Fig. 6. Postoperative intraoral finding and radiograph
Fig. 6. Postoperative intraoral finding and radiograph
Fig. 5. High p53, p63, and Ki-67 reactivity are also observed in the basal cell layer (immunohistological staining, bar 400 μm)
Fig. 5. High p53, p63, and Ki-67 reactivity are also observed in the basal cell layer (immunohistological staining, bar 400 μm)
Fig. 4. Immunohistological findings show a negative staining mosaic pattern for keratin 13 (k13) and positive staining for keratin 17 (k17) (immunohistological staining, bar 400 μm)
Fig. 4. Immunohistological findings show a negative staining mosaic pattern for keratin 13 (k13) and positive staining for keratin 17 (k17) (immunohistological staining, bar 400 μm)
Fig. 3. Pathological microscopic examination reveals thickened squamous epithelia with slight nuclear atypism and disorders of the epithelial rete pegs accompanied by moderate grade inflammatory cell infiltration (HE staining, bar: 400 μm)
Fig. 3. Pathological microscopic examination reveals thickened squamous epithelia with slight nuclear atypism and disorders of the epithelial rete pegs a...
Fig. 2. Panoramic radiograph shows slight vertical bone resorption around the implants in the right side of the mandible
Fig. 2. Panoramic radiograph shows slight vertical bone resorption around the implants in the right side of the mandible
Fig. 1. Well-circumscribed gingival swelling on the lingual side of the right side of the mandible
Fig. 1. Well-circumscribed gingival swelling on the lingual side of the right side of the mandible
Antibody
Sorce
Clone
Staining
Keratin 13
DAKO
DE-K13
...
Noguchi, M., Tsuno, H., Ishizaka, R. et al. Primary peri-implant oral intra-epithelial neoplasia/carcinoma in situ: a case report considering risk factors for carcinogenesis.
Int J Implant Dent 3, 47 (2017). https://doi.org/10.1186/s40729-017-0109-z
Download citation
Received: 15 March 2017
Accepted: 25 October 2017
Published: 16 November 2017
DOI: https://doi.org/10.1186...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Written informed consent was obtained from the patient for publication of this case report and any accompanying images.
Makoto Nogchi, Hiroaki Tsuno, Risa Ishizaka, Kumiko Fujiwara, Shuichi Imaue, and Kei Tomihara declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Correspondence to
Makoto Noguchi.
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani Toyama city, Toyama, 9300194, Japan
Makoto Noguchi, Hiroaki Tsuno, Risa Ishizaka, Kumiko Fujiwara, Shuichi Imaue & Kei Tomihara
Department of Diagnosis Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, Univers...
Vasilescu F, Ceauşu M, Tänsen C, et al. P53, p63 and ki-67 assessment in HPV-induced cervical neoplasia. RJME. 2009;50:357–61.
Ndiaye C, Mena M, Alemany L, et al. HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. Lancet Oncol. 2014;15:1319–31.
Nagy K, Sonkodi I, Szöke I, et al. The microflora associated with human oral carcinoma. ...
Sah JP, Johnson NW, Batsakis JG. Oral cancer. London: Informa Healthcare; 2011. p. 3–32.
Japan Society for Oral Tumors. General rules for clinical and pathological studies on oral cancer. 1st ed. Tokyo: Kanehara-shuppan Co; 2010. p. 44–7.
Laprise C, Shahl HP, Madathil SA, et al. Periodontal diseases and risk of oral cancer in Southern India: results from the HeNCe Life Study. Int J Cancer. 2...
Deoxyribonucleic acid
Human papilloma virus
Oral intra-epithelial neoplasia/carcinoma in situ
Squamous cell carcinoma
In our case, the persistence of peri-implant mucositis or peri-implantitis around the dental implant was implicated as being a plausible risk factor for carcinogenesis. Regular follow-up to ensure the maintenance of oral hygiene after dental implant therapy has again been shown to be important for preventing peri-implantitis, a plausible risk factor for carcinogenesis.
The latest evidence implies that the human papilloma virus (HPV) may be responsible for carcinogenesis in the oral cavity [12, 13]; however, its role is debatable. The interaction of the HPV’s E6 and E7 oncoproteins with cell cycle proteins disturbs the cell cycle mechanism and subsequent alteration in the expression of proteins such as p53, p63, and Ki-67 [14]. In our case, the immunohistochemi...
OIN/CIS can sometimes be difficult to distinguish pathologically from epithelial dysplasia on hematoxylin- and eosin-staining sections; this has proved challenging for oral pathologists [9]. Recently, it has been reported that combined immunohistochemistry for k13 and k17 was useful for the differential diagnosis [9, 10]. K13 is a marker for cellular differentiation toward prickle cells in normal ...
A 65-year-old woman was referred to our clinic with a tumor in the right lower gingiva. Her medical history included breast cancer without metastatic lesion, diabetes mellitus, hyperlipidemia, and hypertension. She had taken orally aspirin, amlodipine, pravastatin, and bepotastine for 2 years. She drank alcohol socially, but she had no history of tobacco smoking habit.
