Fig. 4. e. Margins between bone defect and scaffold are less demarcated due to new bone growth
Fig. 4. a Peri-apical X-ray of zirconia scaffold immediately placed in bone defect. Margins between scaffold and bone are clearly demarcated. b Peri-apical X-ray of zirconia scaffold after completion of healing time. Margins between bone defect and scaffold are less demarcated due to new bone growth
Fig. 3. hite arrow). Mineralized bone formation (black arrow) was less dense compared to HA-enriched scaffolds. b Histological section showing different sizes of pores present in porous zirconia scaffolds (Control specimen). Mineralization started by lining pore walls (white arrow). Unmineralized bone stained blue
Fig. 3. a Histological section demonstrating bone growth in control zirconia sc...
Fig. 2. zirconia scaffold (black arrow). Unmineralized bone stained blue. Almost entire surface porosity was filled with new dense bone. b Histological section demonstrating bone growth in HA-enriched zirconia scaffold starting from the periphery of the surgical wound (white arrow). Islands of entrapped HA particles were surrounded by mineralized boney matrix (black arrow) which were identified ...
Fig. 1. rating agglomeration of nano-hydroxyapatite particles filling the porous structure
Fig. 1. a SEM image, ×10,000, demonstrating internal porosity of the fabricated zirconia scaffolds. b SEM image, ×30,500, demonstrating agglomeration of nano-hydroxyapatite particles filling the porous structure
Aboushelib, M.N., Shawky, R. Osteogenesis ability of CAD/CAM porous zirconia scaffolds enriched with nano-hydroxyapatite particles. Int J Implant Dent 3, 21 (2017). https://doi.org/10.1186/s40729-017-0082-6
Download citation
Received: 15 November 2016
Accepted: 08 May 2017
Published: 19 May 2017
DOI: https://doi.org/10.1186/s40729-017-0082-6
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
Dental Biomaterials Department, Faculty of Dentistry, Alexandria University, Champollion st, Azarita, Alexandria, Egypt
Moustafa N. Aboushelib
Oral Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
Rehab Shawky
You can also search for this author in PubMed Google Scholar
You can also search for this author in PubMed Google Scholar
Correspondence to Moustafa...
Part of this study was supported by STDF reintegration grant number 489 and was performed in collaboration with the Oral Surgery Department, Faculty of Dentistry, Alexandria University, Egypt.
MNA prepared the specimens and performed the characterization process. He participated in preparation of histological section, data collection and analysis, and in preparation of the manuscript. RS performe...
Naleway SE, Fickas KC, Maker YN, Meyers MA, McKittrick J. Reproducibility of ZrO2-based freeze casting for biomaterials. Mater Sci Eng C Mater Biol Appl. 2016;61:105–12.
Song YG, Cho IH. Characteristics and osteogenic effect of zirconia porous scaffold coated with beta-TCP/HA. J Adv Prosthodont. 2014;6:285–94.
Okano T, et al. Absorbed and effective doses from cone beam volumetric imaging for...
Chiapasco M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants. 2009;24:237–59.
Rocchietta I, Fontana F, Simion M. Clinical outcomes of vertical bone augmentation to enable dental implant placement: a systematic review. J Clin Periodontol. 2008;35:203–15.
Louis PJ, Gutta R, Said-Al-Naief N, Bartolucci AA. Reconstruction of the maxilla ...
Within the limitations of this study, hydroxyapatite enhanced osteogenesis ability of porous zirconia scaffolds.
Histomorphometric analysis revealed that bone growth start to develop as early as 6 weeks by lining pore cavity walls. Mineralized bone matrix was observed to penetrate 1–2 mm under the surface of the scaffolds thus providing mechanical stability of the inserted prosthesis. Healing continued by filling the entire pore volume (Fig. 2a, b). The presence of nano-hydroxyapatite particles enhanced...
Porous scaffolds are designed to allow ingrowth of the surrounding bone within the internal porosity of the solid matrix. Different types of bioactive materials were mixed with zirconia to enhance bone formation. Two sizes of pores were incorporated in the structure of the fabricated scaffolds. Micro-pores in range of 50 μm constituted the majority of the entire pore volume (50 wt.%) of the fabr...
