977;16:1–132.
Parmigiani-Izquierdo JM. TécnicaAtraumática en Implantología. Rev esp odontoestomatológica implant. 11:30–5.
Parmigiani-Izquierdo JM, Sánchez-Pérez A, Cabaña-Mu...
Zirconia implants with PEEK restorations can be considered a good alternative for replacing natural teeth. Their biocompatibility and biostability make them a promising material for those patients who suffer from allergies and sensitivity to metal alloys.
PEEK restorations are a valid and alternative recommendation when using zirconia implants because of their cushioning effect and elastic modulu...
In addition to PEEK, new coatings based on PMMA or composite materials (Anaxblent®Anaxdent®, Nexco®Ivoclar®, Solidex®Shofu®, Novo.lign®Bredent®, etc.) which incorporate ceramic fillings have been developed. Due to their molecular structure, these materials have excellent density and homogeneity [24]. The micro filling integrated into the polymer matrix increases abrasion resistance, at the...
In terms of the load-cushioning capacity of the prosthetic elements, the use of PEEK as a prosthetic structure on implants has increased in recent years [14]. PEEK is a high-density thermoplastic polymer with a linear aromatic semi-crystalline structure that has exceptional physical and chemical properties as regards toughness, hardness and elasticity. Also, its low molecular weight, combined with...
Fifteen days after surgery, the appearance of the soft tissue was excellent, with no signs of inflammation in the mucosa. The patient mentioned the absence of bleeding and pain during the post-operation period. At the same time, we made a clinical and radiological evaluation. Three months after surgery, the stumps of the implants were carved to improve their parallelism with a special diamond dril...
A patient who is a 45-year-old woman and non-smoker has no medical record of interest. The patient complained of pain in the right second upper molar. She said that she felt intense pain while chewing. The pain was accentuated with occlusion and while chewing, making normal functioning impossible. The patient mentioned the absence of piece 16, which had been extracted 8 years previously.
Clinica...
In the field of implant dentistry, the most widely used implants over the past 40 years are those manufactured from titanium [1], which are still the most popular.
The recent demands for materials without metal alloys in dentistry, together with the increased sensitivity and allergies of some patients, have promoted the development of new materials.
An example of this is zirconia-based dental i...
One of the disadvantages of the zirconia implants is the lack of elasticity, which is increased with the use of ceramic or zirconia crowns. The consequences that could result from this lack of elasticity have led to the search for new materials with improved mechanical properties.
A patient who is a 45-year-old woman, non-smoker and has no medical record of interest with a longitudinal fracture i...
Fig. 4. Comparative illustration of mean ISQ values
Fig. 4. Comparative illustration of mean ISQ values
Fig. 3. Implants were placed after application of CGF membrane
Fig. 3. Implants were placed after application of CGF membrane
Fig. 2. CGF membrane was applied in study group implant sockets
Fig. 2. CGF membrane was applied in study group implant sockets
Fig. 1. CGF was obtained after centrifugation
Fig. 1. CGF was obtained after centrifugation
Control group
Study group
Immediate–1st week
−2.25 ± 1.713
1.40 ± 1.847
Immediate–4th wee...
Control group
Study group
Immediate
75.75 ± 5.552
78.00 ± 2.828
1st week
...
Case no.
Age
Sex
Group
Implant number
1
20
...
Pirpir, C., Yilmaz, O., Candirli, C. et al. Evaluation of effectiveness of concentrated growth factor on osseointegration.
Int J Implant Dent 3, 7 (2017). https://doi.org/10.1186/s40729-017-0069-3
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Received: 16 December 2016
Accepted: 16 February 2017
Published: 03 March 2017
DOI: https://doi.org/10.1186/s40729-017-0069-3
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Karadeniz Technical University, Trabzon, Turkey
Cagasan Pirpir, Onur Yilmaz, Celal Candirli & Emre Balaban
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Prakash S, Thakur A. Platelet concentrates: past, present and future. J Maxillofac Oral Surg. 2011;10(1):45–9.
Rodella LF, Favero G, Boninsegna R, Buffoli B, Labanca M, Scari G, et al. Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction. Microsc Res Tech. 2011;74(8):772–7.
Ademokun JA, Chapman C, Dunn J, Lander D, Mair K, Proctor SJ, et al...
Huwiler MA, Pjetursson BE, Bosshardt DD, Salvi GE, Lang NP. Resonance frequency analysis in relation to jawbone characteristics and during early healing of implant installation. Clin Oral Implants Res. 2007;18(3):275–80.
Kroese-Deutman HC, Vehof JW, Spauwen PH, Stoelinga PJ, Jansen JA. Orthotopic bone formation in titanium fiber mesh loaded with platelet-rich plasma and placed in segmental defe...
Nurden AT, Nurden P, Sanchez M, Andia I, Anitua E. Platelets and wound healing. Front Biosci. 2008;13:3532–48.
Anitua E, Sanchez M, Zalduendo MM, de la Fuente M, Prado R, Orive G, et al. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009;42(2):162–70.
He L, Lin Y, Hu X, Zhang Y, Wu H. A comparative study of platelet-rich fibrin (PRF) and ...
Raghavendra S, Wood MC, Taylor TD. Early wound healing around endosseous implants: a review of the literature. Int J Oral Maxillofac Implants. 2005;20(3):425–31.
Oncu E, Bayram B, Kantarci A, Gulsever S, Alaaddinoglu EE. Positive effect of platelet rich fibrin on osseointegration. Med Oral Patol Oral Cir Bucal. 2016;21(5):e601–7.
Anitua E. Plasma rich in growth factors: preliminary results o...
Bone morphogenetic protein
Concentrated growth factor
Computed tomography
Insulin-like growth factor
Platelet-derived growth factor
Platelet-rich fibrin
Platelet-rich plasma
Resonance frequency analysis
Transforming growth factor-β1
Transforming growth factor-β2
Vascular endothelial growth factor
Considering this data, it appears that application of CGF enhanced stability of implants and accelerated osseointegration in the early period. CGF has positive effects on the ISQ value at the first week and fourth week. Further laboratory studies are needed to demonstrate the positive effects of blood products on the osseointegration process at the histopathological level.
In a study by Monov et al. using PRP around the implant, a higher stability value was obtained in the study group during the early recovery period (6 weeks) although difference between the groups was not statistically significant [23]. Kim et al. reported in a study that there was a statistically significant increase in bone-implant contact with PRP administration in the vicinity of the implant [...
Introduced in 1998 by Marx, PRP is used in oral and maxillofacial surgeries to speed up the recovery of grafts in bone-grafted areas [14, 26–30]. Although many studies have shown that platelet-rich plasma affects bone healing positively, the results of some other studies suggest otherwise [31, 32].
In recent years, the platelet-rich fibrin (PRF) was described by Choukroun as a second-generation...
Implant stability is one of the important parameters that assess the loading time and dental implant success. Investigators have recommended that implants with ISQ
The study includes 12 patients (5 males, 7 females). Patients participating in the study are between 20–68 years of age and the mean age is 44 years. A total of 40 implants were placed, 20 of these were included in the study group (50%), and the other 20 were included in the control group (50%). Twenty-one implants were placed in type 2 bone, 19 implants in type 3 bone (Table 1). The distribu...
Independent sample t test was applied between the two groups by taking the differences between the data obtained in these periods. Two-way ANOVA and Fisher’s LSD test was used for evaluating the associations among group and insertion torque.
A value of p
All surgical procedures were performed under local anesthesia by the same surgeon. A full-thickness mucoperiosteal flap was removed by incision on the alveolar crest. Implant cavities were prepared according to the surgical protocol of the Bego Semados implant system (BEGO Implant Systems GmbH & Co. KG, Bremen, Germany). The final osteotomy diameters were the same as the placed implants. In the st...
This study was conducted in compliance with the principles of the Declaration of Helsinki, and approval of the ethics committee required for the study was obtained from the Ethics Committee of the Karadeniz Technical University (2015/21). The procedures to be performed were explained in detail and patients signed the consent forms. The study was carried out on individuals who applied to Karadeniz ...
That the implant has sufficient stability after placement is important for providing the necessary bone formation around the implant and for the optimal distribution of functional forces at the implant-bone interface during healing [15–17].
It can be said that resonance frequency analysis (RFA) is a very important tool for tracking the osseointegration process [18, 19]. RFA is a technique that ...
Osseointegration of dental implants is important for long-term success and stability. There is no standardization in terms of the time of osseointegration and the timing of prosthetic loading. This process varies between 0–6 months [1]. Various strategies are being explored to shorten this period. Changes in implant surface properties and design have increased primer stability and helped the pe...
Growth factor-containing products have been reported to increase implant stability and accelerate osseointegration. Concentrated growth factor (CGF) can be used for this purpose with the growth factors it contains. The aim of this study is to assess the effect of CGF on implant stability and osseointegration.
Twelve patients with maxillary anterior toothless were included in the study. Implant ca...
Dattani, A., Richardson, D. & Butterworth, C.J. A novel report on the use of an oncology zygomatic implant-retained maxillary obturator in a paediatric patient.
Int J Implant Dent 3, 9 (2017). https://doi.org/10.1186/s40729-017-0073-7
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Received: 24 November 2016
Accepted: 26 February 2017
Published: 28 March 2017
DOI: https://doi.org/10.1186/s40729-017-00...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Oral and Maxillofacial Surgery, Regional Maxillofacial Unit, University Hospital Aintree, Liverpool, UK
Amit Dattani
Maxillofacial Surgery, Regional Craniofacial Unit, Alder Hey Children’s Hospital, Liverpool, UK
David Richardson
Maxillofacial Prosthodontics, Regional Maxillofacial Unit, University Hospital Aintree, Longmoor Lane, Liverpool, L9 7AL, UK
Chris J. Butterworth
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Brown JS, Shaw RJ. Reconstruction of the maxilla and midface: introducing a new classification. Lancet Oncol. 2010;11(10):1001–8.
Breeze J, Rennie A, Morrison A, Dawson D, Tipper J, Rehman K, et al. Health-related quality of life after maxillectomy: obturator rehabilitation compared with flap reconstruction. Br J Oral Maxillofac Surg. 2016;54(8):857–62.
Kim SM, Park MW, Cho YA, Myoung H, Lee...
The use of zygomatic implants to supplement the stability and retention of the maxillary obturator in this case has improved the function of the prosthesis and provided for a very high-quality rehabilitation for the patient reported with no evidence of disruption to facial growth in the 22 months following surgery.
The use of modified zygomatic implants (Fig. 1) allows improved hygiene by the patient of the implants within the maxillary defect. The threaded portion of the implants is fully engaged into the bone with only the smooth portion protruding into the defect. Clearly this ongoing hygiene by the patient is of utmost importance in preventing peri-implant soft and hard tissue changes, but the implant d...
The difficulty of restoration with a maxillary obturator prosthesis depends on the extent of the surgical resection, with the acceptance that resections with an increasing horizontal component provide a much greater prosthodontic challenge. The number of remaining teeth is a key component in conventional obturator design [9] with the remaining dentition being used exclusively to retain the prosthe...
The paediatric population rarely suffer malignant disease of the oral cavity requiring any form of maxillectomy, and there is little published evidence around the rehabilitation and restorative management of children undergoing such procedures. The seemingly most common approach for a limited low-level maxillary resection in a child would be to consider resection and simple prosthetic obturation a...
Four weeks later, the patient was returned to the operating room for removal and modification of the obturator. The cavity was healing well, and both implants were firm with no evidence of infection. The initial obturator was modified with the application of a soft lining material and the patient subsequently discharged with instructions on the insertion and removal of the obturator.
At the 12-we...
A medically fit and well 13-year 11-month-old male was referred to the oral and maxillofacial surgery department at Alder Hey Children’s Hospital in Liverpool in regard to an intra-oral swelling of the right palatal region (Fig. 2). An incisional biopsy was initially reported as a pleomorphic adenoma of the premolar region. Subsequently, a CT scan showed no significant bony abnormality, and a w...
The characteristics of a good obturator will improve swallowing, speech function, minimise nasal fluid leakage from the antrum and nasal spaces, restore facial aesthetics including the teeth and facilitate masticatory function and speech. A surgical obturator can be provided at the time of surgery to facilitate function and haemostasis in the immediate post-operative period, and this can subsequen...
Maxillary defects of acquired [1] or congenital origin produce a communication between the oral and nasal cavities sometimes via an opening into the maxillary antrum and by direct communication into the nose. This in turn can result in masticatory compromise, swallowing and speech impairment, nasal fluid regurgitation and aesthetic concerns. The management of the maxillectomy patient is a complex ...
This report details the use of zygomatic oncology osseointegrated implants to support and retain a maxillary obturator in a 13-year-old male patient who underwent a right-sided hemi-maxillectomy (Brown Class 2b) (Brown and Shaw, Lancet Oncol 11:1001–8, 2010) for a myxoid spindle cell carcinoma. At the time of maxillary resection, two zygomatic oncology implants were inserted into the right zygom...
Zushi, Y., Takaoka, K., Tamaoka, J. et al. Treatment with teriparatide for advanced bisphosphonate-related osteonecrosis of the jaw around dental implants: a case report.
Int J Implant Dent 3, 11 (2017). https://doi.org/10.1186/s40729-017-0074-6
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Received: 06 December 2016
Accepted: 12 February 2017
Published: 30 March 2017
DOI: https://doi.org/10.1186/s4...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Department of Oral and Maxillofacial Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan
Yusuke Zushi, Kazuki Takaoka, Joji Tamaoka, Miho Ueta, Kazuma Noguchi & Hiromitsu Kishimoto
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Stanton DC, Balasanian E. Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases. J Oral Maxillofac Surg. 2009;67:943–50.Carlson ER, Basile JD. The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2009;67:85–95.Wilde F, Heufelder M, Winter K, et al. The role of surg...
Stanton DC, Balasanian E. Outcome of surgical management of bisphosphonate-related osteonecrosis of the jaws: review of 33 surgical cases. J Oral Maxillofac Surg. 2009;67:943–50.
Carlson ER, Basile JD. The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2009;67:85–95.
Wilde F, Heufelder M, Winter K, et al. The role of ...
Grant BT, Amenedo C, Freeman K, Kraut RA. Outcomes of placing dental implants in patients taking oral bisphosphonates: a review of 115 cases. J Oral Maxillofac Surg. 2008;66:223–30.
Goss A, Bartold M, Sambrook P, Hawker P. The nature and frequency of bisphosphonate-associated osteonecrosis of the jaws in dental implant patients: a South Australian case series. J Oral Maxillofac Surg. 2010;68:33...
Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61:1115–7.
Marx RE, Sawatari J, Fortin M, et al. Bisphosphonate-induced exposed bone (osteonecrosis/osteopetrosis) of the jaws; risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg. 2005;63:1567.
Harper RP, Fung E. Resolution of...
We have reported a case of a severely osteoporotic elderly woman with BRONJ around her dental implants, who was treated successfully with teriparatide. Teriparatide therapy appeared to exert beneficial effects in this patient.
It is therefore important that all patients treated with oral BPs must be given a full explanation of the potential risks of implant failure and BRONJ development in the short and long term. Because the potential role of infection in implant failure and BRONJ occurrence is still debated, great attention should be paid to the long-term oral hygiene and plaque control of implant-prosthetic restorati...
We describe a case of a patient with a 6-year history of alendronate therapy, in which BRONJ developed around her dental implants. In this patient, the dental implants achieved successful osseointegration, and BRONJ occurred after the second surgery. Several factors could have played a role in the development of BRONJ in this patient. Glucocorticoid therapy is associated with an increased risk of ...
In November 2011, after a consultation with an osteoporosis expert at the Orthopedic Medicine Clinic of our hospital, alendronate therapy was stopped and subcutaneous teriparatide therapy at a dose of 20 μg per day was started. During the course of the teriparatide therapy, the patient continued to use 0.02% benzalkonium chloride solution for local irrigation.
In April 2012, after 5 months of ...
A 66-year-old woman was referred to the Oral and Maxillofacial Surgery Clinic at Hyogo College of Medicine Hospital, Japan, in September 2011, for an extraoral fistula and refractory pain of the right mandible associated with a purulent discharge and soft tissue swelling. The patient’s osteoporosis was diagnosed in 2005 and treated with 35 mg of alendronate weekly by the family doctor. The pati...
Oral bisphosphonates (BPs) are used to treat osteoporosis, Paget’s disease, and osteogenesis imperfecta. They are most widely used for treatment of osteoporosis. BP-related osteonecrosis of the jaw (BRONJ) was first reported by Marx in 2003 [1]. The risk of BRONJ in osteoporotic patients treated with BPs remains low compared with that of oncology patients [2]. Recent studies have indicated that ...
We report a case of a 66-year-old severely osteoporotic woman with bisphosphonate-related osteonecrosis of the jaw (BRONJ) around her dental implants, who was treated successfully with teriparatide and sequestrectomy of the mandible. After 5 months of teriparatide therapy, the sequestrum separation had progressed and a sequestrectomy was performed under general anesthesia. Five months after the o...
Fig. 2. xillary sinus) and b, c examples of corresponding images in cone beam computed tomography
Fig. 2. a Panoramic radiography with area of interest (maxillary sinus) and b, c examples of corresponding images in cone beam computed tomography
Fig. 1. maxillary sinus) and b, c examples of corresponding images in cone beam computed tomography
Fig. 1. a Panoramic radiography with area of interest (maxillary sinus) and b, c examples of corresponding images in cone beam computed tomography
Question
General practitioner (n = 2)
Junior maxillofacial surgeon (n = 2)
Senior maxillofacial surgeon (n = 3)
p value*
...
Additional incidental findings in panoramic radiography
Relative incidence (%) in relation to total number of therapy affecting findings
Retained third molar/follicular cyst
22
...
Number of cases
General practitioner (n = 2)
Junior maxillofacial surgeon (n = 2)
Senior maxillofacial surgeon (n = 3)
p value*
...
Question
General practitioner (n = 2)
Junior maxillofacial surgeon (n = 2)
Senior maxillofacial surgeon (n = 3)
p value*
...
Question
General practitioner (n = 2)
Junior maxillofacial surgeon (n = 2)
Senior maxillofacial surgeon (n = 3)
p value*
...
Dau, M., Marciak, P., Al-Nawas, B. et al. Evaluation of symptomatic maxillary sinus pathologies using panoramic radiography and cone beam computed tomography—influence of professional training.
Int J Implant Dent 3, 13 (2017). https://doi.org/10.1186/s40729-017-0075-5
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Received: 10 December 2016
Accepted: 12 March 2017
Published: 05 April 2017
DOI: http...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Department of Oral, Maxillofacial and Plastic Surgery, University Medical Center, Schillingallee 35, 18057, Rostock, Germany
Michael Dau, Bernhard Frerich & Peer Wolfgang Kämmerer
Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre, Mainz, Germany
Paul Marciak & Bial Al-Nawas
Private Dental Praxis Dr. Rossa, Ludwigshafen, Germany
Henning Staedt
Depa...
Quintero JC, et al. Craniofacial imaging in orthodontics: historical perspective, current status, and future developments. Angle Orthod. 1999;69(6):491–506.
Tadinada A, et al. Radiographic evaluation of the maxillary sinus prior to dental implant therapy: a comparison between two-dimensional and three-dimensional radiographic imaging. Imaging Sci Dent. 2015;45(3):169–74.
Ritter L, et al. Pre...
Rivis M, Valeanu AN. Giant maxillary cyst with intrasinusal evolution. Rom J Morphol Embryol. 2013;54(3 Suppl):889–92.
Yilmaz SY, Misirlioglu M, Adisen MZ. A diagnosis of maxillary sinus fracture with cone-beam CT: case report and literature review. Craniomaxillofac Trauma Reconstr. 2014;7(2):85–91.
Lana JP, et al. Anatomic variations and lesions of the maxillary sinus detected in cone beam ...
Gang TI, et al. The effect of radiographic imaging modalities and the observer’s experience on postoperative maxillary cyst assessment. Imaging Sci Dent. 2014;44(4):301–5.
Batra PS, et al. Computed tomography imaging practice patterns in adult chronic rhinosinusitis: survey of the American Academy of Otolaryngology-Head and Neck Surgery and American Rhinologic Society Membership. Int Forum Al...
Dragan E, et al. Maxillary sinus anatomic and pathologic CT findings in edentulous patients scheduled for sinus augmentation. Rev Med Chir Soc Med Nat Iasi. 2014;118(4):1114–21.
Raghav M, et al. Prevalence of incidental maxillary sinus pathologies in dental patients on cone-beam computed tomographic images. Contemp Clin Dent. 2014;5(3):361–5.
Lyros I, et al. An incidental finding on a diagno...
Depending on the observers’ clinical and radiological experience, PAN alone may not be sufficient for evaluation of pathologies of the maxillary sinus. On the contrary, significant benefits of sFOV-CBCT for diagnosing symptomatic maxillary sinus pathologies were reported. Having sFOV-CBCT seems to have added additional information and confidence in comparison to PAN alone. Nonetheless, also with...
The influence of clinical experience of evaluation of PAN [34] as well as the clinical experience and routine analysis of 3D radiographs (as assumed for maxillofacial surgeons when compared to those for general practitioners) strongly influence the diagnostic value of additional three-dimensional imaging. The number of incidental findings in CBCT in addition to those seen in PAN was not of major d...
In dentistry, PAN is a widely available, useful, and important diagnostic tool for diagnosis and general preoperative planning [32] with less radiation exposure then CBCT [21]. While most dentists have used it routinely successful for years and gained significant experience in doing so [33], there are certain limitations in dependence of the region to be examined [10]. The high number of “not vi...
This study focused on three different aspects in our analysis—PAN, PAN and CBCT, as well as the influence of the different clinical and radiological experience (examples in Figs. 1 and 2).
Panoramic radiography (PAN)
When assessing PAN, the ratings were significantly lower at “good visible and can be evaluated” (9.9%) compared to “visible but cannot be evaluated” (39.5%; p
The first question for PAN addressed the imaging quality in the clinical relevant area of interest (clinical data were given). Three answers were possible: 1 = good visibility and can be evaluated, 2 = visible but cannot be evaluated, and 3 = not visible. The second question asked for an additional need for CBCT scans. Three answers were possible: 1 = required, 2 = reasonable, and 3 = not required...
In an experimental diagnostic comparison, radiographic images of 15 female and 13 male patients were assessed. Patients’ radiographs were selected from the Department of Oral, Maxillofacial and Facial Plastic Surgery of the University Medical Centre of Mainz and Rostock, Germany. All patients have had referrals to the hospitals with symptomatic maxillary sinus pathologies and received PAN (Ortho...
In order to justify CBCT use for clinical examination and diagnosis of the maxillary sinus, the aim of this study was to compare the subjective quality rating of PAN and PAN together with a small field of view (sFOV) CBCT to evaluate symptomatic maxillary sinus by clinicians with different training and clinical experience.
Non-symptomatic abnormalities of the maxillary sinus such as mucosal thickening, retention cysts, and opacification are reported to occur in up to 74% of all cases [1–6]. For diagnosis of symptomatic pathologies of the maxillary sinus like retention cysts, polyps, and tumors, panoramic radiographies (PAN) are commonly used and widely available. In PAN, not every area of interest is accurately de...
A comparison of panoramic radiography (PAN) alone and PAN together with small field of view cone beam computed tomography (sFOV-CBCT) for diagnosis of symptomatic pathologies of the maxillary sinus was carried out by clinicians of different experience.
Corresponding radiographic images (PAN/sFOV-CBCT) of 28 patients with symptomatic maxillary sinus pathologies were chosen and analyzed by two gene...
Fig. 6. Micro CT scan images of the MDIs and Ankylos® embedded in rabbit bone 6 weeks post implantation
Fig. 6. Micro CT scan images of the MDIs and Ankylos® embedded in rabbit bone 6 weeks post implantation
Fig. 5. Histological section of standard implant in rabbit tibia stained with methylene blue and basic fuchsin
Fig. 5. Histological section of standard implant in rabbit tibia stained with methylene blue and basic fuchsin
Fig. 4. Histological section of mini dental implant in rabbit tibia stained with methylene blue and basic fuchsin
Fig. 4. Histological section of mini dental implant in rabbit tibia stained with methylene blue and basic fuchsin
Fig. 3. Histological sections being obtained with Leica SP 1600 saw microtome
Fig. 3. Histological sections being obtained with Leica SP 1600 saw microtome
Fig. 2. Leica SP 1600 saw microtome
Fig. 2. Leica SP 1600 saw microtome
Fig. 1. Radiograph showing implants in the rabbit tibia
Fig. 1. Radiograph showing implants in the rabbit tibia
BIC
3M™ ESPE™ MDIs
Ankylos® Friadent (Dentsply)
Median
58.5
57
...
Sample
3M™ESPE™ MDIs
Ankylos®
1.
67
54
2.
...
Dhaliwal, J.S., Albuquerque, R.F., Murshed, M. et al. Osseointegration of standard and mini dental implants: a histomorphometric comparison.
Int J Implant Dent 3, 15 (2017). https://doi.org/10.1186/s40729-017-0079-1Download citationReceived: 22 February 2017Accepted: 26 April 2017Published: 01 May 2017DOI: https://doi.org/10.1186/s40729-017-0079-1
Dhaliwal, J.S., Albuquerque, R.F., Murshed, M. et al. Osseointegration of standard and mini dental implants: a histomorphometric comparison.
Int J Implant Dent 3, 15 (2017). https://doi.org/10.1186/s40729-017-0079-1
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Received: 22 February 2017
Accepted: 26 April 2017
Published: 01 May 2017
DOI: https://doi.org/10.1186/s40729-017-0079-1
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
This article was ammended to correct discrpencies in the Abstract. An erratum has also been published for this manuscript.
An erratum to this article is available at http://dx.doi.org/10.1186/s40729-017-0088-0.
Faculty of Dentistry, McGill University, 2001 McGill College Avenue, Suite 500, Montreal, Quebec, H3A 1G1, Canada
Jagjit S. Dhaliwal, Monzur Murshed & Jocelyne S. Feine
Faculty of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil
Rubens F. Albuquerque Jr
Department of Medicine, McGill University, Montreal, Quebec, Canada
Monzur Murshed
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Schwartz Z, Lohmann CH, Oefinger J, Bonewald LF, Dean DD, Boyan BD. Implant surface characteristics modulate differentiation behavior of cells in the osteoblastic lineage. Adv Dent Res. 1999;13:38–48.
Boyan BD, Lossdorfer S, Wang L, Zhao G, Lohmann CH, Cochran DL, et al. Osteoblasts generate an osteogenic microenvironment when grown on surfaces with rough microtopographies. Eur Cell Mater. 2003...
Hayakawa T, Yoshinari M, Kiba H, Yamamoto H, Nemoto K, Jansen JA. Trabecular bone response to surface roughened and calcium phosphate (Ca-P) coated titanium implants. Biomaterials. 2002;23(4):1025–31.
Sul YT, Byon ES, Jeong Y. Biomechanical measurements of calcium-incorporated oxidized implants in rabbit bone: effect of calcium surface chemistry of a novel implant. Clin Implant Dent Relat Res. ...
Park JW, Kim HK, Kim YJ, An CH, Hanawa T. Enhanced osteoconductivity of micro-structured titanium implants (XiVE S CELLplus) by addition of surface calcium chemistry: a histomorphometric study in the rabbit femur. Clin Oral Implants Res. 2009;20(7):684–90.
Yang GL, He FM, Yang XF, Wang XX, Zhao SF. Bone responses to titanium implants surface-roughened by sandblasted and double etched treatments...
Buser D, Schenk RK, Steinemann S, Fiorellini JP, Fox CH, Stich H. Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs. J Biomed Mater Res. 1991;25(7):889–902.
Gotfredsen K, Wennerberg A, Johansson C, Skovgaard LT, Hjorting-Hansen E. Anchorage of TiO2-blasted, HA-coated, and machined implants: an experimental study with rabbi...
Trisi P, Lazzara R, Rao W, Rebaudi A. Bone-implant contact and bone quality: evaluation of expected and actual bone contact on machined and osseotite implant surfaces. Int J Periodontics Restorative Dent. 2002;22(6):535–45.
Froum SJ, Simon H, Cho SC, Elian N, Rohrer MD, Tarnow DP. Histologic evaluation of bone-implant contact of immediately loaded transitional implants after 6 to 27 months. In...
Hong RK, Heo JM, Ha YK. Lever-arm and mini-implant system for anterior torque control during retraction in lingual orthodontic treatment. Angle Orthod. 2005;75(1):129–41.
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Siddiqui AA, Sosovicka M, Go...
Branemark PI, Adell R, Breine U, Hansson BO, Lindstrom J, Ohlsson A. Intra-osseous anchorage of dental prostheses. I. Experimental studies. Scand J Plast Reconstr Surg. 1969;3(2):81–100.
Boerrigter EM, Stegenga B, Raghoebar GM, Boering G. Patient satisfaction and chewing ability with implant-retained mandibular overdentures: a comparison with new complete dentures with or without preprosthetic ...
The results of this study show that MDIs as well as regular implants osseointegrate in rabbits.