About 10 years prior to h...
Oral cancer ranks sixth among the malignancies in terms of worldwide prevalence, with more than 90% being pathologically squamous cell carcinoma (SCC) [1]. Oral SCC generally develops via multistep carcinogenesis. The squamous epithelium goes into irreversible change, including epithelial dysplasia and oral intra-epithelial neoplasia/carcinoma in-situ (OIN/CIS) [2], finally resulting in the develo...
In this case, prolonged peri-implant mucositis or peri-implantitis may have been a plausible risk factor for carcinogenesis.
Major risk factors for oral squamous cell carcinoma (SCC) are tobacco smoking, a betel quid chewing habit, and heavy alcohol consumption. However, around 15% of oral SCCs cannot be explained by these risk factors. Although oral SCC associated with dental implants is quite rare, there has been a recent gradual accumulation of reports about it. Here, we report a case of primary peri-implant oral int...
Fig. 6. Postoperative intraoral finding and radiograph
Fig. 6. Postoperative intraoral finding and radiograph
Fig. 5. High p53, p63, and Ki-67 reactivity are also observed in the basal cell layer (immunohistological staining, bar 400 μm)
Fig. 5. High p53, p63, and Ki-67 reactivity are also observed in the basal cell layer (immunohistological staining, bar 400 μm)
Fig. 4. Immunohistological findings show a negative staining mosaic pattern for keratin 13 (k13) and positive staining for keratin 17 (k17) (immunohistological staining, bar 400 μm)
Fig. 4. Immunohistological findings show a negative staining mosaic pattern for keratin 13 (k13) and positive staining for keratin 17 (k17) (immunohistological staining, bar 400 μm)
Fig. 3. Pathological microscopic examination reveals thickened squamous epithelia with slight nuclear atypism and disorders of the epithelial rete pegs accompanied by moderate grade inflammatory cell infiltration (HE staining, bar: 400 μm)
Fig. 3. Pathological microscopic examination reveals thickened squamous epithelia with slight nuclear atypism and disorders of the epithelial rete pegs a...
Fig. 2. Panoramic radiograph shows slight vertical bone resorption around the implants in the right side of the mandible
Fig. 2. Panoramic radiograph shows slight vertical bone resorption around the implants in the right side of the mandible
Fig. 1. Well-circumscribed gingival swelling on the lingual side of the right side of the mandible
Fig. 1. Well-circumscribed gingival swelling on the lingual side of the right side of the mandible
Antibody
Sorce
Clone
Staining
Keratin 13
DAKO
DE-K13
...
Noguchi, M., Tsuno, H., Ishizaka, R. et al. Primary peri-implant oral intra-epithelial neoplasia/carcinoma in situ: a case report considering risk factors for carcinogenesis.
Int J Implant Dent 3, 47 (2017). https://doi.org/10.1186/s40729-017-0109-z
Download citation
Received: 15 March 2017
Accepted: 25 October 2017
Published: 16 November 2017
DOI: https://doi.org/10.1186...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were...
Written informed consent was obtained from the patient for publication of this case report and any accompanying images.Makoto Nogchi, Hiroaki Tsuno, Risa Ishizaka, Kumiko Fujiwara, Shuichi Imaue, and Kei Tomihara declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Written informed consent was obtained from the patient for publication of this case report and any accompanying images.
Makoto Nogchi, Hiroaki Tsuno, Risa Ishizaka, Kumiko Fujiwara, Shuichi Imaue, and Kei Tomihara declare that they have no competing interests.
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Correspondence to
Makoto Noguchi.
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani Toyama city, Toyama, 9300194, Japan
Makoto Noguchi, Hiroaki Tsuno, Risa Ishizaka, Kumiko Fujiwara, Shuichi Imaue & Kei Tomihara
Department of Diagnosis Pathology, Graduate School of Medicine and Pharmaceutical Sciences for Research, Univers...
Vasilescu F, Ceauşu M, Tänsen C, et al. P53, p63 and ki-67 assessment in HPV-induced cervical neoplasia. RJME. 2009;50:357–61.
Ndiaye C, Mena M, Alemany L, et al. HPV DNA, E6/E7 mRNA, and p16INK4a detection in head and neck cancers: a systematic review and meta-analysis. Lancet Oncol. 2014;15:1319–31.
Nagy K, Sonkodi I, Szöke I, et al. The microflora associated with human oral carcinoma. ...
Sah JP, Johnson NW, Batsakis JG. Oral cancer. London: Informa Healthcare; 2011. p. 3–32.
Japan Society for Oral Tumors. General rules for clinical and pathological studies on oral cancer. 1st ed. Tokyo: Kanehara-shuppan Co; 2010. p. 44–7.
Laprise C, Shahl HP, Madathil SA, et al. Periodontal diseases and risk of oral cancer in Southern India: results from the HeNCe Life Study. Int J Cancer. 2...