Mercury porosimetery revealed comparable (F = 0.057, P
Six weeks after insertion of the scaffolds, the animals were given an over dose of an anesthetic injection and section blocks were obtained by cutting the mandible maintaining 10 mm of sound bone around the scaffolds. Cut sections were immediately fixed in 4% buffered formaldehyde and dehydrated in graded ethanol solutions using a dehydration system under agitation and vacuum, and the specimens w...
Nano-hydroxyapatite particles were prepared using sol gel chemical precipitation method. The sol was thermally aged at low temperature at 50 °C for 2 h. Upon drying the sol particles agglomerated into a dry gel through van der Waals forces composed of 10–14-nm particles. A crystalline apatite is achieved after sintering at 450 °C resulting in a gained structure of 25–55 nm in diameter. T...
Zirconia powder (50 μm, 3 mol YTZP, E grade, Tosoh, Japan) was mixed with 50 wt.% resin beads (50 μm polymethyl methacrylate powder) added to create microscopic pore sizes. Thirty weight percent coarse sodium chloride particles (500–700 μm) were added to the mix to create large interconnected pores. The powder was mixed in a rotating cylinder for 24 h to insure homogenous powder distribu...
Modern radiographic imaging techniques in combination with advanced computer designing software could reconstruct a three-dimensional image of large boney defects [16]. Designing the shape of the required scaffold could easily be performed to accurately fit the available defect size using advanced imaging and designing software [17]. Finally, the required shape could be directly milled from differ...
Principles of tissue engineering are used today in an attempt to reconstruct damaged human tissue. In the dental field, several types of bone grafting materials are currently available which could be directly used to augment atrophic jaws before implant placement. However, the main drawback of these grafts is related to difficulty of preserving the required shape of the graft during the healing ti...
The aim of this study was to evaluate osteogenesis ability of CAD/CAM porous zirconia scaffolds enriched with hydroxy apatite used to augment large boney defects in a dog model.
Surgical defects were made bilaterally on the lower jaw of 12 Beagle dogs. Cone beam CT images were used to create three dimensional images of the healed defects. Porous zirconia scaffolds were fabricated by milling custo...
Aboushelib, M.N., Shawky, R. Osteogenesis ability of CAD/CAM porous zirconia scaffolds enriched with nano-hydroxyapatite particles.
Int J Implant Dent 3, 21 (2017). https://doi.org/10.1186/s40729-017-0082-6
Download citation
Received: 15 November 2016
Accepted: 08 May 2017
Published: 19 May 2017
DOI: https://doi.org/10.1186/s40729-017-0082-6
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Dental Biomaterials Department, Faculty of Dentistry, Alexandria University, Champollion st, Azarita, Alexandria, Egypt
Moustafa N. Aboushelib
Oral Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
Rehab Shawky
You can also search for this author in
PubMed Google Scholar
You can also search for this author in
...
Part of this study was supported by STDF reintegration grant number 489 and was performed in collaboration with the Oral Surgery Department, Faculty of Dentistry, Alexandria University, Egypt.
MNA prepared the specimens and performed the characterization process. He participated in preparation of histological section, data collection and analysis, and in preparation of the manuscript. RS performe...
Naleway SE, Fickas KC, Maker YN, Meyers MA, McKittrick J. Reproducibility of ZrO2-based freeze casting for biomaterials. Mater Sci Eng C Mater Biol Appl. 2016;61:105–12.
Song YG, Cho IH. Characteristics and osteogenic effect of zirconia porous scaffold coated with beta-TCP/HA. J Adv Prosthodont. 2014;6:285–94.
Okano T, et al. Absorbed and effective doses from cone beam volumetric imaging for...
Chiapasco M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants. 2009;24:237–59.
Rocchietta I, Fontana F, Simion M. Clinical outcomes of vertical bone augmentation to enable dental implant placement: a systematic review. J Clin Periodontol. 2008;35:203–15.