Our study is also in concordance with the results of a removal torque study by Simon et al. [63] in immediately loaded “transitional endosseous implants” in humans. The percentage BIC for MDIs was similar to standard implants.
The surface topography also affects the BIC, Wennerberg et al. [32] measured and compared removal torque values on screw-shaped titanium implants with three surface typ...
The osseointegration potential of 3M™ESPE™ MDIs has not been studied. The MDI is a one-piece implant that simplifies the restorative phase resulting in a reduced cost for the patient. Titanium-aluminum-vanadium alloy (Ti 6Al-4V-ELI) is used for increased strength. The success of these implants led to its use in long-term fixed and removable dental prostheses [51]. Conventional implant treatmen...
On the whole, postoperative wound healing in all the rabbits was good. None of them exhibited any signs of wound infection or exposure. A total of 36 specimens were retrieved for histological examination.
All of the implants in both groups showed osseointegration and displayed a good amount of bone contact length (Figs. 4 and 5). No discernible differences were noticed between both the groups. T...
The saw blade has a thickness of 280 μm and a feed of 310 μm was selected to obtain the final section thickness of 30 μm. The knurled screw was used for the setting of the section thickness. The prepared section was finally removed from the saw blade. The specimens were prepared for histology by the method as described by Donath and Breuner [49].
Subsequently, the sections were stained with...
The specimens were dehydrated in the ascending graded ethanol solution and kept in a pre-filtration solution for 3 h at room temperature and then in the filtration solution at 4 °C for 17 h. The specimens were then embedded in a light curing resin Technovit 9100 NEW (Kulzer & Co., Wehrheim, Germany) polymerization system based on methyl methacrylate, specially developed for embedding mineraliz...
Expected length of the procedure was approximately 1 h. Following placement of the implants, the wound was sutured in layers. The underlying muscle, fascia, and dermal layers were sutured with the help of Vicryl (Polyglactin 910) suture with 3/8 circle reverse cutting needle. The skin was sutured to a primary closer with the same suture material.
Plain X-ray images of all the rabbit tibia were t...
A small longitudinal skin incision just distal to the tibia-femur joint was made. The tibia/femur head was exposed subperiosteally and an osteotomy performed with the delicately placed pilot drill over the entry point and lightly pumped up and down under copius saline irrigation just to enter the cortical bone for the MDIs. This was used for initial bone drilling to depth of 0.5 mm. The 3M™ESPE...
Nine clinically healthy New Zealand white rabbits weighing 3.5 kg and more were used for the study, and the animals were housed in the central animal house facility. The head of tibia/femur of the animals were used for the implantation of samples. Rabbits’ tibiae and femur have been widely used as an animal model by various other authors to study osseointegration of dental implants [36–45].
...
Despite the advantages of the mini dental implants, evidence on their efficacy and long-term success is lacking. The success of these implants will depend on their union with the surrounding bone. New implant systems entering into the market have to be studied with the help of animal models first, to demonstrate the osseointegration potential for their probable success in humans. There is a limite...
The term “osseointegration” was first introduced to explain the phenomenon for stable fixation of titanium to bone by Brånemark et al. in the 1960s [1]. Osseointegrated implants were introduced, a new era in oral rehabilitation began, and many studies were conducted [2, 3]. A success rate of over 90% has been reported [4, 5]. Further, a success rate of 81% in the maxillary bone and 91% in the...
Mini dental implants (MDIs) are becoming increasingly popular for rehabilitation of edentulous patients because of their several advantages. However, there is a lack of evidence on the osseointegration potential of the MDIs. The objective of the study was to histomorphometrically evaluate and compare bone apposition on the surface of MDIs and standard implants in a rabbit model.
Nine New Zealand ...
Fig. 3. Enzymatic degradability of A-PRF, CGF, and PPTF membranes. Each membrane disk (φ8 mm, 1 mm thick) was immersed in PBS containing trypsin and incubated in a CO2 incubator. N = 4. The asterisks represent significant differences (P
Fig. 2. Representative stress-strain curves for A-PRF and CGF membranes and mechanical properties (Young’s modulus, strain at break, and maximum stress) of A-PRF, CGF, and PPTF membranes. N = 3–9
Fig. 2. Representative stress-strain curves for A-PRF and CGF membranes and mechanical properties (Young’s modulus, strain at break, and maximum stress) of A-PRF, CGF, and PPTF membranes. N...
Fig. 1. Surface microstructures of A-PRF, CGF, and fibrin clots prepared by PPP + CaCl2 and PPTF (fibrin clots prepared by PPP and thrombin). Similar observations were obtained from other three independent blood samples. Scale bar = 10 μm. Note: the same magnification (×9000) was used in all the SEM images shown here
Fig. 1. Surface microstructures of A-PRF, CGF, and fibrin clots p...
A-PRF
CGF
PPTF
Centrifugal conditions
198 g × 8 min
692 g × 2 mina
...
Wet weight (g)
Dry weight (g)
Water content (%)
A-PRF
1.905 ± 0.416
0.043 ± 0.014*
...
Size (W × L mm)
Stretching (times longer)
Number
A-PRF
8.6 ± 1.2 × 27.5 ± 3.5
...
Isobe, K., Watanebe, T., Kawabata, H. et al. Mechanical and degradation properties of advanced platelet-rich fibrin (A-PRF), concentrated growth factors (CGF), and platelet-poor plasma-derived fibrin (PPTF).
Int J Implant Dent 3, 17 (2017). https://doi.org/10.1186/s40729-017-0081-7
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Received: 29 January 2017
Accepted: 25 April 2017
Published: 02 May 2017
...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
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Correspondence to
Tomoyuki Kawa...
Tokyo Plastic Dental Society, Kita-ku, Tokyo, Japan
Kazushige Isobe, Taisuke Watanebe, Hideo Kawabata, Yutaka Kitamura, Toshimitsu Okudera & Hajime Okudera
Division of Dental Implantology, Niigata University Medical and Dental Hospital, Niigata, Japan
Kohya Uematsu
Division of Periodontology, Institute of Medicine and Dentistry, Niigata University, Niigata, Japan
Kazuhiro Okuda
Bioscie...
Mosesson MW. Fibrinogen and fibrin structure and functions. J Thromb Haemost. 2005;3:1894–904.
Kawase T, Kamiya M, Kobayashi M, Tanaka T, Okuda K, Wolff LF, Yoshie H. The heat-compression technique for the conversion of platelet-rich fibrin preparation to a barrier membrane with a reduced rate of biodegradation. J Biomed Mater Res B Appl Biomater. 2015;103:825–31.
Hartshorne J, Gluckman H. A...
Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJ, Mouhyi J, Dohan DM. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part V: histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:299–303.
Kawase T. Platelet-rich plasma and its derivatives as promising bioac...
Acid citrate dextrose solution
Advanced platelet-rich fibrin
Concentrated growth factors
Platelet-poor plasma-derived, thrombin-activated fibrin
Platelet-rich plasma
In the mechanical parameters and degradability we tested, CGF membranes were almost identical to A-PRF membranes. In contrast, PPTF membranes were mechanically weaker and highly degradable. Therefore, we conclude that all of these fibrin membranes are tough enough to serve as barrier membranes; however, we should pay attention to their degradability and choose an appropriate membrane type dependin...
Growth factor release is a key function of these fibrin clots for tissue regeneration. Our previous study [16] demonstrated that CGF membranes compressed by the stainless steel compression device contain significantly higher levels of growth factors even after releasing approximately 85% of exudate. Repeated rinsing with PBS failed to completely remove the growth factors from CGF membranes. The ri...
In this study, we found no apparent differences between A-PRF and CGF clot microstructures, especially in fibrin fiber thickness or crosslink density. However, in PPTF clots, which were prepared through direct conversion of fibrinogen by thrombin, fibrin fiber thickness and their crosslink density were substantially thinner and higher, respectively, than those of either A-PTF or CGF clots. This fi...
The main purpose of this study was to compare A-PRF with CGF preparations to find possible differences in mechanical properties. As shown in Table 1, the sizes of A-PRF clots compressed to membranes were 8.6 ± 1.2 mm (W) × 27.5 ± 3.5 mm (L) and very similar to those of CGF clots (8.4 ± 0.8 mm × 27.6 ± 2.5 mm). As reference, PPTF membranes were also prepared by ad...
After pipetting the digestion solution, 50 μL of the digestion solution was collected every 20 min and was stored at −20 °C until protein measurement. Protein levels, which can be considered primarily as levels of digested fibrin fiber, were then determined by a BCA protein assay kit (Takara Bio, Kusatsu, Japan). The protein levels at the time point when the initial fibrin disks were comple...
The mechanical properties of gel sheets were measured at a stretching speed of 1 mm/min with a desktop universal testing machine (EZ test; Shimadzu, Kyoto, Japan), of which maximum load cell capacity was 500 N under standard ambient conditions at 25 ± 3 °C and 50 ± 25% RH. The samples were gripped by clamps at each end (using slip-proof rubber sheets to prevent slippage) such that th...
Blood samples were collected from four non-smoking, healthy, male volunteers with ages ranging from 27 to 56 years. Although having lifestyle-related diseases and receiving medication, these donors had no hindrance in daily life. The study design and consent forms for all procedures performed with the study subjects were approved by the ethical committee for human subjects at Niigata University S...
In this study, we hypothesized that the mechanical properties of the fibrin membrane are closely related to its degradability. We compared these characteristics among A-PRF, CGF, and PPTF membranes through tensile and digestion tests.
Platelet-rich fibrin (PRF), a self-clotted preparation of platelet-concentrated, blood-derived biomaterials, is prepared solely by contact activation of intrinsic coagulation pathways through centrifugation without addition of coagulation factors [1, 2]. Therefore, the preparation protocol is drastically simplified, and the resulting clot can be handled easily with forceps. PRF is further modified...
Fibrin clot membranes prepared from advanced platelet-rich fibrin (A-PRF) or concentrated growth factors (CGF), despite their relatively rapid biodegradability, have been used as bioactive barrier membranes for alveolar bone tissue regeneration. As the membranes degrade, it is thought that the growth factors are gradually released. However, the mechanical and degradable properties of these membran...
Fig. 8. Soft tissue dehiscence (a) CCXBB exposure 15 weeks after bone augmentation, the dehiscence healed 2 weeks later after reducing the graft exposure (b) after soft tissue augmentation and abutment connection leading to the loss of the mesial implant. After partial removal of the bone graft and place a connective tissue graft the area healed properly and a month later it was possible to re...
Fig. 7. Second stage surgery of patient in Fig. 1. a Vestibular depth reduction after augmentation and implant placement. b Partial thickness and apical repositioned flap. c CMX healing and soft tissue dehiscence with CCXBB exposure. d Dehiscence healing after re-contouring and buccal emergency profile. e Buccal aspect of the final restoration. f Buccal ridge contour
Fig. 7. Second stage sur...
Fig. 6. Immunohistochemical analysis of slices from the same sample with four different markers. a TRAP. b OPN. c ALP. d OSC
Fig. 6. Immunohistochemical analysis of slices from the same sample with four different markers. a TRAP. b OPN. c ALP. d OSC
section stained with Levai-Laczkó. b Tissue identification of the ROI. c Closer view aized bone and CCXBB. d Closer view of b
Fig. 5. Histomorphometric analysis of the same sample. a Ground section stained with Levai-Laczkó. b Tissue identification of the ROI. c Closer view a arrow pointing a cement line between new mineralized bone and CCXBB. d Closer view of b
Fig. 4. Histological samples. a CCXBB control without implantation. b Histologic samples with acute inflammatory infiltration. c Histologic sample with limited remaining CCXBB and large bone ingrowth
Fig. 4. Histological samples. a CCXBB control without implantation. b Histologic samples with acute inflammatory infiltration. c Histologic sample with limited remaining CCXBB and large bone ingr...
Fig. 3. Re-entry procedure of patient in Fig. 1. a Buccal aspect of the augmented region. b Horizontal bone augmentation. c Screws and pins removal and bone trephine sampling. d Implants placement and buccal bone width from the implant shoulder. e Primary flap closure. f Implants submerged healing
Fig. 3. Re-entry procedure of patient in Fig. 1. a Buccal aspect of the augmented region. b Ho...
Fig. 2. Lateral bone augmentation of the alveolar crest (a) atrophic ridge. b Perforations and adaptation of the cortical layer. c Shaping, pre-wetting and fixation of CCXBB with titanium screws. d Horizontal contour and peripheral gap between CCXBB and bone layer. e Outlying DBBM filling. f CM stabilized with pins
Fig. 2. Lateral bone augmentation of the alveolar crest (a) atrophic ridge. b ...
Fig. 1. Study chart and follow-up visits
Fig. 1. Study chart and follow-up visits
Differentiated tissues
Implant lost (Yes/no)
Mean
SD
Percentage
SD (%)
...
Patient
TRAP (%)
OPN (%)
ALP (%)
OSC (%)
1
...
Tissue type
Mean
Standard deviation
Median
CI 95%
Mineralized bone
...
Patient
Soft tissue dehiscence
Mineralized bone (%)
CCXBB (%)
Bone marrow (%)
Connect...
Ortiz-Vigón, A., Martinez-Villa, S., Suarez, I. et al. Histomorphometric and immunohistochemical evaluation of collagen containing xenogeneic bone blocks used for lateral bone augmentation in staged implant placement.
Int J Implant Dent 3, 24 (2017). https://doi.org/10.1186/s40729-017-0087-1
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Received: 21 March 2017
Accepted: 12 June 2017
Published: 21 Ju...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
ETEP Research Group, Facultad de Odontología, Universidad Complutense de Madrid, Plaza Ramón y Cajal, 28040, Madrid, Spain
Alberto Ortiz-Vigón, Sergio Martinez-Villa, Iñaki Suarez, Fabio Vignoletti & Mariano Sanz
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We wish to acknowledge the dedication and scientific advise of Prof. Dr. Tord Berglundh on the histological analysis as well as the diligent work in processing the histological samples to Estela Maldonado for the immunohistochemistry and Asal Shikhan and Fernando Muñoz for the histomorphometry. The work of Esperanza Gross on the statistical analysis is highly acknowledged.
This study was partial...
Patti A, Gennari L, Merlotti D, Dotta F, Nuti R. Endocrine actions of osteocalcin. Int J Endocrinol. 2013;2013:846480.
Schwarz F, Herten M, Sager M, Wieland M, Dard M, Becker J. Histological and immunohistochemical analysis of initial and early osseous integration at chemically modified and conventional SLA titanium implants: preliminary results of a pilot study in dogs. Clin Oral Implants Res. 2...
Araujo MG, Linder E, Lindhe J. Bio-Oss collagen in the buccal gap at immediate implants: a 6-month study in the dog. Clin Oral Implants Res. 2011;22:1–8.
Chiapasco M, Colletti G, Coggiola A, Di Martino G, Anello T, Romeo E. Clinical outcome of the use of fresh frozen allogeneic bone grafts for the reconstruction of severely resorbed alveolar ridges: preliminary results of a prospective study. I...
Jeno L, Geza L. A simple differential staining method for semi-thin sections of ossifying cartilage and bone tissues embedded in epoxy resin. Mikroskopie. 1975;31:1–4.
Dias RR, Sehn FP, de Santana Santos T, Silva ER, Chaushu G, Xavier SP. Corticocancellous fresh-frozen allograft bone blocks for augmenting atrophied posterior mandibles in humans. Clin Oral Implants Res. 2016;27:39–46.
Nissan ...
Cremonini CC, Dumas M, Pannuti C, Lima LA, Cavalcanti MG. Assessment of the availability of bone volume for grafting in the donor retromolar region using computed tomography: a pilot study. Int J Oral Maxillofac Implants. 2010;25:374–8.
Nkenke E, Weisbach V, Winckler E, Kessler P, Schultze-Mosgau S, Wiltfang J, et al. Morbidity of harvesting of bone grafts from the iliac crest for preprosthetic...
Sanz M, Vignoletti F. Key aspects on the use of bone substitutes for bone regeneration of edentulous ridges. Dent Mater. 2015;31:640–7.
Benic GI, Hammerle CH. Horizontal bone augmentation by means of guided bone regeneration. Periodontology. 2014;66:13–40.
Beretta M, Cicciu M, Poli PP, Rancitelli D, Bassi G, Grossi GB, et al. A Retrospective Evaluation of 192 Implants Placed in Augmented Bon...
Alkaline phosphatase
Cone beam computed tomography
Collagen containing xenogeneic bone block
Native collagen membrane
Deproteinized bovine bone mineral
Etiology and Therapy of Periodontal Diseases
Osteopontin
Osteocalcine
Tartrate-resistant acid phosphatase
Within the limitations of this clinical study, we may conclude that the use of CCXBB in combination with DBBM particles and a native bilayer collagen membrane for staged lateral bone augmentation in severe atrophic alveolar crests achieved significant horizontal crestal width allowing for staged implant placement in most of the patients. Histological analysis and implant survival records indicate ...
The immune-histochemical results reported expression of osteopontin mainly at the border between mineralized vital bone (MVB) with CCXBB, what coincides with findings from previous reports [38,39,40]. Alkaline phosphatase (ALP) is considered as an early osteoblast differentiation marker [41]. ALP-positive cells were detectable, in all specimens on the periphery of MVB, associated to areas of new b...
When correlating the clinical results and the histological outcomes, there was a positive association between the presence of soft tissue dehiscence with CCXBB exposure and a diminished amount of new mineralized bone (p = 0.06). This lower amount of new bone within the xenogeneic graft suggests a lack of full graft integration and diminished vascular supply, what may have caused the soft tissu...
The purpose of this investigation was to evaluate histologically and immunohistochemically the behavior of CCXBB blocks when used for staged lateral bone augmentation in severe human horizontal residual bone defects. Six months after the regenerative intervention using the CCXBB blocks, the mean increase in bone width was 4.12 mm and hence, this outcome allowed for the placement of dental implant...
The results from the histomorphometric measurements are depicted in Table 2. Bone biopsies were composed by 21.37% (SD 7.36) of residual CCXBB, 26.90% (SD 12.21) of mineralized vital bone (MVB), 47.13% (SD 19.15) of non-mineralized tissue and 0.92% of DBBM (Fig. 5b). Biopsies from patients who lost their implants had a statistical significant lower amount of MVB (p = 0.01u) and a statistical...
Twenty-eight CCXBB blocks were placed in 15 patients that fulfilled the selection criteria (12 women and 3 men) with a mean age of 54.5 (SD 8.34).
The detailed clinical and radiographical outcomes have been reported previously [21]. In brief, one patient experienced pain and soft tissue dehiscence leading to removal of the graft material 3 days after the regenerative procedure. Another patient r...
For the immunohistochemical analysis, the semi-thin sections were incubated over night with primary antibodies at 4 °C (Santa Cruz Biotechnology Inc., Santa Cruz, Calif., USA). The antibody dilutions used were alkaline phosphatase (ALP) 1:100, osteopontin (OPN) 1:100, osteocalcin (OSC) 1:100, and tatrate resistant acid phosphatase (TRAP) 1:100.
The obtained semi-thin sections were evaluated wit...
Twenty-six weeks after the regenerative procedure the patient returned for the re-entry intervention for placement of dental implants. After raising full-thickness flaps, the augmented area was exposed and horizontal crestal width measurements were performed. Then, the surgeon evaluated the bone availability and if implant placement was considered possible, a core bone biopsy was harvested with th...
CCXBB (Bio-Graft® Geistlich Pharma) is a bone substitute material in a natural block form. The dimensions of the Bio-Graft block are 10 mm in height, 10 mm in length and 5 mm in width. It consists of a natural cancellous bone structure of hydroxyapatite and endogenous collagen type I and III, equine origin and is a class III medical device according to the Medical Device Directive 93/42 EECs...
The present manuscript reports the histological outcomes of a prospective single arm study evaluating the safety and clinical performance of CCXBB blocks when used as replacement bone grafts for lateral bone augmentation prior to staged implant placement. The results of the clinical and radiographic outcomes have been reported in a previous publication [21]. For correlation of the histological wit...
Different techniques and grafting materials have been used for the horizontal reconstruction of deficient alveolar processes before implant placement, resulting in different degrees of predictability and clinical outcomes [1]. Among the grafting materials, particulated xenogeneic materials have been extensively studied in both experimental and clinical studies and when combined with porcine-derive...
The osteoconductive properties of collagen containing xenogeneic bone blocks (CCXBB) remain unclear. The aim of this prospective single-arm clinical study was to assess the histological outcomes of CCXBB blocks used as bone replacement grafts for lateral bone augmentation procedures.
In 15 patients with severe horizontal alveolar ridge resorption, lateral augmentation procedures were performed us...
Sagheb, K., Schiegnitz, E., Moergel, M. et al. Clinical outcome of alveolar ridge augmentation with individualized CAD-CAM-produced titanium mesh.
Int J Implant Dent 3, 36 (2017). https://doi.org/10.1186/s40729-017-0097-z
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Received: 15 March 2017
Accepted: 13 July 2017
Published: 26 July 2017
DOI: https://doi.org/10.1186/s40729-017-0097-z
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Keyvan Sagheb reports personal fees and grants from Dentsply, Geistlich, and Nobel Biocare outside the submitted work. Eik Schiegnitz reports personal fees and grants from Septodont, Dentsply, Geistlich, and Straumann outside the submitted work. Maximilian Moergel reports grants from Camlog outside the submitted work. Christian Walter reports grants and personal fees from Straumann outside the sub...
Correspondence to
E. Schiegnitz.
K. Sagheb and E. Schiegnitz contributed equally to this work.
Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Centre of the Johannes Gutenberg-University Mainz, Mainz, Germany
K. Sagheb, E. Schiegnitz, M. Moergel, C. Walter, B. Al-Nawas & W. Wagner
Mediplus, Oral and Maxillofacial Surgery, Private Praxis, Mainz, Germany
C. Walter
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Ali S, Bakry SA, Abd-Elhakam H. Platelet-rich fibrin in maxillary sinus augmentation: a systematic review. The Journal of oral implantology. 2015;41(6):746–53. PubMed PMID: 25536095
Moraschini V, Barboza ES. Effect of autologous platelet concentrates for alveolar socket preservation: a systematic review. Int J Oral Maxillofac Surg. 2015;44(5):632–41. PubMed PMID: 25631334
Torres J, Tamimi F,...
Pieri F, Corinaldesi G, Fini M, Aldini NN, Giardino R, Marchetti C. Alveolar ridge augmentation with titanium mesh and a combination of autogenous bone and anorganic bovine bone: a 2-year prospective study. J Periodontol. 2008;79(11):2093–103. PubMed PMID: 18980518
Proussaefs P, Lozada J. Use of titanium mesh for staged localized alveolar ridge augmentation: clinical and histologic-histomorphom...
von Arx T, Kurt B. Implant placement and simultaneous peri-implant bone grafting using a micro titanium mesh for graft stabilization. Int J Periodontics Restorative Dent. 1998;18(2):117–27. PubMed PMID: 9663090
von Arx T, Kurt B. Implant placement and simultaneous ridge augmentation using autogenous bone and a micro titanium mesh: a prospective clinical study with 20 implants. Clin Oral Implant...
Moraschini V, Poubel LA, Ferreira VF, Barboza ES. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review. Int J Oral Maxillofac Surg. 2015;44(3):377–88. PubMed PMID: 25467739
Al-Nawas B, Kammerer PW, Morbach T, Ladwein C, Wegener J, Wagner W. Ten-year retrospective follow-up study of the TiO...
Within the limitations of this study, being retrospective and having no control group, the results show that individualized CAD-CAM-produced titanium meshes are a safe and predictable procedure for large vertical and horizontal ridge augmentations. The soft tissue covering remains one of the most critical steps using this technique. However, exposure of the mesh does not result in complete loss of...
The results showed that in all 21 augmented sites, a significant ridge augmentation was achieved, with a mean vertical augmentation of 6.5 ± 1.7 mm and a mean horizontal augmentation of 5.5 ± 1.9 mm. To our best knowledge, this is the first study investigating these parameters in individualized CAD-CAM-produced titanium meshes. For conventional titanium meshes, several studies were publish...
In our study, PRF membranes were additionally to collagen membranes used to cover the CAD-CAM mesh. The aim of this clinical approach was to improve and accelerate wound healing. The results with the low exposure rates and the sufficient augmentation heights indicated that these PRF membranes are a promising technique. However, due to low case number in the control group without a PRF membrane, de...
The vertical and horizontal regeneration of resorbed alveolar ridges remains a challenging surgical procedure, especially in the case of extensive bone atrophy. During the past years, different augmentation techniques have been proposed to restore an adequate bone volume. The aim of this study was to evaluate a technique for ridge augmentation in the maxilla and mandible using an individualized CA...
In the investigated time period, 17 patients received 21 TM augmentations. Fourteen of these patients were women and three men. Mean age at the time of augmentation was 37 ± 15 years (17–64 years). Twelve of the patients were non-smoker, and 5 patients were smoker. In 8 patients, a steady periodontal disease could be detected. Sixty-five percent (n = 11) of the patients presented a thin g...
Cone beam computed tomography (CBCT) of the treated sites was performed before augmentation procedure and 6 months postoperatively at time of reentry. Craniofacial bone and TM showed different radio-opacity, which allowed their easy differentiation on the scans after regulating the brightness and contrast. In our department, two different CBCTs were available (Accuitomo, J. Morita Corporation, Ja...
In a retrospective study, the clinical outcome of an individualized CAD-CAM-produced TM (Yxoss CBR®, Filderstadt, Germany) inserted by experienced surgeons in the Department of Oral and Maxillofacial Surgery of the University Medical Centre Mainz, Germany, between December 2014 and January 2017, was analyzed. Therefore, all patients with this CAD-CAM mesh augmentation and reentry operation for im...
The aim of this clinical study was to present the clinical outcome of individualized CAD-CAM-produced TM in combination with particulate autogenous bone mixed with deproteinized bovine bone mineral (DBBM) used to augment horizontal and/or vertical bony defects in both maxillary and mandibular arches, within a two-stage technique. Furthermore, gained horizontal and vertical bone height and the infl...
Dental implant placement is an effective treatment method for the replacement of lost teeth with high survival rates after long-term follow-up [1,2,3]. However, the long-term success and stability of implants in function are directly correlated with the quality and quantity of the available bone at the prospective implant site [4, 5]. Despite the development of various techniques and augmentation ...
The augmentation of the jaw has been and continues to be a sophisticated therapy in implantology. Modern CAD-CAM technologies lead to revival of old and established augmentation techniques such as the use of titanium mesh (TM) for bone augmentation. The aim of this retrospective study was to evaluate the clinical outcome of an individualized CAD-CAM-produced TM based on the CT/DVT-DICOM data of th...
Fig. 5. SEM images of the mesial margin of abrasion under topography contrast (a) and material contrast (b)
Fig. 5. SEM images of the mesial margin of abrasion under topography contrast (a) and material contrast (b)
Fig. 4. Luting agent located mostly in the crown (a) and only sparsely on the implant (b). A crown fragment is remaining on the implant
Fig. 4. Luting agent located mostly in the crown (a) and only sparsely on the implant (b). A crown fragment is remaining on the implant
Fig. 3. Area of abrasion (yellow surface) and maximum vertical wear (arrow)
Fig. 3. Area of abrasion (yellow surface) and maximum vertical wear (arrow)
Fig. 2. Four replicas on specimen stubs and foam pellets in the sample holder of the Micro-CT
Fig. 2. Four replicas on specimen stubs and foam pellets in the sample holder of the Micro-CT
Fig. 1. Luted crown on embedded implant before chewing simulation
Fig. 1. Luted crown on embedded implant before chewing simulation
ANOVA results
Pull-out forces
Maximum wear
Volume wear
F (df)
0.02 (3, 16)
...
CS round (n)
Pull-out forces
Maximum wear
Volume wear
#1 (5)
319.6 (75.4)
...
Voltage
60 kV
Amperage
167 μA
Filter
No filter
...
Baumgart, P., Kirsten, H., Haak, R. et al. Biomechanical properties of polymer-infiltrated ceramic crowns on one-piece zirconia implants after long-term chewing simulation.
Int J Implant Dent 4, 16 (2018). https://doi.org/10.1186/s40729-018-0127-5
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Received: 16 November 2017
Accepted: 20 March 2018
Published: 23 May 2018
DOI: https://doi.org/10.1186/s4072...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
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Pia Baumgart, Holger Kirsten, Rainer Haak, and Constanze Olms declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Department of Dental Prosthodontics and Materials Science, University of Leipzig, Liebigstraße 12, Haus 1, 04103, Leipzig, Germany
Pia Baumgart
Institute for Medical Informatics, Statistics, and Epidemiology (IMISE), Haertelstraße 16-18, 04107, Leipzig, Germany
Holger Kirsten
LIFE Research Center for Civilization Diseases, University of Leipzig, Philipp-Rosenthal-Straße 27, 04103, Leipzig, ...
The authors would like to thank T. Meißner for the lab support.
Not applicable
The datasets supporting the conclusions of this article are available. Availability of data and materials by the corresponding author: constanze.olms@medizin.uni-leipzig.de
Coldea A, Swain MV, Thiel N. Mechanical properties of polymer-infiltrated-ceramic-network materials. Dent Mater. 2013;29:419–26.