Deoxyribonucleic acid
Human papilloma virus
Oral intra-epithelial neoplasia/carcinoma in situ
Squamous cell carcinoma
In our case, the persistence of peri-implant mucositis or peri-implantitis around the dental implant was implicated as being a plausible risk factor for carcinogenesis. Regular follow-up to ensure the maintenance of oral hygiene after dental implant therapy has again been shown to be important for preventing peri-implantitis, a plausible risk factor for carcinogenesis.
The latest evidence implies that the human papilloma virus (HPV) may be responsible for carcinogenesis in the oral cavity [12, 13]; however, its role is debatable. The interaction of the HPV’s E6 and E7 oncoproteins with cell cycle proteins disturbs the cell cycle mechanism and subsequent alteration in the expression of proteins such as p53, p63, and Ki-67 [14]. In our case, the immunohistochemi...
OIN/CIS can sometimes be difficult to distinguish pathologically from epithelial dysplasia on hematoxylin- and eosin-staining sections; this has proved challenging for oral pathologists [9]. Recently, it has been reported that combined immunohistochemistry for k13 and k17 was useful for the differential diagnosis [9, 10]. K13 is a marker for cellular differentiation toward prickle cells in normal ...
A 65-year-old woman was referred to our clinic with a tumor in the right lower gingiva. Her medical history included breast cancer without metastatic lesion, diabetes mellitus, hyperlipidemia, and hypertension. She had taken orally aspirin, amlodipine, pravastatin, and bepotastine for 2 years. She drank alcohol socially, but she had no history of tobacco smoking habit.
About 10 years prior to h...
Oral cancer ranks sixth among the malignancies in terms of worldwide prevalence, with more than 90% being pathologically squamous cell carcinoma (SCC) [1]. Oral SCC generally develops via multistep carcinogenesis. The squamous epithelium goes into irreversible change, including epithelial dysplasia and oral intra-epithelial neoplasia/carcinoma in-situ (OIN/CIS) [2], finally resulting in the develo...
In this case, prolonged peri-implant mucositis or peri-implantitis may have been a plausible risk factor for carcinogenesis.
Major risk factors for oral squamous cell carcinoma (SCC) are tobacco smoking, a betel quid chewing habit, and heavy alcohol consumption. However, around 15% of oral SCCs cannot be explained by these risk factors. Although oral SCC associated with dental implants is quite rare, there has been a recent gradual accumulation of reports about it. Here, we report a case of primary peri-implant oral int...
RFs (log rank, p = 0.006)
Fig. 2. The cumulative survival rates for the different RF groups revealing a significant difference for patients without any and patients with local and systemic RFs (log rank, p = 0.006)
Fig. 1. On Kaplan-Meier survival estimates, the cumulative survival rate was 91.5%
Fig. 1. On Kaplan-Meier survival estimates, the cumulative survival rate was 91.5%
Region
Systemic RF
Local RF
Immediate procedure
Bone grafting
Time of failure (months...
Systemic RF
No. of implants (n = 31)
No. of patients (n = 14)
Local RF
No. of implants (n = 100)
...
Saridakis, S.K., Wagner, W. & Noelken, R. Retrospective cohort study of a tapered implant with high primary stability in patients with local and systemic risk factors—7-year data.
Int J Implant Dent 4, 41 (2018). https://doi.org/10.1186/s40729-018-0151-5
Download citation
Received: 20 May 2018
Accepted: 24 October 2018
Published: 17 December 2018
DOI: https://doi.org/10...
Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were m...
This article contains data obtained during follow-up in a cohort of patients treated with a CE-certified implant in a University Medical Center. Since the product is already approved in accordance with the German Medical Devices Act, no additional ethics approval was not required for treatment. All procedures performed in studies involving human participants were in accordance with the ethical sta...
Department of Oral and Maxillofacial Surgery – Plastic Surgery, University Medical Center, Johannes Gutenberg University of Mainz, Augustusplatz 2, 55131, Mainz, Germany
Sotirios Konstantinos Saridakis, Wilfried Wagner & Robert Noelken
Private Practice for Oral Surgery, Lindau/Lake Constance, Germany
Robert Noelken
You can also search for this author in
PubMed Go...
Not applicable
The work was supported by the Clinic of Oral and Maxillofacial Surgery, University Medical Center, Mainz.
The dataset supporting the conclusions of this article is partially included within the article. The SPSS data can be given on demand of the editor.
Schropp L, Isidor F, Kostopoulos L, Wenzel A. Patient experience of, and satisfaction with, delayed-immediate vs delayed single-tooth implant placement. Clin Oral Implants Res. 2004;15:498–503.
Download references
August M, Chung K, Chang Y, Glowacki J. Influence of estrogen status on endosseous implant osseointegration. J Oral Maxillofac Surg. 2001;59:1285–9.
Hultin M, Gustafsson A, Hallstrom H, Johansson LA, Ekfeldt A, Klinge B. Microbiological findings and host response in patients with periimplantitis. Clin Oral Implants Res. 2002;13:349–58.