Louis PJ, Gutta R, Said-Al-Naief N, Bartolucci AA. Reconstruction of the maxilla ...
Within the limitations of this study, hydroxyapatite enhanced osteogenesis ability of porous zirconia scaffolds.
Histomorphometric analysis revealed that bone growth start to develop as early as 6 weeks by lining pore cavity walls. Mineralized bone matrix was observed to penetrate 1–2 mm under the surface of the scaffolds thus providing mechanical stability of the inserted prosthesis. Healing continued by filling the entire pore volume (Fig. 2a, b). The presence of nano-hydroxyapatite particles enhanced...
Porous scaffolds are designed to allow ingrowth of the surrounding bone within the internal porosity of the solid matrix. Different types of bioactive materials were mixed with zirconia to enhance bone formation. Two sizes of pores were incorporated in the structure of the fabricated scaffolds. Micro-pores in range of 50 μm constituted the majority of the entire pore volume (50 wt.%) of the fabr...
Mercury porosimetery revealed comparable (F = 0.057, P
Six weeks after insertion of the scaffolds, the animals were given an over dose of an anesthetic injection and section blocks were obtained by cutting the mandible maintaining 10 mm of sound bone around the scaffolds. Cut sections were immediately fixed in 4% buffered formaldehyde and dehydrated in graded ethanol solutions using a dehydration system under agitation and vacuum, and the specimens w...
Nano-hydroxyapatite particles were prepared using sol gel chemical precipitation method. The sol was thermally aged at low temperature at 50 °C for 2 h. Upon drying the sol particles agglomerated into a dry gel through van der Waals forces composed of 10–14-nm particles. A crystalline apatite is achieved after sintering at 450 °C resulting in a gained structure of 25–55 nm in diameter. T...
Zirconia powder (50 μm, 3 mol YTZP, E grade, Tosoh, Japan) was mixed with 50 wt.% resin beads (50 μm polymethyl methacrylate powder) added to create microscopic pore sizes. Thirty weight percent coarse sodium chloride particles (500–700 μm) were added to the mix to create large interconnected pores. The powder was mixed in a rotating cylinder for 24 h to insure homogenous powder distribu...
Modern radiographic imaging techniques in combination with advanced computer designing software could reconstruct a three-dimensional image of large boney defects [16]. Designing the shape of the required scaffold could easily be performed to accurately fit the available defect size using advanced imaging and designing software [17]. Finally, the required shape could be directly milled from differ...
Principles of tissue engineering are used today in an attempt to reconstruct damaged human tissue. In the dental field, several types of bone grafting materials are currently available which could be directly used to augment atrophic jaws before implant placement. However, the main drawback of these grafts is related to difficulty of preserving the required shape of the graft during the healing ti...
The aim of this study was to evaluate osteogenesis ability of CAD/CAM porous zirconia scaffolds enriched with hydroxy apatite used to augment large boney defects in a dog model.
Surgical defects were made bilaterally on the lower jaw of 12 Beagle dogs. Cone beam CT images were used to create three dimensional images of the healed defects. Porous zirconia scaffolds were fabricated by milling custo...
Aboushelib, M.N., Shawky, R. Osteogenesis ability of CAD/CAM porous zirconia scaffolds enriched with nano-hydroxyapatite particles.
Int J Implant Dent 3, 21 (2017). https://doi.org/10.1186/s40729-017-0082-6
Download citation
Received: 15 November 2016
Accepted: 08 May 2017
Published: 19 May 2017
DOI: https://doi.org/10.1186/s40729-017-0082-6
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Dental Biomaterials Department, Faculty of Dentistry, Alexandria University, Champollion st, Azarita, Alexandria, Egypt
Moustafa N. Aboushelib
Oral Surgery Department, Faculty of Dentistry, Alexandria University, Alexandria, Egypt
Rehab Shawky
You can also search for this author in
PubMed Google Scholar
You can also search for this author in
...
Part of this study was supported by STDF reintegration grant number 489 and was performed in collaboration with the Oral Surgery Department, Faculty of Dentistry, Alexandria University, Egypt.