Dirxen C, Blunck U, Preissner S. Clinical performance of a new biomimetic double network material. Open Dent J. 2013;7:118–22.
Della Bona A, Corazza PH, Zhang Y. Characterization of a polymer-infiltrated ceramic-network material. Dent Mater. 2014;30:564–9.
Keul ...
Guess PR, Att W, Strub JR. Zirconia in Fixed Implant Prosthodontics. Clin Implant Dent Relat Res. 2012;14:633-45
Wilson TG Jr. The Positive Relationship Between Excess Cement and Peri-Implant Disease: A prospective Clinical Endoscopic Study. J Periodontol. 2009;80:1388–92.
Schwenter J, Schmidli F, Weiger R, Fischer J. Adhesive bonding to polymer infiltrated ceramic. Dent Mater J. 2016;35:796...
Three-dimensional space
Analysis of variance
Computer-aided design/computer-aided manufacturing
confidence interval (exact) according to Clopper-Pearson
Chewing simulation
degrees of freedom
Et alii/et aliae/et alia
F test
Mean
X-ray micro-computed tomography
Number
p value
Polymer-infiltrated ceramic network
Standard deviation
Scanning electron microscope
Vita Enamic
The present study demonstrates that elastic PICN crowns on rigid one-piece zirconia implants seem to be a promising material combination for clinical practice. Though the crowns suffered major wear after CS, the stability was not affected, and no catastrophic failure occurred. However, clinical trials are essential to examine the behavior of the material combination, especially in comparison to ot...
The missing comparison to other PICN materials can be considered a limitation of the study. Since VE is a unicum in the family of PICN materials, it is difficult to find an appropriate material of comparison, especially since Lava Ultimate (3M Espe), a resin nanoceramic, is no longer indicated as a crown material due to a high rate of loosening. The review of Mainjot et al. reported that the loose...
In the study of Naumova et al., volume and vertical wear of PICN crowns, compared to other materials such as a nanoceramic resin and a lithium silicate reinforced ceramic after CS, were tested [11]. They used the same settings of CS as in the present study, but the crowns were luted to extracted molars instead of implants and extracted molars as antagonists were used as well. Concerning volume and...
To the best of our knowledge, it was the first time that the biomechanical properties of polymer-infiltrated ceramic crowns on one-piece zirconia implants after long-term chewing simulation were examined. The present in vitro study investigated the biomechanical properties concerning surface wear and bond strength. No fractures occurred during long-term chewing simulation, and the abrasion of the ...
No failure occurred as none of the tested crowns or implants was fractured or loosened during or after CS.
The tested crowns showed a maximum wear depth of M = 0.31 ± 0.04 mm (mean ± SD) and volume wear of M = 0.74 ± 0.23 mm3 (mean ± SD). Table 2 shows the mean and standard deviation of assessed parameters (pull-out forces, maximum wear, volume wear) of each round o...
For volume assessment of abrasion, each 3D data set was segmented before and after CS in CTAn (CTAnalyzer V.1.15.4.0, Bruker microCT). Both data sets were overlapped, and the remaining volume of abrasion quantified in pixels and converted into cubic millimeters.
The maximum wear depth was determined by “blowing up” virtual bullets within the surface of abrasion. The diameter of the most massi...
The specimens attached to the parallelometer were perpendicularly recessed until only the upper coils of the implants were on view.
To produce replicas of the specimens from the experimental group, the crowns’ occlusal was cast using VPS Hydro Putty und VPS Hydro Light Body (Henry Schein Inc., New York, USA) before and after CS. The impression was grouted with Stycast 1266 (Loctite Henkel Elect...
Twenty-five PICN crowns (Vita Enamic, Vita Zahnfabrik, Bad Säckingen, Germany) for premolars were produced using CAD/CAM technology and polished with the Vita Enamic Polishing Set Technical (Vita Zahnfabrik) as recommended by the manufacturer. All crowns were bonded to identical one-piece zirconia testing implants. The implants were turned from pre-sintered zirconia blocks (VITA In-Ceram® 2000 ...
The demand for tooth-colored dental restorations has increased rapidly within the last few years. Ceramic restorations can often meet these requirements. In dental implantology, zirconia especially—due to its esthetical advantage as well as high flexural strength and outstanding biocompatibility—has gained importance [1]. On the other hand, one-piece zirconia implants are not yet commonly use...
Implant and superstructure provide a complex system, which has to withstand oral conditions. Concerning the brittleness of many ceramics, fractures are a greatly feared issue. Therefore, polymer-infiltrated ceramic networks (PICNs) were developed. Because of its high elastic modulus, the PICN crown on a one-piece zirconia implant might absorb forces to prevent the system from fracturing in order ...
Fig. 2. a Radiographic image of a 3.5-mm-wide by 7-mm-length dental implant at the time of its placement at the mandibular left second premolar in a 63-year-old Caucasian female. b Radiographic image of a three-unit fixed partial denture upon its initial placement. The dental implant is the anterior abutment with the prosthesis screw retained to it. The distal abutment is the mandibular left sec...
Fig. 1. a Initial radiograph exposed at abutment installation on a 5-mm-wide by 7-mm-length dental implant used to help support a removable partial denture for a 71-year-old Caucasian male. b Radiograph of the area taken at 82 months demonstrates good bone stability. c Clinical image of the area 82 months later. Soft tissue remains healthy. The two teeth anterior are in the process of receivin...
Time
ISQ
n
Implant insertion
73.6 ± 8.1
86
1–4 weeks
...
Interval
Implants
Failed
Not followed
CSR (%)
Insertion to 1 year
...
Sex
Age
Smoker
Risk factors
Position
Implant diameter
...
Number
Percent
Jaw
Maxilla
60
69.8
Mandible
...
Number
Percent
Age (years)
20–29
1
1.3
30–39
...
Rosen, P.S., Sahlin, H., Seemann, R. et al. A 1–7 year retrospective follow-up on consecutively placed 7-mm-long dental implants with an electrowetted surface.
Int J Implant Dent 4, 24 (2018). https://doi.org/10.1186/s40729-018-0136-4
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Received: 08 January 2018
Accepted: 21 May 2018
Published: 23 August 2018
DOI: https://doi.org/10.1186/s40729-018-0136...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
The study was performed in compliance with the Declaration of Helsinki. Data collection was performed in such a manner that subjects could not be identified, and therefore, it was exempt from IRB review according to Federal Regulation 45 CFR 46.101(b).
All participants consented to publish their information details through the clinic’s standard patient consent procedure. Also, all images appear...
Clinical Professor of Periodontics, Baltimore College of Dental Surgery, University of Maryland Dental School, Baltimore, MD, USA
Paul S. Rosen
Private Practice limited to Periodontics and Dental Implants, 907 Floral Vale Boulevard, Yardley, PA, 19067, USA
Paul S. Rosen
Neoss Ltd, Gothenburg, Sweden
Herman Sahlin
University Clinic of Craniofacial, Maxillofacial and Oral Surgery, Vienna, Aust...
Due to the ethical and legal responsibility to respect participants’ rights to privacy and to protect their identity, the clinical dataset is not made publicly available.
Srinivasan M, Vazquez L, Rieder P, Moraguez O, Bernard JP, Belser UC. Survival rates of short (6 mm) micro-rough surface implants: a review of literature and meta-analysis. Clin Oral Implants Res. 2014;25(5):539–45.
Chrcanovic BR, Albrektsson T, Wennerberg A. Diabetes and oral implant failure: a systematic review. J Dent Res. 2014;93(9):859–67.
Giro G, Chambrone L, Goldstein A, Rodrigues JA,...
Jemt T, Olsson M, Franke SV. Incidence of first implant failure: a retroprospective study of 27 years of implant operations at one specialist clinic. Clin Implant Dent Relat Res. 2015;17(Suppl 2):e501–10.
Pommer B, Frantal S, Willer J, Posch M, Watzek G, Tepper G. Impact of dental implant length on early failure rates: a meta-analysis of observational studies. J Clin Periodontol. 2011;38(9):856...
Cumulative survival rate
Implant stability quotient
Insertion torque
Odds ratio
Resonance frequency analysis
Relative risk
The current retrospective consecutive case series study provides preliminary data that treatment with 7-mm-length short implants with a hydrophilic electrowetted surface is a reasonable approach in sites with limited vertical bone dimension. It adds to the body of evidence supporting short implant use for compromised sites. The success seen might be attributed to the larger implant diameters that ...
Thirty-six percent of the implants in the study were placed in extraction sockets. Provided that sufficient initial implant stability is achieved, there should be no additional risk factors compared to implants in healed sites. Studies have shown no difference in marginal bone remodeling between immediately placed and delayed implants [15].
The biggest limitation of the current study is its very ...
A wide distribution in implant insertion torque (10–50 Ncm) was seen in the study. This reflects the variety of clinical situations in which the implants were placed. Assessments were made by using both the RFA value and the insertion torque as to first whether an implant should have been left to heal in the first place and if so, how this would be best accomplished, i.e., through its submergen...
This retrospective study is the first to look at short dental implants with a hydrophilic electrowetted surface. The survival data suggest that this treatment is a viable option to care. In a systematic review that identified 13 studies on implants shorter than 10 mm, the CSR from the individual studies ranged from 80 to 100% with a combined CSR of 98.3% after 5 years, 94.8% after 6 years, and ...
The chart review identified 86 placed implants in 75 patients. Table 1 summarizes the patient demographics of the 75 patients. Patients ranged in age from 29 to 88 years with a mean of 61.0 ± 12.5 years. Twenty-seven of the patients were males and 48 were females. Table 2 summarizes the implant and site-related information of the 86 placed implants. Mean insertion torque was 30.1 ± 7...
Baseline parameters, both patient- and implant-related, as well as follow-up parameters (implant survival, follow-up time, and resonance frequency analysis) were collected from a review of the patient records.
The main study parameters (principal outcome parameters) were defined to be implant loss and follow-up time. The cumulative survival rate was estimated. The influence of several factors on ...
A retrospective study on short 7 mm hydrophilic implants from a single center was conducted in a private practice limited to periodontics and surgical dental implant placements from one of the authors, PSR (Yardley, Pennsylvania, USA). An exhaustive chart review identified 75 patients for analysis that were treated with 86 short (7 mm) implants during a 5-year period (September 1, 2009, to Novem...
The aim of this retrospective consecutive case series study was to investigate implant survival rate and analyze possible factors affecting the survival of short implants placed in one surgical practice focused on implantology and periodontology in a temporal cohort.
In the past decades, the osseointegration rate of dental implants has dramatically increased, particularly in sites of softer dental bone, which may be attributed to the introduction of moderately roughened surfaces [1, 2]. Moreover, because of this increase in success, clinicians have attempted to push the envelope and place implants into sites that may provide a greater challenge as they wish to...
This retrospective consecutive case series study was performed to determinate the survival rate and implant stability of short (7 mm length) dental implants with an electrowetted hydrophilic surface that were in function from 1 to 7 years.
A retrospective chart review identified and evaluated 86 consecutively placed 7-mm-long dental implants (ProActive, Neoss Ltd., Harrogate, England) in 75 pat...
Fig. 1. Search strategy for BMAC
Fig. 1. Search strategy for BMAC
Study
Treatment groups
No. of patients (age range)
No. of maxillary sinuses evaluated
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de Oliveira et al. [12]
Pasquali et al. [7]
Payer et al. [2]
Sauerbier et al. [11]
...
Ting, M., Afshar, P., Adhami, A. et al. Maxillary sinus augmentation using chairside bone marrow aspirate concentrates for implant site development: a systematic review of histomorphometric studies.
Int J Implant Dent 4, 25 (2018). https://doi.org/10.1186/s40729-018-0137-3
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Received: 20 February 2018
Accepted: 21 May 2018
Published: 03 September 2018
DOI:...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
This is a systematic review of published data; no patients were involved in the conduct of this review.
Miriam Ting, Philip Afshar, Arik Adhami, Stanton M. Braid, and Jon B. Suzuki declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Correspondence to
Miriam Ting.
Private practice in Periodontology, and Think Dental Learning Institute, Paoli, PA, 19301, USA
Miriam Ting
Temple University Kornberg School of Dentistry, 3223 North Broad Street, Philadelphia, PA, 19140, USA
Philip Afshar & Arik Adhami
Division of Oral and Maxillofacial Surgery, Department of Oral Medicine, Pathology and Surgery, Temple University Kornberg School of Dentistry, 3223 North Br...
All the data generated during this systematic review were included in this manuscript.
Rooney AA, Boyles AL, Wolfe MS, Bucher JR, Thayer KA. Systematic review and evidence integration for literature-based environmental health science assessments. Environ Health Perspect. 2014;122(7):711–8.
Sauerbier S, Rickert D, Gutwald R, Nagursky H, Oshima T, Xavier SP, et al. Bone marrow concentrate and bovine bone mineral for sinus floor augmentation: a controlled, randomized, single-blinded...
Tatum H Jr. Maxillary and sinus implant reconstructions. Dent Clin N Am. 1986;30(2):207–29.
Payer M, Lohberger B, Strunk D, Reich KM, Acham S, Jakse N. Effects of directly autotransplanted tibial bone marrow aspirates on bone regeneration and osseointegration of dental implants. Clin Oral Implants Res. 2014;25(4):468–74.
Chaushu G, Vered M, Mardinger O, Nissan J. Histomorphometric analysis a...
Bone marrow aspirate concentrate
Confidence limits
Ethylenediaminetetraacetic acid
Technique involving bone marrow-derived mononuclear cell isolation by synthetic polysaccharide
Mononuclear cells
Mesenchymal stem cells
Office of Health Assessment and Translation
Standard deviation
Within the limits of this systematic review, the chairside method to harvest BMAC is a viable option for maxillary sinus augmentation for implant site development. The implant survival of the BMAC group was similar to the laboratory FICOLL concentration of BMAC group, without the additional cost and time of laboratory cell isolation techniques. Single or double centrifugation of BMAC does not appe...
In addition, the parameters to evaluate new bone formation were variable. New bone formation and percentage of vital bone are different methods to measure bone formation, and the data from different methods could not be combined or analyzed together. Furthermore, the BMAC evaluated in test groups were prepared differently and were harvested from different sources (tibia or iliac). The control grou...
Although the variations of the materials and methods for BMAC preparation were discussed, this review was not aimed to compare materials and methods for BMAC preparation, but rather the end clinical result for new bone formation and implant survival. Although implant survival and new bone formation were not the only parameters to consider when evaluating sinus augmentation, these parameters were t...
It appears that BMAC offers no statistically significant advantage for regeneration of bone in the maxillary sinus for site preparation of dental implants. BMAC + bovine bone graft results in similar regeneration outcome measures histologically as alveolar bone alone at 3–4 months. Measured histomorphometrically MSCs treated by FICOLL–Hypaque centrifugation to consolidate osteogenic and osteo...
Pasquali et al. [7], in eight patients compared BMAC + bovine bone graft (test group) with bovine bone graft alone (control group). New bone (55.15%) was reported in the test group compared with new bone (27.3%) in the control group based on histomorphometric analyses. This reported observation indicating statistically more new bone regeneration in the BMAC + bovine bone graft group compared with ...
Sauerbier et al. [14] further compared BMAC + bovine bone grafts (test group) with alveolar bone, autologous + bovine bone grafts (control group) for maxillary sinus site preparation. New bone (31.3%) for the test group compared with new bone (19.3%) for the control group statistically indicated equivalence in histomorphometric outcome. Histologic images showing impressive new bone formation were ...
Mesenchymal stem cells (MSCs) in BMAC have the potential to renew, experience clonal expansion, and differentiate into musculoskeletal tissues [16]. MSCs are also known to have an immunoregulatory role and may enhance the normal healing response and angiogenesis [10]. BMAC has been used in bone, cartilage, and tendon injuries with encouraging results [16]. BMAC is a minimally invasive procedure, a...
The search generated 797 reviews in PubMed, 114 in Web of Science, 97 in Cochrane Library, and 319 in Google Scholar (Fig. 1). The following were selected after the title and abstract screening: 18 were selected from PubMed, 23 from Web of Science, 6 from Cochrane Library, 2 from Google Scholar, and 2 from hand searching the reference list of the selected article. After the duplicates were remove...
What are the histomorphometric outcomes of sinus augmentation with bone marrow aspirate concentrates obtained chairside?
PubMed, Web of Science, Cochrane Library, and Google Scholar were searched up to January 2017. Google scholar was searched for gray literature. The following keywords were used: “bone marrow aspirate concentrates,” “stem cells,” “histomorphometric,” and “bone graf...
Maxillary sinus augmentation is indicated when there is an inadequate vertical alveolar bone height to effectively support surgically placed dental implants. The sinus elevation procedure requires grafting bone material onto the sinus floor to regenerate sufficient vertical alveolar bone height [1, 2]. The ideal bone grafting material should be biocompatible, possess no risk of disease transmissio...
Maxillary sinus pneumatization following dental tooth extractions and maxillary alveolar bone resorption frequently leaves inadequate bone levels for implant placement. The objectives of this systematic review are to evaluate the effects of bone marrow aspirate concentrates (BMACs) used in maxillary sinus augmentation for implant site development.
A systematic search was conducted using PubMed, E...
Failure rate
n
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OR
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...
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n
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Mengel, R., Heim, T. & Thöne-Mühling, M. Mucositis, peri-implantitis, and survival and success rates of oxide-coated implants in patients treated for periodontitis 3- to 6-year results of a case-series study.
Int J Implant Dent 3, 48 (2017). https://doi.org/10.1186/s40729-017-0110-6
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Received: 29 August 2017
Accepted: 26 October 2017
Published: 28 Novemb...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
RM is a professor at the Department of Prosthetic Dentistry, School of Dental Medicine, Philipps-University, Marburg/Lahn, Germany. TH is a private practicioner in Gruben, Brandenburg, Germany. MT is a researcher at the Department of Prosthetic Dentistry, School of Dental Medicine, Philipps-University, Marburg/Lahn, Germany.
This clinical study was conducted in accordance with the World Medical A...
Department of Prosthetic Dentistry, School of Dental Medicine, Philipps-University, Marburg/Lahn, Germany
Reiner Mengel & Miriam Thöne-Mühling
Gruben, Brandenburg, Germany
Theresa Heim
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Kim K-K, Sung H-M. Outcomes of dental implant treatment in patients with generalized aggressive periodontitis: a systematic review. J Adv Prosthodont. 2012;4:210–7.
Pettersson K, Mengel R. Comments on the statistical analysis of the paper by Albouy et al comparing four different types of implants with respect to ‘spontaneous’ progression of peri-implantitis. Eur J Oral Implantol. 2011;1:9...
Kinane DF, Radvar M. The effect of smoking on mechanical and antimicrobial periodontal therapy. J Periodontol. 1997;69:467–72.
Swierkot K, Lottholz P, Flores-de-Jacoby L, Mengel R. Mucositis, peri-implantitis, implant success, and survival of implants in patients with treated generalized aggressive periodontitis: 3- to 16-year results of a prospective long-term cohort study. J Periodontol. 2012...
Jungner M, Lundqvist P, Lundgren S. A retrospective comparison of oxidized and turned implants with respect to implant survival, marginal bone level and peri-implant soft tissue conditions after at least 5 years in function. Clin Implant Dent Relat Res. 2014;16:230–7.
Rocci A, Rocci M, Rocci C, Scoccia A, Gargari M, Martignoni M, Gottlow J, Sennerby L. Immediate loading of Brånemark system TiU...
Esposito M, Ardebili Y, Worthington HV. Interventions for replacing missing teeth: different types of dental implants. Cochrane Database Sys Rev. 2014;7:CD003815.
Salata LA, Burgos PM, Rasmusson L, Novaes AB, Papalexiou V, Dahlin C, Sennerby L. Osseointegration of oxidized and turned implants in circumferential bone defects with and without adjunctive therapies: an experimental study on BMP-2 and...
The results of the present case series study should be interpreted in a critical light because of the small study population. However, it can be concluded that periodontally diseased subjects treated in a supportive periodontal therapy can be successfully rehabilitated with oxide-coated dental implants for a follow-up period of 3 to 6 years. The results suggest that implants in the maxilla and in...
These results from long-term clinical studies indicate that oxide-coated implants achieve equivalent survival rates and prevalence of mucositis and peri-implantitis when compared to implants with other surface characteristics. They support the assumption that the implant surface has little influence on the development of mucositis or peri-implantitis. This was subsequently confirmed in a Cochrane ...
The present study examines the success rates of oxide-coated implants in subjects with treated periodontal disease. Several long-term clinical studies on periodontally healthy subjects have revealed survival rates of 97.1 to 99.2% for oxide-coated implants [10, 24, 25]. The results of the present study show a comparable implant survival rate (96.2% in GAP and 97.1% in GCP subjects) for subjects wi...
The univariate analyses showed a significantly higher risk for peri-implantitis in GAP subjects (OR = 3.294 with p = 0.027) and at implants with bone quality grade 3 (OR = 21.200 with p = 0.000). However, these differences were not significant in multivariate analyses.
Both the uni- and multivariate patient-related analyses were non-significant.
The implant success rate was 77.9% for GCP...
All 29 subjects were examined over the period of 3 to 6 years (Table 2). For the duration of the observation period, all the remaining teeth were periodontally healthy, with PDs ≤ 3 mm and negative BOP. All subjects were non-smokers, had excellent oral hygiene, attended the follow-up examinations on a regular basis, and had no systemic disease.
In total, four implants (3.1%) were lost du...
Peri-implant mucositis was defined as PDs ≥ 5 mm with BOP and no bone loss after the first year of loading. Peri-implantitis was defined as PDs > 5 mm with or without BOP and an annual bone loss of > 0.2 mm after the first year of loading.
All technical and surgical complications (e.g., fracture of the abutment screw or superstructure, compromised wound healing) were recorded.
T...
All patients received a supportive periodontal therapy at the Dental School of Medicine, Philipps-University, Marburg, in the course of the observation period. The first clinical examination was 2 to 4 weeks before the non-retainable teeth were extracted. The periodontally healthy residual dentition and the implants were evaluated immediately after the superstructure was inserted. Subsequently, t...
Second-stage surgery was performed in the maxilla after 6 months and in the mandible after 3 months. Implant placement and second-stage surgery were performed by a single periodontist (R.M.).
About 4 weeks after the final abutments were placed, GCP subjects were rehabilitated with single crowns, implant-supported bridges, or removable superstructures, according to the Marburg double crown syst...
A total of 29 partially edentulous subjects were consecutively recruited from the Dental School of Medicine, Philipps-University, Marburg, Germany between April 2010 and April 2013 (Table 1). Subjects were excluded for the following reasons: history of systemic disease (e.g., cardiovascular diseases, diabetes mellitus, osteoporosis), pregnancy, untreated caries, current orthodontic treatment, con...
The aim of this long-term clinical study on partially edentulous subjects treated for periodontal disease was to evaluate the prevalence of mucositis and peri-implantitis and to determine the survival and success rates of dental implants with oxide-coated surfaces.
In recent years, a great number of different implant systems varying in materials, surface structure, and macroscopic design have been introduced to the dental market [1]. In studies using implants with modified surfaces, it was concluded that rough surfaces induce a stronger initial bone response, achieve stability more rapidly, and integrate more fully with extant bone [2,3,4,5,6]. Dental implan...
The aim of this case-series study is to evaluate the prevalence of mucositis, peri-implantitis, and survival and success rates of oxide-coated implants in subjects treated for periodontitis.
Twenty-four subjects treated for generalized chronic periodontitis (GCP) and five treated for generalized aggressive periodontitis (GAP) were orally rehabilitated with a total of 130 dental implants. Subjects...
Fig. 1. Anatomical location of the control and Ca2+-modified dental implants
Fig. 1. Anatomical location of the control and Ca2+-modified dental implants
Variable
Experimental
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P
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...
Anitua, E., Piñas, L. & Alkhraisat, M.H. Early marginal bone stability of dental implants placed in a transalveolarly augmented maxillary sinus: a controlled retrospective study of surface modification with calcium ions.
Int J Implant Dent 3, 49 (2017). https://doi.org/10.1186/s40729-017-0111-5
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Received: 04 September 2017
Accepted: 15 November 2017
Publi...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
An exemption from IRB approval of the study protocol was granted by the author’s institution as it was a retrospective study, and the evaluated medical device had already been approved for clinical use. This study was performed following the Helsinki declaration regarding the investigation with human subjects.
Not applicable.
Eduardo Anitua is the Scientific Director of BTI Biotechnology Insti...
Private practice in oral implantology, Clínica Eduardo Anitua, Vitoria, Spain
Eduardo Anitua
University Institute for Regenerative Medicine and Oral Implantology - UIRMI (UPV/EHU-Fundación Eduardo Anitua), Vitoria, Spain
Eduardo Anitua & Mohammad Hamdan Alkhraisat
BTI Biotechnology Institute, Vitoria, Spain
Eduardo Anitua & Mohammad Hamdan Alkhraisat
Universidad Europea de Madrid, Madr...
Not applicable
No funding was received for this study.
The data will not be shared but are available upon request.
Schulze R, Krummenauer F, Schalldach F, d'Hoedt B. Precision and accuracy of measurements in digital panoramic radiography. Dentomaxillofac Radiol. 2000;29:52–6.
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Jaffin RA, Berman CL. The excessive loss of Branemark fixtures in type IV bone: a 5-year analysis. J Periodontol. 1991;62:2–4.
Anitua E, Alkhraisat MH, Pinas L, Orive G. Efficacy of biologically guided implant site preparation to obtain adequate primary implant stability. Ann Anat. 2015;199:9–15.
Anitua E, Alkhraist MH, Piñas L, Orive G. Association of transalveolar sinus floor elevation, p...
Moraschini V, Poubel LA, Ferreira VF, Barboza Edos S. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review. Int J Oral Maxillofac Surg. 2015;44:377–88.
Berglundh T, Abrahamsson I, Lang NP, Lindhe J. De novo alveolar bone formation adjacent to endosseous implants. Clin Oral Implants Res. 200...
Plasma rich in growth factors
Strengthening the Reporting of Observational studies in Epidemiology
The modification of an acid-etched surface with calcium ions (UnicCa®) seems to enhance the marginal bone stability of dental implants, placed after transalveolar sinus floor elevation.
Unlike Ca2+-modified dental implants, two early implant losses were observed for the same dental implants but without Ca2+. Moderately rough implant surface has enhanced implant osseointegration and has increased the implant secondary stability [2, 3, 19]. Hydrophilic moderately rough surfaces showed faster osseointegration compared to those with hydrophobic characteristics [20, 21]. Ca2+ ions hav...
In this study, 51 patients participated with 65 dental implants. The mean age of the patients was 58 ± 11 years (range 38 to 72 years) at the time of surgery, and 28 were females.
The experimental group had 34 Ca2+-modified dental implants, and the control group had 31 dental implants (without surface modification with calcium ions).
Tables 1 and 2 show the diameters and lengths of the p...
The plasma rich in growth factors (PRGF) was prepared using the Endoret® system following the manufacturer instructions (BTI Biotechnology Institute, Vitoria, Spain). The technique for transalveolar sinus floor elevation is explained elsewhere [15]. Briefly, conventional drills working at low speed (150 rpm) without irrigation was used to prepare the implant site. A frontal cutting drill was the...
The manuscript was written following STROBE (Strengthening the Reporting of Observational studies in Epidemiology) guidelines. All described data and treatments were obtained from a single dental clinic in Vitoria, Spain. The time period of the study was between December 2014 and April 2016. Patients’ records were retrospectively reviewed to identify patients that fulfilled the following inclusi...
Dental implants are nowadays the treatment of choice to replace missing teeth due to their high predictability and long-term success [1]. This success is the outcome of several cellular and molecular events that take place at the implant-bone interface. Although the process of osseointegration is not fully understood, research is ongoing to enhance and accelerate this process. Moderately rough imp...
Recently, components of the extracellular cellular matrix have been assessed to enhance the biological response to dental implants. This study aims to assess the effect of surface modification with calcium ions on the early marginal bone loss of dental implants placed in a transalveolarly augmented maxillary sinus.
A retrospective study of transalveolar sinus floor augmentation was conducted in a...
Maiorana, C., Pivetti, L., Signorino, F. et al. The efficacy of a porcine collagen matrix in keratinized tissue augmentation: a 5-year follow-up study.
Int J Implant Dent 4, 1 (2018). https://doi.org/10.1186/s40729-017-0113-3
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Received: 06 September 2017
Accepted: 20 December 2017
Published: 10 January 2018
DOI: https://doi.org/10.1186/s40729-017-0113-3
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
This study was conducted in compliance with the principles of the Declaration of Helsinki, and the approval of the ethics committee required for the study was obtained from the Ethics Committee of the IRCCS Ospedale Maggiore Policlinico di Milano, Fondazione Ca’ Granda. The procedures to be performed were explained in detail, and the patients signed the consent form.
Carlo Maiorana, Luca Pivett...