Heitz-Mayfield LJA. Peri-implant diseases: diagnosis and...
Chrcanovic BR, Albrektsson T, Wennerberg A. Diabetes and oral implant failure: a systematic review. J Dent Res. 2014;93(9):859–67.
Balshi TJ, Wolfinger GJ. Dental implants in the diabetic patient: a retrospective study. Implant Dent. 1999;8:355–9.
Fiorellini JP, Chen PK, Nevins M, Nevins ML. A retrospective study of dental implants in diabetic patients. Int J Periodontics Restorative Dent. 2...
Kramer FJ, Baethge C, Swennen G, Bremer B, Schwestka-Polly R, Dempf R. Dental implants in patients with orofacial clefts: a long-term follow-up study. Int JOral Maxillofac Surg. 2005;34:715–21.
Ortega-Martinez J, Perez-Pascual T, Mareque-Bueno S, Hernandez-Alfaro F, Ferres-Padro E. Immediate implants following tooth extraction. A systemic review. Med Oral Patol Oral Cir Bucal. 2012;17(2):e251...
U.S. Census Bureau, 2012 Population Estimates and 2014 National Projections. [Zitiert:18.12.2014]. https://www.census.gov/data/tables/2014/demo/popproj/2014-summary-tables.html.
Ikebe K, Wada M, Kagawa R, Maeda Y. Is old age a risk factor for dental implants? Jpn Dent Sci Rev. 2009;45:59–64.
Hu SC, Lan CE. High-glucose environment disturbs the physiologic functions of keratinocytes: focusing o...
This study was based on the recruitment of a quite heterogeneous group of patients treated with NobelActive implants, for the purpose of investigating the influence of local and systemic risk factors on implant survival and marginal bone levels. It can be considered that the presence of local or systemic risk factors does not influence implant survival whereas the combination of local and systemic...
A major weakness of the study is the relative small size of the group with systemic RFs (14 implants by 6 patients) as well as of the group with systematic and local RFs (17 implants by 6 patients). Because of the relative small size of the sample, this study can provide the basis for further investigations based on larger patient samples.
The survival rate for 93 implants in 45 patients with no RFs was 94.8%. Moraschini et al. [44] have exhibited in their systematic review, based on 7711 implants, similar SRs with cumulative mean values of 94.6%. Moreover, in the subcohort of our study, by 44 of the above 93, implants were performed immediate procedures (25 immediate implantations, 35 immediate restorations, 16 both of them) so the...
In one patient with three implants and long intake of corticosteroids against rheumatoid arthritis (7.5 mg prednisolone per day for at least 2 years), no complication was detected in our study. Long-term use of corticosteroids can also lead to implant failures, according to Wood and Vermilyea [34] by modifying the patient’s response to bacterial infection [35], but at the present time, there i...
Most implant studies deal only with local risk factors, although the existence of systemic risk factors plays a significant role to the implant survival. We use the NobelActive dental implant in this study in order to investigate if this promising implant with the special design could achieve better survival rates in difficult situations with several risk factors. The present study revealed no sta...
Regarding the implant shoulder level, the average interproximal marginal bone level was − 0.49 ± 0.83 mm (range, 0 to − 3.3 mm) at the mesial aspect and − 0.51 ± 0.82 mm (range, 0 to − 3.9 mm) at the distal aspect of the implants.
When the marginal bone level was considered as a function of time, there was no strict correlation between the marginal bone status and th...
Ninety-eight patients with 207 implants complied with the treatment protocol attended the follow-up.
During the follow-up period, 15 implants failed in 12 patients. Age and gender were not correlated with a lower implant survival. The implant losses occurred in a time range between 0.5 and 39 months following implant placement (mean 7.3 ± 11.1 months). The reasons for implant failure were ...
Subpopulations within the study group (immediate vs. delayed placement) were compared using the Wilcoxon-Mann-Whitney non-parametric U test. The reported p values were two sided. All calculations were carried out using SPSS for Mac, Version 22 (SPSS Inc., Chicago, IL, USA).
Preservation of all alveolar socket walls via longitudinal extraction after periotomy avoiding oro-vestibular luxation.
Meticulous cleaning of the extraction site.
Placement of rather long implants that allow for a high level of primary stability.
Implant dimensions were as follows: implant length 8.5 mm, 24 implants; 10 mm, 6 implants; 11.5 mm, 64 implants; 13 mm, 80 implants; 15 mm, 31 i...
These patients received a total of 207 NobelActive implants (Nobel Biocare, Zurich, Switzerland) placed by two experienced surgeons. Between November 2011 and February 2015, 188 implants were placed in the maxilla, and 19 implants in the mandible. All implant placement procedures were conducted at the Department of Oral and Maxillofacial Surgery of the University Medical Center, Mainz, Germany. Fi...