MNA prepared the specimens and performed the characterization process. He participated in preparation of histological section, data collection and analysis, and in preparation of the manuscript. RS performe...
Naleway SE, Fickas KC, Maker YN, Meyers MA, McKittrick J. Reproducibility of ZrO2-based freeze casting for biomaterials. Mater Sci Eng C Mater Biol Appl. 2016;61:105–12.
Song YG, Cho IH. Characteristics and osteogenic effect of zirconia porous scaffold coated with beta-TCP/HA. J Adv Prosthodont. 2014;6:285–94.
Okano T, et al. Absorbed and effective doses from cone beam volumetric imaging for...
Chiapasco M, Casentini P, Zaniboni M. Bone augmentation procedures in implant dentistry. Int J Oral Maxillofac Implants. 2009;24:237–59.
Rocchietta I, Fontana F, Simion M. Clinical outcomes of vertical bone augmentation to enable dental implant placement: a systematic review. J Clin Periodontol. 2008;35:203–15.
Louis PJ, Gutta R, Said-Al-Naief N, Bartolucci AA. Reconstruction of the maxilla ...
Within the limitations of this study, hydroxyapatite enhanced osteogenesis ability of porous zirconia scaffolds.
Histomorphometric analysis revealed that bone growth start to develop as early as 6 weeks by lining pore cavity walls. Mineralized bone matrix was observed to penetrate 1–2 mm under the surface of the scaffolds thus providing mechanical stability of the inserted prosthesis. Healing continued by filling the entire pore volume (Fig. 2a, b). The presence of nano-hydroxyapatite particles enhanced...
Porous scaffolds are designed to allow ingrowth of the surrounding bone within the internal porosity of the solid matrix. Different types of bioactive materials were mixed with zirconia to enhance bone formation. Two sizes of pores were incorporated in the structure of the fabricated scaffolds. Micro-pores in range of 50 μm constituted the majority of the entire pore volume (50 wt.%) of the fabr...
Mercury porosimetery revealed comparable (F = 0.057, P
Six weeks after insertion of the scaffolds, the animals were given an over dose of an anesthetic injection and section blocks were obtained by cutting the mandible maintaining 10 mm of sound bone around the scaffolds. Cut sections were immediately fixed in 4% buffered formaldehyde and dehydrated in graded ethanol solutions using a dehydration system under agitation and vacuum, and the specimens w...
Nano-hydroxyapatite particles were prepared using sol gel chemical precipitation method. The sol was thermally aged at low temperature at 50 °C for 2 h. Upon drying the sol particles agglomerated into a dry gel through van der Waals forces composed of 10–14-nm particles. A crystalline apatite is achieved after sintering at 450 °C resulting in a gained structure of 25–55 nm in diameter. T...
Zirconia powder (50 μm, 3 mol YTZP, E grade, Tosoh, Japan) was mixed with 50 wt.% resin beads (50 μm polymethyl methacrylate powder) added to create microscopic pore sizes. Thirty weight percent coarse sodium chloride particles (500–700 μm) were added to the mix to create large interconnected pores. The powder was mixed in a rotating cylinder for 24 h to insure homogenous powder distribu...
Modern radiographic imaging techniques in combination with advanced computer designing software could reconstruct a three-dimensional image of large boney defects [16]. Designing the shape of the required scaffold could easily be performed to accurately fit the available defect size using advanced imaging and designing software [17]. Finally, the required shape could be directly milled from differ...
Principles of tissue engineering are used today in an attempt to reconstruct damaged human tissue. In the dental field, several types of bone grafting materials are currently available which could be directly used to augment atrophic jaws before implant placement. However, the main drawback of these grafts is related to difficulty of preserving the required shape of the graft during the healing ti...
The aim of this study was to evaluate osteogenesis ability of CAD/CAM porous zirconia scaffolds enriched with hydroxy apatite used to augment large boney defects in a dog model.
Surgical defects were made bilaterally on the lower jaw of 12 Beagle dogs. Cone beam CT images were used to create three dimensional images of the healed defects. Porous zirconia scaffolds were fabricated by milling custo...
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