Correspondence to
F. Signorino.
Oral Surgery, Center for Edentulism and Jaw Atrophies, Maxillofacial Surgery and Dentistry Unit, Fondazione IRCCS Cà Granda—Ospedale Maggiore Policlinico, University of Milan, Milan, Italy
C. Maiorana
Center for Edentulism and Jaw Atrophies, Maxillofacial Surgery and Dentistry Unit, Fondazione IRCCS Cà Granda—Ospedale Maggiore Policlinico, University of Milan, Via della Commenda 10, 20122,...
The authors declare no funds for the research.
Schmitt CM, Moest T, Lutz R, Wehrhan F, Neukam FW, Schlegel KA. Long-term outcomes after vestibuloplasty with a porcine collagen matrix (Mucograft®) versus the free gingival graft: a comparative prospective clinical trial. Clin Oral Impl Res. 2016;27:e125–33.
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Harris RJ. Gingival augmentation with an acellular dermal matrix: human histologic evaluation of a case—placement of the graft on periosteum. Int J Periodontics Restorative Dent. 2004;24(4):378–85.
Wei PC, Laurell L, Geivelis M, Lingen MW, Maddalozzo D. Acellular dermal matrix allografts to achieve increased attached gingiva. Part 1. A clinical study. J Periodontol. 2000;71(8):1297–305.
Ha...
Vignoletti F, Nuñez J, Discepoli N, De Sanctis F, Caffesse R, Muñoz F, et al. Clinical and histological healing of a new collagen matrix in combination with the coronally advanced flap for the treatment of Miller class-I recession defects: an experimental study in the minipig. J Clin Periodontol. 2011;38(9):847–55.
Jepsen K, Jepsen S, Zucchelli G, Stefanini M, de Sanctis M, Baldini N, et al. ...
Forman G. Presenile mandibular atrophy: its aetiology, clinical evaluation and treatment by jaw augmentation. Br J Oral Surg. 1976;14(1):47–56.
Chiapasco M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants. 2009;24(Suppl):237–59.
Grusovin MG, Coulthard P, Worthington HV, Esposito M. Maintaining and recovering soft tissue health around...
With the limits of this study, it can be assessed that the CM is an effective option for the keratinized tissue augmentation. The percentage of shrinkage of the graft is comparable to data recovered from other studies and does not represent a problem also after 5 years. The CM integration is slow and constant, providing the necessary scaffold to regenerate keratinized mucosa and ensuring a perfec...
The study was carried out to evaluate the efficacy of a xenogeneic CM when used as a soft tissue substitute in the reconstruction of an adequate amount (at least 2 mm) of keratinized tissue around dental implants. The xenogeneic CMs have already been investigated in order to check their compatibility and effectiveness as scaffold [19, 20]. One of the first studies was conducted by Schoo and Coppe...
A total of 15 patients were enrolled for the study, 12 females and 3 males, aged between 43 and 72 years old. Of these patients, 11 received surgery in the mandible and 4 in the maxilla. No complications were registered during surgeries and the immediate post-operative course was uneventful for all patients. At 1 year, 2 patients dropped out of the study: the first patient experienced a peri-imp...
Since a split-mouth design was not feasible and the defects being corrected by the mucosa particularly in the vestibular portion of the study are not usually symmetrical or bilateral, the use of paired subjects was not a reliable format. All the data were analyzed with IBM’s SPSS Statistics using ANOVA Repeated Measurements statistical method. Mean values for keratinized mucosal width and probin...
The primary endpoints were to evaluate the shrinkage degree of the width of keratinized mucosa and length of the re-epithelization process. The secondary endpoints assessed clinical evaluation of the grafted area, post-operative hemostatic effect, pain level, and length of surgery. Follow-up control visits were scheduled at 3 days after surgery and then 10 days, 2 weeks, 3 weeks, 1 month, 2 ...
The study was designed as a multicentered (Milan University—School of Dentistry/Loma Linda University—School of Dentistry) prospective observational (non-controlled) clinical study according to the STROBE criteria. The participants of the study presented areas of deficient attached and unattached mucosa precluding the construction of effective functioning prosthesis. The study included a total...
A variety of factors can lead to teeth loss. From periodontal disease to trauma, the bone remodeling that always follows this event can complicate the subsequent prosthetical rehabilitation [1]. Both removable and implant-fixed restorations require both an adequate quantity of bone and sorrounding soft tissue. Even in severe atrophies of the jaw, nowadays, many bone augmentation techniques are app...
When keratinized tissue width around dental implants is poorly represented, the clinician could resort to autogenous soft tissue grafting. Autogenous soft tissue grafting procedures are usually associated with a certain degree of morbidity. Collagen matrices could be used as an alternative to reduce morbidity and intra-operatory times. The aim of this study was to assess the efficacy of a xenogene...
Kanazawa, M., Atsuta, I., Ayukawa, Y. et al. The influence of systemically or locally administered mesenchymal stem cells on tissue repair in a rat oral implantation model.
Int J Implant Dent 4, 2 (2018). https://doi.org/10.1186/s40729-017-0112-4
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Received: 19 September 2017
Accepted: 04 December 2017
Published: 13 January 2018
DOI: https://doi.org/10.118...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Miya Kanazawa, Ikiru Atsuta, Yasunori Ayukawa, Takayoshi Yamaza, Ryosuke Kondo, Yuri Matsuura, and Kiyoshi Koyano declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Correspondence to
Ikiru Atsuta.
Section of Implant and Rehabilitative Dentistry, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
Miya Kanazawa, Ikiru Atsuta, Yasunori Ayukawa, Ryosuke Kondo, Yuri Matsuura & Kiyoshi Koyano
Department of Molecular Cell and Oral Anatomy, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
Takayoshi...
This work was supported by JSPS KAKENHI Grant Numbers JP 15H05029 and 15H02573 to Y. Ayukawa.
Bazhanov N, Ylostalo JH, Bartosh TJ, Tiblow A, Mohammadipoor A, Foskett A, Prockop DJ. Intraperitoneally infused human mesenchymal stem cells form aggregates with mouse immune cells and attach to peritoneal organs. Stem Cell Res Ther. 2016;7:27.
Goldmacher GV, Nasser R, Lee DY, Yigit S, Rosenwasser R, Iacovitti L. Tracking transplanted bone marrow stem cells and their effects in the rat MCAO stro...
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Schroeder A, van der Zypen E, Stich H, Sutter F. The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces. J Maxillofac Surg. 1981;9:15–25.
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Zhang L, Li K, Liu X, Li D, Luo C, Fu B, Cui S, Zhu F, Zhao RC, Chen X. Repeated systemic administration of human adipose-derived stem cells attenuates overt diabetic nephropathy in rats. Stem Cells Dev. 2013;22:3074–86.
Zheng B, von See MP, Yu E, Gunel B, Lu K, Vazin T, Schaffer DV, Goodwill PW, Conolly SM. Quantitative magnetic particle imaging monitors the transplantation, biodistribution, a...
Egusa H, Sonoyama W, Nishimura M, Atsuta I, Akiyama K. Stem cells in dentistry—part I: stem cell sources. J Prosthodont Res. 2012;56:151–65.
Lindhe J, Berglundh T. The interface between the mucosa and the implant. Periodontol. 1998;17:47–54.
Ikeda H, Shiraiwa M, Yamaza T, Yoshinari M, Kido MA, Ayukawa Y, Inoue T, Koyano K, Tanaka T. Difference in penetration of horseradish peroxidase trace...
Our study supports systemic administration of MSCs to enable accelerated soft tissue sealing of the Ti surface in our rat oral implantation model. Although local MSC administration had little positive effect in our model, the MSCs accumulated around the peri-implant oral mucosa and were identified in various organs, indicating a wide range of possible applications. This study highlights that clini...
Figure 7C and D showed the suitable amount of MSCs had much better positive effect for the migration and adhesion of OECs to titanium surface. MSC attachment within the upper Transwell chamber was determined 24 h after seeding by fluorescence microscopy, as shown in Fig. 7D (a). The majority of MSCs appeared flattened with numerous cytoplasmic extensions and lamellipodia. The majority of MSCs pass...
Due to the existence of muscles, connective tissue, dermal layer, and basement membrane, cells within the mass of the injected area encounter these barriers, inhibiting the distance of migration between the application region and inflammatory site, which has an estimated diameter of 20–30 μm (Fig. 6). High-density cell injection at the topical region is also an obstacle for homing, thus using a...
Subcutaneously administrated cells or drugs are reported to take a few days to be delivered into the body through vessel bloods [33, 34]. This may be owed to difficulty of the cells in securing vascular accesses to the target site because of a lack of blood vessels at the buccinators, while systemic MSC homing occurs more readily through the bloodstream [35].
The effects of MSC treatment on level...
As shown in Fig. 3b, expression of adhesion proteins on the interface between PIE-implant was significantly lower in the control and local groups compared with the systemic group.
Ln-332 is the major adhesive ligand for integrin α6β4, which interacts with the cytoskeletal elements, and is a component of the hemidesmosomes, epithelial adhesion plaques that tack the plasma membrane of the epithe...
Because MSC treatment is being introduced more widely as a clinically available therapy, the method of administration must be considered to better mitigate risk. Although for a number of other factors also need consideration, including cell source, cell donor condition, cell population, and timing of MSC administration, this study only focused on comparison between systemic and local injection of ...
OEC adhesion assays were conducted according to previously published methods [16, 20]. Non-adherent or weakly attached cells were removed by shaking (3 × 5 min at 75 rpm) using a rotary shaker (NX-20, Nissin, Tokyo, Japan). Adherent cells were then counted and calculated as a percentage of the initial count, which was used to define adhesive strength of the cells.
Scratch assays were perfo...
For apoptosis detection, the 10-μm bucco-palatal sections from around the experimental implant were incubated overnight with FITC-conjugated anti-rat GFP (1:100, Sigma-Aldrich) and 7-amino actinomycin D (7-AAD, Apoptosis Detection Kit; BD Biosciences, Franklin Lakes, NJ) at 4 °C. Apoptotic cells were then counted and calculated as a percentage of the total cells.
MSCs were cultured in osteogen...
Twenty-four hours after implantation, rats were lightly anesthetized with chloral hydrate and lidocaine hydrochloride, and ex vivo expanded P3 green fluorescent protein (GFP)-MSCs (1 × 106 cells) were administrated via one of the following modes: (1) systemic injection via the tail vein (systemic group), (2) local injection into the gingivobuccal fold around the dental implant (local group), ...
Bone marrow cells were flushed out of the femurs and tibias of 4-week-old green fluorescent protein-transgenic Wistar rats. Cells were treated with a 0.85% NH4Cl solution for 10 min to lyse the red blood cells and were passed through a 70-μm cell strainer to obtain a single cell suspension. Cells were seeded into 100-mm plastic culture dishes (1 × 106 cells/dish), washed with phosphate buff...
The purpose of this study was to verify the effects and mechanisms of bone marrow-derived MSCs following their local administration using an oral implantation rat model, to deepen our understanding of this approach for effective utilization of MSCs.
Mesenchymal stem cell (MSC)-based approaches can be broadly divided into two categories: cell therapy and regenerative medicine. Cell therapy is focused on the anti-inflammatory, immune-regulatory, and homeostasis-regulatory actions of MSCs to treat disorders like malignant lymphoma, angina pectoris, and atopic dermatitis. Conversely, regenerative medicine is focused on MSCs playing a tissue engin...
Multipotent mesenchymal stem cells (MSCs) are used clinically in regenerative medicine. Our previous report showed systemically injected MSCs improved peri-implant sealing and accelerated tissue healing. However, the risks of systemic MSC administration, including lung embolism, must be considered; therefore, their local application must be assessed for clinical safety and efficacy. We investigate...
Fig. 3. Forest plot of random effects meta-analysis of the incidence of Schneiderian membrane perforation using piezoelectric devices. The weighted average for the incidence rate of Schneiderian membrane perforation was 8%
Fig. 3. Forest plot of random effects meta-analysis of the incidence of Schneiderian membrane perforation using piezoelectric devices. The weighted average for the incidenc...
Fig. 2. Forest plot of random effects meta-analysis of the incidence of Schneiderian membrane perforation using conventional rotative instruments. The weighted average for the incidence rate of Schneiderian membrane perforation was 24%
Fig. 2. Forest plot of random effects meta-analysis of the incidence of Schneiderian membrane perforation using conventional rotative instruments. The weighted...
Fig. 1. Result of the search strategy and included and excluded studies
Fig. 1. Result of the search strategy and included and excluded studies
Piezoelectric
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Jordi, C., Mukaddam, K., Lambrecht, J.T. et al. Membrane perforation rate in lateral maxillary sinus floor augmentation using conventional rotating instruments and piezoelectric device—a meta-analysis.
Int J Implant Dent 4, 3 (2018). https://doi.org/10.1186/s40729-017-0114-2
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Received: 28 September 2017
Accepted: 20 December 2017
Published: 29 January 20...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
The authors Jordi Corinne, Mukaddam Khaled, Lambrecht Jörg Thomas and Kühl Sebastian state that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Department of Oral Surgery, Oral Radiology and Oral Medicine, University Center for Dental Medicine, University of Basel, Basel, Switzerland
Corinne Jordi, Khaled Mukaddam, Jörg Thomas Lambrecht & Sebastian Kühl
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We would like to express our gratitude to Ms. Irene Mischak for the statistical support.
Delilbasi C, Gurler G. Comparison of piezosurgery and conventional rotative instruments in direct sinus lifting. Implant Dent. 2013;22(6):662–5.
Becker ST, Terheyden H, Steinriede A, Behrens E, Springer I, Wiltfang J. Prospective observation of 41 perforations of the Schneiderian membrane during sinus floor elevation. Clin Oral Implants Res. 2008;19(12):1285–9.
Hernandez-Alfaro F, Torradeflo...
Blus C, Szmukler-Moncler S, Salama M, Salama H, Garber D. Sinus bone grafting procedures using ultrasonic bone surgery: 5-year experience. Int J Periodontics Restorative Dent. 2008;28(3):221–9.
Cortes AR, Cortes DN, Arita ES. Effectiveness of piezoelectric surgery in preparing the lateral window for maxillary sinus augmentation in patients with sinus anatomical variations: a case series. Int J ...
Froum SJ, Khouly I, Favero G, Cho SC. Effect of maxillary sinus membrane perforation on vital bone formation and implant survival: a retrospective study. J Periodontol. 2013;84(8):1094–9.
Stricker A, Voss PJ, Gutwald R, Schramm A, Schmelzeisen R. Maxillary sinus floor augmentation with autogenous bone grafts to enable placement of SLA-surfaced implants: preliminary results after 15-40 months. C...
Wannfors K, Johansson B, Hallman M, Strandkvist T. A prospective randomized study of 1- and 2-stage sinus inlay bone grafts: 1-year follow-up. Int J Oral Maxillofac Implants. 2000;15(5):625–32.
Hallman M, Nordin T. Sinus floor augmentation with bovine hydroxyapatite mixed with fibrin glue and later placement of nonsubmerged implants: a retrospective study in 50 patients. Int J Oral Maxillofac I...
Tawil G, Mawla M. Sinus floor elevation using a bovine bone mineral (Bio-Oss) with or without the concomitant use of a bilayered collagen barrier (Bio-Gide): a clinical report of immediate and delayed implant placement. Int J Oral Maxillofac Implants. 2001;16(5):713–21.
Yilmaz HG, Tozum TF. Are gingival phenotype, residual ridge height, and membrane thickness critical for the perforation of max...
Geminiani A, Tsigarida A, Chochlidakis K, Papaspyridakos PV, Feng C, Ercoli C. A meta-analysis of complications during sinus augmentation procedure. Quintessence Int. 2017;48(3):231–40.
Esposito M, Felice P, Worthington HV. Interventions for replacing missing teeth: augmentation procedures of the maxillary sinus. Cochrane Database Syst Rev. 2014;5:CD008397.
Galindo-Moreno P, Avila G, Fernandez...
Tatum H. Maxillary and sinus implant reconstructions. Dent Clin N Am. 1986;30(2):207–29.
Boyne PJ, James RA. Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg. 1980;38(8):613–6.
Khoury F. Augmentation of the sinus floor with mandibular bone block and simultaneous implantation: a 6-year clinical investigation. Int J Oral Maxillofac Implants. 1999;14(4):557–6...
The aim of the present study was to resume in a review the literature evaluating the incidence of sinus membrane perforation comparing conventional rotating instruments with piezoelectric devices. Since only scarce studies exist comparing both techniques directly, we decided to additionally include any study on MSA in which information on the applied technique, e.g. conventional or piezosurgery, w...
Atieh [11] found no significant difference in perforation risk. In these studies, occurred in the two groups of the RCTs are almost identical perforations. Maybe due to the fact that they included only one RS, while our study included 22, they see no deviation.
The review of Stacchi [12] also described a lower incidence of membrane perforation during piezosurgery (10.9%) than during conventional ...
Though both techniques exist more than 20 years, only single studies could be found in which the incidence of membrane perforation was focused comparing both operative techniques. This was the rationale for our meta-analysis. Principally, there is a controversy in the literature concerning the use of piezosurgical devices for MSA. Torrella et al. showed a reduced risk for perforations of the sinu...
Finally, a significance analysis was performed between both groups in terms of a t test. The significance level was set at p
The database PubMed and the US National Library of Medicine were screened from January 8, 2012, to January 6, 2016, for potential studies reporting on membrane perforations during MSA from 1980 till 2015. The search was conducted independently and in duplicate by two authors (MK and JC). The following search terms were used:
MeSH Terms:
Piezo-surgery
Ultrasound
Ultrasonic Osteotomy
Maxillary ...
Atieh et al. [11] examined the intra- and postoperative events associated with the use of piezoelectric devices and conventional rotary instruments for lateral MSA in a systematic review. They included four studies with 178 lateral MSA in 120 participants. The meta-analysis did not show any significant difference between the two surgical techniques. Stacchi et al. [12] analysed the occurrence of i...
Maxillary sinus augmentation (MSA) is a successful and predictable procedure to rehabilitate the atrophic edentulous posterior maxilla after postextractional pneumatisation of the sinus and bone loss with dental implants. Different approaches to elevate the maxillary sinus floor have been described and were originally introduced by Tatum [1, 2]. The lateral approach provides drilling a window in t...
Maxillary sinus augmentation (MSA) is a successful and predictable intervention with low complication rates. Perforations of the Schneiderian membrane may occur impairing the general success. The aim of this study was to compare the incidence of membrane perforations between conventional rotating instruments and piezoelectric devices in a meta-analysis.
An electronic research on MEDLINE and PubMe...
Fig. 5. Bone resorption in the follow-up of the control group and the perforation group
Fig. 5. Bone resorption in the follow-up of the control group and the perforation group
Fig. 4. The initial bone level of the control group and the perforation group
Fig. 4. The initial bone level of the control group and the perforation group
Fig. 3. Reasons for perforations
Fig. 3. Reasons for perforations
Fig. 2. Overview of the perforation treatment in the study group
Fig. 2. Overview of the perforation treatment in the study group
Fig. 1. Bone levels after sinus floor elevation
Fig. 1. Bone levels after sinus floor elevation
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Beck-Broichsitter, B.E., Westhoff, D., Behrens, E. et al. Impact of surgical management in cases of intraoperative membrane perforation during a sinus lift procedure: a follow-up on bone graft stability and implant success.
Int J Implant Dent 4, 6 (2018). https://doi.org/10.1186/s40729-018-0116-8
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Received: 03 October 2017
Accepted: 03 January 2018
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Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
The authors Benedicta Beck-Broichsitter, Dorothea Westhoff, Eleonore Behrens, Jörg Wiltfang, and Stephan T. Becker declare that there are no existing competing interests concerning this collaborative work.
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Correspondence to
Benedicta E. Beck-Broichsitter.
Department of Oral and Maxillofacial Surgery, Charité–University Medical Center Berlin, Augustenburger Platz 1, 13353, Berlin, Germany
Benedicta E. Beck-Broichsitter
Department of Oral and Maxillofacial Surgery, Schleswig-Holstein University Hospital, Arnold-Heller-Straße 3, Haus 26, 24105, Kiel, Germany
Dorothea Westhoff, Eleonore Behrens, Jörg Wiltfang & Stephan T. Becker
You can al...
This study was not funded.
Shlomi B, Horowitz I, Kahn A, Dobriyan A, Chaushu G. The effect of sinus membrane perforation and repair with Lambone on the outcome of maxillary sinus floor augmentation: a radiographic assessment. Int J Oral Maxillofac Implants. 2004;19(4):559–62.
Moreno Vazquez JC, Gonzalez de Rivera AS, Gil HS, Mifsut RS. Complication rate in 200 consecutive sinus lift procedures: guidelines for prevention ...
Sakkas A, Konstantinidis I, Winter K, Schramm A, Wilde F. Effect of Schneiderian membrane perforation on sinus lift graft outcome using two different donor sites: a retrospective study of 105 maxillary sinus elevation procedures. GMS Interdiscip Plast Reconstr Surg DGPW. 2016;5:Doc11.
Springer IN, Terheyden H, Geiss S, Harle F, Hedderich J, Acil Y. Particulated bone grafts—effectiveness of bone...
Wiltfang J, Schultze-Mosgau S, Nkenke E, Thorwarth M, Neukam FW, Schlegel KA. Onlay augmentation versus sinuslift procedure in the treatment of the severely resorbed maxilla: a 5-year comparative longitudinal study. Int J Oral Maxillofac Surg. 2005;34(8):885–9.
Pikos MA. Maxillary sinus membrane repair: report of a technique for large perforations. Implant Dent. 1999;8(1):29–34.
Cha HS, Kim ...
In conclusion, and within the limits of its retrospective nature, our study implies that in cases of intraoperative perforation of the Schneiderian membrane, a consequent surgical assessment and treatment might avoid complications regarding graft stability and implant survival. Two-stage procedures might be appropriate if primary stability does not seem to be achievable. Augmentation of the sinus ...
The surgical management in cases of a membrane perforation might also influence the overall postoperative outcome and complications. Although the sinus lifting procedure has been established for many years now, there are no evidence-based guidelines for perforation closure or indications to interrupt the procedure. To date, most existing studies recommend sealing smaller sizes of perforations with...
One implant was lost in the perforation group due to early-onset peri-implantitis, whereas all implants in the control group were still in place. As we had previously prospectively reported on the first 6 months after dental implantation in this cohort [11], there was no further impact of membrane perforation on implant loss for at least 12 to 24 months in this retrospective evaluation. The appe...
The aim of this retrospective cohort study was to evaluate the impact of intraoperative perforations of the Schneiderian membrane during sinus floor elevation on the stability of the augmented area and its influence on osseointegration after implant insertion. Therefore, we could re-assess a patient cohort of originally 34 patients with 41 perforations and compare their outcome with a control grou...
The initial bone level differed significantly (p = 0.05) between both groups with a median value of 5.69 mm in the study group and 3.87 mm in the control group (Fig. 4). A Mann-Whitney-U-Wilcoxon test revealed no significant difference between bone level postoperatively (p = 0.7851; median value control group 17.40 mm; median value perforation group 16.91 mm), in follow-up (p = 0....
The mean control interval was 2.69 (± 2.03) years. At the time of the follow-up examination, the average age was 59.95 (± 11.82) years.
In the remaining collective of 31 patients (96.97%; 12 males (37.54%) and 19 females (59.43%)), a total of 92 implants were inserted. The overview of perforation treatment in the study group is given in Fig. 2, and Fig. 3 depicts the reasons for perforati...
One independent oral and maxillofacial surgeon performed the clinical follow-up examinations according to a standardized protocol. A peri-implant probing including probing pocket depths and recessions on four sites of each implant was assessed as was bleeding on probing (BOP) to determine the status of oral hygiene objectively. Signs of gingivitis and pus suppuration were also recorded. The criter...
Three different oral and maxillofacial surgeons performed the sinus lift procedure with an external approach according to comparable surgical standards and inserted all implants examined in this study in a submerged protocol with uncovering after 3–4 months due to the manufacturer’s surgical recommendations. Specifically, a total of 35 external sinus floor elevations were performed through a ...
In accordance with the WMA Declaration of Helsinki—Ethical Principles for Medical Research Involving Human Subjects, approval was given by the local ethics committee of the Christian-Albrechts-University in Kiel (AZ 132/10). All patients gave informed written consent to participate.
A total of 201 sinus floor elevation procedures, which were performed from 2005 to 2006 in the Department of Oral...
Sinus floor elevation procedures have become a predictable and successful treatment, performed when the maxillary alveolar ridge is atrophied and the bone height is not sufficient for primary implantation. If the postoperative course remains uneventful, the outcome is highly predictable [1,2,3]. However, complications may have a negative impact on the overall treatment success. As a common complic...
Until now, sinus floor elevation represents the gold standard procedure in the atrophic maxilla in order to facilitate dental implant insertion. Although the procedure remains highly predictive, the perforation of the Schneiderian membrane might compromise the stability of the augmented bone and implant success due to chronic sinus infection. The aim of this retrospective cohort study was to show ...
Fig. 9. The comparison of two groups at average voxel values for each part. The comparison of voxel values by insertion torque. All specimens were classified into two groups by insertion torque
Fig. 8. The relationship between average voxel value and insertion torque (averaged over the entire treatment area). The comparison of average voxel value among IT groups. Average voxel value was 384.0 ± 154.6 in the low IT group, 387.7 ± 147.7 in the medium IT group, and 619.2 ± 200.4 in the high IT group
Fig. 8. The relationship between average voxel value and insertion torqu...
Fig. 7. The average voxel value between the maxilla and mandible. There was no difference between the maxilla (430.9 ± 211.6) and the mandible (475.6 ± 211.5) in the average voxel value. Also, no difference was found in each part
Fig. 7. The average voxel value between the maxilla and mandible. There was no difference between the maxilla (430.9 ± 211.6) and the mandible (475.6...
Fig. 6. The relationship between ISQ and insertion torque. Percentage of specimens showing ISQ ≥ 73 compared with groups by week. In all groups, a period of rapidly increasing percentages was observed (8–12 weeks in the low IT group, 4–6 weeks in the medium and high IT groups). In the medium and high IT Group, a statistically significant difference was observed between ISQ ≥ 73 a...
Fig. 5. The comparison of ISQ values by the insertion torque. Time-lapse migration of ISQ values was compared with IT groups. Each IT group displayed similar migration. A significant difference in The ISQ was found in the low IT group after 8 weeks
Fig. 5. The comparison of ISQ values by the insertion torque. Time-lapse migration of ISQ values was compared with IT groups. Each IT group displ...
Fig. 4. The classification of the insertion torque. All specimens classified into three groups according to insertion torque. Criteria for the classification are shown in the figure and in the “Methods” section
Fig. 4. The classification of the insertion torque. All specimens classified into three groups according to insertion torque. Criteria for the classification are shown in the figur...
Fig. 3. The evaluation of the average ISQ. Time-lapse migration of average ISQ. Average ISQ of all specimens increased in a time-dependent manner (results indicated by a line). A significant difference was observed by 6 weeks after surgery
Fig. 3. The evaluation of the average ISQ. Time-lapse migration of average ISQ. Average ISQ of all specimens increased in a time-dependent manner (results...
Fig. 2. The measurement of the voxel values. A case of bone quality diagnosis before treatment. Width and height of the bone were measured to select the proper size of the implant body. The selected implant body was simulated on the bone images as a symbol, and then the voxel value was calculated as described in the “Methods” section
Fig. 2. The measurement of the voxel values. A case of ...
Fig. 1. Genesio® Plus implant with Aanchor surface. Scheme of the dental implant body for the Genesio® Plus implants with Aanchor surface used. a Overview picture of Genesio® Plus implants with Aanchor surface. b Image from scanning electron microscopy. Both pictures were provided by GC Corporation. To obtain osseointegration from an early stage, the dental implant body was treated with sandb...
Number of implants
Insertion torque value (N cm)
Implant stability quotient value
0 week
2 weeks
...
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Treatment area (FDI)
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...
Homma, S., Makabe, Y., Sakai, T. et al. Prospective multicenter non-randomized controlled study on intraosseous stability and healing period for dental implants in the posterior region.
Int J Implant Dent 4, 10 (2018). https://doi.org/10.1186/s40729-018-0122-x
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Received: 05 September 2017
Accepted: 25 January 2018
Published: 29 March 2018
DOI: https://doi...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
This research was conducted in accordance with the Helsinki Declaration of 1964 and subsequent ethical standards, with the approval of Tokyo Dental University and Fukuoka Dental College Ethics Committee (World Medical 2013). The surgeon explained the contents of the research to each patient, who then consented to participate in the present study.
All participants consented to publish their inform...
Correspondence to
Shinya Homma.
Department of Oral and Maxillofacial Implantology, Tokyo Dental College, 2-9-18 Misaki-cho, Chiyoda-ku, Tokyo, 101-0061, Japan
Shinya Homma, Yasushi Makabe & Yasutomo Yajima
Section of Oral Implantology, Department of Oral Rehabilitation, Fukuoka Dental College, 2-15-1 Tamura, Sawara-ku, Fukuoka-City, Fukuoka, 814-0175, Japan
Takuya Sakai, Kenzou Morinaga & Hirofumi Kido
Center for Oral ...
Nedir R, Bischof M, Szmukler-Moncler S, Bernard JP, Samson J. Predicting osseointegration by means of implant primary stability. Clin Oral Implants Res. 2004;15(5):520–8.