One hundred and ten patients were invited for follow-up evaluation. All patients were treated in the period from 10/2008 to 02/2015 in the Clinic of Oral and Maxillofacial Surgery, University Medical Center Mainz. Inclusion criteria were as follows: implant placement of a NobelActive implant, study subjects over 18 years old, residual bone dimension in the edentulous region of at least 5 mm in h...
Primary stability is a prerequisite for successful osseointegration and remains the most significant factor for the survival of dental implants [16]. Therefore, current research focuses on amelioration of existing augmentation techniques and materials or on the development of new implants with self-tapping properties for improving bone contact as well for increasing primary stability.
The aim of ...
Based on published demographic data, the median age of the world population constantly increases [1]. This has led to an increase in the number of dental implants inserted in senior individuals with local and systemic risk factors [2]. Nevertheless, despite numerous studies having been conducted on this topic, the results remain controversial, almost 50 years after the first dental implant placem...
This retrospective study examined the mid- to long-term clinical and radiographic performance of a tapered implant in various treatment protocols in patients with local and systemic risk factors (RFs).
Two hundred seven NobelActive implants were inserted in 98 patients in the period from 10/2008 to 02/2015. The subdivision of the cohort was defined by local (n = 40), systemic (n = 6), loc...
Author
Year
Study type
Selection bias (homogeneity and confounders)
Performance bias (fidelity to protocol)
Attrition bias (loss of participants)
Detection bias (reliable measures)
Reporting bias (selective reporting or conflict interests)
Summary assessment risk of bias
Alsaadi
2007
Retrospective
H
U
U
L
L
L
Aguilar-Salvatierra
2015
Prospective
H
L
L
L
L...
Table 1 List of the included studies and its main characteristics
Author
Year
Study type
Diabetes type
Control
Diabetes therapy
Glycemic control [HbA1c %]
Duration of diabetes (years)
Number of patients
Number of implants
Duration of study (years)
Implant survival [%]
Conclusion
Alsaadi
2007
Retrospective
Type II
Non-diabetes
n.d.
n.d.
n.d.
2004 (overall)
6...
Figure 1. Selection process of the included literature
References
Moraschini V, Poubel LA, Ferreira VF, Barboza Edos S. Evaluation of survival and success rates of dental implants reported in longitudinal studies with a follow-up period of at least 10 years: a systematic review. Int J Oral Maxillofac Surg. 2015;44(3):377–88.
Khader YS, Dauod AS, El-Qaderi SS, Alkafajei A, Batayha WQ. Periodontal status of diabetics compared with nondiabetics...
Conclusions
The literature included to this review is very heterogeneous concerning the investigated objects, methods, and conclusions. Diabetes is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. When looking at the complications and side effects resulting from diabetes, it is important to know which type of diabetes the pati...
While four studies conclude better implant survival and less peri-implant complications in the well-controlled group, the three others see no difference in implant success even in the poorly controlled patients. The study of Khandelwal treated exclusively patients with poor glycemic control (HbA1c 7.5–11.4 %) and had 98 % implant survival, after 4 months; therefore, he concluded that impla...
Diabetes and bone augmentation
We identified two prospective studies that evaluated “advanced” implant surgery covering sinus lift procedure and guided bone regeneration.
The study of Erdogan consists of type II diabetics moderately and well-controlled (HbA1c 6–7.5 %) with a mean duration of disease of 7.5 years and a healthy control group. Augmentation of the maxilla was perform...
The bleeding on probing is more often in the poorly controlled population, but the probing depth is not increased.
Diabetes and implant survival
Implant survival is an easily defined and measured endpoint for dental implant therapy. Nearly every study reports its implant survival rate. Our literature search identified 18 publications with these data. We divided them into two groups: the ...
The results in the prospective study of Gomez-Moreno show that elevated HbA1c causes more bone resorption after 3 years, but this effect is not significant.
We identified two prospective studies investigating the influence of type II diabetes on osseointegration.
They are published by the same author but are independent studies from different years. In both studies, the patients included...
Results
Study selection
There are no guidelines existing to the topic of dental implants and diabetes mellitus. A total of 327 potentially relevant titles and abstracts were found by the electronic search and additional evaluation of reference lists. During the first screening, 230 publications were excluded based on the title and keywords. Additionally, 24 titles were excluded based on abstract...
Materials and methods
The substructure of the systematic review is based on the PRISMA statement. The focused question according to the PICO schema is: “Do diabetic patients with dental implants have a higher complication rate in comparison to healthy controls?”
Search strategies
The systematic literature search was performed by an independent scientist (Burkhard Kunzendorf). The following ...
Review
Introduction
Today, dental implants are one of the restorative methods to replace missing teeth. Improvements in implant design, surface characteristics, and surgical protocols made implants a secure and highly predictable procedure with a mean survival rate of 94.6 % and a mean success rate of 89.7 % after more than 10 years. Implant survival is initially dependent on successful osseoi...
Abstract
Dental implant surgery has developed to a widely used procedure for dental rehabilitation and is a secure and predictable procedure. Local and systemic risk factors can result in higher failure rates. Diabetes mellitus is a chronic disease that goes in with hyperglycemia and causes multifarious side effects. Diabetes as a relative contraindication for implant surgery is controversially...
While four studies conclude better implant survival and less peri-implant complications in the well-controlled group, the three others see no difference in implant success even in the poorly controlled patients. The study of Khandelwal treated exclusively patients with poor glycemic control (HbA1c 7.5–11.4 %) and had 98 % implant survival, after 4 months; therefore, he concluded that implant the...
Diabetes and bone augmentation
We identified two prospective studies that evaluated “advanced” implant surgery covering sinus lift procedure and guided bone regeneration. The study of Erdogan consists of type II diabetics moderately and well-controlled (HbA1c 6–7.5 %) with a mean duration of disease of 7.5 years and a healthy control group. Augmentation of the maxilla was performed by g...
The bleeding on probing is more often in the poorly controlled population, but the probing depth is not increased.
Diabetes and implant survival
Implant survival is an easily defined and measured endpoint for dental implant therapy. Nearly every study reports its implant survival rate. Our literature search identified 18 publications with these data. We divided them into two groups: the first on...
We identified two prospective studies investigating the influence of type II diabetes on osseointegration. They are published by the same author but are independent studies from different years. In both studies, the patients included were stratified by HbA1c levels as well-controlled (HbA1c 6.1–8 %), moderately controlled (HbA1c 8.1–10 %), and poorly controlled (HbA1c ≥10 %).
The healthy...
Materials and methods
The substructure of the systematic review is based on the PRISMA statement. The focused question according to the PICO schema is: “Do diabetic patients with dental implants have a higher complication rate in comparison to healthy controls?”
Search strategies
The systematic literature search was performed by an independent scientist (Burkhard Kunzendorf). The follow...
Conclusions
The literature included to this review is very heterogeneous concerning the investigated objects, methods, and conclusions. Diabetes is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. When looking at the complications and side effects resulting from diabetes, it is important to know which type of diabetes the patient suffers from, if...
Results
Study selection
There are no guidelines existing to the topic of dental implants and diabetes mellitus. A total of 327 potentially relevant titles and abstracts were found by the electronic search and additional evaluation of reference lists. During the first screening, 230 publications were excluded based on the title and keywords. Additionally, 24 titles were excluded based on abstract...
Introduction
Today, dental implants are one of the restorative methods to replace missing teeth. Improvements in implant design, surface characteristics, and surgical protocols made implants a secure and highly predictable procedure with a mean survival rate of 94.6 % and a mean success rate of 89.7 % after more than 10 years. Implant survival is initially dependent on successful osseointegration...
Abstract
Dental implant surgery has developed to a widely used procedure for dental rehabilitation and is a secure and predictable procedure. Local and systemic risk factors can result in higher failure rates. Diabetes mellitus is a chronic disease that goes in with hyperglycemia and causes multifarious side effects. Diabetes as a relative contraindication for implant surgery is controversially...
Penelitian pada manusia
Penelitian-penelitian eksperimental pada manusia telah mengevaluasi respons terhadap penumpukan biofilm 3 minggu, sesuai dengan kerangka kala penelitian gingivitis eksperimental oleh Löe et al., di mana reversibilitas lesi radang di seputar gigi ditunjukkan setelah reinstitusi kontrol biofilm setelah 3 minggu. Ada penelitian yang melaporkan biopsi manusia dari jaringan pe...
Indikator risiko
Publiskasi
Ringkasan
Rasio ganjil (95% CI), analisis multivariat
Signifikansi
Keberadaan biofilm plak
Roos‐Jansaker et al.
218 subyek, 9 tahun sampai 14 tahun tindak lanjut, analisis multivariat
1.9 (1.2 –2.9)
P = 0.004
Skor plak:
buruk = skor plak median 1 < x < 2
Ferreira et al.
212 subyek semua non‐smokers, 6 bulan sampai 5 tah...
Persamaan & perbedaan antara indikator / faktor risiko untuk penyakit periodontal vs mukositis peri-implant
Tinjauan sistematis terbaru merinkes indikator risiko potensial untuk mukositis peri-implant dan mengidentifikasi penumpukan biofilm dan merokok sebagai indikator risiko. Selain itu, penelitian lintas bagian menunjukkan bahwa skor plak merupakan indikator risiko mukositis peri-implant den...
Desain prostesis yang didukung implant
Aksesibilitas untuk penghapusan biofilm di sekeliling prostesis yang didukung implant memainkan peran penting dalam upaya pencegahan dan penatalaksanaan penyakit peri‐implant. Implant dengan margin restorasi supramukosa metokke penurunan kedalaman probing yang jauh lebih besar setelah perawatan mukositis peri-implant dibandingkan implant dengan margin rest...