Ito Y, Sato D, Yoneda S, Ito D, Kondo H, Kasugai S. Relevance of resonance frequency analysis to evaluate dental implant stability: simulation and histomorphometrical animal experiments. Clin Oral Implants Res. 2008;19(1):9–...
Boronat López A, Balaguer Martínez J, Lamas Pelayo J, Carrillo García C, Peñarrocha DM. Resonance frequency analysis of dental implant stability during the healing period. Med Oral Patol Oral Cir Bucal. 2008;13(4):E244–7.
Gapski R, Wang HL, Mascarenhas P, Lang NP. Critical review of immediate implant loading. Clin Oral Implants Res. 2003;14(5):515–27.
Esposito M, Hirsch JM, Lekholm U, Th...
Schulte W, Lukas D. The Periotest method. Int Dent J. 1992;42(6):433–40.
Meredith N, Book K, Friberg B, Jemt T, Sennerby L. Resonance frequency measurements of implant stability in vivo. A cross-sectional and longitudinal study of resonance frequency measurements on implants in the edentulous and partially dentate maxilla. Clin Oral Implants Res. 1997;8(3):226–33.
Meredith N. Assessment of i...
Aparicio C, Rangert B, Sennerby L. Immediate/early loading of dental implants. A report from the Sociedad Española de Implantes World Congress consensus meeting in Barcelona, Spain 2002. Implant Dent Relat Res. 2003;5:57–60.
Cochran DL, Moeton D, Weber HP. Consensus statements and recommended clinical procedures regarding loading protocols for endosseous dental implants. Int J Oral Maxillofac ...
Cone beam CT
Computed tomography
Digital Imaging and Communications in Medicine
Implant stability quotient
Insertion torque
Multi-slice CT
The purpose of this study was to evaluate the relationship between the insertion torque value and the ISQ value at the implant treatment using the current rough-surfaced implant. As a result, no significant relationship was found between the insertion torque value and the ISQ value. Also, it was suggested that the ISQ value was considered to be an important indicator for observing the treatment st...
As accurate CT attenuation was not measured due to the lower spatial resolution of CBCT compared with MSCT, a CBCT was recognized as unsuitable for evaluating bone quality. However, several groups have recently reported the potential use of CBCT systems as an apparatus for estimating bone quality. Isoda et al. described a high correlation between voxel values obtained by CBCT and IT of the implant...
In this study, we could not find a significant relationship between insertion torque value and ISQ value. However, insertion torque value is an important indicator for predicting the progress of implant treatment, and ISQ value is considered to be an important indicator for observing the treatment state of the implant. Currently, the insertion torque value is used as the major decision index for t...
Increases or decreases of ISQ values are explained as follows: The inserted dental implant body is supported by mechanical interdigitating force after surgery, but this interdigitating force will be reduced time-dependently by the effects of osteoclasts activation at the initial stage of the bone remodeling process, then osseointegration will be completed by an increasing contact area between the ...
The insertion torque value in this study showed broader (10 to 50 N cm) than the previous publication (Table 2) [22, 32], and the cause of reasons for the difference are as follows: Primary stability may be affected by the bone quantity and bone quality in the treatment area, the micro- and macro-level design of the implant body, and the accuracy of the surgical technique [18, 25]. In this stud...
According to the previous literature, the obtaining osseointegration is integral to the intraosseous stability of the implant body during the healing period [24]; moreover, the importance of postoperative assessment of the intraosseous stability of the implant has also been reported [10]. Intraosseous stability of the implant body is evaluated immediately after the implant insertion and during the...
Average ISQ tended to increase during the healing period in all IT groups (Fig. 5). Average ISQ of the low IT group was 59.81 at 0 week, increasing significantly after ≥ 8 weeks (P
A total of 33 implant bodies (8 in the maxilla, 25 in the mandible) were inserted into the 27 participants (11 men, 16 women), with the average age of 54.6 ± 12.2 years (range, 32–78 years). The average IT value was 32.7 ± 9.2 N cm (32.5 ± 11.6 N cm in the maxilla, 32.8 ± 8.5 N cm in the mandible). The diameter of the implant body was 4.4 mm in 20 (60.6%) and 3.8 mm...
The CBCT was performed using a 3DX Multi-Image Micro CT FPD 8 system (J. MORITA MFG., Kyoto, Japan) (tube voltage, 80 kV; imaging area, 80 × 80 mm), and voxel values were measured with coDiagnostix™ 9.7 (dental wings, Montreal, Canada). The voxel values were calculated based on CT images for bone quality diagnosis. Voxel values were measured three times at 12 locations covering the mesial...
Implant treatment was performed in accordance with the procedure recommended by the manufacturer, without bone augmentation. A healing abutment was connected to the implant bodies after insertion (implant insertion in one stage method). A total of 17 dentists (treatment experience, 5–35 years; average, 11.5 years) performed all implant treatments in this study. All dentists who performed the i...
This prospective study was conducted jointly by Tokyo Dental College (Tokyo, Japan) and Fukuoka Dental College (Fukuoka, Japan) from January to December 2015. All study protocols were conducted in accordance with the Declaration of Helsinki [21] and were approved by the ethics committees of Tokyo Dental College (approval #416) and Fukuoka Dental College (approval #213).
Participants comprised pat...
The purpose of this study is to evaluate the relationship between IT and ISQ at implant treatment using the current rough surfaced implant. We evaluated the implant treatment sites with implant stability quotient (ISQ) values, IT values, and voxel values. We assumed that there is relevance between the insertion torque value and the ISQ value.
Dental implant treatments have improved in both convenience and predictability with refinements in implant bodies and treatment procedures as compared to about 50 years ago when clinical applications were started. Currently, an implant body surface is treated with “rough processing” by sandblasting and acid etching for the purposes of obtaining more reliable osseointegration and shortening tr...
A current implant body surface was treated with “rough processing” by sandblasting and acid etching for the purposes of obtaining more reliable osseointegration and shortening the treatment period. Various reports have examined the healing period with the use of these implant bodies, but a consensus opinion has not yet been obtained. The purpose of this study is to evaluate the relationship be...
A current implant body surface was treated with “rough processing” by sandblasting and acid etching for the purposes of obtaining more reliable osseointegration and shortening the treatment period. Various reports have examined the healing period with the use of these implant bodies, but a consensus opinion has not yet been obtained. The purpose of this study is to evaluate the relationship be...
Fig. 7. Box and Whisker plot representing median and range values of membrane thicknesses with different morphologies
Fig. 7. Box and Whisker plot representing median and range values of membrane thicknesses with different morphologies
Fig. 6. Box plot representing mean values of membrane thicknesses for the investigated groups
Fig. 6. Box plot representing mean values of membrane thicknesses for the investigated groups
Fig. 5. Endoscopic view from the crestal osteotomy site showing perforation of the sinus lining under the power of magnification and illumination of the endoscope
Fig. 5. Endoscopic view from the crestal osteotomy site showing perforation of the sinus lining under the power of magnification and illumination of the endoscope
Fig. 4. Schematic drawing showing entrance of the endoscope from the crestal osteotomy site after sinus membrane elevation to assess the integrity of the membrane
Fig. 4. Schematic drawing showing entrance of the endoscope from the crestal osteotomy site after sinus membrane elevation to assess the integrity of the membrane
Fig. 3. Endoscopic view from the lateral sinus wall showing the dome-shape elevation of sinus lining
Fig. 3. Endoscopic view from the lateral sinus wall showing the dome-shape elevation of sinus lining
Fig. 2. Malleting instruments supplied from InnoBioSurg (IBS) Company, Korea. a magic sinus splitter: used to widen and split the crest. b magic sinus lifter: used to lift the available bone with its attached membrane
Fig. 2. Malleting instruments supplied from InnoBioSurg (IBS) Company, Korea. a magic sinus splitter: used to widen and split the crest. b magic sinus lifter: used to lift the a...
Fig. 1. A trephined hole (4 mm bone) in the lateral wall of the maxillary sinus to allow entrance of the endoscope
Fig. 1. A trephined hole (4 mm bone) in the lateral wall of the maxillary sinus to allow entrance of the endoscope
Morphology
No perforation
Perforation
P value
No. (%)
No. (%)
Flat (n = 4)
...
Morphology
Mean ± SD (mm)
Median (range)
P value
Perforation rate (%)
Flat (n = 4)
...
Group
No perforation
Perforation
P value
No. (%)
No. (%)
Group (A)
...
Group
Membrane thickness
Mean ± SD (mm)
Median (range)
Percentage (%) (from total)
Perforation rate (%...
Elian, S., Barakat, K. Crestal endoscopic approach for evaluating sinus membrane elevation technique.
Int J Implant Dent 4, 15 (2018). https://doi.org/10.1186/s40729-018-0126-6
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Received: 08 November 2017
Accepted: 20 March 2018
Published: 17 May 2018
DOI: https://doi.org/10.1186/s40729-018-0126-6
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Faculty of Dentistry, Minia University ethics committee approved the study. All patients gave the consent to participate in the surgery.
All patients approved for publications.
The authors Samy Elian and Khaled Barakat declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Faculty of Dentistry, Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland
Samy Elian
Faculty of Dental Surgery, Royal College of Physicians and Surgeons of Glasgow, Glasgow, Scotland
Samy Elian
Dentistry Department, Sohag University Hospital, Sohag, Egypt
Samy Elian
Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Minya University, Minya, Egypt
Khaled Barakat
You c...
We would like to express our gratitude to Ass. Prof. Hamed Gad for his clinical collaboration.
This research was carried out without funding.
The data supporting our findings can be requested for free at any time.
Berengo M, Sivolella S, Majzoub Z, Cordioli G. Endoscopic evaluation of the bone-added osteotome sinus floor elevation procedure. Int J Oral Maxillofac Surg. 2004;33(2):189–94.
Nkenke E, Schlegel A, Schultze-Mosgau S, Neukam FW, Wiltfang J. The endoscopically controlled osteotome sinus floor elevation: a preliminary prospective study. Int J Oral Maxillofac Implants. 2002;17(4):557–66.
Nahlie...
Summers RB. A new concept in maxillary implant surgery: the osteotome technique. Compendium. 1994;15(2):152. 54-6, 58 passim; quiz 62
Zitzmann NU, Scharer P. Sinus elevation procedures in the resorbed posterior maxilla. Comparison of the crestal and lateral approaches. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(1):8–17.
Ardekian L, Oved-Peleg E, Mactei EE, Peled M. The clinical ...
Crestal sinus lifting technique is a simple less invasive procedure. Nevertheless, it suffers a serious disadvantage of being a blind technique. Thus, perforation can easily occur without being detected which will lead to later implant failure especially when bone graft is added [1, 12,13,14]. We used endoscopic-assisted evaluation as a dependable method to assess the safety of the Schneiderian me...
On the other hand, assessing the effect of membrane morphology pattern on the perforation risk revealed that the polyp type has the lowest risk of perforation, whereas the irregular type represents the most insecure pattern. There was a relation between different membrane morphology and perforation.
All patients tolerated the procedure without major complications. Minor complications included postoperative swelling, edema, and pain that were managed by antibiotic and anti-inflammatory drugs. All implants were successfully osseo-integrated and loaded after about 6 months.
The floor was lifted without perforation in 83.33% of cases. The lifter was able to raise and stretch the sinus membrane ...
After completing the elevation of the Schneiderian membrane, the endoscope (70° lens) was removed from the lateral wall of the maxillary sinus and re-inserted (with 0°) from the crestal osteotomy site of the implant (Fig. 4) to check the integrity of the Schneiderian membrane, as well as to ensure the absence of any undetected minor perforation (Fig. 5). The implant was finally inserted in the...
Twelve patients (4 males and 8 females) ranging in age from 25 to 60 years were included in the study. All patients have bone height ranging 3–5 mm below the sinus membrane. They all performed closed sinus lifting and simultaneous immediate implant insertion.
Under local anesthesia, the flap was elevated and retracted exposing the crestal and buccal bone. A trephine bur 4 mm diameter on hand...
The evolution of closed sinus lift techniques since 1994 [1] was proposed as a less invasive method for management of atrophic posterior maxillae [2]. However, it is a blind technique that lacks the ability to confirm an intact sinus floor elevation without perforation and thus represented a real shortcoming [3]. Various forms of osteotome lifters were designed to guarantee safe elevation of maxil...
Fig. 1. PRISMA flow diagram
Fig. 1. PRISMA flow diagram
Risk of bias
Study
Maïmoun et al. 2010 [29]
Li et al. 2010 [32]
Li et al. 2012 [33]
...
Study
Tests and overall results
Bone mineral density
Histomorphometric
Biomechanical
...
Study
Sample characteristics
Animal model
Study groups
Treatment start
Duration of ...
Scardueli, C.R., Bizelli-Silveira, C., Marcantonio, R.A.C. et al. Systemic administration of strontium ranelate to enhance the osseointegration of implants: systematic review of animal studies.
Int J Implant Dent 4, 21 (2018). https://doi.org/10.1186/s40729-018-0132-8
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Received: 14 November 2017
Accepted: 23 April 2018
Published: 17 July 2018
DOI: https:/...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
This review was executed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses), and the Cochrane Handbook for Systematic Reviews of Interventions, and no approval by an ethics committee is demanded.
All participants consented to publish their information details.
Cássio Rocha Scardueli, Carolina Bizelli-Silveira, Rosemary Adriana C. Marcantonio, Elcio Ma...
Correspondence to
Cassio Rocha Scardueli.
Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark
Cassio Rocha Scardueli, Carolina Bizelli-Silveira & Rubens Spin-Neto
Department of Periodontology, São Paulo State University (Unesp), School of Dentistry, Araraquara, São Paulo, Brazil
Cassio Rocha Scardueli, Rosemary Adriana C. Marcantonio & Elcio Marcantonio Jr
Department of Periodontology, Faculty of Odonto...
Berardi D, Carlesi T, Rossi F, Calderini M, Volpi R, Perfetti G. Potential applications of biphosphonates in dental surgical implants. Int J Immunopathol Pharmacol. 2007;20:455–65.
Javed F, Almas K. Osseointegration of dental implants in patients undergoing bisphosphonate treatment: a literature review. J Periodontol. 2010;81:479–84.
Jonville-Bera A, Autret-Leca E. Ranélate de strontium (Pr...
Marie PJ, Felsenberg D, Brandi ML. How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis. Osteoporos Int. 2011;22:1659–67.
Canalis E, Hott M, Deloffre P, Tsouderos Y, Marie PJ. The divalent strontium salt S12911 enhances bone cell replication and bone formation in vitro. Bone. 1996;18:517–23.
Peng S, Liu XS, Wang T, Li Z, Zhou G, Luk KD, et al. ...
Arlot ME, Jiang Y, Genant HK, Zhao J, Burt-Pichat B, Roux JP, et al. Histomorphometric and microCT analysis of bone biopsies from postmenopausal osteoporotic women treated with strontium ranelate. J Bone Miner Res. 2008;23:215–22.
Moher D, Liberati A, Tetzlaff J, Altman DG, Group P. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535.
J...
Pemmer B, Hofstaetter JG, Meirer F, Smolek S, Wobrauschek P, Simon R, et al. Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride. J Synchrotron Radiat. 2011;18:835–41.
Peng S, Liu XS, Zhou G, Li Z, Luk KD, Guo XE, et al. Osteoprotegerin deficiency attenuates strontium-mediated inhibition of osteoclastogenes...
Davies JE. Mechanisms of endosseous integration. Int J Prosthodont. 1998;11:391–401.
Davies JE. Understanding peri-implant endosseous healing. J Dent Educ. 2003;67:932–49.
Sakka S, Baroudi K, Nassani MZ. Factors associated with early and late failure of dental implants. J Investig Clin Dent. 2012;3:258–61.
Bastos AS, Spin-Neto R, Conte-Neto N, Galina K, Boeck-Neto RJ, Marcantonio C, et al...
Medical Literature Analysis and Retrieval System Online
Ovariectomy
Strontium
Strontium ranelate
Systematic Review Centre for Laboratory animal Experimentation
Based on the few studies included in this systematic review, it is possible to state that the systemic administration of Sr, in the form of SRAN, seems to enhance peri-implant bone quality and implant osseointegration, however, to a moderate extent. Further studies should focus on standardization of the study designs to properly assess the effects of Sr, including parameters such SRAN dose, admini...
The variability in the results of the studies included in this review, may not only relate to SRAN dose, but may somehow relate to differences in the time-period after ovariectomy, before the animals were included in the study, which differed greatly among studies (from 4 to 12 weeks). Although it is already defined in the literature that initial osteoporosis features appear already at 4 weeks a...
All studies included in this review tested the hypothesis that non-radioactive Sr supplementation would enhance implant osseointegration. Overall, the results of the included studies suggest that the systemic Sr administration enhances peri-implant bone quality and implant osseointegration, however to a moderate extent. Positive results regarding implant osseointegration and the quality of peri-im...
Sr is a metabolic trace element closely related to calcium. Sr2+ ions are incorporated into bone by two main mechanisms: (a) a rapid uptake mechanism, dependent on osteoblast activity, whereby Sr2+ becomes absorbed via ion exchange processes with Ca2+ or binding to osteoid proteins, and (b) Sr2+ ions incorporate into the crystal lattice of the bone mineral phase. [34] When Sr2+ is present in highe...
In three studies from the same research group, female rats with ovariectomy-induced (OVX) osteoporosis were included [31,32,33]. Although the same research group performed the studies, the results were based on diverse animal populations, as it can be inferred from the studies. Rats receiving a high dose of SRAN (SRANH, 1000 mg/kg/day) showed an increased ratio between bone and total voxels in di...
The initial search for publications yielded 578 titles in MEDLINE (PubMed) database, and 152 in Scopus database. After duplicates were removed, there were a total of 553 titles to be screened. After initial screening, using the abstracts and key words, 37 publications remained (31 from PubMed and 6 from Scopus), that potentially met the inclusion criteria. Hand-searching did not reveal any additio...
Three independent researchers (CRS, CBS, and RSN) conducted data extraction and validity assessment of the studies that met the inclusion criteria. Data was extracted focusing on the animal model, study groups, treatment start, duration of the treatment, period of examination, implant specification, evaluation methods, and results (outcomes), according to what was reported in each study (i.e., his...
This review was executed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) [26], and the Cochrane Handbook for Systematic Reviews of Interventions [27].
Animal studies in which the methodology/results included parameters regarding the use of systemic administration of non-radioactive Sr to enhance the osseointegration of implants and/or the remodeling ...
Thus, the aim of this review was to undertake a systematic review of the literature on the available evidence—deriving from animal studies—on the systemic administration of non-radioactive Sr to enhance the osseointegration of titanium implants and/or the bone regeneration (i.e., remodeling) in association with bone grafting techniques.
Following the trauma induced to the bone tissue during dental implant installation, wound healing involves the fine-tuned coupling of bone resorption and formation [1, 2], which finally leads to the direct bone-to-implant contact, i.e., implant osseointegration [3]. The same biological mechanisms are involved in the wound healing (i.e., remodeling) of a bone defect filled with bone graft and/or bo...
The literature states that Strontium (Sr) is able to simultaneously stimulate bone formation and suppress bone resorption. Recent animal studies suggest that the systemic administration of Sr, in the form of strontium ranelate (SRAN), would enhance the osseointegration of implants. The purpose of the present study was to undertake a systematic review on animal studies evaluating the systemic admin...
Fig. 1. PRISMA flow diagram of literature search
Fig. 1. PRISMA flow diagram of literature search
Study (year)
Sample (size)
Treatment group (size)
Methodology
Parameter
...
Study (year)
Sample (size)
Treatment group (size)
Methodology
Parameter
...
Study (year)
Sample
Treatment group
Methodology
Parameter
Outco...
Item
Domain
5
Ethical statement
6
Study design
...
Study
Random sequence generation
Allocation concealment
Blinding of participants/personnel
Blinding of outcome assessment
...
Item
Domain
1
Abstract: structured summary of trial design, methods, results, and conclusions
Introduction
...
Luo, J., Miller, C., Jirjis, T. et al. The effect of non-steroidal anti-inflammatory drugs on the osteogenic activity in osseointegration: a systematic review.
Int J Implant Dent 4, 30 (2018). https://doi.org/10.1186/s40729-018-0141-7
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Received: 22 May 2018
Accepted: 13 July 2018
Published: 09 October 2018
DOI: https://doi.org/10.1186/s40729-018-0141-7
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Not applicable
Not applicable
Jie Denny Luo, Catherine Miller, Tamara Jirjis, Masoud Nasir, and Dileep Sharma declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
College of Medicine & Dentistry, James Cook University, 14-88 McGregor Road, Smithfield, QLD, 4878, Australia
Jie Denny Luo, Tamara Jirjis, Masoud Nasir & Dileep Sharma
College of Public Health, Medical and Veterinary Sciences, James Cook University, 14-88 McGregor Road, Smithfield, QLD, 4878, Australia
Catherine Miller
You can also search for this author in
PubMed...
The authors acknowledge and are grateful for the help and preparation of manuscript by the supporting research supervisors: Dr. Ernest Jennings and Prof. Alan Nimmo.
The systematic review is funded by James Cook University College of Medicine and Dentistry as part of a Dentistry Honours Research Project.
A meta-analysis was not conducted for this systematic review. The critical analysis tables t...
Winnett B, Tenenbaum HC, Ganss B, Jokstad A. Perioperative use of non-steroidal anti-inflammatory drugs might impair dental implant osseointegration. Clin Oral Implants Res. 2016;27(2):E1–7.
Goodman SB, Ma T, Mitsunaga L, Miyanishi K, Genovese MC, Smith RL. Temporal effects of a COX-2-selective NSAID on bone ingrowth. J Biomed Mater Res A. 2005;72((3):279–87.
Ribeiro FV, Cesar-Neto JB, Nocit...
Marquez-Lara A, Hutchinson ID, Nuñez F, Smith TL, Miller AN. Nonsteroidal anti-inflammatory drugs and bone-healing: a systematic review of research quality. JBJS Rev. 2016;4(3). https://doi.org/10.2106/JBJS.RVW.O.00055.
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate...
Salari P, Abdollahi M. Controversial effects of non-steroidal anti-inflammatory drugs on bone: a review. Inflamm Allergy Drug Targets. 2009;8(3):169–75.
Boursinos LA, Karachalios T, Poultsides L, Malizos KN. Do steroids, conventional non-steroidal anti-inflammatory drugs and selective Cox-2 inhibitors adversely affect fracture healing? J Musculoskelet Neuronal Interact. 2009;9(1):44–52.
Kaly...
Cyclooxygenase
Non-steroidal anti-inflammatory drug/s
Prostaglandin
Prostaglandin E2
The analgesic and therapeutic effects of NSAIDs are achieved by COX-2 inhibition [4]. It is likely that COX inhibition by NSAIDs is detrimental to the bone healing process, given the favourable actions of PG on this process [4]. Osteoblasts have the capacity to produce PGs, where PGE2 is most abundant, through the COX pathway though the evidence asserting that PGs have a direct role in bone healin...
The majority of the included studies revealed a high risk of bias, and conclusions from studies that have a high risk of bias are sufficient to affect interpretation of data [16,17,18]. Publication and selection bias is apparent in several included studies, as the negative effects of NSAIDs on osseointegration can be expected in the studies that administered NSAID at a high concentration and/or fo...
The influence of NSAIDS on bone healing in animal models has been shown to be related to the duration of treatment and drug selectivity [5]. A total of seven studies were identified that investigated the effect of NSAIDs on the osseointegration of titanium implants in animals: mice, rabbits, and rats (Table 8).
The duration of treatment is a factor to consider when using NSAIDs, and a study cond...
The effects of NSAIDs on the osteogenic activity of osteoblasts have been extensively studied at the molecular pharmacological level [23]. However, only two studies have been identified that investigated the effect of NSAIDs on osteoblasts attached to titanium surfaces (Table 6). In the study conducted by Boyan et al., their results demonstrated that a non-selective COX inhibitor (indomethacin, 0...
The eligibility and study selection criteria as mentioned above were applied to the 79 full-text articles. A total of 66 studies were excluded after a full-text assessment for the following reasons:
The study did not explore the role of COX pathway in osseointegration (n = 26).
The effects of NSAIDs on osteoblasts were not investigated on titanium (n = 24).
The study was a systematic re...
The full-text manuscripts of included studies were catalogued into in vitro, clinical, and in vivo studies. The data from the included studies were independently extracted by the primary (JDL) and the second reviewer (TJ) according to the “Data items” section as listed below. Disagreements or uncertainties were discussed with the third reviewer (MN) until an agreement was reached.
The data co...
An electronic search into four databases: Ovid, Pubmed, Scopus, and Web of Science was performed to systematically identify the available literature. Articles published between January 1, 1999, and July 7, 2018, were considered.
The focus question, used to guide the search strategy, according to the PICO schema is “Will variables such as the dosage, duration of administration, and selectivity o...
Cyclooxygenases have an important role in the production of PGs where these enzymes in bone tissues show increased activity under the influence of hypoxia-inducible factors [6, 11]. Therefore, local activity of COX enzymes promotes bone formation and resorption through the production of PGs [12]. Non-selective NSAIDs are reported to inhibit the activity of COX-1 equally, if not more than COX-2 [2]...
Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of drugs with anti-inflammatory, analgesic, and antipyretic effects. They are commonly used in dentistry for management of dental pain associated with inflammation. NSAIDs exert their effects through the inhibition of the cyclooxygenase (COX) enzyme, therefore interfering with the synthesis of prostaglandins (PG) and thromboxanes; PGs and ...
Non-steroidal anti-inflammatory drugs are commonly used in implant dentistry for management of post-operative pain. The objective of this systematic review was to analyse the effect of non-steroidal anti-inflammatory drugs on the osteogenic activity of osteoblasts with an emphasis on its effect on osseointegration. A systematic literature search for in vitro, animal models, and clinical trials was...
Fig. 2. a Radiographic image of a 3.5-mm-wide by 7-mm-length dental implant at the time of its placement at the mandibular left second premolar in a 63-year-old Caucasian female. b Radiographic image of a three-unit fixed partial denture upon its initial placement. The dental implant is the anterior abutment with the prosthesis screw retained to it. The distal abutment is the mandibular left sec...
Fig. 1. a Initial radiograph exposed at abutment installation on a 5-mm-wide by 7-mm-length dental implant used to help support a removable partial denture for a 71-year-old Caucasian male. b Radiograph of the area taken at 82 months demonstrates good bone stability. c Clinical image of the area 82 months later. Soft tissue remains healthy. The two teeth anterior are in the process of receivin...
Time
ISQ
n
Implant insertion
73.6 ± 8.1
86
1–4 weeks
...
Interval
Implants
Failed
Not followed
CSR (%)
Insertion to 1 year
...
Sex
Age
Smoker
Risk factors
Position
Implant diameter
...
Number
Percent
Jaw
Maxilla
60
69.8
Mandible
...
Number
Percent
Age (years)
20–29
1
1.3
30–39
...
Rosen, P.S., Sahlin, H., Seemann, R. et al. A 1–7 year retrospective follow-up on consecutively placed 7-mm-long dental implants with an electrowetted surface.
Int J Implant Dent 4, 24 (2018). https://doi.org/10.1186/s40729-018-0136-4
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Received: 08 January 2018
Accepted: 21 May 2018
Published: 23 August 2018
DOI: https://doi.org/10.1186/s40729-018-0136...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
The study was performed in compliance with the Declaration of Helsinki. Data collection was performed in such a manner that subjects could not be identified, and therefore, it was exempt from IRB review according to Federal Regulation 45 CFR 46.101(b).
All participants consented to publish their information details through the clinic’s standard patient consent procedure. Also, all images appear...
Clinical Professor of Periodontics, Baltimore College of Dental Surgery, University of Maryland Dental School, Baltimore, MD, USA
Paul S. Rosen
Private Practice limited to Periodontics and Dental Implants, 907 Floral Vale Boulevard, Yardley, PA, 19067, USA
Paul S. Rosen
Neoss Ltd, Gothenburg, Sweden
Herman Sahlin
University Clinic of Craniofacial, Maxillofacial and Oral Surgery, Vienna, Aust...
Due to the ethical and legal responsibility to respect participants’ rights to privacy and to protect their identity, the clinical dataset is not made publicly available.
Srinivasan M, Vazquez L, Rieder P, Moraguez O, Bernard JP, Belser UC. Survival rates of short (6 mm) micro-rough surface implants: a review of literature and meta-analysis. Clin Oral Implants Res. 2014;25(5):539–45.
Chrcanovic BR, Albrektsson T, Wennerberg A. Diabetes and oral implant failure: a systematic review. J Dent Res. 2014;93(9):859–67.
Giro G, Chambrone L, Goldstein A, Rodrigues JA,...
Jemt T, Olsson M, Franke SV. Incidence of first implant failure: a retroprospective study of 27 years of implant operations at one specialist clinic. Clin Implant Dent Relat Res. 2015;17(Suppl 2):e501–10.
Pommer B, Frantal S, Willer J, Posch M, Watzek G, Tepper G. Impact of dental implant length on early failure rates: a meta-analysis of observational studies. J Clin Periodontol. 2011;38(9):856...