Pada pasien edentula sebagian, mukositis peri-implant pra-ada yang disertai dengan kurangnya kepatuhan pada SIT punya hubungan dengan tingkat kejadian peri-implantitis yang lebih tinggi selama periode tindak lanjut 5 tahun. Weton penelitian itu metokke tingkat kejadian peri-implantitis 5 tahun sebesar 18.0% pada kelompok pasien dengan SIT dan 43.9% dalam kelompok tanpa SIT. Analisis regresi logi...
Kebersihan mulut
Weton penelitian klinis penampang telah dengan jelas menunjukkan bahwa penumpukan biofilm berkaitan dengan adanya mukositis peri-implant di seputar implant gigi yang ter-osseointegrata. Ferreira et al melaporkan tentang 212 pasien yang dirawat dengan tiga sistem implant yang berbeda dan didiagnosis dengan mukositis peri-implant. Semua implant telah berfungsi untuk jangka wayah mu...
Pada Lokakarya Buana sebelumnya tentang Periodontologi, definisi faktor risiko disetujui sebagai "faktor lingkungan, perilaku, atau biologis yang dikonfirmasi oleh urutan temporal, biasanya dalam studi longitudinal, yang jika ada, secara langsung meningkatkan peluang penyakit terjadi dan, jika tidak ada atau dihapus mengurangi peluang itu." Untuk mengidentifikasi faktor risiko yang sebenarnya, but...
Penelitian eksperimental pada manusia dan sato telah menunjukkan bahwa penumpukan biofilm de novo memicu lesi radang dalam mukosa peri-implant dengan migrasi leukosit melalui epitel penghalang dan pembentukan infiltrat radang dengan peningkatan proporsi sel T dan sel B di dalam jaringan ikat yang berada dekat dengan epitel penghalang.
Model sato
Model mukositis peri-implant eksperimental telah...
Meskipun hubungan daruna-daruni antara akumulasi biofilm eksperimental dan pengembangan mukositis peri-implant eksperimental diklaim dalam dua penelitian yang disebutkan sebelumnya, kasus untuk hubungan daruna-daruni yang sebenarnya akan diperosa oleh bukti reversibilitas untuk tingkat pra-eksperimental kesarasan mukosa.
Dalam penelitian oleh Salvi et al, GI di situs implant turun secara signifik...
Mukosa peri-implant yang saras ditandai dengan adanya epitel oral yang meluas ke epitel penghalang non-keratin dengan lamina basal dan hemidesmosome yang menghadap ke permukaan implant atau abutmen. Dalam jaringan ikat yang berdekatan dengan penghalang epitel, ada infiltrat sel radang yang menyulihi pertahanan inang terhadap tantangan bakteri. Dalam kondisi mukosa peri-implant yang saras, epitel p...
Gingivitis
Mukositis peri‐implant
Pengertian
Peradangan gingival tanpa susut perlekatan periodontal
Peradangan mukosa peri‐implant tanpa penyusutan tulang peri-implant berkelanjutan
Tanda klinis
Kemerahan, bengkak, dan perdarahan dengan probing lembut
Kemerahan, bengkak, perdarahan dengan probing lembut, dan nanah
Peradangan eksperimental pada manusia
P...
Mukosa peri-implan telah didefinisikan dalam lokakarya sebelumnya sebagai lesi inflamasi mukosa yang mengelilingi implant endosseous tanpa kehilangan tulang peri-implant pendukung. Kriteria penting untuk pengertian mukositis peri-implant adalah peradangan pada mukosa peri-implant dan tidak adanya keropos tulang peri-implant marjinal yang berkelanjutan. Tanda klinis peradangan adalah pendarahan pad...
Pencarian literatur MEDLINE (PubMed) dan The Cochrane Library hingga dan termasuk 31 Juli 2016, dilakukan menggunakan strategi pencarian (peri-implant[All Fields] AND ("mucositis"[MeSH Terms] OR "mucositis"[All Fields])) OR (periimplant[All Fields] AND mucositis[All Fields]), memunculkan 224 karya kawidyan. Penelitian prospektif, retrospektif, dan lintas bidang dan karya tinjauan yang berfokus pad...
Penyakit peri-implant, termasuk peri-implant mucositis dan peri-implantitis, pertama kali didefinisikan dan dijelaskan pada Lokakarya Eropa Pertama tentang Periodontologi di Ittingen pada tahun 1993. Setelah itu, ada banyak lokakarya yang medhar definisi, kelumrahan, dan pengobatan penyakit ini. penyakit. Mucositis peri-implan dianggap sebagai prekursor peri-implantitis. Tujuan dari tinjauan narat...
Tujuan
Tinjauan naratif ini disiapkan untuk Lokakarya Buana 2017 Akademi Periodontologi Amerika dan Federasi Periodontologi Eropa untuk menanggapi pertanyaan-pertanyaan kunci terkait dengan kondisi klinis mukositis peri-implant, termasuk:
definisi mukositis peri-implant,
perubahan kesarasan peri-implant jadi lesi mukositis peri-implant yang diinduksi oleh biofilm,
reversibilitas mukositis ...
Gambar 1. Peri-implant mucositis vs peri-implantitis vs peri-implant health
Risk indicator
Publication
Summary
Odds ratio (95% CI), multivariate analysis
Significance
Plaque biofilm presence
Roos‐Jansaker et al.
218 subjects, 9‐ to 14‐year follow‐up, multivariate analysis
1.9 (1.2 –2.9)
P = 0.004
Plaque score: poor = median plaque score > 1 and
SIMILARITIES AND DIFFERENCES BETWEEN RISK INDICATORS/FACTORS FOR PERIODONTAL DISEASES VERSUS PERI‐IMPLANT MUCOSITIS
A recent systematic review summarized potential risk indicators for peri‐implant mucositis and identified biofilm accumulation and smoking as risk indicators. In addition, a cross‐sectional study showed that plaque score was a risk indicator for peri‐implant mucositis in a...
Design of implant‐supported prostheses
Accessibility for biofilm removal around implant‐supported prostheses plays an important role in the prevention and management of peri‐implant diseases. Implants with supramucosal restoration margins yielded significantly greater reductions in probing depths following treatment of peri‐implant mucositis compared with those with submucosal restoration...
In partially edentulous patients, pre‐existing peri‐implant mucositis in conjunction with lack of adherence to SIT was associated with a higher incidence of peri‐implantitis during a 5‐year follow‐up period. The outcomes of that study yielded a 5‐year incidence of peri‐implantitis of 18.0% in the group of patients with SIT and of 43.9% in the group without SIT, respectively. The ...
Oral hygiene
Outcomes of cross‐sectional clinical studies have clearly indicated that biofilm accumulation is associated with the presence of peri‐implant mucositis around osseointegrated dental implants. Ferreira et al. reported on 212 patients treated with three different implant systems and diagnosed with peri‐implant mucositis. All implants had been in function for a period ranging f...
At a previous World Workshop on Periodontology the definition of a risk factor was agreed as, “an environmental, behavioral or biologic factor confirmed by temporal sequence, usually in longitudinal studies, which if present, directly increases the probability of a disease occurring and, if absent or removed reduces that probability.” To identify a true risk factor, prospective studies are req...
Experimental studies in humans and animals have demonstrated that de novo biofilm accumulation results in an inflammatory lesion within the peri‐implant mucosa with migration of leukocytes through the barrier epithelium and the establishment of an inflammatory infiltrate with an increased proportion of T‐ and B‐cells in the connective tissue adjacent to the barrier epithelium.
Animal mod...
Although a cause–effect relationship between experimental biofilm accumulation and the development of experimental peri‐implant mucositis was claimed in the two studies mentioned previously, the case for a true cause–effect relationship would be strengthened by the proof of reversibility to pre‐experimental levels of mucosal health. In the study by Salvi et al., the GI at implant sites dr...
Healthy peri‐implant mucosa is characterized by the presence of an oral epithelium extending into a non‐keratinized barrier epithelium with basal lamina and hemidesmosomes facing the implant or abutment surface. In the connective tissue adjacent to the epithelial barrier, inflammatory cell infiltrates representing the host's defense against the bacterial challenge are present. In healthy peri...
Gingivitis
Peri‐implant mucositis
Definition
Gingival inflammation without periodontal attachment loss
Peri‐implant mucosal inflammation in absence of continuous marginal peri‐implant bone loss
Clinical signs
Redness, swelling, and bleeding on gentle probing
Redness, swelling, bleeding on gentle probing, and suppuration
Experimental inflammation in humans
I...
Peri‐implant mucositis has been defined in previous workshops as an inflammatory lesion of the mucosa surrounding an endosseous implant without loss of supporting peri‐implant bone. The important criteria for the definition of peri‐implant mucositis are inflammation in the peri‐implant mucosa and the absence of continuing marginal peri‐implant bone loss. The clinical sign of inflammation...
A literature search of MEDLINE (PubMed) and The Cochrane Library up to and including July 31, 2016, was carried out using the search strategy (peri‐implant[All Fields] AND (“mucositis”[MeSH Terms] OR “mucositis”[All Fields])) OR (periimplant[All Fields] AND mucositis[All Fields]), resulting in 224 papers. Prospective, retrospective, and cross‐sectional studies and review papers focused...
Peri‐implant diseases, including peri‐implant mucositis and peri‐implantitis, were first defined and described at the First European Workshop on Periodontology in Ittingen in 1993. Following this, there have been numerous workshops addressing the definition, prevalence, and treatment of these diseases. Peri‐implant mucositis is considered to be the precursor of peri‐implantitis. The ob...
Objectives
This narrative review was prepared for the 2017 World Workshop of the American Academy of Periodontology and European Federation of Periodontology to address key questions related to the clinical condition of peri‐implant mucositis, including: 1) the definition of peri‐implant mucositis, 2) conversion of peri‐implant health to the biofilm‐induced peri‐implant mucositis lesi...