Cumulative survival rate
Implant stability quotient
Insertion torque
Odds ratio
Resonance frequency analysis
Relative risk
The current retrospective consecutive case series study provides preliminary data that treatment with 7-mm-length short implants with a hydrophilic electrowetted surface is a reasonable approach in sites with limited vertical bone dimension. It adds to the body of evidence supporting short implant use for compromised sites. The success seen might be attributed to the larger implant diameters that ...
Thirty-six percent of the implants in the study were placed in extraction sockets. Provided that sufficient initial implant stability is achieved, there should be no additional risk factors compared to implants in healed sites. Studies have shown no difference in marginal bone remodeling between immediately placed and delayed implants [15].
The biggest limitation of the current study is its very ...
A wide distribution in implant insertion torque (10–50 Ncm) was seen in the study. This reflects the variety of clinical situations in which the implants were placed. Assessments were made by using both the RFA value and the insertion torque as to first whether an implant should have been left to heal in the first place and if so, how this would be best accomplished, i.e., through its submergen...
This retrospective study is the first to look at short dental implants with a hydrophilic electrowetted surface. The survival data suggest that this treatment is a viable option to care. In a systematic review that identified 13 studies on implants shorter than 10 mm, the CSR from the individual studies ranged from 80 to 100% with a combined CSR of 98.3% after 5 years, 94.8% after 6 years, and ...
The chart review identified 86 placed implants in 75 patients. Table 1 summarizes the patient demographics of the 75 patients. Patients ranged in age from 29 to 88 years with a mean of 61.0 ± 12.5 years. Twenty-seven of the patients were males and 48 were females. Table 2 summarizes the implant and site-related information of the 86 placed implants. Mean insertion torque was 30.1 ± 7...
Baseline parameters, both patient- and implant-related, as well as follow-up parameters (implant survival, follow-up time, and resonance frequency analysis) were collected from a review of the patient records.
The main study parameters (principal outcome parameters) were defined to be implant loss and follow-up time. The cumulative survival rate was estimated. The influence of several factors on ...
A retrospective study on short 7 mm hydrophilic implants from a single center was conducted in a private practice limited to periodontics and surgical dental implant placements from one of the authors, PSR (Yardley, Pennsylvania, USA). An exhaustive chart review identified 75 patients for analysis that were treated with 86 short (7 mm) implants during a 5-year period (September 1, 2009, to Novem...
The aim of this retrospective consecutive case series study was to investigate implant survival rate and analyze possible factors affecting the survival of short implants placed in one surgical practice focused on implantology and periodontology in a temporal cohort.
In the past decades, the osseointegration rate of dental implants has dramatically increased, particularly in sites of softer dental bone, which may be attributed to the introduction of moderately roughened surfaces [1, 2]. Moreover, because of this increase in success, clinicians have attempted to push the envelope and place implants into sites that may provide a greater challenge as they wish to...
This retrospective consecutive case series study was performed to determinate the survival rate and implant stability of short (7 mm length) dental implants with an electrowetted hydrophilic surface that were in function from 1 to 7 years.
A retrospective chart review identified and evaluated 86 consecutively placed 7-mm-long dental implants (ProActive, Neoss Ltd., Harrogate, England) in 75 pat...
Fig. 4. Statistical analysis for different variables. a Weighted mean survival rate. b Implant survival rate according to degree of penetration. c Analysis of clinical complications. d Analysis of radiographic complications
Fig. 4. Statistical analysis for different variables. a Weighted mean survival rate. b Implant survival rate according to degree of penetration. c Analysis of clinical com...
Fig. 3. Graphic representation of group 1 ≤ 4 mm penetration and group 2 > 4 mm penetrations
Fig. 3. Graphic representation of group 1 ≤ 4 mm penetration and group 2 > 4 mm penetrations
Fig. 1. Graphic representation of implants intruding sinus perforating or not the Schneiderian membrane
Fig. 1. Graphic representation of implants intruding sinus perforating or not the Schneiderian membrane
Fig. 2. PRISMA flowchart of the screening process
Fig. 2. PRISMA flowchart of the screening process
Reason for exclusion
Investigations
Study design (case series or case report)
Kim et al. (2017), Hatano et al. (2007)
Different grafting techn...
Author (year)
Study design
Follow-up (months)
N of patients
N of implants
Smokers
Le...
Clinical complications
Radiographic complications
Sinusitis
Thickening of Schneiderian membrane
Nasal bleeding, nasal obstruction, nasal secre...
Ragucci, G.M., Elnayef, B., Suárez-López del Amo, F. et al. Influence of exposing dental implants into the sinus cavity on survival and complications rate: a systematic review.
Int J Implant Dent 5, 6 (2019). https://doi.org/10.1186/s40729-019-0157-7
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Received: 09 October 2018
Accepted: 06 January 2019
Published: 05 February 2019
DOI: https://doi.org/10...
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Gian Maria Ragucci, Basel Elnayef, Fernando Suárez López del Amo, Hom-Lay Wang, Federico Hernández-Alfaro, and Jordi Gargallo-Albiol declare that they have no competing interests.
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Correspondence to
Basel Elnayef.
Department of Oral and Maxillofacial Surgery, International University of Catalonia, C/Josep Trueta Sn, Sant Cugat del Vallés, C.P 08195, Barcelona, Spain
Gian Maria Ragucci, Basel Elnayef, Federico Hernández-Alfaro & Jordi Gargallo-Albiol
Department of Periodontics, University of Oklahoma Health Sciences Center – College of Dentistry, Oklahoma City, OK, USA
Fernando Suárez-López del ...
The authors want to thank Mr Juan Luis Gómez Martínez for the support in the statistical analysis.
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The authors do not have any financial interests, either directly or indirectly, in the products or information listed in the paper.
Schwarz L, Schiebel V, Hof M, Ulm C, Watzek G, Pommer B. Risk factors of membrane perforation and postoperative complications in sinus floor elevation surgery: review of 407 augmentation procedures. J Oral Maxillofac Surg. 2015;73:1275–82.
Jung JA, Choi BH, Zhu SJ, Lee SH, Huh JY, You TM, Lee HJ, Li J. The effects of exposing dental implants to the maxillary sinus cavity on sinus complications....
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Van den Ber...
Curi MM, Cardoso CL, de Ribeiro C. Retrospective study of pterygoid implants in the atrophic posterior maxilla: implant and prosthesis survival rates up to 3 years. Int J Oral Maxillofac Implants. 2015;30(2):378–83.
Boyne PJ, James RA. Grafting of the maxillary sinus floor with autogenous marrow and bone. J Oral Surg. 1980;38(8):613–6.
Tatum H.Jr. Maxillary and sinus implant reconstructions....
Roccuzzo M, Bonino L, Dalmasso P, Aglietta M. Long-term results of a three arms prospective cohort study on implants in periodontally compromised patients: 10-year data around sandblasted and acid-etched (SLA) surface. Clin Oral Implants Res. 2014;25(10):1105–12.
Esposito M, Grusovin MG, Rees J, Karasoulos D, Felice P, Alissa R, Worthington H, Coulthard P. Effectiveness of sinus lift procedures...
The current review showed that the exposure of dental implants in the sinus cavity without the augmentation procedure or graft materials shows a high survival rate of 95.6%, without statistically significant differences according to the level of penetration (lower or higher to 4 mm). Changes in maxillary sinuses in relation to protruding implants within the sinus cavity do not statically affect ...
Consequently, it seems that maxillary sinus changes in relation to protruded implants inside the sinus cavity and does not statically affect to implant survival rate neither to clinical nor radiographic complications.
Several limitations could be described for the present review. Firstly, there is a lack of a control group in the included studies, to compare outcomes and complications, with impla...
Pneumatization of the maxillary sinus and resorption of the residual alveolar ridge following tooth extraction can compromise the dental implant placement. Similarly, extension of the dental implants inside the maxillary sinus cavity is not rare. Some studies have observed some differences in relation to the depth of the implant extension inside the sinus cavity. When the implants penetrate inside...
Seven studies [27,28,29,30,31,32,33] provide information on clinical complications with a global sample of 232 patients. Clinical complications among the different authors range from 0 to 14.3%, being the weighted mean complication rate 3.4% with an IC 95% [0 7.5] (Fig. 4c) Clinical complications analyzed in the studies were sinusitis, nasal bleeding, nasal obstruction, nasal secretion, mucopurul...
An initial screening yielded a total of 3551 publications of which 26 potentially relevant articles were selected after an evaluation of their titles and abstracts. Full text of these articles was obtained and evaluated thoroughly. Of these, eight articles [26,27,28,29,30,31,32,33] (Table 2) fulfilled the inclusion criteria and subsequently were included in the qualitative analysis (Fig. 2). Rea...
Heterogeneity was assessed based on calculation of the I2 statistic (percentage variability of estimated effect that can be attributed to the heterogeneity of the effects) and the null statistic test. Galbraith graphs displayed the degree of heterogeneity. In studies where great heterogeneity was detected, a sensitivity analysis was performed to determine its source. Funnel plots and the Egger tes...
Articles were included in this systematic review if they met the following inclusion criteria: human prospective or retrospective studies, reporting outcomes of implant placed perforating the sinus floor with implant burs, and without regenerative procedure (lateral sinus lift or transalveolar technique) and graft material. The intrusion into the sinus cavity can occur during drilling or implant p...
This systematic review and subsequent meta-analysis follow the guidelines of the PRISMA statement.
The following focus question was developed: Is the intrusion of dental implants into the sinus cavity during implant drilling or implant placement, without regenerative procedure (lateral sinus lift or transalveolar technique) and graft material, has an effect on implant survival or increase clinica...
Intrusion of dental implants into the maxillary sinus perforating through the Schneiderian membrane is considered a cause of undesirable complications [24, 25]. However, this phenomenon has never been properly evaluated and systematically studied. For this reason, the aim of this systematic review was to assess the implant survival and complication rates of implants intruding into the sinus cavity...
The edentulous posterior maxillary region often presents with unique challenging conditions in implant dentistry [1]. Limited bone height secondary to pneumatization of the maxillary sinus and the resorption of the alveolar ridge preclude in many instances the installation of dental implants. To compensate for the lack of bone height, several treatment options have been proposed.
The most conserv...
The overall survival rate of the implants into the sinus cavity was 95.6%, without statistical differences according to the level of penetration. The clinical and radiological complications were 3.4% and 14.8% respectively. The most frequent clinical complication was the epistaxis, and the radiological complication was thickening of the Schneiderian membrane, without reaching statistical significa...
After tooth loss, the posterior maxilla is usually characterized by limited bone height secondary to pneumatization of the maxillary sinus and/or collapse of the alveolar ridge that preclude in many instances the installation of dental implants. In order to compensate for the lack of bone height, several treatment options have been proposed. These treatment alternatives aimed at the installation o...
Figure 2. Clinical image of patient 4: a region 21 before implant placement. b, c Implant placement using the GBR procedure with a synthetic bone substitute material composed of HA + β-TCP
Figure 1. Schematic representation of the technical characteristics of the investigated C-Tech Esthetic Line implant system (provided by the manufacturer)
Patient
Implant-localization (region)
Implant loss (+/−)
Buccal width of keratinized peri-implant gingiva (mm)
Buccal thickness of keratinized peri-implant gingiva (mm)
Pink Esthetic Score (PES)
Probing depth (mm) at four sites (mb, db, mo, do)
Bleeding on Probing (+/−) at four sites (mb, db, mo, do)
Peri-implant bone loss (mm)
Presence of peri-implant osteolysis (+/−)
...
Patient
Gender (m/f)
Age (years)
Implant localization (region)
Implant diameter (mm)
Implant length (mm)
Augmentation material
Prosthetic rehabilitation
1
f
50
32
3.5
13
HA + β-TCP
r.p
34
4.3
11
HA + β-TCP
r.p
42
3.5
13
HA + β-TCP
r.p
44
4.3
11
HA + β-TCP
r.p
2
m
61
36
3.5
11
HA + β-TCP
...
Abbreviations
β-TCP:
β-tricalcium phosphate
BOP:
Bleeding on probing
F.P.:
Fixed prosthetics
GBR:
Guided bone regeneration
HA:
Hydroxyapatite
MNGCs:
Multinucleated giant cells
PES:
Pink Esthetic Score
R.P.:
Removable prosthetics
References
Gurgel BC, Montenegro SC, Dantas PM, Pascoal AL, Lima KC, Calderon PD. Frequency o...
Comparing the present results to the aforementioned study with the same implant system on immediately placed implants, it seems that the GBR augmentation procedure has no influence on the long-term stability of the implants. In both studies with different placement modalities and protocols, comparable clinical and radiological results were achieved. This leads to the assumption that the inve...
The tissue reaction, however, did not only differ in bone substitute materials of different origin but also in bone substitute materials of the same origin. In an in vivo trial, two xenogeneic bone substitute materials processed with different techniques were implanted subcutaneously in CD-1 mice for up to 60 days. Both bone substitute materials showed good integration within the peri-impla...
Discussion
In the present retrospective study, C-Tech bone level implants placed simultaneously with a GBR procedure around the implant shoulder were investigated clinically and radiologically after at least 3 years of loading to assess peri-implant tissue conditions and document peri-implant tissue stability.
A total of 47 implants were placed in the upper (23 implants) and lower jaw (24...
Results
Altogether, 47 implants were placed in the upper and lower jaws of a total of 20 patients. In all implants, lateral augmentation in a GBR process was performed simultaneously with implant placement due to reduced horizontal or vertical height of the alveolar crest. A total of 23 implants were placed in the upper jaw and 24 implants in the lower jaw. The implant diameter varied between 3...
C-Tech implant system
In the present retrospective study, bone level implants (C-Tech Esthetic Line implants) were investigated clinically and radiologically. The bone level implant system has a Morse-locking conical implant-abutment connection with platform switching and an indexing hex that allows subcrestal implant placement and aims to prevent peri-implant bone loss. The surface of the implan...
Methods
Patient population
In the present retrospective study, 47 dental implants (C-Tech Esthetic Line implants) from 20 patients (11 female, 9 male) with a mean age of 58.5 years (45–75 years) were analyzed clinically and radiologically. Implant placement and follow-up investigation was performed at the HL Dentclinic in Baden-Baden, Germany. The study was approved by the ethics commissio...
Regarding the stability of peri-implant hard and soft tissue, biological or anatomical factors are not the only elements that could be proven to have an impact. Technical factors such as the implant-abutment connection are also known to be key factors for long-term stable hard- and soft-tissue health [11]. Regarding the implant-abutment connection, which seems to be the key issue, located on the i...
However, in most patients, the local bone amount is reduced due to atrophy, inflammatory processes, or resectional defects. Therefore, in the past few years, different techniques have been described to enlarge the local bone amount in prospective implant sites [7]. Besides methods such as GBR or the sinus augmentation technique, different augmentation materials have been investigated and establish...
Background
The prevalence of peri-implantitis has grown in the past few years and has become a major issue in implant dentistry. Long-term stable and healthy soft- and hard-tissue conditions should be achieved in combination with esthetically and functionally satisfying results. However, the rising number of placed implants in the past decades has come with an increase in the prevalence of ...
Investigation of peri-implant tissue conditions and peri-implant tissue stability in implants placed with simultaneous augmentation procedure: a 3-year retrospective follow-up analysis of a newly developed bone level implant system
Abstract
Background
Guided bone regeneration (GBR) has been proven to be a reliable therapy to regenerate missing bone in cases of atrophy of the alveolar crest. T...
Figure 3. Data from the VAS of patient-related outcome measures at the time of mounting of the implant-supported crown and at the final follow-up of the PRF and control group
Figure 2. Box plot of the radiographic peri-implant marginal bone level at different time points in millimeter. Baseline: the time of implant placement; abutment: the time of abutment operation; impression: the time of impression taking; follow-up: the time of the final follow-up
Figure 1. Intraoperative photos illustrating bone harvesting and lateral bone augmentation in the PRF group. Initially, an incision is made at the lateral aspect of the posterior part of the mandibular corpus (a) followed by exposing the mucoperiosteal flap (b), before making the osteotomy line (c). The bone block (d) is then retrieved before adjusted to the contour at the recipient site and...
Table 4 Patient-related outcome measures at baseline and at the final follow-up
Test group
Control group
Difference
p value
Mean (95% CI)
Mean (95% CI)
Mean (95% CI)
Baseline
9.44 (9.09 to 9.78)
9.57 (9.20 to 9.95)
0.13 (− 0.40 to 0.66)
0.61
Follow-up
9.66 (9.30 to 10.02)
9.55 (9.15 to 9.96)
− 0.10 (-0.66 to 0.46)
0.71
Difference
0.22 (...
Table 3 Radiographic marginal bone level and clinical recession on neighbouring tooth surface
Group
Baseline (mean, 95% CI)
Follow-up (mean, 95% CI)
Difference (mean, 95% CI)
p value
Radiographic marginal bone level in mm
Test
1.94 (1.50 to 2.38)
2.07 (1.64 to 2.51)
− 0.14 (− 0.25 to − 0.02)
p = 0.03
Control
2.34 (1.62 to 3.08)
2.49 (1.73...
Table 2 Radiographic peri-implant marginal bone level in mm
Test group
Control group
Mean difference
95% CI
p value
Obs
Mean
95% CI
Obs
Mean
95% CI
Baseline
14
− 0.24
− 0.48 to 0.00
13
− 0.28
− 0.52 to 0.03
0.04
− 0.314 to 0.39
p = 0.82
Abutment
14
0.07
− 0.17 to 0.30
13
− 0.01
− 0.26 to 0.25
0.08
− 0.278...
Table 1 Demographics and survival rates of implants and implant crowns
Test group (PRF)
Control group
Number of implants
14
13
Mean age, years (range)
47.9 (23–66)
52.3 (24–72)
Gender
Female
6
6
Male
8
7
Smokers
Total
2
1
20 cigarettes per day
1
1
Number of implants
14
13
Implant length (mm) and imp...
Abbreviations
ASC:
Angulated screw channel
BOP:
Bleeding on probing
DBBM:
Deproteinised bovine bone mineral
GBR:
Guided bone regeneration
ICC:
Intraclass correlation coefficient
KT:
Keratinised peri-implant tissue
PCR:
Plaque control record
PD:
Probing depth
PRF:
Platelet-rich fibrin
PROM:
Patient-related outcome measures
RCF:
...
A minor, but statistically significant, radiographic bone loss occurred from baseline to the final follow-up at the neighbouring tooth surfaces in both groups. Moreover, both groups experienced a minor recession of the marginal gingiva from baseline to the final follow-up, but the change was not significant. Recession and the bone level of the neighbouring tooth surfaces to implants placed in ...
The combination of the NobelParallel CC implant launched in 2015 and an abutment with ASC is relatively new and has so far been lined to only few mechanical problems [39, 40], among which rotation of the crown when torqueing the abutment screw was not stated. In both patients, a new implant was placed without any need for additional bone augmentation and without further complications. ...
Discussion
The present study focused on clinical and radiographic characteristics of staged implants placed in autogenous bone grafts covered by either a PRF membrane (PRF group) or a standard procedure (gold standard) involving coverage of the autogenous bone graft using a deproteinised bovine bone mineral and a resorbable collagen membrane (control group).
The PRF group demonstrated a hi...
One patient (control group) expressed minimally changed extraoral sensation in the chin region at both the 1- and 2-week follow-up. However, the extra- and intraoral clinical examination revealed no sensory disturbances. The patient was not affected by this and described the same changed sensation at the final clinical follow-up after 29 months.
Another patient (PRF group) experienced sensory d...
Radiographic peri-implant marginal bone change
The mean peri-implant marginal bone level at the different time points is shown in Table 2 and Fig. 2. The mean marginal bone level at follow-up was 0.26 mm (95% CI: 0.01–0.50 mm) in the PRF group and 0.68 mm (95% CI: 0.41–0.96 mm) in the control group. The difference between the groups was − 0.43 mm (95% CI: − 0.80 to − 0....
Bleeding on probing
The estimated probability or observed proportion of BOP for implants was 0.31 (95% CI: 0.14–0.70) in the PRF group and 0.30 (95% CI: 0.12–0.77) in the control group. The ratio of the probability of observing BOP was 1.046 (95% CI: 0.91–1.20), indicating that the probability of observing BOP is 4.6% higher in the PRF group than in the control group. No statistical differe...
Results
Implant survival
Two of the 27 initially placed implants were lost in the control group (Table 1). Twenty months after placement of the implant-supported crown, one implant (first premolar, regular platform (4.3 mm), length: 13 mm) was lost due to failed osseointegration. No periodontitis or peri-implant marginal bone resorption was obvious at the time of implant removal. A second...
The distance from the implant-abutment connection to the peri-implant marginal bone level was measured mesially and distally in parallel with the long axis of the implant using open-source software (ImageJ, National Institutes of Health, Bethesda, MD, USA). The distance from the cemento-enamel junction to the marginal bone level at the neighbouring tooth surfaces was also measured in parallel with...
Prosthodontic treatment
Forty-nine days (range: 27–113 days) after placement of the healing abutment, the abutment was removed and the implant position was registered by an impression coping on the implant.
The final implant-supported restoration was fabricated by using an individually designed angulated screw channel (ASC) zirconium abutment (Nobel Biocare®, Zürich, Switzerland) and venee...
Methylprednisolone was prescribed the following morning (16 mg) and evening (16 mg). Additionally, postoperative ibuprofen (400 mg, four times daily) and paracetamol (1000 mg, four times daily) were prescribed for 1 week. The patients were instructed to rinse with 0.12% chlorhexidine digluconate twice daily and discontinue the use of their prostheses (if any). Patients were seen for ...
The bone graft was retrieved by making a continuous osteotomy line with a cylindrical and a round bur at the lateral part of the mandible, with a uniform size of approximately 15 × 25 mm (Fig. 1c, d). The bone block containing mainly cortical bone was then gently separated from the mandible using a raspartorium. The block graft was covered with a saline-moistened gauze until used. In the PRF g...
At the time of the bone augmentation procedure, two patients (14%) in the PRF group and one (8%) patient in the control group were smokers. Patients were partially edentulous due to trauma (n = 22), agenesis (n = 3) or marginal periodontitis [2]. Two patients were unavailable for the final follow-up. The referring dentist followed the non-attenders, and telephone interview revealed no subjective o...
Material and methods
The study was performed according to the Declaration of Helsinki and internationally accepted guidelines for RCT, including the CONSORT statement (www.consort-statement.org). The volumetric changes of the augmented bone [26], the histological composition of the augmented bone [27] and pain after the primary bone augmentation procedure [28] were previously described in d...
Despite the shape of a membrane, the PRF membrane does not have the properties of a resorbable barrier membrane [21, 22], due to its fast degradation in the same manner as a natural blood clot (1–2 weeks) [23]. Therefore, the PRF membrane is not believed to replace a barrier membrane in the classic understanding of guide bone regeneration (GBR), but rather to enhance the healing capacity of t...
Background
Implant-supported single crowns are characterised by high long-term survival and few biological and technical complications, which typically includes peri-implant marginal bone loss, screw-loosening and fracture of veneering material complications [1,2,3]. To achieve a successful treatment outcome, the implants must be inserted in sufficient bone volume of an adequate quality to obta...
A clinical and radiographic study of implants placed in autogenous bone grafts covered by either a platelet-rich fibrin membrane or deproteinised bovine bone mineral and a collagen membrane: a pilot randomised controlled clinical trial with a 2-year follow-up
Abstract
Purpose
To compare the survival and clinical performance of implants placed in sites previously augmented with autogenous ...
Figure 6. BIC percentage measured with ImageJ analysis software
Figure 5. Time arrow about the stages of the study
Figure 4. A 2-month period was allowed for plaque retention and peri-implantitis
Figure 3. Silk ligatures placed in a submarginal position around the implants
Figure 2. Edentulous posterior mandible of the dog at 3 months after tooth extraction
Figure 1. Flowchart of the research design employed in the study. *Three dogs were used in each group 1 and 2. Three implants were inserted right side of the mandibles. After peri-implantitis period, extracted implants were inserted into the left side of the mandibles. **Two dogs were used in each group 3 and 4. Six failed implants from human inserted into the one dog’s mandible bilaterall...
Table 3 Inter- and intra-group ISQ analysis and measurements on day of surgery and at 3-month follow-up
Mean ± SDISQ day 0
Mean ± SDISQ at 3 month
p
Group 1
69.33 ± 8.48
77.77 ± 1.78
.019
Group 2
68.88 ± 5.90
79.44 ± 2.55
.001*
Group 3
71.77 ± 5.71
75.11 ± 5.84
.366
Group 4
70.44 ± 5.15
79.12 ± 4...
Table 2 Comparison of BIC percentages of 3 mm crestal area of the implants at 3-month follow-up
Group 1[Mean ± SD]
Group 2[Mean ± SD]
Group3[Mean ± SD]
Group 4[Mean ± SD]
p
77.67 ± 5.03
75.28 ± 10.65
71.86 ± 8.34
80.63 ± 5.58
.144*
Group 1[Mean ± SD]
Group 2[Mean ± SD]
Group3[Mean ± SD]
Group 4[Mean± SD]
p
83.39 ± 6.37
79.93 ± 11.83
75.45 ± 9.09
80.53 ± 5.22
290*
Levin et al. conducted a similar study and investigated the success rate of retrieved dental implants that were re-implanted into dogs. The infected implants were re-implanted into dog jaws without any chemical or mechanical cleaning and the authors reported that there was no difference in terms of BIC percentage between the infected/reinserted and new dental implants after a...
Levin et al. conducted a similar study and investigated the success rate of retrieved dental implants that were re-implanted into dogs. The infected implants were re-implanted into dog jaws without any chemical or mechanical cleaning and the authors reported that there was no difference in terms of BIC percentage between the infected/reinserted and new dental implants after an appropriate he...
Discussion
Approximately two million new dental implants are inserted per year around the world and tens of millions of implants are still in use. Moreover, it is estimated that approximately 200,000–250,000 implants are removed every year. Peri-implantitis is the major cause of the implant retrieval and also the most common complication caused by implant surgery. Mombelli et al. reported...
Results
The experimental period and the laboratory workup of the study were unremarkable. Surgical operations were uneventful and the post-operative healing periods were completed with no complications. Histologic analysis and the ISQ values indicated that osseointegration was achieved in all the implants.
Histomorphometric analysis
Histomorphometric analysis demonstrated that adequate bone f...
Removal and preparation of the implant-bone specimens
The implants with a neighboring bone were removed en bloc, and the adhesive soft tissues were dissected to investigate the healing status and the bone-implant contact (BIC) percentage. The specimens were fixed in 10% neutral buffered formalin for 48 h and dehydrated in subsequent concentrations of 70–99.9% ethanol. After dehydration, the sp...
Subsequently, the implant surfaces were rinsed with sterile saline solution and then all the implants were inserted in the contralateral side of the mandible of the same dog. After a 3-month osseointegration period, the animals were sacrificed with a high dose of pentobarbital (i.v.).
In group 2, the same procedures were applied as in group 1. However, unlike the implants in group 1, the implants...
Infiltration anesthesia with 2% articaine (Ultracaine DS, Sanofi Aventis Drugs, Istanbul, Turkey) was applied to the premolar area for hemostasis and for post-operative pain control. A full-thickness vestibular flap was elevated gently, and surgical tooth extraction was performed using surgical burs with straight elevators. Surgical wounds were closed with 3/0 vicryl sutures and streptomycin 0.5 g...
Methods
Research design
This in vivo study had a comparative, randomized, prospective research design, and each group consisted of 10 male beagle dogs that were veterinarian-controlled, healthy, and of similar weight. Animal Research Reporting in Vivo Experiment (ARRIVE) guidelines were used, and surgical procedure was approved by the Local Animal Experiments Ethical Committee of Erciyes Unive...
Background
Branemark et al. conducted the first experimental trial with titanium dental implants and created a new vision by defining the term “osseointegration” in the 1960s. Despite the advances in implant technology and protocols and the accumulating evidence in the literature, implant failure/loss may still occur due to several reasons. On the other hand, although dental implant therapy...
Reusing dental implants: an experimental study for detecting the success rates of re-osseointegration
Abstract
Background
The aim of this study was to histomorphometrically compare the implant-host integration between retrieved implants and new implants.
Methods
Jaws in 10 male beagle dogs were divided into four groups, and 36 dental implants were inserted into the jaws. In groups 1 and...
Patient
Implant region(FDI)
Implant parameters
Dimensions of implantDiameter [mm]/length [mm]
Explantation[Days after placement]
1
3637
First placementStraumannRN SLactive®(TiZr)
First placementØ: 4.1; L: 10Ø: 4.1; L: 8
3
3637
Second placementStraumannTissue level(TiZr)
Second placementØ :4.1, L: 8Ø :4.1, L: 8
3
36
Third placementConelog ScrewLine(...
Figure 2. a Patient 2. Postoperative orthopantomogram one day after implant placement. b Patient 2. Postoperative orthopantomogram after second Implant placement
Figure 1. a Patient 1. Post grafting orthopantomogram. The bone block was secured with a single microscrew. b Patient 1. The radiograph demonstrates veritable inserted Straumann bone level implants after the first implant placement (1 day after implant placement). A peri-implant osteolysis is not visible. c Patient 1. Postoperative orthopantomogram (1 day after implant placement) afte...
References
Esposito M, Thomsen P, Ericson LE, Lekholm U. Histopathologic observations on early oral implant failures. Int J Oral Maxillofac Implants. 1999;14:798–810.
Olmedo-Gaya MV, Manzano-Moreno FJ, Cañaveral-Cavero E, de Dios Luna-Del Castillo J, Vallecillo-Capilla M. Risk factors associated with early implant failure: a 5-year retrospective clinical study. J Prosthet Dent. 2016;115...
However, a synergistic effect with other factors is conceivable. Some authors stated that implant osseointegration is not simply a wound healing phenomenon but rather complex foreign body reaction with activation of the immune system. Titanium and metal particle release is discussed as cause for implant failure as well as implant dentistry. It is assumed that metal particles influence the ma...
However, a present human study cannot confirm an effect due to vitamin D supplementation on bone formation or graft resorption after maxillary sinus augmentation. Satue et al. found a positive influence of 7-dehydrocholesterol (7-DHC), the precursor of vitamin D, coated implants on osteoblast differentiation in vitro. But whether vitamin D-coated dental implants have an effect of osseo...
Discussion
This article demonstrated that implant placement was successful after vitamin D supplementation in patients with vitamin D deficiency and early failed implants. None of the patients showed systemic disease or did take regular medication, alcohol, nicotine, or drugs. The patients were not immunosuppressed, irradiated, or received chemotherapy. All implants were inserted with the s...
After vitamin D supplementation and a healing period of 6 months, a third surgical intervention was planned and one implant (Conelog ScrewLine) was inserted in region 36 (see Table 1 and Fig. 1d). During implant placement, the former explantation site appeared clinically fully re-ossified. The patient received an intraoperative intravenous single-dose antibiotic therapy with Isocillin 1.2 mega. At...
Patient
The medical history of this 48-year-old male patient showed a high blood pressure; otherwise, the patient was healthy. A successfully completed periodontal therapy was done before implant therapy. The patient demonstrated stable marginal bone levels. Autologous retromolar bone grafting using local anesthesia was performed in the left mandible (see Fig. 1a). This patient received a pos...
Case presentation
Patients and surgical procedure
Patients treated consecutively in one center (Department of Oral- and Craniomaxillofacial Surgery, University Medical Center Freiburg). None of the patients showed systemic disease. Both patients did not take regular medication and were negative for alcohol, nicotine, and drug use. Bothe male patients (48 and 51 years of age) were not immunosu...
Background
Long-term stable osseointegrated implants are the primary goal in dental implantology. Although dental implants have proven clinical reliable in the long term, the failure of implants at a very early stage of osseointegration has been described. The pursuit to identify the mechanisms leading to early implant failure is ongoing to date and include the following: tobacco usage, diabete...
Abstract
An association between vitamin D deficiency and early dental implant failure is not properly verified, but its role in osteoimmunology is discussed. This article illustrates two case reports with vitamin D deficiency and early implant failure. Prior to implant placement, the first patient received crestal bone grafting with autologous material. Both patients received dental implants fr...
Figure 4. Kaplan-Meier implant survival curves for bone and bone substitutes
Figure 3. Kaplan-Meier survival curves for membrane types
Figure 2. Kaplan-Meier implant survival curves for augmentation procedures
Figure 1. a Kaplan-Meier survival curves for implants with or without augmentation. Dashed line 95% confidence interval. b Kaplan-Meier survival curves for single crown implants overall and with or without augmentation. Dashed line 95% confidence interval
Table 5 Implants lost and in function up to 20.2 years after implant insertion using different graft materials
Graft material
Implants (n)
Min/max observation time (years)
Lost implants % (n)
Absolute survival rate %
p value
No graft material
4609
0.0/20.2
5.51 (254)
94.49
Geistlich Bio-Oss
2939
0.0/15.6
2.76 (81)
97.24
0.0004
Autogenous bone particles
...
Table 3 Explantations of implants inserted using different augmentation procedures up to 20.2 years after implantation
Augmentation procedure
Implants(n)
Lost implants % (n)
Absolute survival rate %
p value
No augmentation
4242
5.72 (243)
94.28
Lateral augmentation
3210
4.02 (129)
95.98
0.0010
External sinus lift one-step
1101
4.09 (45)
95.91
0.032...
Table 2 Implant loss in augmented and non-augmented sites up to 20.2 years after implant insertion
Augmentation
Implants (n)
Lost implants % (n)
Early implant loss % (n)
Late implant loss % (n)
Absolute survival rate %
No augmentation
4242
5.73 (243)
0.38 (16)
5.35 (227)
94.27
With augmentation
5916
3.67 (217)
0.32 (19)
3.35 (198)
96.33
Total
10158
4.53 ...
Table 1 Distribution of implants according to the period of observation
Year
Number of implants
Relative number of implants (%)
References
Buser D, Martin W, Belser UC. Optimizing esthetics for implant restorations in the anterior maxilla: anatomic and surgical considerations. Int J Oral Maxillofac Implants. 2004;19(Suppl):43–61.
Nkenke E, Neukam FW. Autogenous bone harvesting and grafting in advanced jaw resorption: morbidity, resorption and implant survival. Eur J Oral Implantol. 2014;7 Suppl 2:S203–17.
von ...
In addition, Buch et al. compared the different criteria proposed for implant success with regard to their clinical value. The authors demonstrated that the proposed criteria led to very different success rates 6 years after implant insertion (75–89%) and did not allow reliable comparison of the results with each other. Thus, during control visits in our practices, only prosthetic complica...
The most often used graft material in our evaluation was Geistlich Bio-Oss (53.0%) followed by autogenous bone (32.5%). When compared to no graft, the use of both grafts resulted in significantly higher implant survival rates. In various studies, the bone substitute was found to promote bone regeneration and to allow for long-term stability of the augmented volume. A recent meta-analysis com...
However, there are also a few clinical studies in which reduced survival rates for implants inserted in grafted areas were found. Differences in numbers of implants analysed, surgical techniques, indications and/or graft materials may account for these inconsistent results and further studies might be needed.
In the retrospective analysis shown here, the comparison of different augmentation...
Discussion
The retrospective analysis presented here evaluates implants inserted in three different private practices with or without augmentation procedures. Treatments were performed according to the standard protocols applied in the private practices. More than 10,000 implants were inserted in various indications and were followed up to 20.2 years from the day of implant insertion. The o...
When looking into the Kaplan-Meier implant survival curves of the augmentation procedures using the log-rank test, the highest implant survival was found for bone condensing followed by lateral augmentation, internal sinus lift, transplantation of bone blocks, bone splitting/spreading, titanium mesh, external sinus lift (one- and two-step) and finally, no augmentation. This sequence was statistica...
Results
Of the 10,158 implants, 58.2% (5916 implants) were inserted using an augmentation procedure. The minimal observation period until the last control visit or until explantation was 0 days (day of implantation); the maximum period was 20.2 years. Distribution of analysed implants according to the period of observation is shown in Table 1.
A total of 4.53% (460 implants) of all implants...
The membranes applied included the native collagen membrane Geistlich Bio-Gide (Geistlich Pharma AG, Wolhusen, Switzerland) either alone or combined with one of the following membranes: Vicryl (Johnson & Johnson Medical GmbH, Norderstedt, Germany), Biovin Membran (OT Medical, Bremen, Germany), Parasorb Vlies (Resorba, Nuremberg, Germany), Gore-Tex Resolut (W.L. Gore & Associates, F...
The membranes applied included the native collagen membrane Geistlich Bio-Gide (Geistlich Pharma AG, Wolhusen, Switzerland) either alone or combined with one of the following membranes: Vicryl (Johnson & Johnson Medical GmbH, Norderstedt, Germany), Biovin Membran (OT Medical, Bremen, Germany), Parasorb Vlies (Resorba, Nuremberg, Germany), Gore-Tex Resolut (W.L. Gore & Associates, Flagstaff, USA), ...
Methods
The retrospective analysis evaluates patients who underwent implant therapy with or without accompanying augmentation procedures between August 1991 and December 2011 in three private practices. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines were followed. To investigate the effect of the different techniques applied on implant survival without ...
Background
Replacing missing teeth with dental implants is a routine treatment in many dental practices. In order to achieve adequate functional and aesthetic results, an optimal three-dimensional implant position has to be assured. Various materials are available to build up missing bone. While autogenous bone is usually regarded to be the gold standard, harvesting may be associated with morbi...
Retrospective analysis of 10,000 implants from insertion up to 20 years—analysis of implantations using augmentative procedures
Abstract
Background
A sufficient amount of bone is essential to ensure long-term stability of dental implants. To support the bone regeneration process, different techniques and materials are available. It has been questioned whether these techniques and materials...
Figure 8. There were moderately significant and positive correlations between the ALP levels and OC levels at all measurements from week 1 to week 12. The OC levels in pg/μg protein were associated with the ALP levels in nM/μg protein at the implant site (a), control site (b), and pooled samples of the control and implant sites (c)
Figure 7. Comparison between the trend of the biomarker levels and the trend of the ISQ values over time
Figure 6. There were weakly significant and positive correlations between the ALP or OC levels and ISQ values at all measurements from week 1 to week 12. At the implant site, the ALP levels in nM/μg protein (a) or the OC levels in pg/μg protein (b) were associated with ISQ values
Figure 5. Change in the median values of the OC level over time. In the test group, the OC level continuously increased with time. There was a statistically significant increase in the OC level at 6, 8, 10, and 12 weeks when compared with 1 week (P
Figure 4. Change in the median values of the ALP level over time. In the test group, the ALP level decreased at 1–4 weeks and then increased at 6, 8, 10, and 12 weeks. There was no statistically significant difference in the ALP level in either the control or the test groups at any measurement
Figure 3. Change in the median values of the GCF (control group) and PICF (test group) volume over time. In the test group, the PICF volume continuously decreased with time (a). There were no significant differences in the median values of the crevicular fluid volume in either the control group or the test groups at any measurement (b)
Figure 2. Change in the mean ISQ values over time. There was a statistically significant decrease in the mean ISQ values between 1 and 3 weeks (P
Figure 1. Timeline of the clinical study. I—implant site, T—contralateral posterior mandibular nonsurgical tooth
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks
8 weeks
10 weeks
12 weeks
Median (interquartile range)
ALP level
(nM/μg protein)
Tooth (control)
175 (215)
203 (308)
148 (269)
143 (112)
266 (427)
145 (96)
181 (148)
191 (263)
107 (128)
Implant (test)
230 (238)
139 (139)
157 (293)
108 (134)
166 (434)
179 (251)
147 (...
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks
8 weeks
10 weeks
12 weeks
Median (interquartile range)
CF volume (μl)
Tooth (control)
0.20 (0.23)
0.26 (0.25)
0.19 (0.20)
0.19 (0.50)
0.17 (0.33)
0.18 (0.08)
0.13 (0.24)
0.23 (0.42)
0.20 (0.17)
Implant (test)
0.26 (0.30)
0.25 (0.41)
0.16 (0.21)
0.17 (0.19)
0.18 (0.33)
0.13 (0.14)
...
Time
Day 0
1 week
2 weeks
3 weeks
4 weeks
6 weeks
8 weeks
10 weeks
12 weeks
Mean ISQ values
77.0 ± 1.32
65.6 ± 2.70a
70.5 ± 2.03a
72.1 ± 1.64a
74.2 ± 1.65
76.1 ± 1.33
78.1 ± 1.38
78.2 ± 1.32
79.6 ± 1.06
Gender
Male (n = 3)
77.0 ± 0.58
59.7 ± 4.62
71.7 ± 3.24
75.0 ± 1.89
7...
Patient no.
Age
Sex
Positiona
Bone qualityb
1
34
Female
46
3
2
38
Female
36
3
3
43
Female
37
3
4
64
Male
46
2
5
30
Female
47
3
6
48
Female
36
2
7
57
Male
36
3
8
28
Female
46
3
9
33
Male
46
2
10
49
Female
46
3
Inclusion criteria
Exclusion criteria
Patients aged 25–65 years
Presence of periodontal disease or periapical lesions
Ability to participate in this study
History of bone augmentation at the implant site in the past 6 months
No systemic diseases (e.g., diabetes, osteoporosis, hypertension, etc.)
History of tooth extraction at the implant site in the past 6 months
...
References
Albrektsson T, Brånemark PI, Hansson HA, Lindström J. Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand. 1981;52:155–70.
Khongkhunthian P. Implant features. In: Khongkhunthian P, editor. PW Plus Thai Dental Implant. Bangkok: STZ Mospace design; 2015. p. 12.
Lacey DL, Timms E, Tan HL, Kelle...
Regarding the relationship between the ISQ values and ALP or OC levels, although the ISQ values were weakly correlated with the bone markers (r = 0.226 for ALP level and r = 0.245 for OC level, P = 0.05), there were significant and positive correlations between the ISQ values and ALP or OC levels at all measurements from week 1 to week 12. These results are in harmony with the ...
That study showed that PICF volume decreased significantly from week 1 to week 3. Alteration of the gingival fluid volume and contents occur according to the condition of the tissues surrounding the teeth. The presence of inflammation increases the gingival fluid volume. Also, changes in peri-implant crevicular fluid contents and volume result from the condition of the peri-implant tis...
Discussion
The results of this study show that, at the time of implantation, the ISQ values ranged between 67.5 and 83. The mean initial ISQ value was 77.0 ± 1.32. These findings are in harmony with those of previous studies. Tallarico et al. (2011) reported that the macro-design of dental implant affects the primary anchorage. They suggested that the high initial ISQ value is a factor...
Results
Ten patients, seven females, and three males, aged 42.4 ± 11.99 years (range, 28 to 64 years), with either a first mandibular or second mandibular molar edentulous area, who required a single nonsubmerged implant participated in this study, as shown in Table 2. The implants used for all patients were 10 mm long and 5 mm in diameter. All patients completed the follow-up. None of t...
The color in the wells changed from blue to yellow. After that, the color solution in each well was measured at 450/540 nm within 30 min. The OC level in each sample was calculated from a standard curve and normalized by total protein.
The level of the ALP activity was measured by colorimetric analysis. Briefly, 80 μl of sample solution were added into each well of a 96-well microplate, and t...
Sample preparation and analysis
GCF/PICF in the Periopaper strip was eluted by adding 320 μl quantity of phosphate-buffered saline (PBS) into the sample tube and incubated at 4 °C, overnight. The eluted protein solution from each gingival fluid sample was used for the biochemical analysis.
Total protein in the gingival fluid sample was measured by the Bradford analysis. Briefly, a 10 μl...
RFA assessments
At implant placement and after 1, 2, 3, 4, 6, 8, 10, and 12 weeks, RFA assessments were performed using the Osstell® ISQ (Integration Diagnostics AB, Goteborg, Sweden) according to the manufacturer’s instructions. A Smartpeg™ (type 47) (Integration Diagnostics AB) was screwed to the implant using a Smartpeg mount. After Smartpeg mount removal, the RFA assessment was perf...
Methods
The study is a prospective clinical study during the 3-month healing period of implant. The study was approved by the Human Experimentation Committee, Faculty of Dentistry, Chiang Mai University. The study outline is shown in Fig. 1.
Patients
Ten patients, who were partially edentulous in the mandibular posterior region for whom a single nonsubmerged implant was planned, participated ...
The second phenomenon is contact osteogenesis, in which bone formation takes place from the implant surface toward the local bone. This osteogenesis consists of the early phase of osteogenic cell migration, osteoconduction, and de novo bone formation. The de novo bone formation at a solid surface has four stages. The first stage is secretion of the two noncollagenous proteins, osteopontin, and bon...
Background
Dental implants have shown a high success rate for rehabilitation of edentulous patients if certain conditions are met during treatment. Nevertheless, the risk of failure remains difficult to predict. The achievement of osseointegration depends on many factors, such as a suitable host, biocompatible materials, careful surgery, and an appropriate healing time.
The primary stability c...
Relation between the stability of dental implants and two biological markers during the healing period: a prospective clinical study
Abstract
Objectives
The purposes of this study were to examine the correlation between the stability of dental implants and bone formation markers during the healing period and to monitor the stability of dental implants using the resonance frequency analysis (R...
Figure 5. Periapical X ray after 1 year of follow-up, the bone was stable and no sign of peri-implantitis was shown
Figure 4. Follow-up after 1 year, no radiographic sign was appreciating and the osseointegration was satisfactory
Figure 3. Final restaurations: The parallelism of the implants is achieved by carving the non-submerged part a occlusal view and b lingual view
Figure 2. Flapless surgical technique, atraumatic surgical procedure for zirconium implants using the circular scalpel (a)–sharp, clean cut without bleeding (b)
Figure 1. Diagnostic radiographic exploration previous to treatment
To avoid exceeding the adaptive limits of the bone and maintain the proper stimulation of mechanical stress that will keep the bone vital, PEEK components seem a viable alternative to obtaining a similar modulus to that of cortical bone. In this way, bone could be stimulated, favouring remodelling without overload. It would concentrate the load by absorbing and distributing the same. Its cap...
Discussion
Intraoral conditions (saliva pH, acidic drinks, bacterial plaque, etc.) interact with metals, increasing corrosion, a phenomenon that also affects titanium implants. Amongst other reasons, this is whereby patients increasingly request the use of materials free of metallic alloys. In response to this growing demand, zirconia implants are considered an alternative, due to their low...
Case presentation
A patient who is a 45-year-old woman and non-smoker has no medical record of interest. The patient complained of pain in the right second upper molar. She said that she felt intense pain while chewing. The pain was accentuated with occlusion and while chewing, making normal functioning impossible. The patient mentioned the absence of piece 16, which had been extracted 8 years...
Background
In the field of implant dentistry, the most widely used implants over the past 40 years are those manufactured from titanium, which are still the most popular.
The recent demands for materials without metal alloys in dentistry, together with the increased sensitivity and allergies of some patients, have promoted the development of new materials.
An example of this is zirconia-based...
Abstract
Background
One of the disadvantages of the zirconia implants is the lack of elasticity, which is increased with the use of ceramic or zirconia crowns. The consequences that could result from this lack of elasticity have led to the search for new materials with improved mechanical properties.
Case presentation
A patient who is a 45-year-old woman, non-smoker and has no medical record...
BIC
3M™ ESPE™ MDIs
Ankylos® Friadent (Dentsply)
Median
58.5
57
Mean
57
56.5
Interquartile range
8
5.5
First quartile
53.25
53.75
Third quartile
61.25
59.25
Sample
3M™ESPE™ MDIs
Ankylos®
1.
67
54
2.
59
67
3.
54
45
4.
51
58
5.
47
57
6.
64
49
7.
50
54
8.
60
56
9.
56
60
10.
61
53
11.
62
59
12.
61
55
13.
59
59
14.
45
51
15.
58
59
16.
54
62
17.
66
62
18.
56
57
Figure 6. Micro CT scan images of the MDIs and Ankylos® embedded in rabbit bone 6 weeks post implantation
Figure 5. Histological section of standard implant in rabbit tibia stained with methylene blue and basic fuchsin
Figure 4. Histological section of mini dental implant in rabbit tibia stained with methylene blue and basic fuchsin
Figure 3. Histological sections being obtained with Leica SP 1600 saw microtome
Figure 2. Leica SP 1600 saw microtome
Figure 1. Radiograph showing implants in the rabbit tibia
Our study is also in concordance with the results of a removal torque study by Simon et al. in immediately loaded “transitional endosseous implants” in humans. The percentage BIC for MDIs was similar to standard implants.
The surface topography also affects the BIC, Wennerberg et al. measured and compared removal torque values on screw-shaped titanium implants with three surface types. ...
Discussion
The osseointegration potential of 3M™ESPE™ MDIs has not been studied. The MDI is a one-piece implant that simplifies the restorative phase resulting in a reduced cost for the patient. Titanium-aluminum-vanadium alloy (Ti 6Al-4V-ELI) is used for increased strength. The success of these implants led to its use in long-term fixed and removable dental prostheses. Conventional imp...
Results
Clinical findings
On the whole, postoperative wound healing in all the rabbits was good. None of them exhibited any signs of wound infection or exposure. A total of 36 specimens were retrieved for histological examination.
Histological observations
All of the implants in both groups showed osseointegration and displayed a good amount of bone contact length (Figs. 4 an...
The built-in water cooling device prevents overheating of the object and removes saw dust from the cutting edge and thus prolongs the lift time of the saw blade. The most favorable feed rate was determined (Fig. 3). After trimming, the first undefined slice was removed from the saw blade. The desired section thickness was selected, considering the thickness of the saw blade and added to the desire...
Sample preparation for embedding
The specimens were dehydrated in the ascending graded ethanol solution and kept in a pre-filtration solution for 3 h at room temperature and then in the filtration solution at 4 °C for 17 h. The specimens were then embedded in a light curing resin Technovit 9100 NEW (Kulzer & Co., Wehrheim, Germany) polymerization system based on methyl methacrylate, speci...
The skin was sutured to a primary closer with the same suture material.
Radiograph
Plain X-ray images of all the rabbit tibia were taken after suturing to confirm the position of implants and to detect any injury/fracture of the bone (Fig. 1).
Post surgical treatment
After the surgical procedure, the animals were housed in a cage under the supervision of a veterinary doctor until they came out...
After mobilizing the mucoperiosteal flap, the 3-mm center punch was used to register a guide for the twist drill. The twist drill was used to establish the axial alignment of the implant and to assist in the guidance of the depth drill. The depth drills were sequentially used to create osteotomy to the subcrestal axial depth of 0.5 mm. The conical reamer was used to develop the conical shape of t...
Antiseptic skin preparation was done starting at the center of the surgical site and moved to the outside of the prepared area in a circular manner. Three scrubs with 2% chlorhexidine solution and three alternating rinses with alcohol were performed. The animal was draped and fixed with clamps on a sterile, impermeable covering to isolate the disinfected area. This was performed by the gloved and ...
Methods
Animal model
Nine clinically healthy New Zealand white rabbits weighing 3.5 kg and more were used for the study, and the animals were housed in the central animal house facility. The head of tibia/femur of the animals were used for the implantation of samples. Rabbits’ tibiae and femur have been widely used as an animal model by various other authors to study osseointegration of dent...
Considerable confusion exists in the literature regarding the best method to monitor the status of a dental implant. Various methods have been used to demonstrate the osseointegration of dental implants. A common and time-tested method to evaluate biological responses to an implant is to measure the extent of bone implant contact (BIC), referred to as histomorphometry at the light microscopic leve...
Background
The term “osseointegration” was first introduced to explain the phenomenon for stable fixation of titanium to bone by Brånemark et al. in the 1960s. Osseointegrated implants were introduced, a new era in oral rehabilitation began, and many studies were conducted. A success rate of over 90% has been reported. Further, a success rate of 81% in the maxillary bone and 91% in the man...
Abstract
Background
Mini dental implants (MDIs) are becoming increasingly popular for rehabilitation of edentulous patients because of their several advantages. However, there is a lack of evidence on the osseointegration potential of the MDIs. The objective of the study was to histomorphometrically evaluate and compare bone apposition on the surface of MDIs and standard implants in a rabbit m...
Figure 9. a Mandibular implant-fixed prosthesis inserted into the mouth.
Figure 8. Periapical radiographs of the implants. a Postoperative, 1 year. b Postoperative, 16 years
Figure 7. a Intraoral photograph. b Gold Dolder bar and screws; marked wear of a prosthetic screw (arrow)
Figure 6. a Mandibular implant-supported overdenture inserted into the mouth. b Panoramic radiograph after insertion of the prosthesis
Figure 3. Photomicrographs of the biopsy specimen showing the intermingling of (a), (b), and (c). a Moderately differentiated epidermoid tumor cells with a duct-like structure (hematoxylin and eosin [H&E], original magnification × 100). b Intermediate cells (H&E, original magnification × 100). c Clear cells (H&E, original magnification × 100)
Figure 4. a Intraoperative photograph of resection of the alveolar ridge and bilateral upper neck dissection. b Transplantation of a lateral tongue flap to cover the alveolar ridge defect. c Surgical specimen
Figure 2. Panoramic radiograph showing notable alveolar bone resorption in the left mandibular premolar region and slight resorption in the right mandibular canine region (arrows)
Figure 1. Intraoral photograph showing diffuse tumor formation on the alveolar gingiva (arrows)
We inserted an implant-supported overdenture on a gold bar retainer splinting four implants. However, the patient was not satisfied with this prosthesis because of the mucosal pain and discomfort that developed over time. In such cases, prosthetic loading of atrophic mucosa is often not well tolerated. As such, we proposed replacement with an implant-fixed prosthesis. Initially, the patient ...
Conclusions
Prosthetic rehabilitation of edentulous patients after surgical management of oral cancer is difficult and therefore often avoided. However, adequate prosthetic rehabilitation is a pivotal factor for patients to regain oral function. In terms of the masticatory rehabilitation of these patients, the application of a removable prosthesis unsupported by implants may be difficult or...
However, she was not satisfied with the prosthesis; she experienced denture discomfort and developed a decubital ulcer in the tongue flap area, and she gradually ceased use of the denture. The patient was followed for more than 10 years on a regular basis to examine recurrence or metastasis of the gingival carcinoma. Mild erythema and swelling of the mandibular and implant-surrounding mucosa secon...
Case presentation
A 16-year-old female patient developed slight tenderness of the gingiva in the left mandibular premolar region, and her dentist referred her to our clinic in April 1992. Oral examination showed erythematous granular swellings that bled easily on the alveolar gingiva involving the area extending from the right second premolar to the left second molar (Fig. 1). The lesion showed...
Background
Surgical treatment of oral cancer may lead to significant disability, including facial deformity, loss of hard and soft tissue, and impaired function of speech, swallowing, and mastication. Bone resection because of surgical treatment of a large mandibular tumor can cause long-term defects. Rehabilitation with a removable prosthesis can be difficult or impossible due to the distorted...
Dental implant treatment in a young woman after marginal mandibulectomy for treatment of mandibular gingival carcinoma: a case report
Abstract
Dental implants play an important role in postoperative rehabilitation after surgical treatment of oral cancer through the provision of prosthetic tooth replacement. Two major implant prosthesis designs are available: fixed implant-supported prostheses ...
Reason for exclusion
Investigations
Study design (case series or case report)
Kim et al. (2017), Hatano et al. (2007)
Different grafting technique (lateral sinus lift or transalveolar technique)
Jensen et al. (1994), Winter et al. (2002), Toffler et al. (2004), Chappuis et al. (2009), Soltan et al. (2011), Xiao et al. (2011), Cricchio et al. (2011), Scala et al. (2012), Brus...
Author (year)
Study design
Follow-up (months)
N of patients
N of implants
Smokers
Length and diameter (mm)
Implant system
Shihab 2017
Retrospective
60
35
70
NA
5–12 × 3.0–5.7
IDI FMD Nucleoss
Ghanem 2014
Retrospective
72
10
10
NA
NA
NA
Nooh 2013
Prospective
12
56
63
0
4 × 8 4.3 × 10 5 × 8 5 × 10
Nobel Biocare
...
Clinical complications
Radiographic complications
Sinusitis
Thickening of Schneiderian membrane
Nasal bleeding, nasal obstruction, nasal secretion
Bone reaction to the implants
Headache and pain or tenderness in the region of the sinus
Sinus pathology
Decreased sense of smell
Figure 4. Statistical analysis for different variables. a Weighted mean survival rate. b Implant survival rate according to degree of penetration. c Analysis of clinical complications. d Analysis of radiographic complications
Figure 3. Graphic representation of group 1 ≤ 4 mm penetration and group 2 > 4 mm penetrations
Figure 2. PRISMA flowchart of the screening process
The secondary outcome of this review was the analysis of the clinical and radiological complications related to the penetration of implants in the maxillary sinus. Clinical complication among the different authors ranges from 0 to 14.3%, with a weighted mean complication rate of 3.4%, without finding statistical difference according to the level of implant penetration. The most common clinic...
Figure 1. Graphic representation of implants intruding sinus perforating or not the Schneiderian membrane
Analysis of clinical complications
Seven studies provide information on clinical complications with a global sample of 232 patients. Clinical complications among the different authors range from 0 to 14.3%, being the weighted mean complication rate 3.4% with an IC 95% [0 7.5] (Fig. 4c) Clinical complications analyzed in the studies were sinusitis, nasal bleeding, nasal obstruction, nasal sec...
Results
Study screening
An initial screening yielded a total of 3551 publications of which 26 potentially relevant articles were selected after an evaluation of their titles and abstracts. Full text of these articles was obtained and evaluated thoroughly. Of these, eight articles (Table 2) fulfilled the inclusion criteria and subsequently were included in the qualitative analysis (Fig. 2). Re...
Eligibility criteria
Articles were included in this systematic review if they met the following inclusion criteria: human prospective or retrospective studies, reporting outcomes of implant placed perforating the sinus floor with implant burs, and without regenerative procedure (lateral sinus lift or transalveolar technique) and graft material. The intrusion into the sinus cavity can occur du...
Materials and methods
This systematic review and subsequent meta-analysis follow the guidelines of the PRISMA statement.
Focus question
The following focus question was developed: Is the intrusion of dental implants into the sinus cavity during implant drilling or implant placement, without regenerative procedure (lateral sinus lift or transalveolar technique) and graft material, has an effec...
Introduction
The edentulous posterior maxillary region often presents with unique challenging conditions in implant dentistry. Limited bone height secondary to pneumatization of the maxillary sinus and the resorption of the alveolar ridge preclude in many instances the installation of dental implants. To compensate for the lack of bone height, several treatment options have been proposed.
The ...
Influence of exposing dental implants into the sinus cavity on survival and complications rate: a systematic review
Abstract
Background
After tooth loss, the posterior maxilla is usually characterized by limited bone height secondary to pneumatization of the maxillary sinus and/or collapse of the alveolar ridge that preclude in many instances the installation of dental implants. In order ...
Number of implants
Insertion torque value (N cm)
Implant stability quotient value
0 week
2 weeks
4 weeks
6 weeks
8 weeks
12 weeks
1
25
33.0
75.0
77.0
78.3
79.7
77.0
2
40
68.0
70.3
70.0
72.0
75.7
75.3
3
40
78.3
77.0
78.0
78.7
80.0
80.0
4
35
74.0
43.0
61.0
73.0
75.7
80.0
5
45
85.3
85.7
84.0
83.3
84.0
83.0
6...
Number of implants
Treatment area (FDI)
Size of implant (mm)
Length
Diameter
1
14
10
3.8
2
14
10
3.8
3
14
10
3.8
4
16
8
3.8
5
16
10
4.4
6
16
8
4.4
7
16
8
4.4
8
17
10
4.4
9
36
10
3.8
10
36
10
4.4
11
36
8
3.8
12
36
10
3.8
13
36
12
4.4
14
36
10
4.4
15
36
10
4.4
...
Figure 9. The comparison of two groups at average voxel values for each part. The comparison of voxel values by insertion torque. All specimens were classified into two groups by insertion torque
Figure 8. The relationship between average voxel value and insertion torque (averaged over the entire treatment area). The comparison of average voxel value among IT groups. Average voxel value was 384.0 ± 154.6 in the low IT group, 387.7 ± 147.7 in the medium IT group, and 619.2 ± 200.4 in the high IT group
Figure 7. The average voxel value between the maxilla and mandible. There was no difference between the maxilla (430.9 ± 211.6) and the mandible (475.6 ± 211.5) in the average voxel value. Also, no difference was found in each part
Figure 6. The relationship between ISQ and insertion torque. Percentage of specimens showing ISQ ≥ 73 compared with groups by week. In all groups, a period of rapidly increasing percentages was observed (8–12 weeks in the low IT group, 4–6 weeks in the medium and high IT groups). In the medium and high IT Group, a statistically significant difference was observed between ISQ ...
Figure 5. The comparison of ISQ values by the insertion torque. Time-lapse migration of ISQ values was compared with IT groups. Each IT group displayed similar migration. A significant difference in The ISQ was found in the low IT group after 8 weeks
Figure 4. The classification of the insertion torque. All specimens classified into three groups according to insertion torque. Criteria for the classification are shown in the figure and in the “Methods” section
Figure 3. The evaluation of the average ISQ. Time-lapse migration of average ISQ. Average ISQ of all specimens increased in a time-dependent manner (results indicated by a line). A significant difference was observed by 6 weeks after surgery
Figure 2. The measurement of the voxel values. A case of bone quality diagnosis before treatment. Width and height of the bone were measured to select the proper size of the implant body. The selected implant body was simulated on the bone images as a symbol, and then the voxel value was calculated as described in the "Method" section
Figure 1. Genesio® Plus implant with Aanchor surface. Scheme of the dental implant body for the Genesio® Plus implants with Aanchor surface used. a Overview picture of Genesio® Plus implants with Aanchor surface. b Image from scanning electron microscopy. Both pictures were provided by GC Corporation. To obtain osseointegration from an early stage, the dental implant body was treated...
According to the measurement of the average voxel values in this study, a significant difference was seen between the high IT group and the low/medium IT group, but no significant difference was found between the low and medium IT groups (Fig. 7). Specimens showing IT ≥ 40 N cm were thought to have a good bone quality, and voxel values at each part of the implant (neck, middle apex) were...
A bone quality of the treated area may affect primary stability as described above, preoperative analysis of bone quality is important for clarifying the primary stability of dental implants. This study analyzed bone quality using voxel values obtained using Digital Imaging and Communications in Medicine (DICOM) data from CBCT. According to the result of that analysis, it was...
A significant difference was observed between 0 and ≥ 8 weeks (Fig. 5). The ISQ did not change significantly during the experimental period in the medium or high IT groups, but the percentage of high ISQ (≥ 73) specimens was significantly higher at 4 to 6 weeks compared to other time periods in both groups (Figs. 5 and 6). The results in this study suggest that if the...
Other studies have suggested that ISQ immediately after implant insertion should be about 60, with ISQ subsequently decreasing over weeks 0–4 and increasing over weeks 4–8 after surgery. ISQ values 57–70 may indicate that intraosseous stability of the implant body is constant.
Increases or decreases of ISQ values are explained as follows: The inserted dental implant bo...
The insertion torque value in this study showed broader (10 to 50 N cm) than the previous publication (Table 2), and the cause of reasons for the difference are as follows: Primary stability may be affected by the bone quantity and bone quality in the treatment area, the micro- and macro-level design of the implant body, and the accuracy of the surgical technique. In this ...
Discussion
According to the previous literature, the obtaining osseointegration is integral to the intraosseous stability of the implant body during the healing period; moreover, the importance of postoperative assessment of the intraosseous stability of the implant has also been reported. Intraosseous stability of the implant body is evaluated immediately after the implant ...
Average ISQ tended to increase during the healing period in all IT groups (Fig. 5). Average ISQ of the low IT group was 59.81 at 0 week, increasing significantly after ≥ 8 weeks (P
Methods
Research design and study participants
This prospective study was conducted jointly by Tokyo Dental College (Tokyo, Japan) and Fukuoka Dental College (Fukuoka, Japan) from January to December 2015. All study protocols were conducted in accordance with the Declaration of Helsinki and were approved by the ethics committees of Tokyo Dental College (approval #416) and Fukuoka Dental Colle...
Results
Study overview
A total of 33 implant bodies (8 in the maxilla, 25 in the mandible) were inserted into the 27 participants (11 men, 16 women), with the average age of 54.6 ± 12.2 years (range, 32–78 years). The average IT value was 32.7 ± 9.2 N cm (32.5 ± 11.6 N cm in the maxilla, 32.8 ± 8.5 N cm in the mandible). The diameter of the implant body wa...
Methods
Research design and study participants
This prospective study was conducted jointly by Tokyo Dental College (Tokyo, Japan) and Fukuoka Dental College (Fukuoka, Japan) from January to December 2015. All study protocols were conducted in accordance with the Declaration of Helsinki and were approved by the ethics committees of Tokyo Dental College (approval #416) and Fuku...
Background
Dental implant treatments have improved in both convenience and predictability with refinements in implant bodies and treatment procedures as compared to about 50 years ago when clinical applications were started. Currently, an implant body surface is treated with “rough processing” by sandblasting and acid etching for the purposes of obtaining more reliable osseo...
Abstract
Background
A current implant body surface was treated with “rough processing” by sandblasting and acid etching for the purposes of obtaining more reliable osseointegration and shortening the treatment period. Various reports have examined the healing period with the use of these implant bodies, but a consensus opinion has not yet been obtained. The purpose of this study is to eval...
At 5 years of function
At 10 years of function
Patient level
Implant level
Patient level
Implant level
n
%
n
%
n
%
n
%
Failure
15
3.16%
31
1.56%
24
5.05%
47
2.36%
Δ 5‐ to 10‐year failure
1.89%
0.80%
Peri‐implantitis
40
8.42%
61
3.19%
76
16%
186
9.72%
Δ 5‐ to 10‐year peri‐impla...
Figure 1. Peri‐implantitis over the study period of 10 years at patient and implant level
Rehab. solution
Patient level
Implant level
Survival rate
Total
91.8%
96.1%
Fixed full‐arch bridge
90.5%
Implant‐supported overdenture
82.9%
Fixed partial denture
99.2%
Single‐tooth replacement
99.6%
Peri‐implantitis rate
Total
24.4%
12.9%
Fixed full‐arch bridge
14.3%
Implant‐...
Cumulative survival rate
Cumulative success rate
Time of functional loading (Years)
Patient level
Implant level
Patient level
Implant level
1 to 2
100%
100%
98.7%
99.5%
2 to 3
99.2%
99.7%
97.2%
98.8%
3 to 4
98.5%
99.4%
95.5%
97.9%
4 to 5
97.7%
98.9%
93.5%
96.7%
5 to 6
96.6%
98.4%
91.3%
95.3%
6 to 7
95.5%
97.9%
88.5%
93.6...
Demographic variables
Implants (%)
Age
≥61 years
315 (15.8)
≤60 years
1,676 (84.2)
Sex
Male
904 (45.4)
Female
1087 (54.6)
Systemic disorders11 under medical supervision.
With
173 (8.7)
Without
1,818 (91.3)
Smoking habits22 ≤20 cigarettes.
With
146 (7.3)
Without
1,845 (92.7)
Anatomic variables
...
Total
Patients
Implants
Clinical condition
Men
Women
n
%
Rehab. solution
n
%
n
%
Totally edentulous
40
50
90
19
Fixed full‐arch bridge
32
6.74
348
17.48
Implant‐supported overdenture
58
12.21
211
10.60
Partially edentulous
73
82
155
33
Fixed partial denture
155
32.63
732
36.77
Mono‐edentul...
CONCLUSIONS
Peri‐implantitis began to appear more frequently after the fifth year of functional loading, with a peak of incidence observed after the seventh year, especially between the seventh and eighth years. The incidence of peri‐implantitis increased when the data were analyzed from the fifth year to 10 years of function. Consequently, studies that consider a follow‐up period
The rate of peri‐implantitis observed in this study at 10 years, agreed with that described by Bragger et al. and Karoussis et al. in which peri‐implantitis occurred in 15.4% of the implants after a mean observation period of 10 years. Simonis et al. (2010) reported a prevalence of 16.9% of peri‐implantitis after an observation period of 10 to 16 years.
The study of de Waal et al. desc...
During the interval between the sixth and seventh year of functional loading, a slightly higher rate of failures than that in the previous years was observed.
The ratio between the rate of peri‐implant complications and the time of function was even more evident for peri‐implantitis, which showed a significant increase after the seventh year of functional loading, with a more evident increase...
The aim of this retrospective study was to assess the survival and success rates as well as the incidence of peri‐implantitis in patients with a history of periodontitis who followed an individual maintenance program and supportive periodontal and peri‐implant treatment (SPT), and with 1 to 10 years of implant functional loading.
The results obtained in the present study show that peri‐impl...
A total of 1,991 implants (475 patients) with 10 years of functional loading met the inclusion criteria and were included in this study: 90 patients were totally edentulous (559 implants), 155 patients were partially edentulous (732 implants), and 230 patients were mono‐edentulous (700 implants) (Tables 1 and 2).
Table 3 shows the life table analysis and cumulative survival and success rate and...
When a two‐stage technique was performed (i.e., sinus floor augmentation without implant insertion or staged‐approach GBR), a healing period of at least 6 months was observed before implant insertion. The implants were functionally loaded after 3 to 6 months of the implant placement.
2.3.3 Follow‐up
After surgery, for a maintenance program, all patients followed an individual SPT. The ...
Where a deficient posterior alveolar ridge and increased pneumatization of the maxillary sinus appeared, implants were inserted with simultaneous sinus floor augmentation (one‐step procedure) (osteotome technique, or lateral window technique) or after a previous sinus floor augmentation with bone grafting (two‐step procedure).
Sites that exhibited localized horizontal bone...
Successful tissue integration was examined using predefined criteria of success, as follows:
Absence of persistent subjective complaints, such as pain, foreign body sensation and/or dysesthesia.
Absence of implant mobility.
Absence of continuous radiolucency around the implant.
Implant prosthesis functional loading ≥1 year.
Absence of exude or suppuration at acupressure o...
2.2 Clinical parameters
Periodical clinical examinations assessed before treatment and during follow‐up were recorded. Clinical parameters at baseline and after prosthesis positioning were used as a reference of development of peri‐implant disease.
Based on the suggestion of Mombelli and Lang, and confirmed by the successive EWP consensus workshops published in 2008, 2011, and 2012, peri...
This is a retrospective cohort study started from the analysis of clinical records of patients referring to private dental practices in central Italy (AP) treated between February 1998 and December 2002 by three different operators, and then included into a follow‐up program. We followed the Strengthening the Reporting of OBservational studies in Epidemiology (STROBE) guidelines for an accurate ...
INTRODUCTION
Implant‐prosthetic rehabilitation is a clinical procedure used to solve cases of partial or total edentulism. A functioning implant may be subject to plaque‐associated biological complications, such as mucositis and peri‐implantitis.
Peri‐implant mucositis has been described as a reversible inflammatory lesion of the peri‐implant mucosa, whilst peri‐implantitis also desc...
A retrospective cohort study on peri‐implant complications in implants up to 10 years of functional loading in periodontally compromised patients
Abstract
Background
Prevalence of peri‐implantitis is directly proportional to the time of functional loading. The aim of this retrospective study was to assess the survival and success rates as well as the incidence of peri‐implantitis ...
Pengukuran tulang (bone sounding)
Bone sounding atau transmucosal sounding (TS) adalah pengukuran yang digunakan untuk menentukan ketinggian seluruh cuff (manset) jaringan lunak pada berbagai kelompok gigi dan implant. Matra mukosa peri-implan dan gingiva pada letak gigi yang berdekatan dipelajari dengan pengukuran klinis yang dilakukan terutama pada subjek edentulous sebagian yang telah dirawa...
The implant device lacks tooth characteristic structures such as root cementum, periodontal ligament, and bundle bone (alveolar bone proper). The dento‐alveolar and the dento‐gingival fiber bundles connect the soft tissues with the tooth (root cementum), while no such fiber bundles are apparent in the peri‐implant tissues. At periodontally healthy sites, the margin of the gingiva follow...
Bone tissue in the edentulous ridge
In a study involving partially edentulous subjects, hard tissue biopsies were sampled from the maxilla and the mandible with the use of trephine drills. The bone tissue was found to include a blend of mainly lamellar bone (46%) and bone marrow (23%) with less amounts of fibrous (12%) and osteoid (4%) tissue. Bone marrow was the dominant tissu...
KERATINIZED MUCOSA (KM)
Keratinized mucosa is a term used to describe the masticatory mucosa that is present at many, but not all, implant sites. Keratinized mucosa extends from the margin of the peri‐implant mucosa to the movable lining (oral) mucosa. Keratinized mucosa is comprised of a lamina propria (fibrous connective tissue that contains fibroblasts and equal amounts of ty...
BONE SOUNDING
Bone sounding or transmucosal sounding (TS) is a measurement that is used to determine the height of the entire soft tissue cuff at various groups of teeth and implants. The dimensions of the peri‐implant mucosa and the gingiva at adjacent tooth sites was studied by clinical measurements performed mainly in partially edentulous subjects who had been treated with im...
PERI‐IMPLANT TISSUES IN CLINICAL HEALTH
The gingiva and the peri‐implant mucosa and their adhesion (seal) are consistently challenged by the oral environment, including the steady exposure to microorganisms in the biofilm present on the tooth and implant surfaces. In the clinically normal peri‐implant mucosa (and gingiva), the continuous host response includes both vascular ...
Animal studies
The dimension of the peri‐implant mucosa, often called the biological width or dimension, was examined in biopsies mainly obtained from studies in dogs. Such measurements disclosed that a certain width of soft tissue may be required to cover the peri‐implant bone. The studies referred to the length of the epithelium (from the peri‐implant mucosa margin to the...
The formation of the mucosal adhesion was studied in a dog model. One‐piece implant devices were placed in the edentulous mandible of dogs, and healing was monitored using light microscopic examination of biopsies sampled at different intervals during a 3‐month period. In the initial phase of the wound between the implant and cut connective tissue, a fibrin clot/coagulum formed that was inf...
PERI‐IMPLANT MUCOSA
Most information regarding the structural features of the peri‐implant mucosa is derived from animal studies using dog models. In such studies implants were placed in the edentulous ridge (alternatively, the fresh extraction socket), the outer osseous part of which was covered with masticatory mucosa. It was also shown that the healed peri‐implant mucosa on the buccal a...
Peri‐implant tissues are those that occur around osseointegrated dental implants. They are divided into soft and hard tissue compartments. The soft tissue compartment is denoted “peri‐implant mucosa” and is formed during the wound healing process that follows implant/abutment placement. The hard tissue compartment forms a contact relationship to the implant surface to secure implant stab...
Abstract
Objective
The aim is to define clinical and histologic characteristics of peri‐implant tissues in health and describe the mucosa–implant interface.
Importance
An understanding of the characteristics of healthy peri‐implant tissues facilitates the recognition of disease (i.e., departure from health).
Findings
The healthy peri‐implant mucosa is, at the microscopic ...
Figure 50. Buccal wall
The margin of the buccal wall is shifted apically by approximately 2 mm over the 8 weeks of healing, as indicated by the yellow arrow. Bone loss is greater in the buccal wall than in the lingual wall during socket healing for several reasons. First, the crestal portion of the buccal bone wall, especially in the anterior region, is occupied by bundle bone. As mentioned e...
Figure 49. Dimensional ridge alternation : 8 weeks
At 8 weeks after tooth extraction, the entrance to the extraction site is bridged with cortical bone. The woven bone in the socket is replaced with bone marrow and some trabeculae of lamellar bone. At the crests of the buccal and lingual cortical plates, there are signs of ongoing bone resorption.
Figure 48. Dimensional ridge alterations: 4 weeks
At 4 weeks after tooth extraction, the socket is filled with woven bone. Osteoclasts are present on the outer surfaces at the margin of the buccal and lingual walls, signaling resorption of cortical plates. The resorption of the bundle bone is almost complete. Osteoclasts also line the trabeculae of woven bone present in the central and latera...
Figure 47. Dimensional ridge alterations: 2 weeks
At 2 weeks after tooth extraction, the apical and lateral parts of the socket are filled with woven bone, while the central and marginal portions of the socket are occupied by provisional connective tissue. On the inner and outer surfaces of the socket walls, numerous osteoclasts can be seen. In several areas of the socket wall, the bundle bon...
Figure 46. Dimensional ridge alterations in 1 week
Araujo and Lindhe described the edentulous ridge profile alterations following tooth extraction in an experimental study in a dog model. During the first week of post-extraction healing, the socket area is occupied by coagulum and granulation tissue. A large number of osteoclasts are seen on the outer as well as on the inner s...
Figure 36. Day 60 - 180 : Initial periosteum formation
After 60 to 90 days, newly formed woven bone forms a bridge across the entrance of the socket. The epithelium covering the bone is keratinized. Soft tissue healing at this stage has been completed. At 90 to 180 days after tooth extraction, the woven bone is gradually remodeled into cortical bone. A periosteum is established with collagen ...
Figure 35. Day 21 - 30 : keratinized epithelium
After 21 to 30 days, the marginal soft tissue compartment of the socket is characterized by a well-organized fibrous connective tissue lined with a keratinized epithelium.
Figure 34. Day 4 - 14 : Epithelial proliferation & connective tissue
After 4 to 5 days, the epithelium from the margins of the soft tissue starts to proliferate to cover the granulation tissue in the socket. At 14 days, the connective tissue at the marginal portion of the extraction socket is partially lined by epithelial cells.
Weton
Pencarian metuken 5 artikel. Tiga di antaranya disertakan dalam tinjauan.11, 34, 35 Dua artikel dikecualikan karena tidak melaporkan tentang implant gigi PEEK.36, 37
Dari artikel yang disertakan, 2 artikel melaporkan penelitian pada sato34, 35 dan 1 artikel melaporkan tentang penelitian elemen terbatas in vitro.11
Tujuan dari penelitian elemen terbatas 3 dimensi ini adalah untuk membandin...
Conclusion
Literature reporting on dental implants made from PEEK demonstrate that PEEK is basically osseointegrated as biocompatible material in vivo. Further investigations are necessary to find ways to improve the biomechanical behavior to achieve a more homogenous stress distribution to the surrounding bone, which has not yet been experimentally proven. Long-term investigation...
Table 4. Differences in the mean insertion depths between submerged and nonsubmerged implants from Table 3
Nonsubmerged implants, mean insertion depths from Table 3, mm
Submerged implants, mean insertion depths from Table 3, mm
Differences in the Mean Insertion Depths, mm*
Zirconia
-2.15
-2.62
+0.47
Coated zirconia
-2.56
-2.25
-0.31
Titanium
...
Table 3. Mean values of bone-related and implant-related bone level (BL) (Koch et al) and the mean insertion depths
Mean bone-related BL, mm
Mean implant-related BL, mm
Mean insertion depth, mm
Nonsubmerged
Zirconia
-0.53
-1.62
-2.15
Coated zirconia
-0.59
-1.97
-2.56
Titanium
-0.37
-1.65
-2.02
PEEK
-1.3
-0.44
-1.74
Submerged
...
Discussion
Referring to a 3-dimensional finite element analysis of a CFR-PEEK and a titanium implant (Table 1), the authors concluded that due to its higher stress concentrations, the CFR-PEEK implant could not be recommended.11
This deformation rate could probably be diminished by an inner stiffening of the implant, for example, by an abutment connection bolt which extends to the apical region ...
Table 2. Overview of 2 in vivo animal investigations
Author
Cook and Rust-Dawicki
Year of publication
1995
Number of animals
4 (mongrel dogs)
Number of implants
40
Number of implants/ animal
10
Implantation site
Femur
Healing period
4 weeks (n = 2); 8 weeks (n = 2)
Implant design
Cylindrical
Healing method
Submerged/ unloaded
Implant mat...
Author
Sarot et al
Year of publication
2009
Implantation site
Virtual 3-dimensional model of a lower jawa of region 35, based on a randomly chosen computerized tomography scan with a total of 212 transversal slices wit 0.25 mm in length, consisting of medullar bone covered by a 1.0-mm thick layer of cortical bone, designed with the software Ansys DesignModeler v11 (ANSYS Inc...
Results
The search yielded 5 articles, of which 3 were included in the review.11, 34, 35 Two articles were excluded, because they did not report on dental implants of PEEK.36, 37
Of the included articles, 2 reported on animal investigations34, 35 and 1 on an in vitro finite element study.11
The aim of the 3-dimensional finite element study was to compare the stress distribution to the peri-impl...
Materials and Methods
Literature search
The articles for the current review were found using the PubMed search engine and searching for references cited within these articles. All articles published until December 2010 were reviewed. The following search terms were used together: “dental implant PEEK.”
Inclusion criteria
Only articles about dental implants from PEEK or modified PEEK publis...
Introduction
Dental implants increase the quality of life for many patients with tooth loss.1 The material of choice for oral endosseous implants is pure titanium, introduced at the end of the 1960s by Branemark.2 Although implants based on titanium and titanium alloys, such as Ti-6Al-7Nb and Ti- 6Al-4V,3, 4 are well evidence-based, it was demonstrated that their use can be correl...
Andreas Schwitalla, DDS ; Wolf-Dieter Müller, PhD
J Oral Implantol (2013) 39 (6): 743–749.
https://doi.org/10.1563/AAID-JOI-D-11-00002
Abstract
The insertion of dental implants containing titanium can be associated with various complications (eg, hypersensitivity to titanium). The aim of this article is to evaluate whether there are existing studies reporting on PEEK as an alternative m...
2. Surface analyses
Analisis permukaan dilakukan dalam 4 penelitian. Dalam penelitian pertama, Yang et al meneliti zirkonia dengan 4% CeO2 dan zirkonia dengan 3% lapisan Y2O3, yang diendapkan pada implant titanium dan implant CoCrMo menggunakan teknik semprotan plasma. Properti adesif, morfologis, dan struktur pada lapisan yang disemprot plasma dievaluasi. Rata-rata kekasaran permukaan zirkonia d...
2. Surface analyses
Surface analyses were performed in 4 studies. In the first study, Yang et al investigated zirconia with 4% CeO2 and zirconia with 3% Y2O3 coatings, which were deposited on titanium and CoCrMo implants using the plasma spraying technique. Adhesive, morphologic, and structural properties of the plasma-sprayed coatings were evaluated. The average surface roug...
1. Oseointegrasi, analisis histologis, dan BIC
Eighteen articles discussed osseous healing, histologic analyses, and BIC of zirconia dental implants. Seven of these articles evaluated zirconia as a coating material, evaluated zirconia dental implants.
Delapan belas artikel medhar penyembuhan osseus, analisis histologis, dan BIC dari implant gigi zirkonia. Tujuh di antara artikel ini mengevaluasi...
1. Osseointegration, histologic analyses, and BIC
Eighteen articles discussed osseous healing, histologic analyses, and BIC of zirconia dental implants. Seven of these articles evaluated zirconia as a coating material, evaluated zirconia dental implants.
Zirconia as a Coating Material
Cranin et al investigated the osseointegration of vitallium implants with the addit...
Conclusions
The porous Col-HA composites developed in the present study are biocompatible and can be used as scaffolds for bone tissue regeneration. The Col-HA ratio is an important factor in promoting the attachment and proliferation of mouse MSCs. The Col-HA composite complexes have strong potentials in bone tissue regeneration applications. hPDSCs may be a suitable resource of cells for maxi...
Discussion
The findings of the presented study indicate that the porous sponge-like Col-HA composites have good biocompatibility and biomimetic properties and may be used as scaffolds for bone tissue regeneration. The Col-HA composites with ratios 80:20 and 50:50 supported the attachments and proliferations of mouse MSCs and hPDSCs. These findings indicate that Col-HA composite complexes have str...
Results
The sponge-like plugs of prototype Col-HA composites were successfully fabricated with different collagen and HA ratios. The macroscopic and SEM views of the prototype type I collagen without HA and 3 different ratios of collagen-HA (20%Col-80%HA; 50%Col-50%HA; 80%Col-20%HA) composites are shown in Figure 1. The SEM views show the inside microstructures of the prototype pure type I colla...
Materials and Methods
Synthesis of the Col-HA composites by direct precipitation in situ
Solutions of calcium salt and phosphoric acid (Ca/P = 1.66 mol) were used to synthesize HA particles and incorporate them on bovine type I collagen fibrils by a direct precipitation technique in situ. This technique was optimized to produce 3 different ratios of Col-HA composites (20%Col-80%HA; 50%Col-50%H...
Introduction
Combining a scaffold and living cells to form a tissue-engineering construct is an important concept for promoting the repair and regeneration of bone tissues. Mesenchymal stem cells are often used in such constructs due to their abilities to proliferate and differentiate toward bone-forming cells. The design and fabrication of scaffolds, stem cell isolation and characterization, and...
Abstract
Current bone grafting materials have significant limitations for repairing maxillofacial and dentoalveolar bone deficiencies. An ideal bone tissue-engineering construct is still lacking. The purpose of the present study was first to synthesize and develop a collagen-hydroxyapatite (Col-HA) composite through controlled in situ mineralization on type I collagen fibrils with nanometer-sized...
RESEARCH
Porous Collagen-Hydroxyapatite Scaffolds With Mesenchymal Stem Cells for Bone Regeneration
Li Ning, DDS, PhD , Hans Malmström, DDS , Yan-Fang Ren, DDS, MPH, PhD
Correspondence:
* Corresponding author, e-mail: yanfang_ren@urmc.rochester.edu
Article Citation:
Li Ning, Hans Malmström, Yan-Fang Ren, Porous Collagen-Hydroxyapatite Scaffolds With Mesench...
Lanjutan dari epitelium gingiva.
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Dari keberadaan gigi berlubang pada primata, kita dapat mempertimbangkan bahwa sumber natural karbohidrat bisa menimbulkan lesi karies. Bakteri dalam mulut manusia dapat memroses karbohidrat menjadi gula dan asam yang dapat merusak gigi.
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Pemasangan dan perawatan implan gigi identik dengan harga yang kurang murah. Beraneka faktor menyebabkan harga implant sulit untuk ditekan. Walau begitu, ada cara untuk mendapat perawatan ini gratis. Mau tahu gimana caranya?Penyedia implan gigi gratisKeluarga.Jika Anda punya anak, cucu, keponakan, orangtua, bibi, paman, atau kerabat dekat lain yang jadi dokter gigi implan, Anda cukup beruntung....
Sekalipun permintaan terhadap perawatan implan gigi cukup tinggi, namun perlu disadari bahwa tidak semua pasien memenuhi syarat untuk menerima perawatan implant gigi. Syarat penerima implan gigi meliputi antara lain:
Tulang pendukung implant memadai, yaitu tipe 1 dan tipe 2.
Tulang tipe 1 dan 2 mempunyai peluang yang lebih tinggi bagi kesuksesan implant ketimbang tulang tipe 3 dan 4.
Ti...